Antigenic analysis of Strongyloides ratti infective larvae and adult worms.

abstract：:Sustained-release vaccine delivery systems may enhance the immunogenicity of subunit vaccines and reduce the need for multiple vaccinations. The aim of this study was to develop a thermoresponsive hydrogel using poloxamer 407-chitosan (CP) grafted copolymer as a delivery system for single-shot sustained-release vaccin...

journal_title：Immunology and cell biology

authors： Bobbala S,Gibson B,Gamble AB,McDowell A,Hook S

更新日期：2018-07-01 00:00:00

abstract：:The mucosal system is the first line of defense against many pathogens. It is continuously exposed to dietary and microbial antigens, and thus the host must maintain a homeostatic environment between commensal microbiota and pathogenic infections. Following infections and inflammatory events, a rapid innate immune res...

journal_title：Immunology and cell biology

authors： Mangan NE,Fung KY

更新日期：2012-05-01 00:00:00

abstract：:During the development of the nervous system neurons extend axons through a complex embryonic environment. To find a correct target, often located at a long distance, the neuronal growth cones travel along highly specific and stereotyped pathways. Proper neuronal pathfinding is thought to be accomplished by the specif...

journal_title：Immunology and cell biology

authors： Sanchez D,Ganfornina MD,Bastiani MJ

更新日期：1995-12-01 00:00:00

abstract：:The Australian populations of rainbow trout (Onchorhynchus mykiss) and Atlantic salmon (Salmo salar) were found to have similar immunological responses to local strains of Vibrio anguillarum as those reported for the more genetically diverse populations of these fish and strains of V. anguillarum found in the Northern...

journal_title：Immunology and cell biology

authors： Munday BL,Carson J,Whittington R,Alexander J

更新日期：1992-12-01 00:00:00

abstract：:Peripheral tolerance mechanisms limit autoimmunity by constitutively eliminating self-reactive CD8+ T cells from the periphery in a process called deletion. Previous work has demonstrated that this deletion process is mediated by BIM-dependent apoptotic death due to transcriptional induction of the Bim gene. Currently...

journal_title：Immunology and cell biology

authors： Wagle MV,Parish IA

更新日期：2016-10-01 00:00:00

abstract：:Tumour necrosis factor (TNF) is a highly potent, proinflammatory cytokine with broad-ranging functions from the regulation of endothelial cell adhesion molecules to facilitate entry of leucocytes into tissues, to direct induction of cellular cytotoxicity. This diversity of function potentially attributable to TNF in t...

journal_title：Immunology and cell biology

authors： Körner H,Sedgwick JD

更新日期：1996-10-01 00:00:00

abstract：:This article attempts to assemble theoretical-teleological argument to explore possible answers to the question of why class I MHC molecules bind smaller peptides than class II MHC molecules and the associated question of why the size of peptides binding to class I molecules is approaching the limit of the self-non-se...

journal_title：Immunology and cell biology

authors： Blanden RV

更新日期：1995-02-01 00:00:00

abstract：:The present study demonstrates that SRBC can be opsonized with untreated human serum such that lysis by active complement components is minimal but sufficient opsonization occurs to permit high rates of complement-mediated phagocytosis. Phagocytosis of SRBC opsonized with 2% whole human serum by human monocyte-derived...

journal_title：Immunology and cell biology

authors： Chan HT,Kedzierska K,O'Mullane J,Crowe SM,Jaworowski A

更新日期：2001-10-01 00:00:00

abstract：:Dendritic cell (DC)-based immunotherapy has recently demonstrated a great potential for clinical applications; however, additional progress in the methods of tumor-specific antigen delivery to DCs is necessary for the further development of anti-tumor vaccines. To this end, a capsid-optimized adeno-associated virus se...

journal_title：Immunology and cell biology

authors： Pandya J,Ortiz L,Ling C,Rivers AE,Aslanidi G

更新日期：2014-02-01 00:00:00

abstract：:The surface phenotype of T cells reflects both their relative maturity and their activation state. To determine the pattern of surface markers characteristic of activated T cells, purified mature T cells were stimulated in vitro for periods of 0.5-5 days with Concanavalin-A (Con-A) or phorbol myristic acetate (PMA) an...

journal_title：Immunology and cell biology

authors： Kelly K,Shortman K,Scollay R

更新日期：1988-08-01 00:00:00

abstract：:Depending on the microenvironment conditions, macrophages display phenotypic and functional heterogeneity. This study characterized the programmed cell death-ligand 2 (PD-L2)-expressing macrophage-like cells drained from surgical wound zones, and investigated their influence on helper T (Th) cell responses. Although a...

journal_title：Immunology and cell biology

authors： Tavukcuoglu E,Horzum U,Yilmaz KB,Esendagli G

更新日期：2020-02-01 00:00:00

abstract：:It is shown how Ig specificities, randomly generated in conventional B cells, come to be expressed in the genetically-determinate B1 population. Thus the adaptive antibody population facilitates the evolution of the natural antibody repertoire, in accordance with the Baldwin effect in the evolution of instinct. The ev...

journal_title：Immunology and cell biology

authors： Anderson RW

更新日期：1996-06-01 00:00:00

abstract：:Pseudomonas aeruginosa ocular infection causes extensive corneal neovascularization. The purpose of the present study was to investigate the role of the angiogenic factors macrophage inflammatory protein-2 (MIP-2) and vascular endothelial growth factor (VEGF) in the regulation of corneal neovascularization during P. a...

journal_title：Immunology and cell biology

authors： Xue ML,Thakur A,Willcox M

更新日期：2002-08-01 00:00:00

abstract：:Genetic variants of interleukin 2 (IL-2) and its receptor are associated with murine and human susceptibility to Type 1 diabetes, yet the role of IL-2 in controlling pancreatic islet-reactive T cells is unknown. Here, we develop a model where IL-2 deficiency precipitates a breakdown of self-tolerance and progression t...

journal_title：Immunology and cell biology

authors： Liston A,Siggs OM,Goodnow CC

更新日期：2007-06-01 00:00:00

abstract：:One of the major limitations for cancer immunotherapy is related to the frequent existence of an intra-tumoral immunosuppressive environment, to which STAT3 (Signal transducer and activator of transcription-3) activation in tumor and dendritic cells (DCs) are believed to contribute. In this study, we tested the hypoth...

journal_title：Immunology and cell biology

authors： Molavi O,Ma Z,Hamdy S,Lai R,Lavasanifar A,Samuel J

更新日期：2008-08-01 00:00:00

abstract：:Substance abuse is a growing world-wide problem. The big four drugs of abuse that might lend themselves to immunotherapy are nicotine, cocaine, morphine/heroin and methamphetamine. Tobacco abuse has a well-known enormous impact on major chronic cardiovascular and pulmonary diseases, while the last three, aside from th...

journal_title：Immunology and cell biology

authors： Kinsey BM,Jackson DC,Orson FM

更新日期：2009-05-01 00:00:00

abstract：:Granzyme B (GrB) plays a well-established intracellular role in cytotoxic lymphocyte (CL)-mediated killing of abnormal cells; however, emerging evidence suggests that it participates in extracellular matrix remodeling and target cell destruction through anoikis. As these processes require the release of GrB from the C...

journal_title：Immunology and cell biology

authors： Prakash MD,Bird CH,Bird PI

更新日期：2009-03-01 00:00:00

abstract：:Productive immune responses to T-cell-dependent antigens ultimately generate two long-lived compartments: memory B cells and bone marrow-resident plasma cells, which both arise from within germinal centres. The ability of a B-cell clone to populate these effector compartments requires its descendents to outcompete tho...

journal_title：Immunology and cell biology

authors： Tarlinton DM

更新日期：2008-02-01 00:00:00

abstract：:Heterogeneity of T cells is a hallmark of a successful adaptive immune response, harnessing the vast diversity of antigen-specific T cells into a coordinated evolution of effector and memory outcomes. The T cell receptor (TCR) repertoire is highly diverse to account for the highly heterogeneous antigenic world. During...

journal_title：Immunology and cell biology

authors： Eltahla AA,Rizzetto S,Pirozyan MR,Betz-Stablein BD,Venturi V,Kedzierska K,Lloyd AR,Bull RA,Luciani F

更新日期：2016-07-01 00:00:00

abstract：:The immune system has developed mechanisms to detect and initiate responses to a continual barrage of immunological challenges. Dendritic cells (DC), a heterogeneous population of leucocytes, play a major role as immunosurveillance agents. To accomplish this function, DC are equipped with highly efficient mechanisms t...

journal_title：Immunology and cell biology

authors： Wilson NS,Villadangos JA

更新日期：2004-02-01 00:00:00

abstract：:There is increasing evidence that a small percentage of individuals exposed to the hepatitis C virus have the capacity to generate a strong cellular immune response against the virus and avoid persistent infection, and perhaps do so repeatedly after re-exposure. This article reviews the evidence that the responses ide...

journal_title：Immunology and cell biology

authors： Elliot LN,Lloyd AR,Ziegler JB,Ffrench RA

更新日期：2006-06-01 00:00:00

abstract：:The adaptive immune system arose 600 million years ago in a cold-blooded fish. Over countless generations, our antecedents tuned the function of the T-cell receptor (TCR). The TCR system is arguably the most complex known to science. The TCR evolved hypervariability to fight the hypervariability of pathogens and cance...

journal_title：Immunology and cell biology

authors： Watkins TS,Miles JJ

更新日期：2020-07-16 00:00:00

abstract：:Cloned Th1 cells, but not Th2 cells, specific for malaria antigen, produce nitric oxide (NO) when activated with specific antigen or Con A. Furthermore, NO inhibits proliferation of, and production of IL-2 and IFN-gamma by, Th1 but not Th2 cells. Here, it is demonstrated that the inhibition of Th1 cell proliferation b...

journal_title：Immunology and cell biology

authors： Taylor-Robinson AW

更新日期：1997-04-01 00:00:00

abstract：:Our earlier studies have demonstrated that gonadotropin-releasing hormone (GnRH) agonists suppress immune system function in female mice. No systematic studies regarding the effect of gender on immune system function following GnRH agonist treatment, however, have been reported. This study, therefore, investigated seq...

journal_title：Immunology and cell biology

authors： Rao LV,Cleveland RP,Kimmel RJ,Ataya KM

更新日期：1996-04-01 00:00:00

abstract：:The differentiation of myeloid cells into macrophages and granulocytes is accompanied by marked changes in adhesive phenotype. Here we seek to understand the regulation of expression and functionality of the VLA-4 (alpha 4 beta 1), LPAM-1 (alpha 4 beta 7) and HML-1 (alpha E beta 7) integrins on monocytes/macrophages a...

journal_title：Immunology and cell biology

authors： Yang Y,Harrison JE,Print CG,Lehnert K,Sammar M,Lazarovits A,Krissansen GW

更新日期：1996-10-01 00:00:00

abstract：:The effect of serum on LPS-induced activation of a murine macrophage-like cell line, WEHI-3, was examined. Foetal calf serum strongly inhibited the production of nitric oxide (NO) and TNF-alpha by LPS-stimulated WEHI-3 cells, while it enhanced the production of both by other macrophage-like cell lines, J774.1 and BAM3...

journal_title：Immunology and cell biology

authors： Ohki K,Amano F,Yamamoto S,Kohashi O

更新日期：1999-04-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I heavy chain/beta(2)m heterodimers assemble with antigenic peptides through interactions with peptide-loading complex proteins, including tapasin and ERp57. In human cells, a cysteine residue within tapasin (C95) has been shown to form a covalent bond with ERp57. In this s...

journal_title：Immunology and cell biology

authors： Simone LC,Wang X,Tuli A,Solheim JC

更新日期：2010-01-01 00:00:00

abstract：:The discovery of functional long noncoding RNAs (lncRNAs) coupled with the ever-increasing accessibility of genomic and transcriptomic technology has led to an explosion of functional and mechanistic investigation and discovery into what was once dismissed as junk DNA. Over the past decade, a significant number of lnc...

journal_title：Immunology and cell biology

authors： Yu AD,Wang Z,Morris KV

更新日期：2015-03-01 00:00:00

abstract：:Thy-1 (CD90) expressed by mouse T cells is known to have signal transducing properties, but the ability of Thy-1 to enhance cytotoxic T lymphocyte (CTL) development is not well understood. Here we show that stimulation of mouse T cells with monoclonal antibodies (mAb) to CD3, CD28 and Thy-1 (clone G7), which were coim...

journal_title：Immunology and cell biology

authors： Haeryfar SM,Conrad DM,Musgrave B,Hoskin DW

更新日期：2005-08-01 00:00:00

abstract：:The peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors. There are three genes that code for the PPAR isoforms: PPARalpha, PPARbeta and PPARgamma. In the present review, studies characterizing the various PPAR isoforms are discussed. Peroxisome proliferator-activated receptor ...

journal_title：Immunology and cell biology

authors： Roberts-Thomson SJ

更新日期：2000-08-01 00:00:00