How the thymus shaped immunology and beyond.


:Barely 60 years ago, the thymus was considered to be a vestigial organ with no known function or just a graveyard for dying lymphocytes. Now, the thymus and its cells cover a vast area of immunology, genetics and epigenetics relating to medicine, including inflammation, infection, vaccination, dysbiosis, immunodeficiency, allergy, autoimmunity, transplantation, tissue repair, pregnancy and cancer. New technology and approaches, now becoming available, will lead to a much deeper understanding of many of these conditions. Hence, the thymus and its cells will be occupying researchers and clinicians for decades to come.


Immunol Cell Biol


Miller J




Has Abstract


2019-03-01 00:00:00












  • Regulation of mucosal mast cell activation by short interfering RNAs targeting syntaxin4.

    abstract::Mucosal mast cells (MMCs) have an important role in allergic inflammation, and effective antagonists are required for their regulation. To discover a possible mechanism of controlling the activation of MMCs, we investigated the expression and function of syntaxin4, one of the soluble membrane N-ethylmaleimide-sensitiv...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Liu S,Nugroho AE,Shudou M,Maeyama K

    更新日期:2012-03-01 00:00:00

  • Diesel exhaust particulate matter induces multinucleate cells and zinc transporter-dependent apoptosis in human airway cells.

    abstract::The cellular effects of biodiesel emissions particulate matter (BDEP) and petroleum diesel emissions particulate matter (PDEP) were compared using a human airway cell line, A549. At concentrations of 25 microg/ml, diesel particulate matter induced the formation of multinucleate cells. In cells treated with a mixture o...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Ackland ML,Zou L,Freestone D,van de Waasenburg S,Michalczyk AA

    更新日期:2007-11-01 00:00:00

  • The influence of hypoxia on the differentiation capacities and immunosuppressive properties of clonal mouse mesenchymal stromal cell lines.

    abstract::Multipotent mesenchymal stromal cells are multipotent cells capable of differentiating into different mesodermal cell types. Enigmatically, mesenchymal stromal cells present in the bone marrow support early lymphopoiesis yet can inhibit mature lymphocyte growth. Critical features of the bone marrow microenvironment, s...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Prado-Lòpez S,Duffy MM,Baustian C,Alagesan S,Hanley SA,Stocca A,Griffin MD,Ceredig R

    更新日期:2014-08-01 00:00:00

  • Atopy and the ectopic immune response.

    abstract::A hypothesis if formulated for the mode of action of the 'atopy gene': the gene(s) causing an increased tendency to mount an IgE immune response to trivial environmental antigens. It is postulated that some antigens are not efficiently transported to the lymphoid organs, the location of the 'eutopic' immune system; mi...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审


    authors: Aalberse RC

    更新日期:1996-04-01 00:00:00

  • Redox balance of mouse medullary CD4 single-positive thymocytes.

    abstract::After positive selection, the newly differentiated single-positive (SP) thymocytes undergo negative selection to eliminate autoreactive T cells, functional maturation to acquire immunocompetence and egress capability. To investigate whether the intracellular reduction/oxidation (redox) balance has an important role on...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Jin R,Teng F,Xu X,Yao Y,Zhang S,Sun X,Zhang Y,Ge Q

    更新日期:2013-11-01 00:00:00

  • Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses.

    abstract::The haematopoietic-specific RhoGTPase, Rac2, has been indirectly implicated in T-lymphocyte development and function, and as a pivotal regulator of T Helper 1 (T(H)1) responses. In other haematopoietic cells it regulates cytoskeletal rearrangement downstream of extracellular signals. Here we demonstrate that Rac2 defi...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Croker BA,Handman E,Hayball JD,Baldwin TM,Voigt V,Cluse LA,Yang FC,Williams DA,Roberts AW

    更新日期:2002-06-01 00:00:00

  • Lpr-induced systemic autoimmunity is unaffected by mast cell deficiency.

    abstract::The function of mast cells in allergic and organ-specific autoimmune responses is highly controversial. In the current study, we aimed to dissect the role of mast cells in systemic autoimmunity in the B6(lpr/lpr) mouse, a spontaneous model of systemic lupus erythematosus. B6(lpr/lpr) mice were interbred with C57Bl/6-K...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: van Nieuwenhuijze AE,Cauwe B,Klatt D,Humblet-Baron S,Liston A

    更新日期:2015-11-01 00:00:00

  • Can MHC class II genes mediate resistance to type 1 diabetes?

    abstract::Numerous studies have associated carriage of HLA-DRB1*1501, DQA1*0102 and DQB1*0602 (DR15, DQ6) with dominant resistance to type 1 diabetes and have concluded that one or more of the component HLA class II molecules mediate this effect. Mechanisms for MHC class II-mediated resistance to diabetes have been proposed fro...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Price P,Cheong KY,Boodhoo A,Witt CS,McCann V,Christiansen FT,Allcock RJ

    更新日期:2001-12-01 00:00:00

  • Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains.

    abstract::The present paper describes a comparative analysis of light chains associated with primary and secondary IgM, as well as with secondary IgG antibodies to fluorescein, undertaken in order to explore the relationship between light chain somatic hypermutation and the isotype switch. The data reveal a disparity in the fre...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: van der Keyl H,Gellad ZF,Owen JA

    更新日期:2000-06-01 00:00:00

  • Human beta-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response.

    abstract::Regulatory mechanisms in mucosal secretions and tissues recognize antigens and attenuate pro-inflammatory cytokine responses. Here, we asked whether human beta-defensin 3 (HBD3) serves as an upstream suppressor of cytokine signaling that binds and attenuates pro-inflammatory cytokine responses to recombinant hemagglut...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Pingel LC,Kohlgraf KG,Hansen CJ,Eastman CG,Dietrich DE,Burnell KK,Srikantha RN,Xiao X,Bélanger M,Progulske-Fox A,Cavanaugh JE,Guthmiller JM,Johnson GK,Joly S,Kurago ZB,Dawson DV,Brogden KA

    更新日期:2008-11-01 00:00:00

  • Idiopathic pulmonary fibrosis and a role for autoimmunity.

    abstract::Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. It is typically associated with extensive and progressive fibrosis, and is fatal and has limited treatment options. Characteristically IPF patients display large lymphocyte aggregates composed of CD3+ T cells and CD20+ B ...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审


    authors: Hoyne GF,Elliott H,Mutsaers SE,Prêle CM

    更新日期:2017-08-01 00:00:00

  • Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement.

    abstract::Granzyme B (GrB) plays a well-established intracellular role in cytotoxic lymphocyte (CL)-mediated killing of abnormal cells; however, emerging evidence suggests that it participates in extracellular matrix remodeling and target cell destruction through anoikis. As these processes require the release of GrB from the C...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Prakash MD,Bird CH,Bird PI

    更新日期:2009-03-01 00:00:00

  • Circulating CD1c(+) DCs are superior at activating Th2 responses upon Phl p stimulation compared with basophils and pDCs.

    abstract::The contributing role of circulating human dendritic cell (DC) populations and basophils in the presentation and augmentation of Th2 responses remains to be determined. The present study aimed at elucidating the functional role of CD1c(+) myeloid DCs (mDCs), CD123(+) plasmacytoid DCs (pDCs), monocyte-derived DCs and b...

    journal_title:Immunology and cell biology

    pub_type: 临床试验,杂志文章


    authors: Rydnert F,Lundberg K,Greiff L,Lindstedt M

    更新日期:2014-07-01 00:00:00

  • Osteopontin contributes to effective neutrophil recruitment, IL-1β production and apoptosis in Aspergillus fumigatus keratitis.

    abstract::Fungal keratitis is a major cause of corneal ulcers, resulting in significant visual impairment and blindness. A phosphorylated glycoprotein secreted by immunocompetent cells, osteopontin (OPN) mediates cluster formation of the host fungal receptors and enhances the phagocytosis and clearance of pathogenic fungi. Howe...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Zhao G,Hu M,Li C,Lee J,Yuan K,Zhu G,Che C

    更新日期:2018-04-01 00:00:00

  • Separate roles of IL-6 and oncostatin M in mouse macrophage polarization in vitro and in vivo.

    abstract::Arginase-1 (Arg-1)-expressing M2-like macrophages are associated with Th2-skewed immune responses, allergic airway pathology, ectopic B16 melanoma cancer growth in murine models, and can be induced by Oncostatin M (OSM) transient overexpression in vivo. Here, we compare OSM to the gp130-cytokine IL-6 in mediating macr...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Dubey A,Izakelian L,Ayaub EA,Ho L,Stephenson K,Wong S,Kwofie K,Austin RC,Botelho F,Ask K,Richards CD

    更新日期:2018-03-01 00:00:00

  • Tumour-specific CTL response requiring interactions of four different cell types and recognition of MHC class I and class II restricted tumour antigens.

    abstract::This study demonstrates that a syngeneic specific cytotoxic T lymphocyte (CTL) response to a class I major histocompatibility complex (MHC) positive tumour requires dual processing and recognition of tumour antigens. One type of antigen is processed and expressed in association with class I MHC at the surface of intac...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Schirrmacher V,Schild HJ,Gückel B,von Hoegen P

    更新日期:1993-08-01 00:00:00

  • Relevance of necroptosis in cancer.

    abstract::Resistance to caspase-dependent apoptosis is often responsible for treatment failures in cancer. Finding novel therapeutic strategies that can activate alternative cell death programs appears to be appealing. Necroptosis is a form of programmed necrosis that occurs under caspase-deficient conditions. This alternative ...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审


    authors: Lalaoui N,Brumatti G

    更新日期:2017-02-01 00:00:00

  • Type I interferons in regulation of mucosal immunity.

    abstract::The mucosal system is the first line of defense against many pathogens. It is continuously exposed to dietary and microbial antigens, and thus the host must maintain a homeostatic environment between commensal microbiota and pathogenic infections. Following infections and inflammatory events, a rapid innate immune res...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审


    authors: Mangan NE,Fung KY

    更新日期:2012-05-01 00:00:00

  • Microglial cells from psychologically stressed mice as an accelerator of cerebral cryptococcosis.

    abstract::Severe stress decreases the resistance of hosts exposed to microbial infections. As compared with two groups of control mice (normal mice, food-and-water-deprived mice [FWD mice]), restraint-stressed mice (RST mice) were shown to be greatly susceptible to intracerebral growth of Cryptococcus neoformans. The susceptibi...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Shimoda M,Jones VC,Kobayashi M,Suzuki F

    更新日期:2006-12-01 00:00:00

  • Neuronal antigens modulate the immune response associated with experimental autoimmune encephalomyelitis.

    abstract::Rats primed with bovine myelin (BM) in complete Freunds adjuvant, develop acute experimental autoimmune encephalomyelitis (EAE). We have previously described that intraperitoneal administration prior to the active induction of the disease of a bovine synaptosomal fraction (BSF) and BM were effective ways of suppressin...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Degano AL,Ditamo Y,Roth GA

    更新日期:2004-02-01 00:00:00

  • Interaction of monocytoid cells with the mucosal addressin MAdCAM-1 via the integrins VLA-4 and LPAM-1.

    abstract::The differentiation of myeloid cells into macrophages and granulocytes is accompanied by marked changes in adhesive phenotype. Here we seek to understand the regulation of expression and functionality of the VLA-4 (alpha 4 beta 1), LPAM-1 (alpha 4 beta 7) and HML-1 (alpha E beta 7) integrins on monocytes/macrophages a...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Yang Y,Harrison JE,Print CG,Lehnert K,Sammar M,Lazarovits A,Krissansen GW

    更新日期:1996-10-01 00:00:00

  • Leukaemogenic progression: the importance of differentiation and associated genetic events.

    abstract::A feature common to many blood cell cancers is the uncoupling of normal proliferative and differentiative events, both of which are intimately linked in the cell's developmental programme. In some cancers, further differentiative events have been associated with oncogenic progression and, in other cancers, terminal di...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审


    authors: Ho ES,O'Neill HC

    更新日期:1995-06-01 00:00:00

  • Disentangling the complexity of the skin dendritic cell network.

    abstract::Using 'knockin' mice to track and ablate dendritic cells (DCs) expressing notably the langerin (Cd207) gene, it has been possible to identify five DC subsets within the skin and to assess whether functional specialization exists among them. The present review summarizes recent information concerning the phenotype and ...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审


    authors: Henri S,Guilliams M,Poulin LF,Tamoutounour S,Ardouin L,Dalod M,Malissen B

    更新日期:2010-05-01 00:00:00

  • Culture-differentiated CD8(+) T cells acquire innate memory-like traits and respond to a pathogen-associated molecule.

    abstract::Selection of conventional CD4(+) or CD8(+) T cells is usually driven by the interaction of double-positive CD4(+)CD8(+) thymocytes with epithelial cells. Here, we demonstrate preferential selection of CD8(+) thymocytes from in vitro differentiation of CD4(+)CD8(+) double-positive thymocytes exhibiting the characterist...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Biswas R,Mukherjee S,Sinha D,Ghosh AK,Biswas T

    更新日期:2014-04-01 00:00:00

  • Development of prophylactic and therapeutic vaccines using the ISCOMATRIX adjuvant.

    abstract::Adjuvants are components that when added to subunit antigen (Ag) vaccines boost their immunogenicity and thus immune efficacy. However, there are few adjuvants that are approved for clinical use resulting in a critical need for the development of safe and effective adjuvants for use in both prophylactic and therapeuti...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章,评审


    authors: Maraskovsky E,Schnurr M,Wilson NS,Robson NC,Boyle J,Drane D

    更新日期:2009-07-01 00:00:00

  • Synergistic antitumor effects of CpG oligodeoxynucleotide and STAT3 inhibitory agent JSI-124 in a mouse melanoma tumor model.

    abstract::One of the major limitations for cancer immunotherapy is related to the frequent existence of an intra-tumoral immunosuppressive environment, to which STAT3 (Signal transducer and activator of transcription-3) activation in tumor and dendritic cells (DCs) are believed to contribute. In this study, we tested the hypoth...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Molavi O,Ma Z,Hamdy S,Lai R,Lavasanifar A,Samuel J

    更新日期:2008-08-01 00:00:00

  • A CD2 high-expressing stress-resistant human plasmacytoid dendritic-cell subset.

    abstract::Human plasmacytoid dendritic cells (pDCs) were considered to be a phenotypically and functionally homogeneous cell population; however, recent analyses indicate potential heterogeneity. This is of major interest, given their importance in the induction of anti-viral responses and their role in creating immunologically...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Bryant C,Fromm PD,Kupresanin F,Clark G,Lee K,Clarke C,Silveira PA,Suen H,Brown R,Newman E,Cunningham I,Ho PJ,Gibson J,Bradstock K,Joshua D,Hart DNj

    更新日期:2016-05-01 00:00:00

  • T cells recognizing a 11mer influenza peptide complexed to H-2D(b) show promiscuity for peptide length.

    abstract::T-cell repertoire is selected according to self peptide-MHC (major histocompatibility complex) complexes in the thymus. Although most peripheral T cells recognize specific pathogen-derived peptides complexed to self-MHC exclusively, some possess cross-reactivity to other self or foreign peptides presented by self-MHC ...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Zanker D,Quinn K,Waithman J,Lata R,Murphy R,La Gruta NL,Chen W

    更新日期:2015-05-01 00:00:00

  • mTORC1 signaling is crucial for regulatory T cells to suppress macrophage-mediated inflammatory response after acute myocardial infarction.

    abstract::Post-infarction inflammatory response results in worse remodeling and dysfunction following myocardial infarction (MI). Supression of post-infarction inflammation would be a logical approach of alleviating post-infarction injury and promoting cardiac repair. In this study, we investigated the significance of mTORC1 si...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Yang K,Zhang Y,Xu C,Li X,Li D

    更新日期:2016-03-01 00:00:00

  • Initiation of antigen receptor endocytosis and B lymphocyte activation lie on independent biochemical pathways.

    abstract::Peroxidase-conjugated anti-surface immunoglobulin (sIg) was used quantitatively to monitor endocytosis of crosslinked sIg on murine B lymphocytes. The role of biochemical second messengers in the initiation of endocytosis was assessed by employing several inhibitors. A novel peroxidase detection system was used and te...

    journal_title:Immunology and cell biology

    pub_type: 杂志文章


    authors: Shuler RL,Owen CS

    更新日期:1993-02-01 00:00:00