Abstract：
:Inflammation, a precursor to many diseases including cancer and atherosclerosis, induces differential surface expression of specific vascular molecules. Blood-borne nanoparticles (NPs), loaded with therapeutic and imaging agents, can recognize and use these molecules as vascular docking sites. Here, a computational model is developed within the isogeometric analysis framework to understand and predict the vascular deposition of NPs within an inflamed arterial tree. The NPs have a diameter ranging from 0.1 to 2.0 μm and are decorated with antibodies directed toward three endothelial adhesion molecules, namely intravascular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin, whose surface density depends on the local wall shear stress. Results indicate VCAM-1 targeted NPs adhere more, with ICAM-1 directed NPs adhering least efficiently, resulting in approximately an order-of-magnitude lower average particle surface density. ICAM-1 and E-selectin directed 0.5 μm NPs are distributed more uniformly (heterogeneity index ≈ 0.9 and 1.0, respectively) over the bifurcating vascular branches compared to their VCAM-1 counterparts (heterogeneity index ≈ 1.4). When the NPs are coated with antibodies for VCAM-1 and E-selectin in equal proportions, a more uniform vascular distribution is achieved compared with VCAM-1-only targeted particles, thus demonstrating the advantage of NP multivalency in vascular targeting. Furthermore, the larger NPs (2 μm) adhere more (≈ 200%) in the lower branches compared to the upper branch. This computational framework provides insights into how size, ligand type, density, and multivalency can be manipulated to enhance NP vascular adhesion in an individual patient.
journal_name
Biomech Model Mechanobioljournal_title
Biomechanics and modeling in mechanobiologyauthors
Hossain SS,Hughes TJ,Decuzzi Pdoi
10.1007/s10237-013-0520-1subject
Has Abstractpub_date
2014-06-01 00:00:00pages
585-97issue
3eissn
1617-7959issn
1617-7940journal_volume
13pub_type
杂志文章abstract：:The first carpometacarpal (CMC) joint, located at the base of the thumb and formed by the junction between the first metacarpal and trapezium, is a common site for osteoarthritis of the hand. The shape of both the first metacarpal and trapezium contributes to the intrinsic bony stability of the joint, and variability ...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-019-01257-8
更新日期：2020-08-01 00:00:00
abstract：:The influence of an aortic aneurysm on blood flow waveforms is well established, but how to exploit this link for diagnostic purposes still remains challenging. This work uses a combination of experimental and computational modelling to study how aneurysms of various size affect the waveforms. Experimental studies are...
journal_title：Biomechanics and modeling in mechanobiology
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abstract：:Disease alters tissue microstructure, which in turn affects the macroscopic mechanical properties of tissue. In elasticity imaging, the macroscopic response is measured and is used to infer the spatial distribution of the elastic constitutive parameters. When an empirical constitutive model is used, these parameters c...
journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-020-01360-1
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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doi：10.1007/s10237-009-0164-3
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-016-0830-1
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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更新日期：2019-04-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-013-0498-8
更新日期：2014-01-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-013-0524-x
更新日期：2014-06-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-020-01413-5
更新日期：2021-01-22 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-004-0054-7
更新日期：2004-11-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-005-0003-0
更新日期：2005-12-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-019-01122-8
更新日期：2019-08-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-006-0048-8
更新日期：2006-11-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-017-0945-z
更新日期：2018-02-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-016-0826-x
更新日期：2017-04-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-014-0643-z
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-019-01123-7
更新日期：2019-08-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-017-0980-9
更新日期：2018-04-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-009-0158-1
更新日期：2010-02-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-012-0448-x
更新日期：2013-10-01 00:00:00
abstract：:Mineralized collagen fibrils have been usually analyzed like a two-phase composite material where crystals are considered as platelets that constitute the reinforcement phase. Different models have been used to describe the elastic behavior of the material. In this work, it is shown that when Halpin-Tsai equations are...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-013-0507-y
更新日期：2014-04-01 00:00:00
abstract：:Long-term adaptation of soft tissues is realized through growth and remodeling (G&R). Mathematical models are powerful tools in testing hypotheses on G&R and supporting the design and interpretation of experiments. Most theoretical G&R studies concentrate on description of either growth or remodeling. Our model combin...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-010-0204-z
更新日期：2010-12-01 00:00:00
