Abstract：
:A feature common to many blood cell cancers is the uncoupling of normal proliferative and differentiative events, both of which are intimately linked in the cell's developmental programme. In some cancers, further differentiative events have been associated with oncogenic progression and, in other cancers, terminal differentiation of cells has been shown to result in reversal of malignancy and death of the cancer cell. Clearly the development of cancer is not the result of a single oncogenic event, but rather a myriad of events which appear to proceed in concert in a step-wise fashion and which are likely to be influenced by the cellular environment. Here we review some of the major genetic changes which occur in leukaemogenesis and discuss the possible role of differentiative events in the development of leukaemia.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Ho ES,O'Neill HCdoi
10.1038/icb.1995.32subject
Has Abstractpub_date
1995-06-01 00:00:00pages
193-7issue
3eissn
0818-9641issn
1440-1711journal_volume
73pub_type
杂志文章,评审abstract：:The review articles in this special feature reflect the current status of knowledge in the field of exercise immunology, with a focus on how exercise affects the human immune system and the health implications for resistance to infections and neoplastic diseases. In an Olympic year, the emphasis of exercise immunology...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/j.1440-1711.2000.t01-13-.x
更新日期：2000-10-01 00:00:00
abstract：:The relationship between interleukin-1 (IL-1) and interleukin-2 (IL-2) production and immunophenotype marker profiles was studied in a panel of 29 leukaemia and human T cell lymphotropic virus-1 (HTLV-1)-transformed T cell lines. Culture supernatants from six of the 29 T cell lines tested increased IL-2 production by ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1993.56
更新日期：1993-12-01 00:00:00
abstract：:Rats primed with bovine myelin (BM) in complete Freunds adjuvant, develop acute experimental autoimmune encephalomyelitis (EAE). We have previously described that intraperitoneal administration prior to the active induction of the disease of a bovine synaptosomal fraction (BSF) and BM were effective ways of suppressin...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/j.1440-1711.2004.01200.x
更新日期：2004-02-01 00:00:00
abstract：:Immunization of Lewis rats with guinea-pig myelin basic protein (Gp-MBP) induced T cell responses to primary and secondary encephalitogenic determinants, as well as to a third non-encephalitogenic epitope, residues 55-69. This sequence is of interest due to its protective activity against experimental autoimmune encep...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1711.1998.00720.x
更新日期：1998-02-01 00:00:00
abstract：:FOXP3+ regulatory T (Treg) cells are indispensable for immune homeostasis, but their study in humans is complicated by heterogeneity within Treg, the difficulty in purifying Tregs using surface marker expression (e.g. CD25) and the transient expression of FOXP3 by activated effector cells. Here, we report that express...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2015.90
更新日期：2016-03-01 00:00:00
abstract：:The haematopoietic-specific RhoGTPase, Rac2, has been indirectly implicated in T-lymphocyte development and function, and as a pivotal regulator of T Helper 1 (T(H)1) responses. In other haematopoietic cells it regulates cytoskeletal rearrangement downstream of extracellular signals. Here we demonstrate that Rac2 defi...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.2002.01077.x
更新日期：2002-06-01 00:00:00
abstract：:There is an urgent need for new, powerful adjuvants suitable for use with sub-unit and peptide vaccines in humans. We have measured the humoral immune response in BALB/c mice to vaccine formulations using recombinant HBsAg antigens, and gamma inulin and alum adjuvants. Using Merck, Sharpe & Dohme (MSD) HBsAg at 10 mic...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1990.15
更新日期：1990-04-01 00:00:00
abstract：:The effect of serum on LPS-induced activation of a murine macrophage-like cell line, WEHI-3, was examined. Foetal calf serum strongly inhibited the production of nitric oxide (NO) and TNF-alpha by LPS-stimulated WEHI-3 cells, while it enhanced the production of both by other macrophage-like cell lines, J774.1 and BAM3...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.1999.00807.x
更新日期：1999-04-01 00:00:00
abstract：:Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I-restricted pathway of antigen presentatio...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.1996.85
更新日期：1996-12-01 00:00:00
abstract：:The cytokine Tumor Necrosis Factor Superfamily member 14, TNFSF14 (or LIGHT), is a controversial player in numerous diseases. We investigated the role of endogenously expressed TNFSF14 in diet-induced obesity in vivo. Firstly, we studied the effects of Tnfsf14 ablation on the development of obesity, glucose intoleranc...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.1002
更新日期：2018-01-01 00:00:00
abstract：:There has been a tremendous explosion in the area of DNA vaccine research over the last 4 years, particularly in relation to antiviral vaccines. This report discusses the development and application of this new technology with regard to parasitic infections. Progress has been made towards the development of a vaccine ...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.1997.58
更新日期：1997-08-01 00:00:00
abstract：:Selection of conventional CD4(+) or CD8(+) T cells is usually driven by the interaction of double-positive CD4(+)CD8(+) thymocytes with epithelial cells. Here, we demonstrate preferential selection of CD8(+) thymocytes from in vitro differentiation of CD4(+)CD8(+) double-positive thymocytes exhibiting the characterist...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2013.94
更新日期：2014-04-01 00:00:00
abstract：:The multimammate rat Mastomys natalensis, when infected with the filarial parasite Acanthocheilonema viteae, develops amicrofilaraemia. Worm recovery and the duration and intensity of microfilaraemia were analysed and related to the humoral and cellular immune responses of the host by using an antibody-dependent cell-...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1990.3
更新日期：1990-02-01 00:00:00
abstract：:Parturition is associated with myometrial and cervical inflammation. The causes and consequences of this inflammatory response are not clear. Mast cells (MCs) are important inducers of allergic and non-allergic inflammation, and their secreted products can induce myometrial contractions. Thus, mast cell activation has...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2011.40
更新日期：2012-03-01 00:00:00
abstract：:Resistance to caspase-dependent apoptosis is often responsible for treatment failures in cancer. Finding novel therapeutic strategies that can activate alternative cell death programs appears to be appealing. Necroptosis is a form of programmed necrosis that occurs under caspase-deficient conditions. This alternative ...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2016.120
更新日期：2017-02-01 00:00:00
abstract：:Ex vivo mammary explant systems are an excellent model to study interactions between epithelium and stromal cell types because they contain physiologically relevant heterotypic interactions in the background of genetically diverse patients. The intact human mammary tissue, termed patient-derived explant (PDE), can be ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.12381
更新日期：2020-11-01 00:00:00
abstract：:Previous data from this laboratory have shown that fluorescein-specific cytotoxic T cells derived from naive mice are capable of distinguishing between different isomeric forms of the fluorescein hapten, as well as between the iodoacetamido-, isothiocyanate- and dichlorotriazinyl amino-fluorescein derivatives. In this...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1995.24
更新日期：1995-04-01 00:00:00
abstract：:Dendritic cells (DCs) orchestrate the innate and adaptive immune systems to induce tolerance and immunity. DC plasticity and subsets are prominent determinants in the regulation of immune responses. Our recent studies suggest that humoral and cellular immunity is regulated by different myeloid DC subsets with distinct...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2010.28
更新日期：2010-05-01 00:00:00
abstract：:Intravenous (i.v.) immunization of mice with recombinant vaccinia viruses stimulated the highest antibody and cytotoxic T lymphocyte (CTL) responses when i.v., intraperitoneal (i.p.), intranasal (i.n.), footpad (f.p.) and tail scarification (t.s.) routes were compared. Intraperitoneal immunization of mice resulted in ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1989.48
更新日期：1989-10-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease affecting predominantly motor neurons in the spinal cord and motor cortex. Neurodegeneration in ALS is accompanied by a well-characterized neuroinflammatory reaction within the central nervous system and, as described more recentl...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2016.89
更新日期：2017-02-01 00:00:00
abstract：:The 120-kDa protein product of the c-Cbl proto-oncogene is a ubiquitously expressed cytoplasmic protein that is especially abundant in the thymus, indicating an important role for Cbl in thymic signalling. c-Cbl possesses a highly conserved N-terminal phosphotyrosine binding domain, a C3HC4 RING finger motif, multiple...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1711.1998.00768.x
更新日期：1998-10-01 00:00:00
abstract：:There are estimated to be 350 million chronic carriers of hepatitis B infection worldwide. Patients with chronic hepatitis B are at risk of liver cirrhosis with associated mortality because of hepatocellular carcinoma and other complications. An important goal, therefore, is the development of an effective therapeutic...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/j.0818-9641.2004.01278.x
更新日期：2004-10-01 00:00:00
abstract：:Adoptive transfer of tumor-specific cytotoxic T cells is a promising advance in cancer therapy. Similarly, checkpoint inhibition has shown striking clinical results in some patients. Here we combine adoptive cell transfer with ablation of the checkpoint protein Src homology 2-domain-containing phosphatase 1 (SHP-1, Pt...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2016.45
更新日期：2016-09-01 00:00:00
abstract：:Cells with a low density of parasite-specific antigens on their surface are postulated to be susceptible to a cell-mediated attack but not to effector mechanisms normally activated following the binding of specific antibody to the infected cell. It is further postulated that such infected cells normally induce a cell-...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.1992.44
更新日期：1992-10-01 00:00:00
abstract：:The broadest definition of dendritic cells (DCs) is white blood cells that can take up antigen, process it and then present antigen-derived peptides to activate cognate naive T cells. Although this definition is by no means perfect, it is nevertheless now textbook. The source of frustration more recently has focused o...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2008.28
更新日期：2008-07-01 00:00:00
abstract：:This study investigated the role of gamma delta T cells in experimental allergic encephalomyelitis (EAE), a chronic inflammatory disease of the central nervous system (CNS) that resembles multiple sclerosis. The strategy was to assess the effect on EAE of TCR peptide immunization directed against V gamma 6 T cells, sh...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1997.14
更新日期：1997-02-01 00:00:00
abstract：:zeta (CD3-zeta) and gamma (Fc epsilon RI gamma) chains associate with CD16, the low affinity receptor for IgG (Fc gamma RIII) on human NK cells and are essential for the cell surface expression of CD16 and for CD16-mediated effector functions. This study has investigated whether, on NK cells, molecules other than CD16...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1994.13
更新日期：1994-02-01 00:00:00
abstract：:Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology and neuroinflammation. Recently, there has been considerable interest in the role of neuroinflammation in directly contributing to the progression of AD. Studies in mice and humans have identified a role for microglial cells, th...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1111/imcb.12301
更新日期：2020-01-01 00:00:00
abstract：:We recently demonstrated that 17beta-estradiol (E2) enhances killing of Leishmania mexicana in macrophages from both male and female DBA/2 mouse by increasing nitric oxide (NO) production. Here, we analyzed the effect of E2 on leishmanicidal activity and cytokine production by bone marrow-derived macrophages (BMDMs) f...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2008.39
更新日期：2008-08-01 00:00:00
abstract：:The recognition of T cell receptors (TCR) by purified major histocompatibility complex (MHC) class II-peptide complexes in the absence of costimulatory signals leads to the induction of T cell non-responsiveness or anergy. In a recent study using human T cell clones, it was observed that prolonged incubation of restin...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1996.13
更新日期：1996-02-01 00:00:00
