Gαs-coupled GPCRs GPR65 and GPR174. Downers for immune responses.

abstract：:The molecular interactions between the T-cell receptor (TCR) and peptide-MHC (pMHC) have been elucidated in recent years. Nevertheless, the fact that binding of only slightly different ligands by a TCR, or ligation of the same pMHC at different developmental stages of the T cell, can have opposing consequences, contin...

journal_title：Immunology and cell biology

authors： Regner M

更新日期：2001-04-01 00:00:00

abstract：:Previous studies established that the high density (resting) natural killer (NK) cell subset (R-NK) of peripheral blood NK cells is unresponsive to interleukin-2 (IL-2) but can be induced to proliferate when cultured with gamma-irradiated malignant melanoma (MM-170) cells or mitomycin-C-treated activated T cells in th...

journal_title：Immunology and cell biology

authors： Warren HS,Kinnear BF,Skipsey LJ

更新日期：1993-04-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) and urokinase-type plasminogen activator (uPA) can contribute to the progression of chronic inflammatory diseases with possible involvement of macrophages. In this study, we investigated the role of both GM-CSF and uPA in Porphyromonas gingivalis-induced experi...

journal_title：Immunology and cell biology

authors： Lam RS,O'Brien-Simpson NM,Hamilton JA,Lenzo JC,Holden JA,Brammar GC,Orth RK,Tan Y,Walsh KA,Fleetwood AJ,Reynolds EC

更新日期：2015-09-01 00:00:00

abstract：:The Kunjin replicon was used to express a polytope that consisted of seven hepatitis C virus cytotoxic T lymphocyte epitopes and one influenza cytotoxic T lymphocyte epitope for vaccination studies. The self-replicating nature of, and expression from, the ribonucleic acid was confirmed in vitro. Initial vaccinations w...

journal_title：Immunology and cell biology

authors： Ward SM,Tindle RW,Khromykh AA,Gowans EJ

更新日期：2003-02-01 00:00:00

abstract：:Immunization of Lewis rats with guinea-pig myelin basic protein (Gp-MBP) induced T cell responses to primary and secondary encephalitogenic determinants, as well as to a third non-encephalitogenic epitope, residues 55-69. This sequence is of interest due to its protective activity against experimental autoimmune encep...

journal_title：Immunology and cell biology

authors： Vandenbark AA,Chou YK,Whitham R,Bourdette DN,Offner H

更新日期：1998-02-01 00:00:00

abstract：:Viral infections can disturb the functions of adipose tissues and thus result in metabolic diseases. Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRR...

journal_title：Immunology and cell biology

authors： Yu L,Liu G,Yang C,Song X,Wang H

更新日期：2016-10-01 00:00:00

abstract：:Genetic fusion of tandem repeats of the complement molecule C3d has been shown to considerably enhance immune responses to genetic vaccines. We have investigated the applicability of this approach to augment humoral immune responses toward vaccines delivered by recombinant adeno-associated virus (AAV) vectors. C3d(3)-...

journal_title：Immunology and cell biology

authors： Logan GJ,Wang L,Zheng M,Coppel RL,Alexander IE

更新日期：2010-02-01 00:00:00

abstract：:A derivative of ammonia caramel colour (AC) is known to induce a selective lymphopenia in rats. Accordingly, the haematological effects were studied in mice of oral administration in drinking water of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI), the component of AC responsible for lymphopenia. Initially five groups...

journal_title：Immunology and cell biology

authors： Iscaro A,Mackay IR,O'Brien C

更新日期：1988-10-01 00:00:00

abstract：:Fluorescent dyes are increasingly being exploited to track lymphocyte migration and proliferation. The present paper reviews the properties and performance of some 14 different fluorescent dyes that have been used during the last 20 years to monitor lymphocyte migration. Of the 14 dyes discussed, two stand out as bein...

journal_title：Immunology and cell biology

authors： Parish CR

更新日期：1999-12-01 00:00:00

abstract：:Leishmaniasis, a group of visceral and cutaneous diseases, is caused by parasites belonging to one genus comprising approximately 13 different species. Many methods including serological, biochemical and molecular biological techniques have been used by various workers to characterize these different species and isola...

journal_title：Immunology and cell biology

authors： Arora SK,Kapoor GS,Sehgal S

更新日期：1998-04-01 00:00:00

abstract：:Influx of Ca2+ via Ca2+ channels is the major step triggering exocytosis of pituitary somatotropes to release growth hormone (GH). Voltage-gated Ca2+ and K+ channels, the primary determinants of the influx of Ca2+, are regulated by GH-releasing hormone (GHRH) through G-protein-coupled intracellular signalling systems....

journal_title：Immunology and cell biology

authors： Chen C,Xu R,Clarke IJ,Ruan M,Loneragan K,Roh SG

更新日期：2000-08-01 00:00:00

abstract：:Urinary tract infections are a major problem in human medicine for which better understanding of native immune defenses may reveal new pathways for therapeutic intervention. Tamm-Horsfall glycoprotein (THP), the most abundant urinary protein, interacts with bacteria including uropathogenic Escherichia coli (UPEC) as w...

journal_title：Immunology and cell biology

authors： Patras KA,Coady A,Olson J,Ali SR,RamachandraRao SP,Kumar S,Varki A,Nizet V

更新日期：2017-11-01 00:00:00

abstract：:NK cell activity has been detected in the early murine decidua, and hypothesized to be mediated by granulated metrial gland (GMG) cells. The possibility that natural cytotoxic (NC) cells are also present in the decidua has not been investigated. In this study mAb to NK cells (anti-NK-1.1) and NC cells (anti-NC-1.1) we...

journal_title：Immunology and cell biology

authors： Clarke GR,Roberts TK,Smart YC

更新日期：1994-04-01 00:00:00

abstract：:Tamm-Horsfall protein (THP) binds strongly to complement 1q (C1q), a key component of the classical complement pathway. The goals of this study were to determine whether THP altered the activation of the classical complement pathway and whether the carbohydrate portion of THP was involved in this glycoprotein's bindin...

journal_title：Immunology and cell biology

authors： Rhodes DC

更新日期：2006-08-01 00:00:00

abstract：:As previously reported by others for immunoglobulin (Ig)G, we observed that IgA can induce interleukin (IL)-10 expression in human monocytes. In this study, we explored the molecular mechanisms of IL-10 induction by IgA in monocytes and monocyte-derived dendritic cells (MD-DCs). Monomeric IgA induced IL-10 production ...

journal_title：Immunology and cell biology

authors： Pilette C,Detry B,Guisset A,Gabriels J,Sibille Y

更新日期：2010-05-01 00:00:00

abstract：:Peripheral tolerance mechanisms limit autoimmunity by constitutively eliminating self-reactive CD8+ T cells from the periphery in a process called deletion. Previous work has demonstrated that this deletion process is mediated by BIM-dependent apoptotic death due to transcriptional induction of the Bim gene. Currently...

journal_title：Immunology and cell biology

authors： Wagle MV,Parish IA

更新日期：2016-10-01 00:00:00

abstract：:Inappropriate activation of p34cdc2 kinase has been shown to occur during apoptosis induced by cytotoxic T-cell derived perforin and fragmentin. We analysed the effect of two inhibitors of p34cdc2 kinase on alloreactive Tc-cell-mediated lysis and DNA fragmentation of P815 and L1210 target cells. Olomoucine, a specific...

journal_title：Immunology and cell biology

authors： Waring P,Müllbacher A

更新日期：2001-06-01 00:00:00

abstract：:Human regulatory T cells (Tregs) expressing the transcription factor FoxP3 play indispensable roles for the maintenance of immunological self-tolerance and immune homeostasis. In this review, we discuss immunological characteristics of human FoxP3(+) Tregs and to what extent they are similar to or different from the m...

journal_title：Immunology and cell biology

authors： Miyara M,Sakaguchi S

更新日期：2011-03-01 00:00:00

abstract：:Productive immune responses to T-cell-dependent antigens ultimately generate two long-lived compartments: memory B cells and bone marrow-resident plasma cells, which both arise from within germinal centres. The ability of a B-cell clone to populate these effector compartments requires its descendents to outcompete tho...

journal_title：Immunology and cell biology

authors： Tarlinton DM

更新日期：2008-02-01 00:00:00

abstract：:Somatostatin inhibits in vitro lymphocyte proliferative responses from a variety of species including human, mouse and rat. The immunoinhibitory effects of somatostatin are thought to involve binding to specific cell surface somatostatin receptors on immunocompetent cells. This report describes an in vivo immunoinhibi...

journal_title：Immunology and cell biology

authors： Eglezos A,Andrews PV,Helme RD

更新日期：1993-04-01 00:00:00

abstract：:There is a logarithmic increase in the cost and complexity of the research and development process when transitioning a promising candidate vaccine from the laboratory into the clinic. Managing complex development programs involving people from diverse technical, cultural and geographical backgrounds is a specialised ...

journal_title：Immunology and cell biology

authors： Sullivan M

更新日期：2009-07-01 00:00:00

abstract：:Interleukin (IL)-15 overexpression in eosinophilic gastrointestinal disorders is reported, but IL-15's role in promoting eosinophilic gastroenteritis is largely unknown. Therefore, we generated enterocyte-overexpressed IL-15 transgenic mice using Fabpi promoter. The Fabpi-IL-15 (iIL-15) transgenic mice showed induced ...

journal_title：Immunology and cell biology

authors： Mussarat A,Manohar M,Verma AK,Upparahalli Venkateshaiah S,Zaidi A,Sanders NL,Zhu X,Mishra A

更新日期：2018-03-01 00:00:00

abstract：:Mice infected with Sarcocystis muris showed a significant reduction in plaque-forming cells (PFC) and delayed-type hypersensitivity (DHS) responses to an unrelated protein antigen, bovine gamma-globulin, when compared with uninfected controls. This immunosuppression was observed only when infection preceded immunizati...

journal_title：Immunology and cell biology

authors： Gill HS,Charleston WA,Moriarty KM

更新日期：1988-01-01 00:00:00

abstract：:The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated temporally during an immune response or upon activation in a secondary r...

journal_title：Immunology and cell biology

authors： de Jong BG,IJspeert H,Marques L,van der Burg M,van Dongen JJ,Loos BG,van Zelm MC

更新日期：2017-10-01 00:00:00

abstract：:The relationship between interleukin-1 (IL-1) and interleukin-2 (IL-2) production and immunophenotype marker profiles was studied in a panel of 29 leukaemia and human T cell lymphotropic virus-1 (HTLV-1)-transformed T cell lines. Culture supernatants from six of the 29 T cell lines tested increased IL-2 production by ...

journal_title：Immunology and cell biology

authors： Holán V,Minowada J

更新日期：1993-12-01 00:00:00

abstract：:Activin A, a member of the transforming growth factor-β superfamily, is a critical early mediator of acute inflammation. Activin A release coincides with the release of tumour necrosis factor-α (TNF-α) in models of lipopolysaccharide (LPS)-induced inflammation. The source of circulating activin A during acute inflamma...

journal_title：Immunology and cell biology

authors： Chen Y,Wu H,Winnall WR,Loveland KL,Makanji Y,Phillips DJ,Smith JA,Hedger MP

更新日期：2011-11-01 00:00:00

abstract：:Natural killer (NK) cells are the founding members of the innate lymphoid cell family and contribute to the rapid production of inflammatory mediators upon pathogen detection. The evolution of receptors for self major histocompatibility complex-I and stress-induced ligands also bestows upon NK cells an important effec...

journal_title：Immunology and cell biology

authors： Huntington ND

更新日期：2014-03-01 00:00:00

abstract：:Peyer's patches (PP) are important inductive sites for the mucosal immune response. It is well known that lymphocytes that migrate into PP are mainly of T-cell lineage from thymus-derived cells (i.e. alphabetaTCR(high) cells). In this study, we further characterized the properties of PP lymphocytes in mice using a mou...

journal_title：Immunology and cell biology

authors： Takahashi S,Kawamura T,Kanda Y,Taniguchi T,Nishizawa T,Iiai T,Hatakeyama K,Abo T

更新日期：2005-10-01 00:00:00

abstract：:Human cytomegalovirus (HCMV), the β-herpesvirus prototype, has evolved a wide spectrum of mechanisms to counteract host immunity. Among them, HCMV uses cellular captured genes encoding molecules capable of interfering with the original host function or of fulfilling new immunomodulatory tasks. Here, we report on UL7, ...

journal_title：Immunology and cell biology

authors： Engel P,Pérez-Carmona N,Albà MM,Robertson K,Ghazal P,Angulo A

更新日期：2011-10-01 00:00:00

abstract：:The MS4A (membrane-spanning 4-domain family, subfamily A) family of proteins contains some well-known members including MS4A1 (CD20), MS4A2 (FcɛRIβ) and MS4A3 (HTm4). These three MS4A family members are expressed on the cell surface of specific leukocyte subsets and have been well characterized as having key roles in ...

journal_title：Immunology and cell biology

authors： Eon Kuek L,Leffler M,Mackay GA,Hulett MD

更新日期：2016-01-01 00:00:00