Infant brain subjected to oscillatory loading: material differentiation, properties, and interface conditions.

abstract：:Biological materials can undergo large deformations and also show viscoelastic behaviour. One such material is the network of actin filaments found in biological cells, giving the cell much of its mechanical stiffness. A theory for predicting the relaxation behaviour of actin networks cross-linked with the cross-linke...

journal_title：Biomechanics and modeling in mechanobiology

authors： Fallqvist B,Kroon M

更新日期：2013-04-01 00:00:00

abstract：:Recently, physiological and biomechanical studies on animal models with metal implants filling full-thickness cartilage defects have resulted in good clinical outcomes. The knowledge of the time-dependent macroscopic behavior of cartilage surrounding the metal implant is essential for understanding the joint function ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Manda K,Eriksson A

更新日期：2012-05-01 00:00:00

abstract：:A growing volume of experimental evidence demonstrates that mechanical stress plays a significant role in growth, proliferation, apoptosis, gene expression, electrophysiological properties and many other aspects of neurons. In this review, first, the mechanical microenvironment and properties of neurons under in vivo ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Wang Y,Wang W,Li Z,Hao S,Wang B

更新日期：2016-10-01 00:00:00

abstract：:Accurate and reliable assessment of bone quality requires predictive methods which could probe bone microstructure and provide information on bone mechanical properties. Multiscale modelling and simulation represent a fast and powerful way to predict bone mechanical properties based on experimental information on bone...

journal_title：Biomechanics and modeling in mechanobiology

authors： Sansalone V,Gagliardi D,Desceliers C,Bousson V,Laredo JD,Peyrin F,Haïat G,Naili S

更新日期：2016-02-01 00:00:00

abstract：:Cardiovascular implantable devices alter the biofluid dynamics and biochemistry of the blood in which they are placed. These perturbations can lead to thrombus formation which may or may not be desired, depending on the application. In this work, a computational model is developed that couples biofluid dynamics and bi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Horn JD,Maitland DJ,Hartman J,Ortega JM

更新日期：2018-12-01 00:00:00

abstract：:Adherent cells sense their mechanical environment, which, in turn, regulates their functions. During the past decade, a growing body of evidence has indicated that a deformable, solid-state intracellular structure known as the cytoskeleton (CSK) plays a major role in transmitting and distributing mechanical stresses w...

journal_title：Biomechanics and modeling in mechanobiology

authors： Stamenović D,Ingber DE

更新日期：2002-06-01 00:00:00

abstract：:By following the common definition of forward-dynamics simulations, i.e. predicting movement based on (neural) muscle activity, this work describes, for the first time, a forward-dynamics simulation framework of a musculoskeletal system, in which all components are represented as continuous, three-dimensional, volumet...

journal_title：Biomechanics and modeling in mechanobiology

authors： Röhrle O,Sprenger M,Schmitt S

更新日期：2017-06-01 00:00:00

abstract：:Long-term adaptation of soft tissues is realized through growth and remodeling (G&R). Mathematical models are powerful tools in testing hypotheses on G&R and supporting the design and interpretation of experiments. Most theoretical G&R studies concentrate on description of either growth or remodeling. Our model combin...

journal_title：Biomechanics and modeling in mechanobiology

authors： Machyshyn IM,Bovendeerd PH,van de Ven AA,Rongen PM,van de Vosse FN

更新日期：2010-12-01 00:00:00

abstract：:A systematic correlation between finite element models (FEMs) and histopathology is needed to define deformation thresholds associated with traumatic brain injury (TBI). In this study, a FEM of a transected piglet brain was used to reverse engineer the range of optimal shear moduli for infant (5 days old, 553-658 Pa) ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Sullivan S,Eucker SA,Gabrieli D,Bradfield C,Coats B,Maltese MR,Lee J,Smith C,Margulies SS

更新日期：2015-08-01 00:00:00

abstract：:During angiogenesis, sprouting microvessels interact with the extracellular matrix (ECM) by degrading and reorganizing the matrix, applying traction forces, and producing deformation. Morphometric features of the resulting microvascular network are affected by the interaction between the matrix and angiogenic microves...

journal_title：Biomechanics and modeling in mechanobiology

authors： Edgar LT,Maas SA,Guilkey JE,Weiss JA

更新日期：2015-08-01 00:00:00

abstract：:Inflammation, a precursor to many diseases including cancer and atherosclerosis, induces differential surface expression of specific vascular molecules. Blood-borne nanoparticles (NPs), loaded with therapeutic and imaging agents, can recognize and use these molecules as vascular docking sites. Here, a computational mo...

journal_title：Biomechanics and modeling in mechanobiology

authors： Hossain SS,Hughes TJ,Decuzzi P

更新日期：2014-06-01 00:00:00

abstract：:A mechanics-based mathematical model of retinal detachment due to the geometric changes of the eye associated with the evolution of myopia is developed. This includes deformation of the retina due to biological growth of the retina, as well as elastic deformation imposed on the retina by the myopic change in shape of ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lakawicz JM,Bottega WJ,Fine HF,Prenner JL

更新日期：2020-04-01 00:00:00

abstract：:Aortic valve (AV) calcification is a highly prevalent disease with serious impact on mortality and morbidity. The exact causes and mechanisms of AV calcification are unclear, although previous studies suggest that mechanical forces play a role. It has been clinically demonstrated that calcification preferentially occu...

journal_title：Biomechanics and modeling in mechanobiology

authors： Yap CH,Saikrishnan N,Yoganathan AP

更新日期：2012-01-01 00:00:00

abstract：:Bone tissue regeneration using scaffolds is receiving an increasing interest in orthopedic surgery and tissue engineering applications. In this study, we present the geometrical characterization of a specific family of scaffolds based on a face cubic centered (FCC) arrangement of empty pores leading to analytical form...

journal_title：Biomechanics and modeling in mechanobiology

authors： Sanz-Herrera JA,Garcia-Aznar JM,Doblare M

更新日期：2008-10-01 00:00:00

abstract：:Computational fluid dynamics (CFD) is an increasingly used method for investigation of hemodynamic parameters and their alterations under pathological conditions, which are important indicators for diagnosis of cardiovascular disease. In hemodynamic simulation models, the employment of appropriate boundary conditions ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Xu P,Liu X,Zhang H,Ghista D,Zhang D,Shi C,Huang W

更新日期：2018-12-01 00:00:00

abstract：:Lattice Boltzmann models (LBM) are rapidly showing their ability to simulate a lot of fluid dynamics problems that previously required very complex approaches. This study presents a LBM for simulating diffusion-advection transport of substrate in a 2-D laminar flow. The model considers the substrate influx into a set ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Moaty Sayed AA,Hussein MA,Becker T

更新日期：2010-04-01 00:00:00

abstract：:Medical studies have consistently shown that the best defense against cancer is early detection. Due to this, many efforts have been made to develop methods of screening patient blood quickly and cheaply. These methods range from separation via differences in size, electrostatic potential, chemical potential, antibody...

journal_title：Biomechanics and modeling in mechanobiology

authors： Becton M,Averett RD,Wang X

更新日期：2019-04-01 00:00:00

abstract：:The primary capillary plexus in early yolk sacs is remodeled into matured vitelline vessels aligned in the direction of blood flow at the onset of cardiac contraction. We hypothesized that the influence of fluid shear stress on cellular behaviors may be an underlying mechanism by which some existing capillary channels...

journal_title：Biomechanics and modeling in mechanobiology

authors： Blatnik JS,Schmid-Schönbein GW,Sung LA

更新日期：2005-12-01 00:00:00

abstract：:One of only a few approved and available anabolic treatments for severe osteoporosis is daily injections of PTH (1-34). This drug has a specific dual action which can act either anabolically or catabolically depending on the type of administration, i.e. intermittent or continuous, respectively. In this paper, we prese...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lavaill M,Trichilo S,Scheiner S,Forwood MR,Cooper DML,Pivonka P

更新日期：2020-10-01 00:00:00

abstract：:This research studies dynamic culture for 3D tissue construct development with computational fluid dynamics. It proposes a mathematical model to evaluate the impact of flow rates and flow shear stress on cell growth in 3D constructs under perfusion. The modeling results show that dynamic flow, even at flow rate as low...

journal_title：Biomechanics and modeling in mechanobiology

authors： Liu D,Chua CK,Leong KF

更新日期：2013-01-01 00:00:00

abstract：:Disease alters tissue microstructure, which in turn affects the macroscopic mechanical properties of tissue. In elasticity imaging, the macroscopic response is measured and is used to infer the spatial distribution of the elastic constitutive parameters. When an empirical constitutive model is used, these parameters c...

journal_title：Biomechanics and modeling in mechanobiology

authors： Liu T,Hall TJ,Barbone PE,Oberai AA

更新日期：2017-04-01 00:00:00

abstract：:Micro-indentation is a new experimental approach to assess physical cellular properties. Here we attempt to quantify the contribution of geometrical parameters to a cylindrical plant cell's resistance to lateral deformation. This information is important to correctly interpret data obtained from experiments using the ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Bolduc JE,Lewis LJ,Aubin CE,Geitmann A

更新日期：2006-11-01 00:00:00

abstract：:A computationally efficient method is described for simulating the dynamics of the left ventricle (LV) in three dimensions. LV motion is represented as a combination of a limited number of deformation modes, chosen to represent observed cardiac motions while conserving volume in the LV wall. The contribution of each m...

journal_title：Biomechanics and modeling in mechanobiology

authors： Hong BD,Moulton MJ,Secomb TW

更新日期：2019-12-01 00:00:00

abstract：:Ventricular growth is widely considered to be an important feature in the adverse progression of heart diseases, whereas reverse ventricular growth (or reverse remodeling) is often considered to be a favorable response to clinical intervention. In recent years, a number of theoretical models have been proposed to mode...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lee LC,Genet M,Acevedo-Bolton G,Ordovas K,Guccione JM,Kuhl E

更新日期：2015-04-01 00:00:00

abstract：:Determining the biomechanical behavior of heart valve leaflet tissues in a noninvasive manner remains an important clinical goal. While advances in 3D imaging modalities have made in vivo valve geometric data available, optimal methods to exploit such information in order to obtain functional information remain to be ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Aggarwal A,Sacks MS

更新日期：2016-08-01 00:00:00

abstract：:The integrity of articular cartilage depends on the proper functioning and mechanical stimulation of chondrocytes, the cells that synthesize extracellular matrix and maintain tissue health. The biosynthetic activity of chondrocytes is influenced by genetic factors, environmental influences, extracellular matrix compos...

journal_title：Biomechanics and modeling in mechanobiology

authors： Han SK,Federico S,Grillo A,Giaquinta G,Herzog W

更新日期：2007-04-01 00:00:00

abstract：:As a degenerative and inflammatory desease of elderly patients, about 80% of abdominal aortic aneurysms (AAA) show considerable wall calcification. Effect of calcifications on computational wall stress analyses of AAAs has been rarely treated in literature so far. Calcifications are heterogeneously distributed, non-fi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Maier A,Gee MW,Reeps C,Eckstein HH,Wall WA

更新日期：2010-10-01 00:00:00

abstract：:In this paper we introduce a novel method for prescribing terminal boundary conditions in one-dimensional arterial flow networks. This is carried out by coupling the terminal arterial vessel with a poro-elastic tube, representing the flow resistance offered by microcirculation. The performance of the proposed porous m...

journal_title：Biomechanics and modeling in mechanobiology

authors： Coccarelli A,Prakash A,Nithiarasu P

更新日期：2019-08-01 00:00:00

abstract：:This study evaluated the ability of different in vitro mechanical loading tests to promote new mineral formation at bonded dentin interfaces. This research demonstrated a sequential transition in the dentin remineralizing procedure through the analysis of the mineral and matrix gradients. Mechanical loading in phospho...

journal_title：Biomechanics and modeling in mechanobiology

authors： Toledano M,Aguilera FS,Cabello I,Osorio R

更新日期：2014-11-01 00:00:00

abstract：:Mechanical cues that trigger pathological remodeling in smooth muscle tissues remain largely unknown and are thought to be pivotal triggers for strain-induced remodeling. Thus, an understanding of the effects mechanical stimulation is important to elucidate underlying mechanisms of disease states and in the developmen...

journal_title：Biomechanics and modeling in mechanobiology

authors： Heise RL,Parekh A,Joyce EM,Chancellor MB,Sacks MS

更新日期：2012-01-01 00:00:00