A CD2 high-expressing stress-resistant human plasmacytoid dendritic-cell subset.

Abstract:

:Human plasmacytoid dendritic cells (pDCs) were considered to be a phenotypically and functionally homogeneous cell population; however, recent analyses indicate potential heterogeneity. This is of major interest, given their importance in the induction of anti-viral responses and their role in creating immunologically permissive environments for human malignancies. For this reason, we investigated the possible presence of human pDC subsets in blood and bone marrow, using unbiased cell phenotype clustering and functional studies. This defined two major functionally distinct human pDC subsets, distinguished by differential expression of CD2. The CD2(hi) and CD2(lo) pDCs represent discontinuous subsets, each with hallmark pDC functionality, including interferon-alpha production. The rarer CD2(hi) pDC subset demonstrated a significant survival advantage over CD2(lo) pDC during stress and upon exposure to glucocorticoids (GCs), which was associated with higher expression of the anti-apoptotic molecule BCL2. The differential sensitivity of these two human pDC subsets to GCs is demonstrated in vivo by a relative increase in CD2(hi) pDC in multiple myeloma patients treated with GCs. Hence, the selective apoptosis of CD2(lo) pDC during stress represents a novel mechanism for the control of innate responses.

journal_name

Immunol Cell Biol

authors

Bryant C,Fromm PD,Kupresanin F,Clark G,Lee K,Clarke C,Silveira PA,Suen H,Brown R,Newman E,Cunningham I,Ho PJ,Gibson J,Bradstock K,Joshua D,Hart DNj

doi

10.1038/icb.2015.116

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

447-57

issue

5

eissn

0818-9641

issn

1440-1711

pii

icb2015116

journal_volume

94

pub_type

杂志文章
  • T-cell activation RhoGTPase-activating protein plays an important role in TH17-cell differentiation.

    abstract::T-cell activation RhoGTPase-activating protein (TAGAP) is a GTPase-activating protein specific for RhoA that is exclusively expressed in activated T cells. Genome-wide association studies and metagenome SNPs analyses have indicated that TAGAP is associated with the pathogenesis of multiple autoimmune diseases, includi...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.2017.27

    authors: Tamehiro N,Nishida K,Yanobu-Takanashi R,Goto M,Okamura T,Suzuki H

    更新日期:2017-09-01 00:00:00

  • The correlation between proinflammatory cytokines, MAdCAM-1 and cellular infiltration in the inflamed colon from TNF-alpha gene knockout mice.

    abstract::Tumour necrosis factor (TNF) is important in the development of inflammatory bowel disease. TNF-alpha-deficient mice show more severe colonic inflammation than wild-type (Wt) mice, but the underlying mechanism remains unclear. Using immunohistochemistry, enzyme-linked-immunosorbent assay and histopathology, we found t...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/sj.icb.7100112

    authors: Xu Y,Hunt NH,Bao S

    更新日期:2007-11-01 00:00:00

  • Gp91(phox) contributes to the development of experimental inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is related to dysfunction of intestinal immunity. Neutrophils have an important role in innate immunity via the oxidative burst, using the p47phox- and gp91(phox)-containing NAD(P)H oxidase known as Nox2. In dextran sulphate sodium (DSS)-induced colitis, no significant difference in in...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.2011.4

    authors: Bao S,Carr ED,Xu YH,Hunt NH

    更新日期:2011-11-01 00:00:00

  • Production of a polyspecific human monoclonal antibody reacting with an epidermal antigen.

    abstract::A clone of cells secreting an antibody to an epidermal antigen was generated from a patient with a blistering skin lesion. Although produced by fusion of human lymphocytes to a HAT-sensitive myeloma, this clone of cells did not have characteristics of a hybridoma. A true hybridoma was produced by fusion of this clone ...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1988.30

    authors: Hohmann AW,Coleman M,Comacchio RM,Skinner JM,Bradley J

    更新日期:1988-01-01 00:00:00

  • Interleukin-2 activates the gamma-interferon gene in newborn mice.

    abstract::Spleen cells from newborn mice are immunologically nonreactive and do not respond by proliferation upon stimulation with the T cell mitogen concanavalin-A (Con-A) or with recombinant interleukin-2 (IL-2). We have found that, in spite of the observed non-reactivity in the proliferative tests, cells from newborn mice we...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1991.59

    authors: Lipoldová M,Holán V

    更新日期:1991-12-01 00:00:00

  • Establishment of a natural suppressor cell line producing soluble suppressor factor other than transforming growth factor-beta.

    abstract::Natural suppressor (NS) cell line (Clone 59) was established from the bone marrow of adult C3H/Hej mice in the presence of WEHI-3 conditioned media. Clone 59 cells suppressed the generation of cytotoxic T lymphocytes from normal mouse spleen. This suppression was seen at a responder-to-suppressor cell ratio of 1000:1 ...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1995.51

    authors: Yanagië H,Sugiyama H,Sekiguchi M

    更新日期:1995-08-01 00:00:00

  • Tumour susceptibility to innate and adaptive immunotherapy changes during tumour maturation.

    abstract::Immunotherapy of tumours using T cells expanded in vitro has met with mixed clinical success suggesting that a greater understanding of tumour/T-cell interaction is required. We used a HPV16E7 oncoprotein-based mouse tumour model to study this further. In this study, we demonstrate that a HPV16E7 tumour passes through...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1111/j.0818-9641.2004.01273.x

    authors: Stewart TJ,Fernando GJ,Frazer IH,Leggatt GR

    更新日期:2004-10-01 00:00:00

  • Binding of Tamm-Horsfall protein to complement 1q and complement 1, including influence of hydrogen-ion concentration.

    abstract::The goal of this study was to further characterize the interaction between an abundant urinary glycoprotein, Tamm-Horsfall protein, and complement 1q to determine the robustness of this reaction under different environmental conditions (particularly pH) and to begin to determine the specificity of this reaction. The i...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1711.2002.01125.x

    authors: Rhodes DC

    更新日期:2002-12-01 00:00:00

  • T cell response to grass pollen allergens: correlation with skin test reactivity and serum IgE levels.

    abstract::T cell proliferative responses to rye and Bermuda grass pollen allergens have been studied in a series of 51 atopic and 18 non-atopic subjects. Mean T cell responses were higher in the atopic group than in the non-atopic group (P < 0.001), and there was a strong correlation between the magnitude of reaction in the T c...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1995.3

    authors: Blaher B,McCluskey J,Puy R,Czarny D,Rolland JM

    更新日期:1995-02-01 00:00:00

  • Comparison of strategies for the construction of libraries of artificial antibodies.

    abstract::Construction of libraries of artificial antibodies has been reported by several groups of investigators. Various forms of antibody fused to surface protein, cpII, are expressed on the surface of filamentous phage. Since phages that encode desired antibodies can be easily grown in Escherichia coli after selection with ...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1997.33

    authors: Iba Y,Kurosawa Y

    更新日期:1997-04-01 00:00:00

  • Atopy and the ectopic immune response.

    abstract::A hypothesis if formulated for the mode of action of the 'atopy gene': the gene(s) causing an increased tendency to mount an IgE immune response to trivial environmental antigens. It is postulated that some antigens are not efficiently transported to the lymphoid organs, the location of the 'eutopic' immune system; mi...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/icb.1996.28

    authors: Aalberse RC

    更新日期:1996-04-01 00:00:00

  • Single-cell technologies are revolutionizing the approach to rare cells.

    abstract::In the last lustrum single-cell techniques such as single-cell quantitative PCR, RNA and DNA sequencing, and the state-of-the-art cytometry by time of flight (CyTOF) mass cytometer have allowed a detailed analysis of the sub-composition of different organs from the bone marrow hematopoietic compartment to the brain. T...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/icb.2015.106

    authors: Proserpio V,Lönnberg T

    更新日期:2016-03-01 00:00:00

  • Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction.

    abstract::The mammalian testis is an immunoprivileged organ where male germ cell autoantigens are immunologically ignored. Both systemic immune tolerance to autoantigens and local immunosuppressive milieu contribute to the testicular immune privilege. Testicular immunosuppression has been intensively studied, but information on...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.2014.97

    authors: Li N,Liu Z,Zhang Y,Chen Q,Liu P,Cheng CY,Lee WM,Chen Y,Han D

    更新日期:2015-03-01 00:00:00

  • Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity.

    abstract::Several histone deacetylases (HDACs) are involved in the regulation of forkhead box protein P3 (FOXP3) expression and function by affecting features of FOXP3 protein stability. FOXP3, a forkhead family transcription factor specially expressed in regulatory T (Treg) cells, controls the expression of many key immune-reg...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/icb.2011.101

    authors: Zhang H,Xiao Y,Zhu Z,Li B,Greene MI

    更新日期:2012-01-01 00:00:00

  • Inhibitory effect of glycyrrhizin on the neutrophil-dependent increase of R5 HIV replication in cultures of macrophages.

    abstract::It has been described that polymorphonuclear neutrophils (PMNs) enhance the replication of CC-chemokine receptor 5/macrophage-tropic (R5) HIV in cultures of monocyte-derived macrophages (MDMs). In this study, the inhibitory effect of glycyrrhizin (GL) on R5 HIV replication influenced by PMNs was investigated in MDM cu...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.2009.40

    authors: Yoshida T,Kobayashi M,Li XD,Pollard RB,Suzuki F

    更新日期:2009-10-01 00:00:00

  • Beneficial effects of endotoxin treatment on metabolism in tumour-bearing rats.

    abstract::The effects of endotoxin treatment on host metabolism in tumour-bearing rats were investigated. Metabolism in control rats (non-tumour-bearing) was slightly altered by endotoxin treatment, whereas in tumour-bearing rats a number of biochemical parameters that were initially perturbed by the presence of the tumour had ...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1992.1

    authors: Rofe AM,Bourgeois CS,Coyle P

    更新日期:1992-02-01 00:00:00

  • The alpha-gal epitope and the anti-Gal antibody in xenotransplantation and in cancer immunotherapy.

    abstract::The alpha-gal epitope (Galalpha1-3Galbeta1-(3)4GlcNAc-R) is abundantly synthesized on glycolipids and glycoproteins of non-primate mammals and New World monkeys by the glycosylation enzyme alpha1,3galactosyltransferase (alpha1,3GT). In humans, apes and Old World monkeys, this epitope is absent because the alpha1,3GT g...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1711.2005.01366.x

    authors: Galili U

    更新日期:2005-12-01 00:00:00

  • Intestinal overexpression of interleukin (IL)-15 promotes tissue eosinophilia and goblet cell hyperplasia.

    abstract::Interleukin (IL)-15 overexpression in eosinophilic gastrointestinal disorders is reported, but IL-15's role in promoting eosinophilic gastroenteritis is largely unknown. Therefore, we generated enterocyte-overexpressed IL-15 transgenic mice using Fabpi promoter. The Fabpi-IL-15 (iIL-15) transgenic mice showed induced ...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1111/imcb.1036

    authors: Mussarat A,Manohar M,Verma AK,Upparahalli Venkateshaiah S,Zaidi A,Sanders NL,Zhu X,Mishra A

    更新日期:2018-03-01 00:00:00

  • Antigen-specific apoptosis in immortalized T cells by soluble MHC class II-peptide complexes.

    abstract::The recognition of T cell receptors (TCR) by purified major histocompatibility complex (MHC) class II-peptide complexes in the absence of costimulatory signals leads to the induction of T cell non-responsiveness or anergy. In a recent study using human T cell clones, it was observed that prolonged incubation of restin...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1996.13

    authors: Arimilli S,Mumm JB,Nag B

    更新日期:1996-02-01 00:00:00

  • Depression of cell-mediated immunity in plasmacytoma-bearing mice.

    abstract::Previous reports have documented that mice bearing plasmacytomas (PC) are suppressed in their ability to mount a primary antibody response, whereas cellular immunity appears to be normal. Studies presented here provide evidence that T cell responsiveness is also depressed in BALB/c mice bearing the Lieberman plasmacyt...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1991.3

    authors: Ruszala-Mallon V,Silva J,Lumanglas AL,Durr FE,Wang BS

    更新日期:1991-02-01 00:00:00

  • Clearance of Brugia pahangi microfilariae in immunized mice.

    abstract::Active Brugia pahangi microfilariae (Mf) were injected into naive male BALB/c mice intraperitoneally. Microfilaraemia was studied for 28 days; and Mf circulated in blood in optimum numbers from 3 to 14 days. Anti-Mf response was assessed by the rate of disappearance of Mf from blood as well as their absence from visce...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1988.43

    authors: Rajasekariah GR,Puri PM,Chandrashekar R,Subrahmanyam D

    更新日期:1988-10-01 00:00:00

  • Molecular cloning and characterization of a ruminant interleukin-6 cDNA.

    abstract::By hybridization with a human interleukin-6 (IL-6) cDNA fragment a corresponding ruminant (ovine) cDNA was isolated from a lipopolysaccharide (LPS)-stimulated alveolar macrophage library. The nucleotide sequence of the cDNA and the predicted amino acid sequence of the protein showed significant homology to the human a...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1993.39

    authors: Andrews AE,Barcham GJ,Ashman K,Meeusen EN,Brandon MR,Nash AD

    更新日期:1993-08-01 00:00:00

  • LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins.

    abstract::The role of the immunoproteasome is perceived as confined to adaptive immune responses given its ability to produce peptides ideal for MHC Class-I binding. Here, we demonstrate that the immunoproteasome subunit, LMP2, has functions beyond its immunomodulatory role. Using LMP2-deficient mice, we demonstrate that LMP2 i...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1111/imcb.12163

    authors: Zanker D,Pang K,Oveissi S,Lu C,Faou P,Nowell C,Mbogo GW,Carotta S,Quillici C,Karupiah G,Hibbs ML,Nutt SL,Neeson P,Puthalakath H,Chen W

    更新日期:2018-10-01 00:00:00

  • Human natural killer (NK) cells: requirements for cell proliferation and expansion of phenotypically novel subpopulations.

    abstract::Previous studies established that the high density (resting) natural killer (NK) cell subset (R-NK) of peripheral blood NK cells is unresponsive to interleukin-2 (IL-2) but can be induced to proliferate when cultured with gamma-irradiated malignant melanoma (MM-170) cells or mitomycin-C-treated activated T cells in th...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.1993.9

    authors: Warren HS,Kinnear BF,Skipsey LJ

    更新日期:1993-04-01 00:00:00

  • The corneal response to infection with Staphylococcus aureus in the absence of interleukin-4.

    abstract::Interleukin-4 (IL-4) has previously been implicated in a protective response to Staphylococcus aureus corneal infection. Consequently, the specific role of IL-4 during S. aureus corneal infection was investigated using IL-4 gene knockout mice. The eyes of IL-4-/- mice and wild-type mice were challenged topically with ...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/sj.icb.7100043

    authors: Cole N,Hume EB,Khan S,Garthwaite L,Schubert T,Reeve V,Willcox MD

    更新日期:2007-06-01 00:00:00

  • Novel homozygous variants in the SERPING1 gene in two Turkish families with hereditary angioedema of recessive inheritance.

    abstract::Hereditary angioedema as a result of deficiency of the C1 inhibitor (HAE-C1INH; MIM# 106100) is a rare autosomal disorder and affected individuals are generally heterozygous for dominant negative variants in the SERPING1 gene. Homozygosity for SERPING1 pathogenic variants was long considered to be embryonically lethal...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1111/imcb.12362

    authors: Mete Gökmen N,Rodríguez-Alcalde C,Gülbahar O,Lopez-Trascasa M,Onay H,López-Lera A

    更新日期:2020-09-01 00:00:00

  • Mycoplasma infection can sensitize host cells to apoptosis through contribution of apoptotic-like endonuclease(s).

    abstract::Mycoplasma infection may lead to various pathologies in a broad range of hosts. It has been shown that Mycoplasma may trigger cell death in cell cultures; however, the mechanism remains unknown. In the present paper we show that Mycoplasma infection of different lymphocyte and epithelial tumour cell lines leads to the...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1711.1998.00781.x

    authors: Sokolova IA,Vaughan AT,Khodarev NN

    更新日期:1998-12-01 00:00:00

  • Antigen-driven CD4+ T-cell anergy: a pathway to peripheral T regulatory cells.

    abstract::In their recent publication, Kuczma and colleagues have provided evidence that advances the relationship between naive T cells, T cell anergy and T regulatory cells. Their findings strengthen the understanding of how these T cell subsets function in relation to self and microbiota-derived epitopes to promote and maint...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1111/imcb.12424

    authors: Eggenhuizen PJ,Ng BH,Ooi JD

    更新日期:2020-12-04 00:00:00

  • Redox balance of mouse medullary CD4 single-positive thymocytes.

    abstract::After positive selection, the newly differentiated single-positive (SP) thymocytes undergo negative selection to eliminate autoreactive T cells, functional maturation to acquire immunocompetence and egress capability. To investigate whether the intracellular reduction/oxidation (redox) balance has an important role on...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章

    doi:10.1038/icb.2013.57

    authors: Jin R,Teng F,Xu X,Yao Y,Zhang S,Sun X,Zhang Y,Ge Q

    更新日期:2013-11-01 00:00:00

  • Life and death in the granuloma: immunopathology of tuberculosis.

    abstract::During tuberculosis (TB) infection, the granuloma provides the microenvironment in which antigen-specific T cells colocate with and activate infected macrophages to inhibit the growth of Mycobacterium tuberculosis. Although the granuloma is the site for mycobacterial killing, virulent mycobacteria have developed a var...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审

    doi:10.1038/sj.icb.7100027

    authors: Saunders BM,Britton WJ

    更新日期:2007-02-01 00:00:00