Evaluation of thrombus detection in a rabbit model using a technetium-99m-labelled anti-fibrin monoclonal antibody.

abstract：:Mycoplasma infection may lead to various pathologies in a broad range of hosts. It has been shown that Mycoplasma may trigger cell death in cell cultures; however, the mechanism remains unknown. In the present paper we show that Mycoplasma infection of different lymphocyte and epithelial tumour cell lines leads to the...

journal_title：Immunology and cell biology

authors： Sokolova IA,Vaughan AT,Khodarev NN

更新日期：1998-12-01 00:00:00

abstract：:A general criterion is formulated to decide if the recycling of B cells exists in germinal centre (GC) reactions. The criterion is independent of the selection and affinity maturation process and based solely on total centroblast population arguments. An experimental test is proposed to verify whether the criterion is...

journal_title：Immunology and cell biology

authors： Meyer-Hermann M

更新日期：2002-02-01 00:00:00

abstract：:Follicular dendritic cells (FDC) play a crucial role in the regulation of humoral immunity. They are believed to be responsible for long-term persistence of antibody, due to their role in antibody response induction and their ability to retain antigen in immunogenic form for long periods. In this article, a regulatory...

journal_title：Immunology and cell biology

authors： Almudevar A

更新日期：2017-10-01 00:00:00

abstract：:Non-toxic agents that target intracellular signalling pathways in apoptosis may have potential therapeutic use in many diseases. One such agent is the transition metal Zn, a dietary cytoprotectant and anti-oxidant, which stimulates cell proliferation and suppresses apoptosis. Zn is maintained in discrete subcellular p...

journal_title：Immunology and cell biology

authors： Chai F,Truong-Tran AQ,Ho LH,Zalewski PD

更新日期：1999-06-01 00:00:00

abstract：:Irradiated malaria sporozoites induce better protection than viable untreated sporozoites. We observed early differences between irradiated and viable untreated sporozoites in priming responses in vivo to a protective CD8 T-cell epitope, pb9, of the circumsporozoite protein of Plasmodium berghei. Sporozoites were proc...

journal_title：Immunology and cell biology

authors： Plebanski M,Hannan CM,Behboudi S,Flanagan KL,Apostolopoulos V,Sinden RE,Hill AV

更新日期：2005-06-01 00:00:00

abstract：:After positive selection, the newly differentiated single-positive (SP) thymocytes undergo negative selection to eliminate autoreactive T cells, functional maturation to acquire immunocompetence and egress capability. To investigate whether the intracellular reduction/oxidation (redox) balance has an important role on...

journal_title：Immunology and cell biology

authors： Jin R,Teng F,Xu X,Yao Y,Zhang S,Sun X,Zhang Y,Ge Q

更新日期：2013-11-01 00:00:00

abstract：:Recombinant DNA techniques were used to clone, construct and express the bifunctional molecule FV/IL-2. The FV/IL-2 is a single-chain 37 kDa fusion protein expressed in Escherichia coli under control of the strong T7 bacteriophage promoter in the expression vector pT7-7-FV-IL-2. The fused gene fragment FV-IL-2 contain...

journal_title：Immunology and cell biology

authors： Xiang J,Liu E,Moyana T,Qi Y

更新日期：1994-08-01 00:00:00

abstract：:PVG rats are resistant to actively induced experimental autoimmune encephalomyelitis (EAE) and this appears to be directly related to high and sustained systemic levels of reactive nitrogen intermediates(RNI) following sensitization for EAE when compared to the highly susceptible Lewis rat. An apparent cellular basis ...

journal_title：Immunology and cell biology

authors： Staykova MA,Cowden W,Willenborg DO

更新日期：2002-04-01 00:00:00

abstract：:Post-infarction inflammatory response results in worse remodeling and dysfunction following myocardial infarction (MI). Supression of post-infarction inflammation would be a logical approach of alleviating post-infarction injury and promoting cardiac repair. In this study, we investigated the significance of mTORC1 si...

journal_title：Immunology and cell biology

authors： Yang K,Zhang Y,Xu C,Li X,Li D

更新日期：2016-03-01 00:00:00

abstract：:The multimammate rat Mastomys natalensis, when infected with the filarial parasite Acanthocheilonema viteae, develops amicrofilaraemia. Worm recovery and the duration and intensity of microfilaraemia were analysed and related to the humoral and cellular immune responses of the host by using an antibody-dependent cell-...

journal_title：Immunology and cell biology

authors： Chandrashekar R,Rao UR,Subrahmanyam D

更新日期：1990-02-01 00:00:00

abstract：:Cells with a low density of parasite-specific antigens on their surface are postulated to be susceptible to a cell-mediated attack but not to effector mechanisms normally activated following the binding of specific antibody to the infected cell. It is further postulated that such infected cells normally induce a cell-...

journal_title：Immunology and cell biology

authors： Bretscher PA

更新日期：1992-10-01 00:00:00

abstract：:The mammalian testis is an immunoprivileged organ where male germ cell autoantigens are immunologically ignored. Both systemic immune tolerance to autoantigens and local immunosuppressive milieu contribute to the testicular immune privilege. Testicular immunosuppression has been intensively studied, but information on...

journal_title：Immunology and cell biology

authors： Li N,Liu Z,Zhang Y,Chen Q,Liu P,Cheng CY,Lee WM,Chen Y,Han D

更新日期：2015-03-01 00:00:00

abstract：:It has been described that polymorphonuclear neutrophils (PMNs) enhance the replication of CC-chemokine receptor 5/macrophage-tropic (R5) HIV in cultures of monocyte-derived macrophages (MDMs). In this study, the inhibitory effect of glycyrrhizin (GL) on R5 HIV replication influenced by PMNs was investigated in MDM cu...

journal_title：Immunology and cell biology

authors： Yoshida T,Kobayashi M,Li XD,Pollard RB,Suzuki F

更新日期：2009-10-01 00:00:00

abstract：:The relationship between interleukin-1 (IL-1) and interleukin-2 (IL-2) production and immunophenotype marker profiles was studied in a panel of 29 leukaemia and human T cell lymphotropic virus-1 (HTLV-1)-transformed T cell lines. Culture supernatants from six of the 29 T cell lines tested increased IL-2 production by ...

journal_title：Immunology and cell biology

authors： Holán V,Minowada J

更新日期：1993-12-01 00:00:00

abstract：:As host immunological defenses are impaired during HIV infection, it is difficult to elicit good responses when attempting to develop therapeutic vaccines against HIV. To try to solve this situation, adjuvants, particularly cytokines, are currently under evaluation. Owing to the fact that adenosine deaminase (ADA) is ...

journal_title：Immunology and cell biology

authors： Climent N,Martinez-Navio JM,Gil C,Garcia F,Rovira C,Hurtado C,Miralles L,Gatell JM,Gallart T,Mallol J,Lluis C,Franco R

更新日期：2009-11-01 00:00:00

abstract：:Inappropriate activation of p34cdc2 kinase has been shown to occur during apoptosis induced by cytotoxic T-cell derived perforin and fragmentin. We analysed the effect of two inhibitors of p34cdc2 kinase on alloreactive Tc-cell-mediated lysis and DNA fragmentation of P815 and L1210 target cells. Olomoucine, a specific...

journal_title：Immunology and cell biology

authors： Waring P,Müllbacher A

更新日期：2001-06-01 00:00:00

abstract：:Influx of Ca2+ via Ca2+ channels is the major step triggering exocytosis of pituitary somatotropes to release growth hormone (GH). Voltage-gated Ca2+ and K+ channels, the primary determinants of the influx of Ca2+, are regulated by GH-releasing hormone (GHRH) through G-protein-coupled intracellular signalling systems....

journal_title：Immunology and cell biology

authors： Chen C,Xu R,Clarke IJ,Ruan M,Loneragan K,Roh SG

更新日期：2000-08-01 00:00:00

abstract：:Elucidating pathways that regulate cytokine production in the context of autoimmune disease will likely lead to the development of novel therapeutics. Herein, we review data suggesting that microRNAs (miRs) represent one such level of regulatory activity, with particular emphasis on the pathogenesis of rheumatoid arth...

journal_title：Immunology and cell biology

authors： Baxter D,McInnes IB,Kurowska-Stolarska M

更新日期：2012-03-01 00:00:00

abstract：:Over the past few years a great deal of research has examined how T cell-dependent immune responses are initiated and subsequently regulated. Ligation of the TCR with an antigenic peptide bound to an MHC protein on a professional APC provides the crucial antigen-specific stimulus required for T cell activation. Intera...

journal_title：Immunology and cell biology

authors： McCoy KD,Le Gros G

更新日期：1999-02-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I heavy chain/beta(2)m heterodimers assemble with antigenic peptides through interactions with peptide-loading complex proteins, including tapasin and ERp57. In human cells, a cysteine residue within tapasin (C95) has been shown to form a covalent bond with ERp57. In this s...

journal_title：Immunology and cell biology

authors： Simone LC,Wang X,Tuli A,Solheim JC

更新日期：2010-01-01 00:00:00

abstract：:There is a logarithmic increase in the cost and complexity of the research and development process when transitioning a promising candidate vaccine from the laboratory into the clinic. Managing complex development programs involving people from diverse technical, cultural and geographical backgrounds is a specialised ...

journal_title：Immunology and cell biology

authors： Sullivan M

更新日期：2009-07-01 00:00:00

abstract：:Even though smallpox has been eradicated, the threat of accidental or intentional release has highlighted the fact there is little consensus about correlates of protective immunity or immunity against re-infection with the causative poxvirus, variola virus (VARV). As the existing vaccine for smallpox has unacceptable ...

journal_title：Immunology and cell biology

authors： Panchanathan V,Chaudhri G,Karupiah G

更新日期：2008-01-01 00:00:00

abstract：:By hybridization with a human interleukin-6 (IL-6) cDNA fragment a corresponding ruminant (ovine) cDNA was isolated from a lipopolysaccharide (LPS)-stimulated alveolar macrophage library. The nucleotide sequence of the cDNA and the predicted amino acid sequence of the protein showed significant homology to the human a...

journal_title：Immunology and cell biology

authors： Andrews AE,Barcham GJ,Ashman K,Meeusen EN,Brandon MR,Nash AD

更新日期：1993-08-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is important in the development of inflammatory bowel disease. TNF-alpha-deficient mice show more severe colonic inflammation than wild-type (Wt) mice, but the underlying mechanism remains unclear. Using immunohistochemistry, enzyme-linked-immunosorbent assay and histopathology, we found t...

journal_title：Immunology and cell biology

authors： Xu Y,Hunt NH,Bao S

更新日期：2007-11-01 00:00:00

abstract：:The identification of the genes that make up rearranged immunoglobulin genes is critical to many studies. For example, the enumeration of mutations in immunoglobulin genes is important for the prognosis of chronic lymphocytic leukemia, and this requires the accurate identification of the germline genes from which a pa...

journal_title：Immunology and cell biology

authors： Wang Y,Jackson KJ,Sewell WA,Collins AM

更新日期：2008-02-01 00:00:00

abstract：:Neospora caninum is a coccidian parasite causative of clinical infections in a wide range of animal hosts. The maturation and activation of splenic conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) were studied here in BALB/c mice challenged intraperitoneal with N. caninum tachyzoites. The nu...

journal_title：Immunology and cell biology

authors： Teixeira L,Botelho AS,Mesquita SD,Correia A,Cerca F,Costa R,Sampaio P,Castro AG,Vilanova M

更新日期：2010-01-01 00:00:00

abstract：:Sustained-release vaccine delivery systems may enhance the immunogenicity of subunit vaccines and reduce the need for multiple vaccinations. The aim of this study was to develop a thermoresponsive hydrogel using poloxamer 407-chitosan (CP) grafted copolymer as a delivery system for single-shot sustained-release vaccin...

journal_title：Immunology and cell biology

authors： Bobbala S,Gibson B,Gamble AB,McDowell A,Hook S

更新日期：2018-07-01 00:00:00

abstract：:Understanding how inhibitor of apoptosis proteins (IAPs) regulate apoptosis and necroptosis has been fast-forwarded by the use of Smac mimetics (SMs) to deplete or inhibit the IAPs, specifically cIAP1, cIAP2 and XIAP. The loss or inhibition of cIAP1, cIAP2 and XIAP causes the majority of cells to be sensitized to deat...

journal_title：Immunology and cell biology

authors： Vasilikos L,Spilgies LM,Knop J,Wong WW

更新日期：2017-02-01 00:00:00

abstract：:Natural killer (NK) cells are potent immune effector cells that can respond to infection and cancer, as well as allowing maternal adaptation to pregnancy. In response to malignant transformation or pathogenic invasion, NK cells can secrete cytokine and may be directly cytolytic, as well as exerting effects indirectly ...

journal_title：Immunology and cell biology

authors： Pegram HJ,Andrews DM,Smyth MJ,Darcy PK,Kershaw MH

更新日期：2011-02-01 00:00:00

abstract：:During the development of the nervous system neurons extend axons through a complex embryonic environment. To find a correct target, often located at a long distance, the neuronal growth cones travel along highly specific and stereotyped pathways. Proper neuronal pathfinding is thought to be accomplished by the specif...

journal_title：Immunology and cell biology

authors： Sanchez D,Ganfornina MD,Bastiani MJ

更新日期：1995-12-01 00:00:00