Abstract：
:Disease alters tissue microstructure, which in turn affects the macroscopic mechanical properties of tissue. In elasticity imaging, the macroscopic response is measured and is used to infer the spatial distribution of the elastic constitutive parameters. When an empirical constitutive model is used, these parameters cannot be linked to the microstructure. However, when the constitutive model is derived from a microstructural representation of the material, it allows for the possibility of inferring the local averages of the spatial distribution of the microstructural parameters. This idea forms the basis of this study. In particular, we first derive a constitutive model by homogenizing the mechanical response of a network of elastic, tortuous fibers. Thereafter, we use this model in an inverse problem to determine the spatial distribution of the microstructural parameters. We solve the inverse problem as a constrained minimization problem and develop efficient methods for solving it. We apply these methods to displacement fields obtained by deforming gelatin-agar co-gels and determine the spatial distribution of agar concentration and fiber tortuosity, thereby demonstrating that it is possible to image local averages of microstructural parameters from macroscopic measurements of deformation.
journal_name
Biomech Model Mechanobioljournal_title
Biomechanics and modeling in mechanobiologyauthors
Liu T,Hall TJ,Barbone PE,Oberai AAdoi
10.1007/s10237-016-0831-0subject
Has Abstractpub_date
2017-04-01 00:00:00pages
479-496issue
2eissn
1617-7959issn
1617-7940pii
10.1007/s10237-016-0831-0journal_volume
16pub_type
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