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Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV.

Abstract：

:As host immunological defenses are impaired during HIV infection, it is difficult to elicit good responses when attempting to develop therapeutic vaccines against HIV. To try to solve this situation, adjuvants, particularly cytokines, are currently under evaluation. Owing to the fact that adenosine deaminase (ADA) is a member of the family of growth factor with deaminase activity, we tested whether it could improve immune responses in the development of HIV dendritic-cell-based therapeutic vaccines. A co-culture model approach has been used to test the usefulness of ADA as adjuvant. Monocyte-derived dendritic cells from HIV-infected patients were pulsed with inactivated HIV, matured and co-cultured with autologous T cells. Addition of ADA to the co-cultures resulted in enhanced CD4(+) and CD8(+) T-cell proliferation and robust ADA-induced increase in cytokine production (IFN-gamma, TNF-alpha and IL-6). As IFN-gamma, TNF-alpha and IL-6 promote the Th1 versus Th2 phenotype and improve T helper proliferation responses and antigen-specific CTL responses ADA may be considered a promising candidate for therapeutic vaccine adjuvant.

journal_name

Immunol Cell Biol

journal_title

Immunology and cell biology

authors

Climent N,Martinez-Navio JM,Gil C,Garcia F,Rovira C,Hurtado C,Miralles L,Gatell JM,Gallart T,Mallol J,Lluis C,Franco R

doi

10.1038/icb.2009.53

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

634-9

issue

8

eissn

0818-9641

issn

1440-1711

pii

icb200953

journal_volume

87

pub_type

杂志文章

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