Abstract:
:The MS4A (membrane-spanning 4-domain family, subfamily A) family of proteins contains some well-known members including MS4A1 (CD20), MS4A2 (FcɛRIβ) and MS4A3 (HTm4). These three MS4A family members are expressed on the cell surface of specific leukocyte subsets and have been well characterized as having key roles in regulating cell activation, growth and development. However, beyond MS4A1-3 there are a large number of related molecules (18 to date in humans) where our understanding of their biological roles is at a relatively nascent stage. This review examines the larger MS4A family focusing on their structure, expression, regulation and characterized and/or emerging biological roles. Our own work on one family member MS4A8B, and its possible role in epithelial cell regulation, is also highlighted.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Eon Kuek L,Leffler M,Mackay GA,Hulett MDdoi
10.1038/icb.2015.48subject
Has Abstractpub_date
2016-01-01 00:00:00pages
11-23issue
1eissn
0818-9641issn
1440-1711pii
icb201548journal_volume
94pub_type
杂志文章,评审abstract::Antigen presentation by enterocytes isolated from the rat small bowel was studied by using T cell proliferation, and immunoregulatory function in an antigen-driven culture system, as indicator systems. Lymph node T cells obtained from rats immunized with ovalbumin (OA) failed to divide when cultured for 4 days in the ...
journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:1999-12-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
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pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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更新日期:1998-06-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.1989.29
更新日期:1989-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
doi:10.1038/icb.2010.18
更新日期:2010-08-01 00:00:00
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
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journal_title:Immunology and cell biology
pub_type: 杂志文章,评审
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