当前位置： SCI文献检索 > IMMUNOLOGY AND CELL BIOLOGY期刊下所有文献 > Elevated granzyme B+ B-cell level in SIV-infection correlate with viral load and low CD4 T-cell count.

Elevated granzyme B+ B-cell level in SIV-infection correlate with viral load and low CD4 T-cell count.

Abstract：

:Granzyme B-expressing (GrB+) B cells are thought to contribute to immune dysfunctions in HIV patients, but so far their exact role is unknown. This report demonstrates for the first time the existence of GrB+ B cells in SIV-infected rhesus macaques, which represent the most commonly used nonhuman primate model for HIV research. Similar to HIV patients, we found significantly higher frequencies of these cells in the blood of chronically SIV-infected rhesus monkeys compared with uninfected healthy ones. These frequencies correlated with plasma viral load and inversely with absolute CD4 T-cell counts. When investigating GrB+ B cells in different compartments, levels were highest in blood, spleen and bone marrow, but considerably lower in lymph nodes and tonsils. Analysis of expression of various surface markers on this particular B-cell subset in SIV-infected macaques revealed differences between the phenotype in macaques and in humans. GrB+ B cells in SIV-infected rhesus macaques exhibit an elevated expression of CD5, CD10, CD25 and CD27, while expression of CD19, CD185 and HLA-DR is reduced. In contrast to human GrB+ B cells, we did not observe a significantly increased expression of CD43 and CD86. B-cell receptor stimulation in combination with IL-21 of purified B cells from healthy animals led to the induction of GrB expression. Furthermore, initial functional analyses indicated a regulatory role on T-cell proliferation. Overall, our data pave the way for longitudinal analyses including studies on the functionality of GrB+ B cells in the nonhuman primate model for AIDS.

journal_name

Immunol Cell Biol

journal_title

Immunology and cell biology

authors

Kotb A,Klippert A,Daskalaki M,Sauermann U,Stahl-Hennig C,Neumann B

doi

10.1038/icb.2016.96

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

316-320

issue

3

eissn

0818-9641

issn

1440-1711

pii

icb201696

journal_volume

95

pub_type

杂志文章

相关文献

IMMUNOLOGY AND CELL BIOLOGY文献大全
  • Relevance of necroptosis in cancer.

    abstract：:Resistance to caspase-dependent apoptosis is often responsible for treatment failures in cancer. Finding novel therapeutic strategies that can activate alternative cell death programs appears to be appealing. Necroptosis is a form of programmed necrosis that occurs under caspase-deficient conditions. This alternative ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2016.120

    authors： Lalaoui N,Brumatti G

    更新日期：2017-02-01 00:00:00

  • Effect of a tapasin mutant on the assembly of the mouse MHC class I molecule H2-K(d).

    abstract：:Major histocompatibility complex (MHC) class I heavy chain/beta(2)m heterodimers assemble with antigenic peptides through interactions with peptide-loading complex proteins, including tapasin and ERp57. In human cells, a cysteine residue within tapasin (C95) has been shown to form a covalent bond with ERp57. In this s...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2009.59

    authors： Simone LC,Wang X,Tuli A,Solheim JC

    更新日期：2010-01-01 00:00:00

  • In vivo inhibition of the rat primary antibody response to antigenic stimulation by somatostatin.

    abstract：:Somatostatin inhibits in vitro lymphocyte proliferative responses from a variety of species including human, mouse and rat. The immunoinhibitory effects of somatostatin are thought to involve binding to specific cell surface somatostatin receptors on immunocompetent cells. This report describes an in vivo immunoinhibi...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1993.13

    authors： Eglezos A,Andrews PV,Helme RD

    更新日期：1993-04-01 00:00:00

  • Listeria species escape from the phagosomes of interleukin-4-deactivated human macrophages independent of listeriolysin.

    abstract：:Listeria monocytogenes is the causative agent of infections like sepsis and meningitis, especially in immunocompromised hosts. Human macrophages are able to phagocytose and digest L. monocytogenes but IL-4 prevents human macrophages from killing the bacteria, the mechanisms of which are unknown. In the present study, ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1711.2003.01196.x

    authors： Neumann K,Eppler E,Filgueira L,Groscurth P,Gasal E,Schaffner A,Schoedon G,Schneemann M

    更新日期：2003-12-01 00:00:00

  • Mechanisms of interference with the MHC class I-restricted pathway of antigen presentation by herpesviruses.

    abstract：:Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I-restricted pathway of antigen presentatio...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1996.85

    authors： Hill AB

    更新日期：1996-12-01 00:00:00

  • Contributions of an orthopteran to the understanding of neuronal pathfinding.

    abstract：:During the development of the nervous system neurons extend axons through a complex embryonic environment. To find a correct target, often located at a long distance, the neuronal growth cones travel along highly specific and stereotyped pathways. Proper neuronal pathfinding is thought to be accomplished by the specif...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1995.90

    authors： Sanchez D,Ganfornina MD,Bastiani MJ

    更新日期：1995-12-01 00:00:00

  • Production of interleukin-1 alpha and interleukin-2 by separate, phenotypically different leukaemia and human T cell lymphotropic virus-1-transformed T cell clones.

    abstract：:The relationship between interleukin-1 (IL-1) and interleukin-2 (IL-2) production and immunophenotype marker profiles was studied in a panel of 29 leukaemia and human T cell lymphotropic virus-1 (HTLV-1)-transformed T cell lines. Culture supernatants from six of the 29 T cell lines tested increased IL-2 production by ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1993.56

    authors： Holán V,Minowada J

    更新日期：1993-12-01 00:00:00

  • Eph/ephrinB signalling is involved in the survival of thymic epithelial cells.

    abstract：:The signals that determine the survival/death of the thymic epithelial cells (TECs) component during embryonic development of the thymus are largely unknown. In this study, we combine different in vivo and in vitro experimental approaches to define the role played by the tyrosine kinase receptors EphB2 and EphB3 and t...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2012.59

    authors： García-Ceca J,Alfaro D,Montero-Herradón S,Zapata AG

    更新日期：2013-02-01 00:00:00

  • The correlation between proinflammatory cytokines, MAdCAM-1 and cellular infiltration in the inflamed colon from TNF-alpha gene knockout mice.

    abstract：:Tumour necrosis factor (TNF) is important in the development of inflammatory bowel disease. TNF-alpha-deficient mice show more severe colonic inflammation than wild-type (Wt) mice, but the underlying mechanism remains unclear. Using immunohistochemistry, enzyme-linked-immunosorbent assay and histopathology, we found t...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/sj.icb.7100112

    authors： Xu Y,Hunt NH,Bao S

    更新日期：2007-11-01 00:00:00

  • Embryonic macrophages of early rat yolk sac: Immunohistochemistry and ultrastructure with reference to endodermal cell layer.

    abstract：:Macrophages are multifunctional cells that participate in numerous biological processes; they actively phagocytose foreign particles and cell debris. Embryonic tissue macrophages are present at early stages of mammalian development; their ontogeny and function is still under investigation. Our study used immunohistoch...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.2002.01109.x

    authors： El-Nefiawy N,Abdel-Hakim K,Yamashita A,Kanayama N

    更新日期：2002-10-01 00:00:00

  • Phagocytosis and transcytosis by the follicle-associated epithelium of the ileal Peyer's patch in calves.

    abstract：:Latex beads, 250 and 610 nm in diameter, and parapox virus isolated from ecthyma in sheep, were injected into intestinal loops containing either jejunal or ileal Peyer's patches (PP) of 3-4 week old calves. Uptake of latex and parapox virus was restricted to the ileal PP, 30-60 min after injection. The latex beads see...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1988.35

    authors： Landsverk T

    更新日期：1988-08-01 00:00:00

  • Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity.

    abstract：:The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. By contrast, each parent strain, NZB or NZW, has limited autoimmunity, suggesting traits of both strains contribute to pathogenesis. Although many of the contributing genes have been identified, the contributing cellul...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/imcb.12313

    authors： Zhan Y,Kong I,Chopin M,Macri C,Zhang JG,Xie J,Nutt SL,O'Keeffe M,Hawkins ED,Morand EF,Lew AM

    更新日期：2020-03-01 00:00:00

  • Mycoplasma infection can sensitize host cells to apoptosis through contribution of apoptotic-like endonuclease(s).

    abstract：:Mycoplasma infection may lead to various pathologies in a broad range of hosts. It has been shown that Mycoplasma may trigger cell death in cell cultures; however, the mechanism remains unknown. In the present paper we show that Mycoplasma infection of different lymphocyte and epithelial tumour cell lines leads to the...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1711.1998.00781.x

    authors： Sokolova IA,Vaughan AT,Khodarev NN

    更新日期：1998-12-01 00:00:00

  • Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo.

    abstract：:Lethal giant larvae-1 (Lgl-1) is an evolutionary conserved protein that regulates cell polarity in diverse lineages; however, the role of Lgl-1 in the polarity and function of immune cells remains to be elucidated. To assess the role of Lgl-1 in T cells, we generated chimeric mice with a hematopoietic system deficient...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.2015.82

    authors： Ramsbottom KM,Sacirbegovic F,Hawkins ED,Kallies A,Belz GT,Van Ham V,Haynes NM,Durrant MJ,Humbert PO,Russell SM,Oliaro J

    更新日期：2016-03-01 00:00:00

  • The surface phenotype of activated T lymphocytes.

    abstract：:The surface phenotype of T cells reflects both their relative maturity and their activation state. To determine the pattern of surface markers characteristic of activated T cells, purified mature T cells were stimulated in vitro for periods of 0.5-5 days with Concanavalin-A (Con-A) or phorbol myristic acetate (PMA) an...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1988.39

    authors： Kelly K,Shortman K,Scollay R

    更新日期：1988-08-01 00:00:00

  • Lymphoid organ dendritic cells: beyond the Langerhans cells paradigm.

    abstract：:The immune system has developed mechanisms to detect and initiate responses to a continual barrage of immunological challenges. Dendritic cells (DC), a heterogeneous population of leucocytes, play a major role as immunosurveillance agents. To accomplish this function, DC are equipped with highly efficient mechanisms t...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2004.01216.x

    authors： Wilson NS,Villadangos JA

    更新日期：2004-02-01 00:00:00

  • Immunopathogenesis of poxvirus infections: forecasting the impending storm.

    abstract：:Variola virus, the causative agent of smallpox, is a member of the poxvirus family and one of the most virulent human pathogens known. Although smallpox was eradicated almost 30 years ago, it is not understood why the mortality rates associated with the disease were high, why some patients recovered, and what constitu...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/sj.icb.7100033

    authors： Stanford MM,McFadden G,Karupiah G,Chaudhri G

    更新日期：2007-02-01 00:00:00

  • Autophagy as a pro-death pathway.

    abstract：:The evolutionarily conserved catabolic process of autophagy involves the degradation of cytoplasmic components through lysosomal enzymes. Basal levels of autophagy maintain cellular homeostasis and under stress conditions high levels of autophagy are induced. It is often under such stress conditions that high levels o...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2014.85

    authors： Denton D,Xu T,Kumar S

    更新日期：2015-01-01 00:00:00

  • An hypothesis to explain why cell-mediated immunity alone can contain infections by certain intracellular parasites and how immune class regulation of the response against such parasites can be subverted.

    abstract：:Cells with a low density of parasite-specific antigens on their surface are postulated to be susceptible to a cell-mediated attack but not to effector mechanisms normally activated following the binding of specific antibody to the infected cell. It is further postulated that such infected cells normally induce a cell-...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1992.44

    authors： Bretscher PA

    更新日期：1992-10-01 00:00:00

  • Natural killer and natural cytotoxic cells are present at the maternal-fetal interface during murine pregnancy.

    abstract：:NK cell activity has been detected in the early murine decidua, and hypothesized to be mediated by granulated metrial gland (GMG) cells. The possibility that natural cytotoxic (NC) cells are also present in the decidua has not been investigated. In this study mAb to NK cells (anti-NK-1.1) and NC cells (anti-NC-1.1) we...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1994.23

    authors： Clarke GR,Roberts TK,Smart YC

    更新日期：1994-04-01 00:00:00

  • Modulation of experimental allergic encephalomyelitis in mice by immunization with a peptide specific for the gamma delta T cell receptor.

    abstract：:This study investigated the role of gamma delta T cells in experimental allergic encephalomyelitis (EAE), a chronic inflammatory disease of the central nervous system (CNS) that resembles multiple sclerosis. The strategy was to assess the effect on EAE of TCR peptide immunization directed against V gamma 6 T cells, sh...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1997.14

    authors： Olive C

    更新日期：1997-02-01 00:00:00

  • 3D computation modelling of the influence of cytokine secretion on Th-cell development suggests that negative selection (inhibition of Th1 cells) is more effective than positive selection by IL-4 for Th2 cell dominance.

    abstract：:Th-cell development has been suggested to include selective mechanisms in which certain cytokines select either Th1 or Th2 cells to proliferate and grow. The selective theory is based on the observation that Th2 cells secrete IL-4, a cytokine that promotes Th2 development, whereas Th1 cells secrete interferon-gamma (I...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/sj.icb.7100023

    authors： Jansson A,Harlen M,Karlsson S,Nilsson P,Cooley M

    更新日期：2007-04-01 00:00:00

  • Inflammation during skeletal muscle regeneration and tissue remodeling: application to exercise-induced muscle damage management.

    abstract：:Increase in the practice of sport by more and more numerous people in the Western countries is associated with an increase in muscle injuries, and in demand for improving muscle function and acceleration of muscle recovery after damage. Most of the treatments used target inflammation. Indeed, several lines of experime...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2015.97

    authors： Chazaud B

    更新日期：2016-02-01 00:00:00

  • Demystifying the development of dendritic cell subtypes, a little.

    abstract：:The broadest definition of dendritic cells (DCs) is white blood cells that can take up antigen, process it and then present antigen-derived peptides to activate cognate naive T cells. Although this definition is by no means perfect, it is nevertheless now textbook. The source of frustration more recently has focused o...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2008.28

    authors： Naik SH

    更新日期：2008-07-01 00:00:00

  • Disentangling the complexity of the skin dendritic cell network.

    abstract：:Using 'knockin' mice to track and ablate dendritic cells (DCs) expressing notably the langerin (Cd207) gene, it has been possible to identify five DC subsets within the skin and to assess whether functional specialization exists among them. The present review summarizes recent information concerning the phenotype and ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2010.34

    authors： Henri S,Guilliams M,Poulin LF,Tamoutounour S,Ardouin L,Dalod M,Malissen B

    更新日期：2010-05-01 00:00:00

  • Restoration of hepatic mast cells and expression of a different mast cell protease phenotype in regenerating rat liver after 70%-hepatectomy.

    abstract：:Mast cells (MC) can undergo significant changes in number and phenotype; these alterations result in the differential expression of growth factors and cytokines. Kit ligand (KL; stem cell factor) is produced by mesenchymal cells, and in the liver by biliary epithelial cells. Recent studies suggest that KL, and its rec...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2005.01368.x

    authors： Zweifel M,Breu K,Matozan K,Renner E,Welle M,Schaffner T,Clavien PA

    更新日期：2005-12-01 00:00:00

  • How adaptive antibodies facilitate the evolution of natural antibodies.

    abstract：:It is shown how Ig specificities, randomly generated in conventional B cells, come to be expressed in the genetically-determinate B1 population. Thus the adaptive antibody population facilitates the evolution of the natural antibody repertoire, in accordance with the Baldwin effect in the evolution of instinct. The ev...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.1996.50

    authors： Anderson RW

    更新日期：1996-06-01 00:00:00

  • Tumor-associated carbohydrate antigens: a possible avenue for cancer prevention.

    abstract：:Here we examine the use of glycopeptides containing tumour-associated carbohydrate antigens (TACA) as potential preventive vaccines for carcinomas. Our recent results suggest that CD8+ T cells (CTL) are capable of recognizing TACA in a conventional class I MHC-restricted fashion. The ThomsenFriedenreich antigen (TF), ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1711.2005.01347.x

    authors： Xu Y,Sette A,Sidney J,Gendler SJ,Franco A

    更新日期：2005-08-01 00:00:00

  • Antigen-specific apoptosis in immortalized T cells by soluble MHC class II-peptide complexes.

    abstract：:The recognition of T cell receptors (TCR) by purified major histocompatibility complex (MHC) class II-peptide complexes in the absence of costimulatory signals leads to the induction of T cell non-responsiveness or anergy. In a recent study using human T cell clones, it was observed that prolonged incubation of restin...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章

    doi：10.1038/icb.1996.13

    authors： Arimilli S,Mumm JB,Nag B

    更新日期：1996-02-01 00:00:00

  • The importance of co-stimulation in the orchestration of T helper cell differentiation.

    abstract：:Upon their activation, CD4 T cells can differentiate into distinct T helper cell subsets with specialised functions. Different T helper cell subsets produce specific cytokines that mediate beneficial and sometimes detrimental effects, depending on the infection or disease setting. CD4 T-cell priming relies on signals ...

    journal_title：Immunology and cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/icb.2015.45

    authors： Coquet JM,Rausch L,Borst J

    更新日期：2015-10-01 00:00:00