Abstract：
:It is known today that the immune system is influenced by various types of psychological and physiological stressors, including physical activity. It is well known that physical activity can influence neuropeptide levels both in the central nervous system as well as in peripheral blood. The reported changes of immune function in response to exercise have been suggested to be partly regulated by the activation of different neuropeptides and the identification of receptors for neuropeptides and steroid hormones on cells of the immune system has created a new dimension in this endocrine-immune interaction. It has also been shown that immune cells are capable of producing neuropeptides, creating a bidirectional link between the nervous and immune systems. The most common neuropeptides mentioned in this context are the endogenous opioids. The activation of endogenous opioid peptides in response to physical exercise is well known in the literature, as well as the immunomodulation mediated by opioid peptides. The role of endogenous opioids in the exercise-induced modulation of immune function is less clear. The present paper will also discuss the role of other neuroendocrine factors, such as substance P, neuropeptide Y and vasoactive intestinal peptide, and pituitary hormones, including growth hormone, prolactin and adrenocorticotrophin, in exercise and their possible effects on immune function.
journal_name
Immunol Cell Bioljournal_title
Immunology and cell biologyauthors
Jonsdottir IHdoi
10.1111/j.1440-1711.2000.t01-10-.xsubject
Has Abstractpub_date
2000-10-01 00:00:00pages
562-70issue
5eissn
0818-9641issn
1440-1711pii
icb961journal_volume
78pub_type
杂志文章,评审abstract：:Peripheral tolerance mechanisms limit autoimmunity by constitutively eliminating self-reactive CD8+ T cells from the periphery in a process called deletion. Previous work has demonstrated that this deletion process is mediated by BIM-dependent apoptotic death due to transcriptional induction of the Bim gene. Currently...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2016.53
更新日期：2016-10-01 00:00:00
abstract：:Somatostatin inhibits in vitro lymphocyte proliferative responses from a variety of species including human, mouse and rat. The immunoinhibitory effects of somatostatin are thought to involve binding to specific cell surface somatostatin receptors on immunocompetent cells. This report describes an in vivo immunoinhibi...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1993.13
更新日期：1993-04-01 00:00:00
abstract：:During a chronic infection such as tuberculosis, the pool of tissue dendritic cells (DC) must be renewed by recruitment of both circulating DC progenitors and monocytes (Mo). However, the microenvironment of the inflammatory site affects Mo differentiation. As DC are critical for initiating a Mycobacterium tuberculosi...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2010.22
更新日期：2010-10-01 00:00:00
abstract：:Mycoplasma infection may lead to various pathologies in a broad range of hosts. It has been shown that Mycoplasma may trigger cell death in cell cultures; however, the mechanism remains unknown. In the present paper we show that Mycoplasma infection of different lymphocyte and epithelial tumour cell lines leads to the...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.1998.00781.x
更新日期：1998-12-01 00:00:00
abstract：:Spleen cells from newborn mice are immunologically nonreactive and do not respond by proliferation upon stimulation with the T cell mitogen concanavalin-A (Con-A) or with recombinant interleukin-2 (IL-2). We have found that, in spite of the observed non-reactivity in the proliferative tests, cells from newborn mice we...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1991.59
更新日期：1991-12-01 00:00:00
abstract：:The three modes of antibody production, natural, T independent (TI) and T dependent (TD) are conserved among vertebrate species suggesting an important role for each in protection against pathogens. Here, I use an artificial 'universe' to argue that the three modes of antibody production represent layers that evolved ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1997.95
更新日期：1997-12-01 00:00:00
abstract：:Over the past few years a great deal of research has examined how T cell-dependent immune responses are initiated and subsequently regulated. Ligation of the TCR with an antigenic peptide bound to an MHC protein on a professional APC provides the crucial antigen-specific stimulus required for T cell activation. Intera...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1711.1999.00795.x
更新日期：1999-02-01 00:00:00
abstract：:The gut mucosal system must fulfil conflicting roles in suppressing immune responses against orally fed antigens (tolerance) while still retaining the ability to respond to potential enteric pathogens. It must also, to a large degree, not mount an immune response against commensal enteric bacteria and the administrati...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.2000.00883.x
更新日期：2000-02-01 00:00:00
abstract：:Hereditary angioedema as a result of deficiency of the C1 inhibitor (HAE-C1INH; MIM# 106100) is a rare autosomal disorder and affected individuals are generally heterozygous for dominant negative variants in the SERPING1 gene. Homozygosity for SERPING1 pathogenic variants was long considered to be embryonically lethal...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.12362
更新日期：2020-09-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2009.29
更新日期：2009-07-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.1996.28
更新日期：1996-04-01 00:00:00
abstract：:Our earlier studies have demonstrated that gonadotropin-releasing hormone (GnRH) agonists suppress immune system function in female mice. No systematic studies regarding the effect of gender on immune system function following GnRH agonist treatment, however, have been reported. This study, therefore, investigated seq...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1996.18
更新日期：1996-04-01 00:00:00
abstract：:Numerous studies have associated carriage of HLA-DRB1*1501, DQA1*0102 and DQB1*0602 (DR15, DQ6) with dominant resistance to type 1 diabetes and have concluded that one or more of the component HLA class II molecules mediate this effect. Mechanisms for MHC class II-mediated resistance to diabetes have been proposed fro...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.2001.01043.x
更新日期：2001-12-01 00:00:00
abstract：:The ability to accurately quantitate and experimentally examine epigenetic modifications across the human genome has exploded in the past decade. This has given rise to a wealth of new information concerning the contributions of epigenetic regulatory networks to the pathogenesis of human disease. In particular, immuno...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.2014.105
更新日期：2015-03-01 00:00:00
abstract：:NKT cells are a minor subset of T cells that have important roles in controlling immune responses in disease states including cancer, autoimmunity and pathogenic infections. In contrast to conventional T cells, NKT cells express an invariant TCR and respond to glycolipids presented by CD1d. In this study, we sought to...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/j.1440-1711.2005.01396.x
更新日期：2006-02-01 00:00:00
abstract：:Respiratory syncytial virus (RSV) is a common virus that causes lower respiratory infections across a wide range of ages. A licensed RSV vaccine is not available because vaccination with formalin-inactivated RSV (FI-RSV) and the subsequent RSV infection cause not only insufficient induction of neutralizing antibodies ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2017.61
更新日期：2017-11-01 00:00:00
abstract：:Biallelic mutations in the human lipopolysaccharide responsive beige-like anchor (LRBA) gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a broad range of clinical manifestations including autoimmunity, organomegaly, hypogammaglobulinemia and recurrent infections. Considering the pheno...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2017.52
更新日期：2017-10-01 00:00:00
abstract：:Follicular dendritic cells (FDC) play a crucial role in the regulation of humoral immunity. They are believed to be responsible for long-term persistence of antibody, due to their role in antibody response induction and their ability to retain antigen in immunogenic form for long periods. In this article, a regulatory...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2017.55
更新日期：2017-10-01 00:00:00
abstract：:The V region antigenic determinants (idiotopes (Ids)) of antibodies (Abs) have been suggested to be involved in regulating the immune system. Certain diseases such as diabetes mellitus have recently been associated with a disequilibrium between Id(+) and anti-Id Abs. However, it is unknown how Abs carrying complementa...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2009.118
更新日期：2010-07-01 00:00:00
abstract：:During tuberculosis (TB) infection, the granuloma provides the microenvironment in which antigen-specific T cells colocate with and activate infected macrophages to inhibit the growth of Mycobacterium tuberculosis. Although the granuloma is the site for mycobacterial killing, virulent mycobacteria have developed a var...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/sj.icb.7100027
更新日期：2007-02-01 00:00:00
abstract：:Pseudomonas aeruginosa ocular infection causes extensive corneal neovascularization. The purpose of the present study was to investigate the role of the angiogenic factors macrophage inflammatory protein-2 (MIP-2) and vascular endothelial growth factor (VEGF) in the regulation of corneal neovascularization during P. a...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.2002.01094.x
更新日期：2002-08-01 00:00:00
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journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2013.110
更新日期：2014-05-01 00:00:00
abstract：:Natural suppressor (NS) cell line (Clone 59) was established from the bone marrow of adult C3H/Hej mice in the presence of WEHI-3 conditioned media. Clone 59 cells suppressed the generation of cytotoxic T lymphocytes from normal mouse spleen. This suppression was seen at a responder-to-suppressor cell ratio of 1000:1 ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1995.51
更新日期：1995-08-01 00:00:00
abstract：:The effect of serum on LPS-induced activation of a murine macrophage-like cell line, WEHI-3, was examined. Foetal calf serum strongly inhibited the production of nitric oxide (NO) and TNF-alpha by LPS-stimulated WEHI-3 cells, while it enhanced the production of both by other macrophage-like cell lines, J774.1 and BAM3...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.1440-1711.1999.00807.x
更新日期：1999-04-01 00:00:00
abstract：:Productive immune responses to T-cell-dependent antigens ultimately generate two long-lived compartments: memory B cells and bone marrow-resident plasma cells, which both arise from within germinal centres. The ability of a B-cell clone to populate these effector compartments requires its descendents to outcompete tho...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/sj.icb.7100148
更新日期：2008-02-01 00:00:00
abstract：:During the development of the nervous system neurons extend axons through a complex embryonic environment. To find a correct target, often located at a long distance, the neuronal growth cones travel along highly specific and stereotyped pathways. Proper neuronal pathfinding is thought to be accomplished by the specif...
journal_title：Immunology and cell biology
pub_type： 杂志文章,评审
doi：10.1038/icb.1995.90
更新日期：1995-12-01 00:00:00
abstract：:The Kunjin replicon was used to express a polytope that consisted of seven hepatitis C virus cytotoxic T lymphocyte epitopes and one influenza cytotoxic T lymphocyte epitope for vaccination studies. The self-replicating nature of, and expression from, the ribonucleic acid was confirmed in vitro. Initial vaccinations w...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1046/j.0818-9641.2002.01137.x
更新日期：2003-02-01 00:00:00
abstract：:The recognition of T cell receptors (TCR) by purified major histocompatibility complex (MHC) class II-peptide complexes in the absence of costimulatory signals leads to the induction of T cell non-responsiveness or anergy. In a recent study using human T cell clones, it was observed that prolonged incubation of restin...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.1996.13
更新日期：1996-02-01 00:00:00
abstract：:The role of the immunoproteasome is perceived as confined to adaptive immune responses given its ability to produce peptides ideal for MHC Class-I binding. Here, we demonstrate that the immunoproteasome subunit, LMP2, has functions beyond its immunomodulatory role. Using LMP2-deficient mice, we demonstrate that LMP2 i...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1111/imcb.12163
更新日期：2018-10-01 00:00:00
abstract：:Gαq, the α-subunit of Gq protein, is ubiquitously expressed in mammalian cells. It initially attracted attention for its physiological significance in cardiovascular system. In recent years, studies have also indicated the important roles of Gαq in regulating immunity, supplying us a new insight into the mechanism of ...
journal_title：Immunology and cell biology
pub_type： 杂志文章
doi：10.1038/icb.2015.13
更新日期：2015-08-01 00:00:00
