当前位置： SCI文献检索 > IMMUNOLOGY AND CELL BIOLOGY期刊下所有文献 > Direct processing and presentation of antigen from malaria sporozoites by professional antigen-presenting cells in the induction of CD8 T-cell responses.

Direct processing and presentation of antigen from malaria sporozoites by professional antigen-presenting cells in the induction of CD8 T-cell responses.

Abstract：

:Irradiated malaria sporozoites induce better protection than viable untreated sporozoites. We observed early differences between irradiated and viable untreated sporozoites in priming responses in vivo to a protective CD8 T-cell epitope, pb9, of the circumsporozoite protein of Plasmodium berghei. Sporozoites were processed for MHC class I presentation by dendritic cells (DC) to prime pb9-specific IFN-gamma-producing CD8 T cells. DC pulsed with untreated and irradiated sporozoites were similarly capable of priming central memory T-cell responses, detectable by the IFN-gamma cultured ELISPOT assay. However, irradiation significantly enhanced sporozoites' ability to prime effector T-cell responses detectable by the IFN-gammaex vivo ELISPOT assay. Irradiation also enhanced the ability of splenic APC to process and present sporozoites in order to re-stimulate pb9-specific polyclonal and clonal T-cell responses. Sporozoites did not stimulate T cells in the absence of APC. Over-irradiation decreased the sporozoites' T-cell stimulating capacity in vitro at high parasite doses, which may indicate that an optimal irradiation dose is necessary to induce protective immunity by sporozoite inoculation. The induction of sporozoite-specific CD8 T-cell responses without the need for liver stage infection identifies a potentially important mechanism in the development of pre-erythrocytic immunity.

journal_name

Immunol Cell Biol

journal_title

Immunology and cell biology

authors

Plebanski M,Hannan CM,Behboudi S,Flanagan KL,Apostolopoulos V,Sinden RE,Hill AV

doi

10.1111/j.1440-1711.2005.01325.x

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

307-12

issue

3

eissn

0818-9641

issn

1440-1711

pii

ICB1325

journal_volume

83

pub_type

杂志文章

相关文献

IMMUNOLOGY AND CELL BIOLOGY文献大全
  • Characterization of ovine umbilical vein endothelial cells and their expression of cell adhesion molecules: comparative study with human endothelial cells.

    abstract：:This paper reports the isolation and characterization of sheep umbilical vein endothelial cells (ShUVEC) and examines the kinetics of the expression of intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). In culture, the cells demonstrate the classical endothelial cell phenot...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1997.4

    authors： Grooby WL,Krishnan R,Russ GR

    更新日期：1997-02-01 00:00:00

  • Interactions of tunicate immunomodulatory proteins with mammalian cells.

    abstract：:The ability of a tunicate immunomodulatory protein, tunIL1, to interact with mammalian cells was investigated. TunIL1 is known to regulate inflammatory defence reactions in tunicates and to stimulate the proliferation of mammalian thymocytes. In the current study, tunIL1 was shown to enchance L929 fibroblast prolifera...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1996.3

    authors： Raftos D

    更新日期：1996-02-01 00:00:00

  • Inflammation during skeletal muscle regeneration and tissue remodeling: application to exercise-induced muscle damage management.

    abstract：:Increase in the practice of sport by more and more numerous people in the Western countries is associated with an increase in muscle injuries, and in demand for improving muscle function and acceleration of muscle recovery after damage. Most of the treatments used target inflammation. Indeed, several lines of experime...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2015.97

    authors： Chazaud B

    更新日期：2016-02-01 00:00:00

  • Lung homing T-cell generation is dependent on strength and timing of antigen delivery to lymph nodes.

    abstract：:Inhaled allergens are known for their immediate and ongoing effects in the respiratory tract (RT). In this report, we track inhaled antigen in normal mice for 7 days and find that while it is cleared from the airways, inhaled antigen persists in peripheral lung tissue and the draining lymph nodes (DLNs). The persisten...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2010.18

    authors： Wikstrom ME,Batanero E,Judd SR,Wiqvist K,Holt PG,Stumbles PA

    更新日期：2010-08-01 00:00:00

  • A role for tumour necrosis factor-alpha in the human mixed lymphocyte culture reaction.

    abstract：:The possible role and influence of tumour necrosis factor-alpha (TNF-alpha) in the human mixed lymphocyte culture (MLC) reaction was investigated. Polyclonal rabbit sera to recombinant human-TNF-alpha (rhTNF-alpha) consistently inhibited the MLC, and this could be reversed by simultaneous addition of rhTNF-alpha to th...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1992.15

    authors： Matthews SJ,Sullivan JS

    更新日期：1992-04-01 00:00:00

  • Molecular associations involving CD16, CD45 and zeta and gamma chains on human natural killer cells.

    abstract：:zeta (CD3-zeta) and gamma (Fc epsilon RI gamma) chains associate with CD16, the low affinity receptor for IgG (Fc gamma RIII) on human NK cells and are essential for the cell surface expression of CD16 and for CD16-mediated effector functions. This study has investigated whether, on NK cells, molecules other than CD16...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1994.13

    authors： Altin JG,Pagler EB,Kinnear BF,Warren HS

    更新日期：1994-02-01 00:00:00

  • Nasal vaccination stimulates CD8(+) T cells for potent protection against mucosal Brucella melitensis challenge.

    abstract：:Brucellosis remains a significant zoonotic threat worldwide. Humans and animals acquire infection via their oropharynx and upper respiratory tract following oral or aerosol exposure. After mucosal infection, brucellosis develops into a systemic disease. Mucosal vaccination could offer a viable alternative to conventio...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2016.5

    authors： Clapp B,Yang X,Thornburg T,Walters N,Pascual DW

    更新日期：2016-05-01 00:00:00

  • Effect of a tapasin mutant on the assembly of the mouse MHC class I molecule H2-K(d).

    abstract：:Major histocompatibility complex (MHC) class I heavy chain/beta(2)m heterodimers assemble with antigenic peptides through interactions with peptide-loading complex proteins, including tapasin and ERp57. In human cells, a cysteine residue within tapasin (C95) has been shown to form a covalent bond with ERp57. In this s...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2009.59

    authors： Simone LC,Wang X,Tuli A,Solheim JC

    更新日期：2010-01-01 00:00:00

  • Mechanisms involved in the inhibition of growth of a human B lymphoma cell line, B104, by anti-MHC class II antibodies.

    abstract：:The mechanisms involved in the inhibition of growth of a human B lymphoma cell line, B104, by anti-MHC class II antibodies (Ab) were compared with those in anti-IgM Ab-induced B104 growth inhibition. Two anti-MHC class II Ab, L227 and 2.06, inhibited the growth of B104 cells, although 2.06, but not L227, needed to be ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1994.31

    authors： Higaki Y,Hata D,Kanazashi S,Horiguchi Y,Yamaoka K,Ohshima Y,Kim KM,Heike T,Mayumi M

    更新日期：1994-06-01 00:00:00

  • Importance of carbohydrate in the interaction of Tamm-Horsfall protein with complement 1q and inhibition of classical complement activation.

    abstract：:Tamm-Horsfall protein (THP) binds strongly to complement 1q (C1q), a key component of the classical complement pathway. The goals of this study were to determine whether THP altered the activation of the classical complement pathway and whether the carbohydrate portion of THP was involved in this glycoprotein's bindin...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2006.01434.x

    authors： Rhodes DC

    更新日期：2006-08-01 00:00:00

  • Mycobacterium tuberculosis impairs dendritic cell response by altering CD1b, DC-SIGN and MR profile.

    abstract：:During a chronic infection such as tuberculosis, the pool of tissue dendritic cells (DC) must be renewed by recruitment of both circulating DC progenitors and monocytes (Mo). However, the microenvironment of the inflammatory site affects Mo differentiation. As DC are critical for initiating a Mycobacterium tuberculosi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2010.22

    authors： Balboa L,Romero MM,Yokobori N,Schierloh P,Geffner L,Basile JI,Musella RM,Abbate E,de la Barrera S,Sasiain MC,Alemán M

    更新日期：2010-10-01 00:00:00

  • Embryonic macrophages of early rat yolk sac: Immunohistochemistry and ultrastructure with reference to endodermal cell layer.

    abstract：:Macrophages are multifunctional cells that participate in numerous biological processes; they actively phagocytose foreign particles and cell debris. Embryonic tissue macrophages are present at early stages of mammalian development; their ontogeny and function is still under investigation. Our study used immunohistoch...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2002.01109.x

    authors： El-Nefiawy N,Abdel-Hakim K,Yamashita A,Kanayama N

    更新日期：2002-10-01 00:00:00

  • CD4+ T cells cross-compete for MHC class II-restricted peptide antigen complexes on the surface of antigen presenting cells.

    abstract：:CD4(+) T cells are activated upon recognition of peptide antigen in the context of MHC class II molecules, expressed by specialized APC. In this study, we show that CD4(+) T cells cross-compete for antigenic complexes on the surface of APC, inhibiting activation of other potentially reactive T cells of the same and di...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.0818-9641.2004.01233.x

    authors： Hayball JD,Robinson BW,Lake RA

    更新日期：2004-04-01 00:00:00

  • The role of CD45 and CD45-associated molecules in T cell activation.

    abstract：:CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells. On T cells the extracellular domain of CD45 is expressed in several different isoforms, and the particular isoform(s) expressed depends ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1997.68

    authors： Altin JG,Sloan EK

    更新日期：1997-10-01 00:00:00

  • FOXO3 is differentially required for CD8+ T-cell death during tolerance versus immunity.

    abstract：:Peripheral tolerance mechanisms limit autoimmunity by constitutively eliminating self-reactive CD8+ T cells from the periphery in a process called deletion. Previous work has demonstrated that this deletion process is mediated by BIM-dependent apoptotic death due to transcriptional induction of the Bim gene. Currently...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2016.53

    authors： Wagle MV,Parish IA

    更新日期：2016-10-01 00:00:00

  • Generation of CTL responses using Kunjin replicon RNA.

    abstract：:The Kunjin replicon was used to express a polytope that consisted of seven hepatitis C virus cytotoxic T lymphocyte epitopes and one influenza cytotoxic T lymphocyte epitope for vaccination studies. The self-replicating nature of, and expression from, the ribonucleic acid was confirmed in vitro. Initial vaccinations w...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.0818-9641.2002.01137.x

    authors： Ward SM,Tindle RW,Khromykh AA,Gowans EJ

    更新日期：2003-02-01 00:00:00

  • Production of interleukin-1 alpha and interleukin-2 by separate, phenotypically different leukaemia and human T cell lymphotropic virus-1-transformed T cell clones.

    abstract：:The relationship between interleukin-1 (IL-1) and interleukin-2 (IL-2) production and immunophenotype marker profiles was studied in a panel of 29 leukaemia and human T cell lymphotropic virus-1 (HTLV-1)-transformed T cell lines. Culture supernatants from six of the 29 T cell lines tested increased IL-2 production by ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1993.56

    authors： Holán V,Minowada J

    更新日期：1993-12-01 00:00:00

  • Linking the T cell receptor to the single cell transcriptome in antigen-specific human T cells.

    abstract：:Heterogeneity of T cells is a hallmark of a successful adaptive immune response, harnessing the vast diversity of antigen-specific T cells into a coordinated evolution of effector and memory outcomes. The T cell receptor (TCR) repertoire is highly diverse to account for the highly heterogeneous antigenic world. During...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2016.16

    authors： Eltahla AA,Rizzetto S,Pirozyan MR,Betz-Stablein BD,Venturi V,Kedzierska K,Lloyd AR,Bull RA,Luciani F

    更新日期：2016-07-01 00:00:00

  • Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction.

    abstract：:The mammalian testis is an immunoprivileged organ where male germ cell autoantigens are immunologically ignored. Both systemic immune tolerance to autoantigens and local immunosuppressive milieu contribute to the testicular immune privilege. Testicular immunosuppression has been intensively studied, but information on...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2014.97

    authors： Li N,Liu Z,Zhang Y,Chen Q,Liu P,Cheng CY,Lee WM,Chen Y,Han D

    更新日期：2015-03-01 00:00:00

  • Initiation of antigen receptor endocytosis and B lymphocyte activation lie on independent biochemical pathways.

    abstract：:Peroxidase-conjugated anti-surface immunoglobulin (sIg) was used quantitatively to monitor endocytosis of crosslinked sIg on murine B lymphocytes. The role of biochemical second messengers in the initiation of endocytosis was assessed by employing several inhibitors. A novel peroxidase detection system was used and te...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1993.1

    authors： Shuler RL,Owen CS

    更新日期：1993-02-01 00:00:00

  • Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity.

    abstract：:Several histone deacetylases (HDACs) are involved in the regulation of forkhead box protein P3 (FOXP3) expression and function by affecting features of FOXP3 protein stability. FOXP3, a forkhead family transcription factor specially expressed in regulatory T (Treg) cells, controls the expression of many key immune-reg...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2011.101

    authors： Zhang H,Xiao Y,Zhu Z,Li B,Greene MI

    更新日期：2012-01-01 00:00:00

  • How adaptive antibodies facilitate the evolution of natural antibodies.

    abstract：:It is shown how Ig specificities, randomly generated in conventional B cells, come to be expressed in the genetically-determinate B1 population. Thus the adaptive antibody population facilitates the evolution of the natural antibody repertoire, in accordance with the Baldwin effect in the evolution of instinct. The ev...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1996.50

    authors： Anderson RW

    更新日期：1996-06-01 00:00:00

  • Long-term stroma-dependent cultures are a consistent source of immunostimulatory dendritic cells.

    abstract：:A long-term culture (LTC) system has been established that supports the continuous production of dendritic cells (DC) from haemopoietic cells present in the culture. The production of cells depends on the presence of an intact stromal cell layer containing a mixture of fibroblasts and endothelial cells. Cells are shed...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1711.1999.00851.x

    authors： O'Neill HC,Ni K,Wilson H

    更新日期：1999-10-01 00:00:00

  • Disentangling the complexity of the skin dendritic cell network.

    abstract：:Using 'knockin' mice to track and ablate dendritic cells (DCs) expressing notably the langerin (Cd207) gene, it has been possible to identify five DC subsets within the skin and to assess whether functional specialization exists among them. The present review summarizes recent information concerning the phenotype and ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2010.34

    authors： Henri S,Guilliams M,Poulin LF,Tamoutounour S,Ardouin L,Dalod M,Malissen B

    更新日期：2010-05-01 00:00:00

  • Inhibitory effect of glycyrrhizin on the neutrophil-dependent increase of R5 HIV replication in cultures of macrophages.

    abstract：:It has been described that polymorphonuclear neutrophils (PMNs) enhance the replication of CC-chemokine receptor 5/macrophage-tropic (R5) HIV in cultures of monocyte-derived macrophages (MDMs). In this study, the inhibitory effect of glycyrrhizin (GL) on R5 HIV replication influenced by PMNs was investigated in MDM cu...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2009.40

    authors： Yoshida T,Kobayashi M,Li XD,Pollard RB,Suzuki F

    更新日期：2009-10-01 00:00:00

  • Separate roles of IL-6 and oncostatin M in mouse macrophage polarization in vitro and in vivo.

    abstract：:Arginase-1 (Arg-1)-expressing M2-like macrophages are associated with Th2-skewed immune responses, allergic airway pathology, ectopic B16 melanoma cancer growth in murine models, and can be induced by Oncostatin M (OSM) transient overexpression in vivo. Here, we compare OSM to the gp130-cytokine IL-6 in mediating macr...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/imcb.1035

    authors： Dubey A,Izakelian L,Ayaub EA,Ho L,Stephenson K,Wong S,Kwofie K,Austin RC,Botelho F,Ask K,Richards CD

    更新日期：2018-03-01 00:00:00

  • Does HIV cause depletion of CD4+ T cells in vivo by the induction of apoptosis?

    abstract：:The central pathogenic feature of AIDS is the dramatic loss of CD4+ lymphocytes. Despite more than a decade of intense research, the exact mechanism by which HIV causes this is still not understood. A major model for T cell depletion, proposed originally by Ameison and Capron in a report published in 1991, is that HIV...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1711.1999.00798.x

    authors： Jaworowski A,Crowe SM

    更新日期：1999-02-01 00:00:00

  • Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA.

    abstract：:Elucidating pathways that regulate cytokine production in the context of autoimmune disease will likely lead to the development of novel therapeutics. Herein, we review data suggesting that microRNAs (miRs) represent one such level of regulatory activity, with particular emphasis on the pathogenesis of rheumatoid arth...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2011.114

    authors： Baxter D,McInnes IB,Kurowska-Stolarska M

    更新日期：2012-03-01 00:00:00

  • On the opposing views of the self-nonself discrimination by the immune system.

    abstract：:Today's generally accepted view of the self-nonself discrimination was voiced by Miller(1) in 2004 in a thought-provoking essay. In spite of its popularity, this position has its limitations, which are analyzed here with a view toward establishing an interactive discussion that hopefully will culminate in agreed upon ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2008.96

    authors： Cohn M

    更新日期：2009-02-01 00:00:00

  • LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins.

    abstract：:The role of the immunoproteasome is perceived as confined to adaptive immune responses given its ability to produce peptides ideal for MHC Class-I binding. Here, we demonstrate that the immunoproteasome subunit, LMP2, has functions beyond its immunomodulatory role. Using LMP2-deficient mice, we demonstrate that LMP2 i...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/imcb.12163

    authors： Zanker D,Pang K,Oveissi S,Lu C,Faou P,Nowell C,Mbogo GW,Carotta S,Quillici C,Karupiah G,Hibbs ML,Nutt SL,Neeson P,Puthalakath H,Chen W

    更新日期：2018-10-01 00:00:00