Dynamic modeling for shear stress induced ATP release from vascular endothelial cells.

abstract：:Detailed knowledge about the mechanical properties of brain can improve numerical modeling of the brain under various loading conditions. The success of this modeling depends on constitutive model and reliable extraction of its material constants. The isotropy of the brain tissue is a key factor which affects the form...

journal_title：Biomechanics and modeling in mechanobiology

authors： Felfelian AM,Baradaran Najar A,Jafari Nedoushan R,Salehi H

更新日期：2019-12-01 00:00:00

abstract：:In its permanent quest of mechanobiological homeostasis, our vasculature significantly adapts across multiple length and timescales in various physiological and pathological conditions. Computational modeling of vascular growth and remodeling (G&R) has significantly improved our insights into the mechanobiological pro...

journal_title：Biomechanics and modeling in mechanobiology

authors： Mousavi SJ,Farzaneh S,Avril S

更新日期：2019-12-01 00:00:00

abstract：:This study presents a method for estimating the spatial variations in material properties of elastic membranes, such as biological tissue, which contain both inhomogeneous strain fields and inhomogeneous material properties. In order to validate the method, an inhomogeneous, isotropic rubber membrane was biaxially loa...

journal_title：Biomechanics and modeling in mechanobiology

authors： Nielsen PM,Malcolm DT,Hunter PJ,Charette PG

更新日期：2002-12-01 00:00:00

abstract：:Computational studies of chondrocyte mechanics, and cell mechanics in general, have typically been performed using single cell models embedded in an extracellular matrix construct. The assumption of a single cell microstructural model may not capture intercellular interactions or accurately reflect the macroscale mech...

journal_title：Biomechanics and modeling in mechanobiology

authors： Halloran JP,Sibole SC,Erdemir A

更新日期：2018-02-01 00:00:00

abstract：:The calcaneus bone is formed of extensive trabecular bone and is therefore well suited to be used as an example of loaded bone to establish the ability of combining microfinite element (microFE) technique with high-resolution peripheral quantitative computed tomography (HR-pQCT) in determining its mechanical propertie...

journal_title：Biomechanics and modeling in mechanobiology

authors： Alsayednoor J,Metcalf L,Rochester J,Dall'Ara E,McCloskey E,Lacroix D

更新日期：2018-12-01 00:00:00

abstract：:The superficial femoral artery (SFA) is a typical atherosclerosis-prone site. We aimed to explore whether the tortuosity of the SFA associates with the occurrence of atherosclerosis and investigate how vascular tortuosity influences the characteristics of blood flow. Ten patients diagnosed with atherosclerotic disease...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li X,Liu X,Li X,Xu L,Chen X,Liang F

更新日期：2019-08-01 00:00:00

abstract：:Evidence suggests that mechanical load is related to structural destruction of disk annulus fibrosus (AF) either in adult disk degeneration or in child disk acute injury. Both biochemical and biomechanical properties are different between immature and mature disks. However, the effects of mechanical compression on imm...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li P,Gan Y,Xu Y,Song L,Wang H,Zhang C,Wang L,Zhao C,Luo L,Zhou Q

更新日期：2017-04-01 00:00:00

abstract：:It was reported that a single-strand DNA (ssDNA) could be inbreathed spontaneously into a carbon nanotube (CNT). In this work, the complementary process, i.e. pulling a piece of ssDNA out of a single-walled (SW) CNT, is simulated using molecular dynamic methods. The pulling force is found to fluctuate around a plateau...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li Z,Yang W

更新日期：2011-04-01 00:00:00

abstract：:Tissue morphogenesis in multicellular organisms is accompanied by proliferative cell behaviors: cell division (increase in cell number after each cell cycle) and cell growth (increase in cell volume during each cell cycle). These proliferative cell behaviors can be regulated by multicellular dynamics to achieve proper...

journal_title：Biomechanics and modeling in mechanobiology

authors： Okuda S,Inoue Y,Eiraku M,Sasai Y,Adachi T

更新日期：2013-10-01 00:00:00

abstract：:A systematic correlation between finite element models (FEMs) and histopathology is needed to define deformation thresholds associated with traumatic brain injury (TBI). In this study, a FEM of a transected piglet brain was used to reverse engineer the range of optimal shear moduli for infant (5 days old, 553-658 Pa) ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Sullivan S,Eucker SA,Gabrieli D,Bradfield C,Coats B,Maltese MR,Lee J,Smith C,Margulies SS

更新日期：2015-08-01 00:00:00

abstract：:Nanomechanics of individual collagen fibrils govern the mechanical behavior of the majority of connective tissues, yet the current models lack significant details. Majority of the current models assume a rod-shape molecule with homogenous mechanical properties. Recent X-ray crystallography revealed significantly diffe...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zhou Z,Minary-Jolandan M,Qian D

更新日期：2015-06-01 00:00:00

abstract：:To investigate the relationship between cellular microelasticity and the structural features of cytoskeletons (CSKs), a microindentation test for apical cell membranes and observation of the spatio-distribution of actin CSKs of fibroblasts were performed by fluorescence and atomic force microscopy (FM/AFM). The indent...

journal_title：Biomechanics and modeling in mechanobiology

authors： Kidoaki S,Matsuda T,Yoshikawa K

更新日期：2006-11-01 00:00:00

abstract：:The immersed boundary method (IBM) has been frequently utilized to simulate the motion and deformation of biological cells and capsules in various flow situations. Despite the convenience in dealing with flow-membrane interaction, direct implementation of membrane viscosity in IBM suffers severe numerical instability....

journal_title：Biomechanics and modeling in mechanobiology

authors： Li P,Zhang J

更新日期：2020-12-01 00:00:00

abstract：:Recently, physiological and biomechanical studies on animal models with metal implants filling full-thickness cartilage defects have resulted in good clinical outcomes. The knowledge of the time-dependent macroscopic behavior of cartilage surrounding the metal implant is essential for understanding the joint function ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Manda K,Eriksson A

更新日期：2012-05-01 00:00:00

abstract：:A three-dimensional finite-element fluid/structure interaction model of an intravascular lymphatic valve was constructed, and its properties were investigated under both favourable and adverse pressure differences, simulating valve opening and valve closure, respectively. The shear modulus of the neo-Hookean material ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Bertram CD

更新日期：2020-12-01 00:00:00

abstract：:Cardiovascular implantable devices alter the biofluid dynamics and biochemistry of the blood in which they are placed. These perturbations can lead to thrombus formation which may or may not be desired, depending on the application. In this work, a computational model is developed that couples biofluid dynamics and bi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Horn JD,Maitland DJ,Hartman J,Ortega JM

更新日期：2018-12-01 00:00:00

abstract：:We use supersonic shear wave imaging (SSI) technique to measure not only the linear but also the nonlinear elastic properties of brain matter. Here, we tested six porcine brains ex vivo and measured the velocities of the plane shear waves induced by acoustic radiation force at different states of pre-deformation when ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Jiang Y,Li G,Qian LX,Liang S,Destrade M,Cao Y

更新日期：2015-10-01 00:00:00

abstract：:The mechanical behavior of most biological soft tissue is nonlinear viscoelastic rather than elastic. Many of the models previously proposed for soft tissue involve ad hoc systems of springs and dashpots or require measurement of time-dependent constitutive coefficient functions. The model proposed here is a system of...

journal_title：Biomechanics and modeling in mechanobiology

authors： Haslach HW Jr

更新日期：2005-03-01 00:00:00

abstract：:Tissue expansion is a common surgical procedure to grow extra skin through controlled mechanical over-stretch. It creates skin that matches the color, texture, and thickness of the surrounding tissue, while minimizing scars and risk of rejection. Despite intense research in tissue expansion and skin growth, there is a...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zöllner AM,Buganza Tepole A,Gosain AK,Kuhl E

更新日期：2012-07-01 00:00:00

abstract：:In this manuscript, we present a combined experimental and computational technique that can identify the heterogeneous elastic properties of planar soft tissues. By combining inverse membrane analysis, digital image correlation, and bulge inflation tests, we are able to identify a tissue's mechanical properties locall...

journal_title：Biomechanics and modeling in mechanobiology

authors： Davis FM,Luo Y,Avril S,Duprey A,Lu J

更新日期：2015-10-01 00:00:00

abstract：:Uniaxial tensile and relaxation tests were carried out on annulus fibrosus samples carved out in the circumferential direction. Images were shot perpendicularly to the loading direction. Digital image correlation techniques accurately measured the evolution of full displacement fields in both transverse directions: pl...

journal_title：Biomechanics and modeling in mechanobiology

authors： Baldit A,Ambard D,Cherblanc F,Royer P

更新日期：2014-06-01 00:00:00

abstract：:In myocardial infarction, muscle tissue of the heart is damaged as a result of ceased or severely impaired blood flow. Survivors have an increased risk of further complications, possibly leading to heart failure. Material properties play an important role in determining post-infarction outcome. Due to spatial variatio...

journal_title：Biomechanics and modeling in mechanobiology

authors： Balaban G,Finsberg H,Funke S,Håland TF,Hopp E,Sundnes J,Wall S,Rognes ME

更新日期：2018-10-01 00:00:00

abstract：:One of only a few approved and available anabolic treatments for severe osteoporosis is daily injections of PTH (1-34). This drug has a specific dual action which can act either anabolically or catabolically depending on the type of administration, i.e. intermittent or continuous, respectively. In this paper, we prese...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lavaill M,Trichilo S,Scheiner S,Forwood MR,Cooper DML,Pivonka P

更新日期：2020-10-01 00:00:00

abstract：:An efficient solver for large-scale linear [Formula: see text] simulations was extended for nonlinear material behavior. The material model included damage-based tissue degradation and fracture. The new framework was applied to 20 trabecular biopsies with a mesh resolution of [Formula: see text]. Suitable material par...

journal_title：Biomechanics and modeling in mechanobiology

authors： Stipsitz M,Zysset PK,Pahr DH

更新日期：2020-06-01 00:00:00

abstract：:In the present work, a constitutive model for articular cartilage is proposed in finite elasto-viscoplasticity. For simplification, articular cartilage is supposed to be a typical composite composed of a soft basis and a fiber assembly. The stress tensor and free energy function are hence accordingly divided into two ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zhu Y

更新日期：2018-12-01 00:00:00

abstract：:Mathematical and computational modeling of the dynamic process where tissue scaffolds are cultured in perfusion bioreactors is able to provide insight into the cell and tissue growth which can facilitate the design of tissue scaffolds and selection of optimal operating conditions. To date, a resolved-scale simulation ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Hossain MS,Bergstrom DJ,Chen XB

更新日期：2015-04-01 00:00:00

abstract：:Continuum mechanical tools are used to describe the deformation, energy density, and material symmetry of a lipid bilayer with spontaneous curvature. In contrast to conventional approaches in which lipid bilayers are modeled by material surfaces, here we rely on a three-dimensional approach in which a lipid bilayer is...

journal_title：Biomechanics and modeling in mechanobiology

authors： Maleki M,Seguin B,Fried E

更新日期：2013-10-01 00:00:00

abstract：:A mechanics-based mathematical model of retinal detachment due to the geometric changes of the eye associated with the evolution of myopia is developed. This includes deformation of the retina due to biological growth of the retina, as well as elastic deformation imposed on the retina by the myopic change in shape of ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lakawicz JM,Bottega WJ,Fine HF,Prenner JL

更新日期：2020-04-01 00:00:00

abstract：:The present study examines the possibility of attenuating blood pulses by means of introducing prosthetic viscoelastic materials able to absorb energy and damp such pulses. Vascular prostheses made of polymeric materials modify the mechanical properties of blood vessels. The effect of these materials on the blood puls...

journal_title：Biomechanics and modeling in mechanobiology

authors： Menacho J,Rotllant L,Molins JJ,Reyes G,García-Granada AA,Balcells M,Martorell J

更新日期：2018-04-01 00:00:00

abstract：:Flow-induced damage to red blood cells has been an issue of considerable importance since the introduction of the first cardiovascular devices. Early blood damage prediction models were based on measurements of damage by shear stress only. Subsequently, these models were extrapolated to include other components of the...

journal_title：Biomechanics and modeling in mechanobiology

authors： Faghih MM,Sharp MK

更新日期：2020-02-01 00:00:00