Abstract：
:Natural suppressor (NS) cell line (Clone 59) was established from the bone marrow of adult C3H/Hej mice in the presence of WEHI-3 conditioned media. Clone 59 cells suppressed the generation of cytotoxic T lymphocytes from normal mouse spleen. This suppression was seen at a responder-to-suppressor cell ratio of 1000:1 and lacked antigen specificity or MHC restriction. Clone 59 cells expressed the 'null' surface phenotype (Thy1.2-, CD3-, Lyt-2-, L3T4-, surface Ig-, MAC-1-) by immunofluorescent staining. Clone 59 cells exhibited no cytolytic activity against NK cell-sensitive YAC-1 and natural cytotoxic L929 target cell lines. Non-specific suppression, with a cell-free supernatant from the Clone 59-NS cells, also was observed. The supernatant did not inhibit [3H]-thymidine uptake by CTLL-2 cells which were proliferating in response to IL-2. Anti-transforming growth factor-beta (TGF-beta) monoclonal antibody had no effect on suppression, suggesting that the non-specific suppression is mediated by some soluble factors other than TGF-beta. Clone 59 cells may be useful in identifying non-specific suppressor cells in adult bone marrow and studying their functional role in the regulation of tolerance and self-reactivity.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Yanagië H,Sugiyama H,Sekiguchi Mdoi
10.1038/icb.1995.51subject
Has Abstractpub_date
1995-08-01 00:00:00pages
333-9issue
4eissn
0818-9641issn
1440-1711journal_volume
73pub_type
杂志文章abstract：:Cells with a low density of parasite-specific antigens on their surface are postulated to be susceptible to a cell-mediated attack but not to effector mechanisms normally activated following the binding of specific antibody to the infected cell. It is further postulated that such infected cells normally induce a cell-...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.1992.44
更新日期：1992-10-01 00:00:00
abstract：:Over the past few years a great deal of research has examined how T cell-dependent immune responses are initiated and subsequently regulated. Ligation of the TCR with an antigenic peptide bound to an MHC protein on a professional APC provides the crucial antigen-specific stimulus required for T cell activation. Intera...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1711.1999.00795.x
更新日期：1999-02-01 00:00:00
abstract：:During an allergic inflammatory response in the airway, if a failure of the epithelial cell barrier occurs before the systemic immune response is triggered by allergens, more allergens can invade. Using a rat model of asthma, we previously found that mucosal mast cells, which localise to the epithelial layer of the ai...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2010.90
更新日期：2011-02-01 00:00:00
abstract：:Human cytomegalovirus (HCMV), the β-herpesvirus prototype, has evolved a wide spectrum of mechanisms to counteract host immunity. Among them, HCMV uses cellular captured genes encoding molecules capable of interfering with the original host function or of fulfilling new immunomodulatory tasks. Here, we report on UL7, ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2011.55
更新日期：2011-10-01 00:00:00
abstract：:Somatostatin inhibits in vitro lymphocyte proliferative responses from a variety of species including human, mouse and rat. The immunoinhibitory effects of somatostatin are thought to involve binding to specific cell surface somatostatin receptors on immunocompetent cells. This report describes an in vivo immunoinhibi...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1993.13
更新日期：1993-04-01 00:00:00
abstract：:Ikaros, Aiolos and Helios encode zinc finger transcription factors that are important regulators of lymphoid development and differentiation. These proteins are involved in the control of gene expression and when associated with nuclear complexes, participate in nucleosome remodeling. Because differential splicing pro...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1711.2003.01159.x
更新日期：2003-06-01 00:00:00
abstract：:This study demonstrates that a syngeneic specific cytotoxic T lymphocyte (CTL) response to a class I major histocompatibility complex (MHC) positive tumour requires dual processing and recognition of tumour antigens. One type of antigen is processed and expressed in association with class I MHC at the surface of intac...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1993.36
更新日期：1993-08-01 00:00:00
abstract：:Hereditary angioedema as a result of deficiency of the C1 inhibitor (HAE-C1INH; MIM# 106100) is a rare autosomal disorder and affected individuals are generally heterozygous for dominant negative variants in the SERPING1 gene. Homozygosity for SERPING1 pathogenic variants was long considered to be embryonically lethal...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.12362
更新日期：2020-09-01 00:00:00
abstract：:Interleukin (IL)-15 overexpression in eosinophilic gastrointestinal disorders is reported, but IL-15's role in promoting eosinophilic gastroenteritis is largely unknown. Therefore, we generated enterocyte-overexpressed IL-15 transgenic mice using Fabpi promoter. The Fabpi-IL-15 (iIL-15) transgenic mice showed induced ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.1036
更新日期：2018-03-01 00:00:00
abstract：:It has been described that polymorphonuclear neutrophils (PMNs) enhance the replication of CC-chemokine receptor 5/macrophage-tropic (R5) HIV in cultures of monocyte-derived macrophages (MDMs). In this study, the inhibitory effect of glycyrrhizin (GL) on R5 HIV replication influenced by PMNs was investigated in MDM cu...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2009.40
更新日期：2009-10-01 00:00:00
abstract：:It is known today that the immune system is influenced by various types of psychological and physiological stressors, including physical activity. It is well known that physical activity can influence neuropeptide levels both in the central nervous system as well as in peripheral blood. The reported changes of immune ...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1711.2000.t01-10-.x
更新日期：2000-10-01 00:00:00
abstract：:Intravenous (i.v.) immunization of mice with recombinant vaccinia viruses stimulated the highest antibody and cytotoxic T lymphocyte (CTL) responses when i.v., intraperitoneal (i.p.), intranasal (i.n.), footpad (f.p.) and tail scarification (t.s.) routes were compared. Intraperitoneal immunization of mice resulted in ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1989.48
更新日期：1989-10-01 00:00:00
abstract：:Interferon regulatory factor (IRF) family members impart cell-type specificity to toll-like receptor (TLR) signalling, and we recently identified a role for IRF6 in TLR2 signalling in epithelial cells. TLR3 has a well-characterized role in wound healing in the skin, and here, we examined TLR3-dependent IRF6 functions ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2015.77
更新日期：2015-10-01 00:00:00
abstract：:During tuberculosis (TB) infection, the granuloma provides the microenvironment in which antigen-specific T cells colocate with and activate infected macrophages to inhibit the growth of Mycobacterium tuberculosis. Although the granuloma is the site for mycobacterial killing, virulent mycobacteria have developed a var...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/sj.icb.7100027
更新日期：2007-02-01 00:00:00
abstract：:Macrophages are multifunctional cells that participate in numerous biological processes; they actively phagocytose foreign particles and cell debris. Embryonic tissue macrophages are present at early stages of mammalian development; their ontogeny and function is still under investigation. Our study used immunohistoch...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.2002.01109.x
更新日期：2002-10-01 00:00:00
abstract：:Irradiated malaria sporozoites induce better protection than viable untreated sporozoites. We observed early differences between irradiated and viable untreated sporozoites in priming responses in vivo to a protective CD8 T-cell epitope, pb9, of the circumsporozoite protein of Plasmodium berghei. Sporozoites were proc...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/j.1440-1711.2005.01325.x
更新日期：2005-06-01 00:00:00
abstract：:Lethal giant larvae-1 (Lgl-1) is an evolutionary conserved protein that regulates cell polarity in diverse lineages; however, the role of Lgl-1 in the polarity and function of immune cells remains to be elucidated. To assess the role of Lgl-1 in T cells, we generated chimeric mice with a hematopoietic system deficient...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2015.82
更新日期：2016-03-01 00:00:00
abstract：:The relationship between interleukin-1 (IL-1) and interleukin-2 (IL-2) production and immunophenotype marker profiles was studied in a panel of 29 leukaemia and human T cell lymphotropic virus-1 (HTLV-1)-transformed T cell lines. Culture supernatants from six of the 29 T cell lines tested increased IL-2 production by ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1993.56
更新日期：1993-12-01 00:00:00
abstract：:Activins and inhibins are members of the transforming growth factor-β superfamily that have been considered crucial regulators of cell processes, such as differentiation, proliferation and apoptosis, in different cell types. Initial studies about the function of activin A in the immune system focused on the regulation...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2011.32
更新日期：2012-02-01 00:00:00
abstract：:Urinary tract infections are a major problem in human medicine for which better understanding of native immune defenses may reveal new pathways for therapeutic intervention. Tamm-Horsfall glycoprotein (THP), the most abundant urinary protein, interacts with bacteria including uropathogenic Escherichia coli (UPEC) as w...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2017.63
更新日期：2017-11-01 00:00:00
abstract：:Multiple levels of regulation of collagenase (matrix metalloproteinase 1; MMP-1), have been demonstrated in a clonal rat epithelial cell line (A5P/B10). Secreted enzyme could not be demonstrated in culture medium from A5P/B10 cells but, using antibodies specific for collagenase, the enzyme was detected within the cyto...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1993.4
更新日期：1993-02-01 00:00:00
abstract：:Regulating the strength and class of an immune response requires lymphocytes to act as complex signal integrating "machines", taking information from multiple sources while making decisions that affect the final outcome. Describing and understanding the decision-making behaviour of lymphocytes within the context of th...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/sj.icb.7100061
更新日期：2007-06-01 00:00:00
abstract：:The function of mast cells in allergic and organ-specific autoimmune responses is highly controversial. In the current study, we aimed to dissect the role of mast cells in systemic autoimmunity in the B6(lpr/lpr) mouse, a spontaneous model of systemic lupus erythematosus. B6(lpr/lpr) mice were interbred with C57Bl/6-K...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2015.49
更新日期：2015-11-01 00:00:00
abstract：:The utility of T-cell receptor (TCR) transgenic mice in medical research has been considerable, with applications ranging from basic biology all the way to translational and clinical investigations. Crossing of TCR transgenic mice with either recombination-activating gene (RAG)-1 or RAG-2 knockouts is frequently used ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.12033
更新日期：2018-07-01 00:00:00
abstract：:We recently demonstrated that 17beta-estradiol (E2) enhances killing of Leishmania mexicana in macrophages from both male and female DBA/2 mouse by increasing nitric oxide (NO) production. Here, we analyzed the effect of E2 on leishmanicidal activity and cytokine production by bone marrow-derived macrophages (BMDMs) f...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2008.39
更新日期：2008-08-01 00:00:00
abstract：:In the last lustrum single-cell techniques such as single-cell quantitative PCR, RNA and DNA sequencing, and the state-of-the-art cytometry by time of flight (CyTOF) mass cytometer have allowed a detailed analysis of the sub-composition of different organs from the bone marrow hematopoietic compartment to the brain. T...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2015.106
更新日期：2016-03-01 00:00:00
abstract：:We sought to model the mechanism by which leucocytes may be actively repulsed by a beta-chemokine signal. This model is used to interpret an apparent paradox in chemokine biology, whereby high levels of a T-cell chemoattractant, stromal cell derived factor-1 (SDF-1), are present in bone marrow and thymic tissues despi...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.2001.01015.x
更新日期：2001-08-01 00:00:00
abstract：:Peyer's patches (PP) are important inductive sites for the mucosal immune response. It is well known that lymphocytes that migrate into PP are mainly of T-cell lineage from thymus-derived cells (i.e. alphabetaTCR(high) cells). In this study, we further characterized the properties of PP lymphocytes in mice using a mou...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/j.1440-1711.2005.01361.x
更新日期：2005-10-01 00:00:00
abstract：:Increase in the practice of sport by more and more numerous people in the Western countries is associated with an increase in muscle injuries, and in demand for improving muscle function and acceleration of muscle recovery after damage. Most of the treatments used target inflammation. Indeed, several lines of experime...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2015.97
更新日期：2016-02-01 00:00:00
abstract：:Brucellosis remains a significant zoonotic threat worldwide. Humans and animals acquire infection via their oropharynx and upper respiratory tract following oral or aerosol exposure. After mucosal infection, brucellosis develops into a systemic disease. Mucosal vaccination could offer a viable alternative to conventio...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2016.5
更新日期：2016-05-01 00:00:00
