当前位置： SCI文献检索 > IMMUNOLOGY AND CELL BIOLOGY期刊下所有文献 > Modulation of experimental allergic encephalomyelitis in mice by immunization with a peptide specific for the gamma delta T cell receptor.

Modulation of experimental allergic encephalomyelitis in mice by immunization with a peptide specific for the gamma delta T cell receptor.

Abstract：

:This study investigated the role of gamma delta T cells in experimental allergic encephalomyelitis (EAE), a chronic inflammatory disease of the central nervous system (CNS) that resembles multiple sclerosis. The strategy was to assess the effect on EAE of TCR peptide immunization directed against V gamma 6 T cells, shown recently to predominate in the CNS of mice during the early stages of EAE. The data show that TCR peptide immunization specific for V gamma 6 chains does not induce protection against EAE, since the incidence of EAE in TCR treated animals was similar to control mice, and therefore does not affect disease susceptibility per se, but rather alters the development of the disease. Specifically, there was a delay in the onset of EAE and a reduction in disease severity in TCR treated animals, although the effects were not highly significant. These findings suggest a role for gamma delta T cells in the development of EAE; however, further studies are necessary to confirm the specificity of TCR peptide immunization.

journal_name

Immunol Cell Biol

journal_title

Immunology and cell biology

authors

Olive C

doi

10.1038/icb.1997.14

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

102-6

issue

1

eissn

0818-9641

issn

1440-1711

journal_volume

75

pub_type

杂志文章

相关文献

IMMUNOLOGY AND CELL BIOLOGY文献大全
  • Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection.

    abstract：:The present report provides the first extensive characterization of the OT-I TCR transgenic line, which produces MHC class I-restricted, ovalbumin-specific, CD8+ T cells (OT-I cells). These cells are shown to be positively selected in vivo in H-2b C57BL/6 mice and in bm5 mice, which express the Kbm5 mutant molecule. I...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2000.00889.x

    authors： Clarke SR,Barnden M,Kurts C,Carbone FR,Miller JF,Heath WR

    更新日期：2000-04-01 00:00:00

  • T-cell activation RhoGTPase-activating protein plays an important role in TH17-cell differentiation.

    abstract：:T-cell activation RhoGTPase-activating protein (TAGAP) is a GTPase-activating protein specific for RhoA that is exclusively expressed in activated T cells. Genome-wide association studies and metagenome SNPs analyses have indicated that TAGAP is associated with the pathogenesis of multiple autoimmune diseases, includi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2017.27

    authors： Tamehiro N,Nishida K,Yanobu-Takanashi R,Goto M,Okamura T,Suzuki H

    更新日期：2017-09-01 00:00:00

  • T cell response to grass pollen allergens: correlation with skin test reactivity and serum IgE levels.

    abstract：:T cell proliferative responses to rye and Bermuda grass pollen allergens have been studied in a series of 51 atopic and 18 non-atopic subjects. Mean T cell responses were higher in the atopic group than in the non-atopic group (P < 0.001), and there was a strong correlation between the magnitude of reaction in the T c...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1995.3

    authors： Blaher B,McCluskey J,Puy R,Czarny D,Rolland JM

    更新日期：1995-02-01 00:00:00

  • Can MHC class II genes mediate resistance to type 1 diabetes?

    abstract：:Numerous studies have associated carriage of HLA-DRB1*1501, DQA1*0102 and DQB1*0602 (DR15, DQ6) with dominant resistance to type 1 diabetes and have concluded that one or more of the component HLA class II molecules mediate this effect. Mechanisms for MHC class II-mediated resistance to diabetes have been proposed fro...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2001.01043.x

    authors： Price P,Cheong KY,Boodhoo A,Witt CS,McCann V,Christiansen FT,Allcock RJ

    更新日期：2001-12-01 00:00:00

  • Natural killer and natural cytotoxic cells are present at the maternal-fetal interface during murine pregnancy.

    abstract：:NK cell activity has been detected in the early murine decidua, and hypothesized to be mediated by granulated metrial gland (GMG) cells. The possibility that natural cytotoxic (NC) cells are also present in the decidua has not been investigated. In this study mAb to NK cells (anti-NK-1.1) and NC cells (anti-NC-1.1) we...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1994.23

    authors： Clarke GR,Roberts TK,Smart YC

    更新日期：1994-04-01 00:00:00

  • CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation.

    abstract：:Natural killer (NK) cells are part of the first line defense against tumors, parasites and virus-infected cells. Therefore, factors that control NK-cell numbers and their function are important. CD27 is constitutively expressed on NK cells and its expression correlates with sequential phases in NK-cell development, di...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2010.171

    authors： De Colvenaer V,Taveirne S,Delforche M,De Smedt M,Vandekerckhove B,Taghon T,Boon L,Plum J,Leclercq G

    更新日期：2011-10-01 00:00:00

  • Development of a nasal vaccine for chronic hepatitis B infection that uses the ability of hepatitis B core antigen to stimulate a strong Th1 response against hepatitis B surface antigen.

    abstract：:There are estimated to be 350 million chronic carriers of hepatitis B infection worldwide. Patients with chronic hepatitis B are at risk of liver cirrhosis with associated mortality because of hepatocellular carcinoma and other complications. An important goal, therefore, is the development of an effective therapeutic...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.0818-9641.2004.01278.x

    authors： Aguilar JC,Lobaina Y,Muzio V,García D,Pentón E,Iglesias E,Pichardo D,Urquiza D,Rodríguez D,Silva D,Petrovsky N,Guillén G

    更新日期：2004-10-01 00:00:00

  • T cells recognizing a 11mer influenza peptide complexed to H-2D(b) show promiscuity for peptide length.

    abstract：:T-cell repertoire is selected according to self peptide-MHC (major histocompatibility complex) complexes in the thymus. Although most peripheral T cells recognize specific pathogen-derived peptides complexed to self-MHC exclusively, some possess cross-reactivity to other self or foreign peptides presented by self-MHC ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2014.113

    authors： Zanker D,Quinn K,Waithman J,Lata R,Murphy R,La Gruta NL,Chen W

    更新日期：2015-05-01 00:00:00

  • Human natural killer (NK) cells: requirements for cell proliferation and expansion of phenotypically novel subpopulations.

    abstract：:Previous studies established that the high density (resting) natural killer (NK) cell subset (R-NK) of peripheral blood NK cells is unresponsive to interleukin-2 (IL-2) but can be induced to proliferate when cultured with gamma-irradiated malignant melanoma (MM-170) cells or mitomycin-C-treated activated T cells in th...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1993.9

    authors： Warren HS,Kinnear BF,Skipsey LJ

    更新日期：1993-04-01 00:00:00

  • Lymphocyte activation as measured by interleukin-2 receptor expression to gluten fraction 111 in coeliac disease.

    abstract：:Lymphocyte activation was examined by interleukin-2 (IL-2) receptor expression on peripheral blood mononuclear cells from coeliac and control subjects. Purified T cells were incubated with gluten fraction 111 (a known toxic peptide for coeliac subjects), soyabean hydrolysate (an unrelated hydrolysed food antigen), and...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1990.22

    authors： Penttila IA,Gibson CE,Forrest BD,Cummins AG,LaBrooy JT

    更新日期：1990-06-01 00:00:00

  • Expression of the T cell receptor delta-chain repertoire in mouse lymph node.

    abstract：:Despite the potential for extensive diversity of gamma delta TCR, especially for delta-chains, expression of the gamma delta TCR repertoire in various mouse epithelial tissues is highly restricted. This implies that the recognition of antigen by gamma delta T cells may also be limited. To date, however, few studies ha...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1996.56

    authors： Olive C

    更新日期：1996-08-01 00:00:00

  • FOXO3 is differentially required for CD8+ T-cell death during tolerance versus immunity.

    abstract：:Peripheral tolerance mechanisms limit autoimmunity by constitutively eliminating self-reactive CD8+ T cells from the periphery in a process called deletion. Previous work has demonstrated that this deletion process is mediated by BIM-dependent apoptotic death due to transcriptional induction of the Bim gene. Currently...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2016.53

    authors： Wagle MV,Parish IA

    更新日期：2016-10-01 00:00:00

  • Production of interleukin-1 alpha and interleukin-2 by separate, phenotypically different leukaemia and human T cell lymphotropic virus-1-transformed T cell clones.

    abstract：:The relationship between interleukin-1 (IL-1) and interleukin-2 (IL-2) production and immunophenotype marker profiles was studied in a panel of 29 leukaemia and human T cell lymphotropic virus-1 (HTLV-1)-transformed T cell lines. Culture supernatants from six of the 29 T cell lines tested increased IL-2 production by ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1993.56

    authors： Holán V,Minowada J

    更新日期：1993-12-01 00:00:00

  • Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo.

    abstract：:Lethal giant larvae-1 (Lgl-1) is an evolutionary conserved protein that regulates cell polarity in diverse lineages; however, the role of Lgl-1 in the polarity and function of immune cells remains to be elucidated. To assess the role of Lgl-1 in T cells, we generated chimeric mice with a hematopoietic system deficient...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2015.82

    authors： Ramsbottom KM,Sacirbegovic F,Hawkins ED,Kallies A,Belz GT,Van Ham V,Haynes NM,Durrant MJ,Humbert PO,Russell SM,Oliaro J

    更新日期：2016-03-01 00:00:00

  • Regulation of human Th9 differentiation by type I interferons and IL-21.

    abstract：:Interleukin (IL)-9-producing CD4(+) T cells are a novel subset of T helper (Th) cells that develops independently of the Th1, Th2, Th17 and regulatory T-cell lineages. Similar to the murine model, transforming growth factor (TGF)-beta and IL-4 directed human naive CD4(+) T cells to produce IL-9. Whereas IL-4 suppresse...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2010.53

    authors： Wong MT,Ye JJ,Alonso MN,Landrigan A,Cheung RK,Engleman E,Utz PJ

    更新日期：2010-08-01 00:00:00

  • Long-term stroma-dependent cultures are a consistent source of immunostimulatory dendritic cells.

    abstract：:A long-term culture (LTC) system has been established that supports the continuous production of dendritic cells (DC) from haemopoietic cells present in the culture. The production of cells depends on the presence of an intact stromal cell layer containing a mixture of fibroblasts and endothelial cells. Cells are shed...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1711.1999.00851.x

    authors： O'Neill HC,Ni K,Wilson H

    更新日期：1999-10-01 00:00:00

  • Secretory products from infective forms of Nippostrongylus brasiliensis induce a rapid allergic airway inflammatory response.

    abstract：:Allergic asthma is responsible for widespread morbidity and mortality and its incidence has increased dramatically in industrialized countries over the past two decades. Here, we describe a new murine model of allergic asthma utilizing a novel allergen with intrinsic enzymatic activity similar to that reported for man...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2004.01303.x

    authors： Marsland BJ,Camberis M,Le Gros G

    更新日期：2005-02-01 00:00:00

  • Human cytomegalovirus UL7, a homologue of the SLAM-family receptor CD229, impairs cytokine production.

    abstract：:Human cytomegalovirus (HCMV), the β-herpesvirus prototype, has evolved a wide spectrum of mechanisms to counteract host immunity. Among them, HCMV uses cellular captured genes encoding molecules capable of interfering with the original host function or of fulfilling new immunomodulatory tasks. Here, we report on UL7, ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2011.55

    authors： Engel P,Pérez-Carmona N,Albà MM,Robertson K,Ghazal P,Angulo A

    更新日期：2011-10-01 00:00:00

  • Immune stimulating complexes as mucosal vaccines.

    abstract：:There is a need for non-living adjuvant vectors that will allow a full range of local and systemic immune responses to orally administered purified antigens. Here we describe our experience with lipophilic immune-stimulating complexes (ISCOMs) containing the saponin adjuvant Quil A. When given orally, ISCOMs containin...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1711.1998.00749.x

    authors： Smith RE,Donachie AM,Mowat AM

    更新日期：1998-06-01 00:00:00

  • Single-chain antibody variable region-targeted interleukin-2 stimulates T cell killing of human colorectal carcinoma cells.

    abstract：:Recombinant DNA techniques were used to clone, construct and express the bifunctional molecule FV/IL-2. The FV/IL-2 is a single-chain 37 kDa fusion protein expressed in Escherichia coli under control of the strong T7 bacteriophage promoter in the expression vector pT7-7-FV-IL-2. The fused gene fragment FV-IL-2 contain...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1994.42

    authors： Xiang J,Liu E,Moyana T,Qi Y

    更新日期：1994-08-01 00:00:00

  • Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies.

    abstract：:Ikaros, Aiolos and Helios encode zinc finger transcription factors that are important regulators of lymphoid development and differentiation. These proteins are involved in the control of gene expression and when associated with nuclear complexes, participate in nucleosome remodeling. Because differential splicing pro...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1711.2003.01159.x

    authors： Rebollo A,Schmitt C

    更新日期：2003-06-01 00:00:00

  • Gαs-coupled GPCRs GPR65 and GPR174. Downers for immune responses.

    abstract：:See also: Outstanding Observation by Wirasinha et al., Short Communication by Barnes & Cyster. ...

    journal_title：Immunology and cell biology

    pub_type： 评论,杂志文章

    doi：10.1111/imcb.12027

    authors： Robert R,Mackay CR

    更新日期：2018-04-01 00:00:00

  • Production of a recombinant form of early pregnancy factor that can prolong allogeneic skin graft survival time in rats.

    abstract：:Early pregnancy factor (EPF), an extracellular chaperonin 10 homologue, has immunosuppressive and growth factor properties. In order to carry out more extensive studies on the in vivo characteristics of EPF, a recombinant form of the molecule has been prepared. Recombinant human EPF (rEPF) was expressed in Escherichia...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2000.00951.x

    authors： Morton H,McKay DA,Murphy RM,Somodevilla-Torres MJ,Swanson CE,Cassady AI,Summers KM,Cavanagh AC

    更新日期：2000-12-01 00:00:00

  • The cellular mechanism by which complementary Id+ and anti-Id antibodies communicate: T cells integrated into idiotypic regulation.

    abstract：:The V region antigenic determinants (idiotopes (Ids)) of antibodies (Abs) have been suggested to be involved in regulating the immune system. Certain diseases such as diabetes mellitus have recently been associated with a disequilibrium between Id(+) and anti-Id Abs. However, it is unknown how Abs carrying complementa...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2009.118

    authors： Jacobsen JT,Lunde E,Sundvold-Gjerstad V,Munthe LA,Bogen B

    更新日期：2010-07-01 00:00:00

  • Moving candidate vaccines into development from research: lessons from HIV.

    abstract：:There is a logarithmic increase in the cost and complexity of the research and development process when transitioning a promising candidate vaccine from the laboratory into the clinic. Managing complex development programs involving people from diverse technical, cultural and geographical backgrounds is a specialised ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2009.30

    authors： Sullivan M

    更新日期：2009-07-01 00:00:00

  • Exogenous, TAP-independent lysosomal presentation of a respiratory syncytial virus CTL epitope.

    abstract：:Respiratory syncytial virus causes lower respiratory tract infections in infancy and old age, affecting also immunocompromised patients. The viral fusion protein is an important vaccine candidate eliciting antibody and cell-mediated immune responses. CD8(+) cytotoxic T lymphocytes (CTLs) are known to have a role in bo...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2012.43

    authors： Johnstone C,Ramos M,García-Barreno B,López D,Melero JA,Del Val M

    更新日期：2012-11-01 00:00:00

  • Characterization of a bioassay for detection of recombinant and native ovine interleukin-5.

    abstract：:In order to analyse Th2-type immune responses in sheep by the assay of interleukin (IL)-5 in biological fluids, the ovine IL-5 gene was cloned and expressed in Spodoptera frugiperda Sf9 insect cells using the baculovirus expression vector system. The recombinant product was purified as BAC-OV-IL-5 from the supernatant...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.1999.00831.x

    authors： Bosward K,Emery DL,McWaters PW,Husband AJ,Bendixsen T

    更新日期：1999-08-01 00:00:00

  • Th17 cells are not required for maintenance of IL-17A-producing γδ T cells in vivo.

    abstract：:γδ T cells producing interleukin-17A (γδT17) are thought to develop spontaneously in the thymus and to be maintained in the periphery. Previous studies suggested a role for T-helper 17 (Th17) cells in the maintenance of γδT17 via the expression of transforming growth factor-β1 (TGFβ1). However, we have previously foun...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2016.94

    authors： Gupta PK,Wagner SR,Wu Q,Shilling RA

    更新日期：2017-03-01 00:00:00

  • Listeria species escape from the phagosomes of interleukin-4-deactivated human macrophages independent of listeriolysin.

    abstract：:Listeria monocytogenes is the causative agent of infections like sepsis and meningitis, especially in immunocompromised hosts. Human macrophages are able to phagocytose and digest L. monocytogenes but IL-4 prevents human macrophages from killing the bacteria, the mechanisms of which are unknown. In the present study, ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1711.2003.01196.x

    authors： Neumann K,Eppler E,Filgueira L,Groscurth P,Gasal E,Schaffner A,Schoedon G,Schneemann M

    更新日期：2003-12-01 00:00:00

  • Excretory-secretory antigens from adult Nematospiroides dubius.

    abstract：:Adult Nematospiroides dubius excretory-secretory (ES) products were collected from worms cultured in vitro, radiolabelled and separated by sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE). The components were characterized and assessed for molecular weight (MW) after autoradiography and gel staining, for a...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1989.16

    authors： Monroy FG,Adams JH,East IJ,Dobson C

    更新日期：1989-04-01 00:00:00