Abstract：
:Productive immune responses to T-cell-dependent antigens ultimately generate two long-lived compartments: memory B cells and bone marrow-resident plasma cells, which both arise from within germinal centres. The ability of a B-cell clone to populate these effector compartments requires its descendents to outcompete those of other clones participating in the response. Selection occurs at several stages of the response and the criteria differ at these different stages. While affinity predominates as the key, underlying driving force of selection, there is a distinction made at the point at which germinal centre cells initiate entry into the plasma cell and memory B-cell compartments. Becoming a plasma cell requires high affinity and cannot be subverted by blocking cell death, while becoming a memory B cell is dependent on survival alone. While such survival is typically mediated by affinity within the GC, the distinction has important mechanistic implications.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Tarlinton DMdoi
10.1038/sj.icb.7100148subject
Has Abstractpub_date
2008-02-01 00:00:00pages
133-8issue
2eissn
0818-9641issn
1440-1711pii
7100148journal_volume
86pub_type
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journal_title：Immunology and cell biology
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pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2000-04-01 00:00:00
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journal_title：Immunology and cell biology
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pub_type： 杂志文章
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更新日期：2001-10-01 00:00:00
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