abstract：:Congenital heart defects (CHDs) are abnormalities in the heart structure present at birth. One important condition is hypoplastic left heart syndrome (HLHS) where severely underdeveloped left ventricle (LV) cannot support systemic circulation. HLHS usually initiates as localized tissue malformations with no underlying...

journal_title：Biomechanics and modeling in mechanobiology

authors： Salman HE,Alser M,Shekhar A,Gould RA,Benslimane FM,Butcher JT,Yalcin HC

更新日期：2021-01-22 00:00:00

abstract：:The monitoring of the ciliated walls in the uterine tube has supreme importance in enhancing the sperm to reach the egg (capacitation processes), and at peristaltic ciliary flow has a more favorable residual time along the canal when compared to the peristaltic flow. Based on the importance of this study, a mathematic...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zaher AZ,Moawad AMA,Mekheimer KS,Bhatti MM

更新日期：2021-01-03 00:00:00

abstract：:We propose a mechanical model of generation of vitreoretinal tractions in the presence of posterior vitreous detachment (PVD). PVD is a common occurrence with aging, and it consists in the separation of the vitreous body from the retina at the back pole of the eye, due to progressive shrinking of the vitreous gel. Dur...

journal_title：Biomechanics and modeling in mechanobiology

authors： Di Michele F,Tatone A,Romano MR,Repetto R

更新日期：2020-12-01 00:00:00

abstract：:Bridging veins (BVs) drain the blood from the cerebral cortex into dural sinuses. BVs have one end attached to the brain and the other to the superior sagittal sinus (SSS), which is attached to the skull. Relative movement between these two structures can cause BV to rupture producing acute subdural haematoma, a head ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Kapeliotis M,Gavrila Laic RA,Peñas AJ,Vander Sloten J,Vanden Berghe P,Famaey N,Depreitere B

更新日期：2020-12-01 00:00:00

abstract：:The immersed boundary method (IBM) has been frequently utilized to simulate the motion and deformation of biological cells and capsules in various flow situations. Despite the convenience in dealing with flow-membrane interaction, direct implementation of membrane viscosity in IBM suffers severe numerical instability....

journal_title：Biomechanics and modeling in mechanobiology

authors： Li P,Zhang J

更新日期：2020-12-01 00:00:00

abstract：:A three-dimensional finite-element fluid/structure interaction model of an intravascular lymphatic valve was constructed, and its properties were investigated under both favourable and adverse pressure differences, simulating valve opening and valve closure, respectively. The shear modulus of the neo-Hookean material ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Bertram CD

更新日期：2020-12-01 00:00:00

abstract：:One of only a few approved and available anabolic treatments for severe osteoporosis is daily injections of PTH (1-34). This drug has a specific dual action which can act either anabolically or catabolically depending on the type of administration, i.e. intermittent or continuous, respectively. In this paper, we prese...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lavaill M,Trichilo S,Scheiner S,Forwood MR,Cooper DML,Pivonka P

更新日期：2020-10-01 00:00:00

abstract：:Formins promote actin assembly and are involved in force-dependent cytoskeletal remodeling. However, how force alters the formin functions still needs to be investigated. Here, using atomic force microscopy and biomembrane force probe, we investigated how mechanical force affects formin-mediated actin interactions at ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li Z,Lee H,Eskin SG,Ono S,Zhu C,McIntire LV

更新日期：2020-10-01 00:00:00

abstract：:Nasal emission is a speech disorder where undesired airflow enters the nasal cavity during speech due to inadequate closure of the velopharyngeal valve. Nasal emission is typically inaudible with large velopharyngeal openings and very distorting with small openings. This study aims to understand how flow characteristi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Sundström E,Boyce S,Oren L

更新日期：2020-10-01 00:00:00

abstract：:Growth and remodeling in the heart is driven by a combination of mechanical and hormonal signals that produce different patterns of growth in response to exercise, pregnancy, and various pathologies. In particular, increases in afterload lead to concentric hypertrophy, a thickening of the walls that increases the cont...

journal_title：Biomechanics and modeling in mechanobiology

authors： Estrada AC,Yoshida K,Saucerman JJ,Holmes JW

更新日期：2020-09-24 00:00:00

abstract：:Human embryonic stem cells (hESCs) can differentiate to three germ layers within biochemical and biomechanical niches. The complicated mechanical environments in vivo could have diverse effects on the fate decision and biological functions of hESCs. To globally screen mechanosensitive molecules, three typical types of...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zhang F,Wang J,Lü D,Zheng L,Shangguan B,Gao Y,Wu Y,Long M

更新日期：2020-08-18 00:00:00

abstract：:Actin stress fibers (SFs), a contractile apparatus in nonmuscle cells, possess a contractile unit that is apparently similar to the sarcomere of myofibrils in muscles. The function of SFs has thus often been addressed based on well-characterized properties of muscles. However, unlike the fixed number of myosin molecul...

journal_title：Biomechanics and modeling in mechanobiology

authors： Saito T,Huang W,Matsui TS,Kuragano M,Takahashi M,Deguchi S

更新日期：2020-08-10 00:00:00

abstract：:The first carpometacarpal (CMC) joint, located at the base of the thumb and formed by the junction between the first metacarpal and trapezium, is a common site for osteoarthritis of the hand. The shape of both the first metacarpal and trapezium contributes to the intrinsic bony stability of the joint, and variability ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Rusli WMR,Kedgley AE

更新日期：2020-08-01 00:00:00

abstract：:The compliance of the proximal aortic wall is a major determinant of cardiac afterload. Aortic compliance is often estimated based on cross-sectional area changes over the pulse pressure, under the assumption of a negligible longitudinal stretch during the pulse. However, the proximal aorta is subjected to significant...

journal_title：Biomechanics and modeling in mechanobiology

authors： Pagoulatou SZ,Ferraro M,Trachet B,Bikia V,Rovas G,Crowe LA,Vallée JP,Adamopoulos D,Stergiopulos N

更新日期：2020-07-31 00:00:00

abstract：:An efficient solver for large-scale linear [Formula: see text] simulations was extended for nonlinear material behavior. The material model included damage-based tissue degradation and fracture. The new framework was applied to 20 trabecular biopsies with a mesh resolution of [Formula: see text]. Suitable material par...

journal_title：Biomechanics and modeling in mechanobiology

authors： Stipsitz M,Zysset PK,Pahr DH

更新日期：2020-06-01 00:00:00

abstract：:Conventional brain injury metrics are scalars that treat the whole head/brain as a single unit but do not characterize the distribution of brain responses. Here, we establish a network-based "response feature matrix" to characterize the magnitude and distribution of impact-induced brain strains. The network nodes and ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Wu S,Zhao W,Rowson B,Rowson S,Ji S

更新日期：2020-06-01 00:00:00

abstract：:A mechanics-based mathematical model of retinal detachment due to the geometric changes of the eye associated with the evolution of myopia is developed. This includes deformation of the retina due to biological growth of the retina, as well as elastic deformation imposed on the retina by the myopic change in shape of ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lakawicz JM,Bottega WJ,Fine HF,Prenner JL

更新日期：2020-04-01 00:00:00

abstract：:The diseases of human blood vessels are closely associated with local mechanical variations. A better understanding of the quantitative correlation in mechanical environment between the current mechano-biological studies and vascular physiological or pathological conditions in vivo is crucial for evaluating numerous e...

journal_title：Biomechanics and modeling in mechanobiology

authors： Yang S,Gong X,Qi Y,Jiang Z

更新日期：2020-04-01 00:00:00

abstract：:We propose and analyse the properties of a new class of models for the electromechanics of cardiac tissue. The set of governing equations consists of nonlinear elasticity using a viscoelastic and orthotropic exponential constitutive law, for both active stress and active strain formulations of active mechanics, couple...

journal_title：Biomechanics and modeling in mechanobiology

authors： Propp A,Gizzi A,Levrero-Florencio F,Ruiz-Baier R

更新日期：2020-04-01 00:00:00

abstract：:It is believed that non-mammals have poor hearing at high frequencies because the sound-conduction performance of their single-ossicle middle ears declines above a certain frequency. To better understand this behavior, a dynamic three-dimensional finite-element model of the chicken middle ear was constructed. The effe...

journal_title：Biomechanics and modeling in mechanobiology

authors： Muyshondt PGG,Dirckx JJJ

更新日期：2020-02-01 00:00:00

abstract：:Flow-induced damage to red blood cells has been an issue of considerable importance since the introduction of the first cardiovascular devices. Early blood damage prediction models were based on measurements of damage by shear stress only. Subsequently, these models were extrapolated to include other components of the...

journal_title：Biomechanics and modeling in mechanobiology

authors： Faghih MM,Sharp MK

更新日期：2020-02-01 00:00:00

abstract：:In its permanent quest of mechanobiological homeostasis, our vasculature significantly adapts across multiple length and timescales in various physiological and pathological conditions. Computational modeling of vascular growth and remodeling (G&R) has significantly improved our insights into the mechanobiological pro...

journal_title：Biomechanics and modeling in mechanobiology

authors： Mousavi SJ,Farzaneh S,Avril S

更新日期：2019-12-01 00:00:00

abstract：:Detailed knowledge about the mechanical properties of brain can improve numerical modeling of the brain under various loading conditions. The success of this modeling depends on constitutive model and reliable extraction of its material constants. The isotropy of the brain tissue is a key factor which affects the form...

journal_title：Biomechanics and modeling in mechanobiology

authors： Felfelian AM,Baradaran Najar A,Jafari Nedoushan R,Salehi H

更新日期：2019-12-01 00:00:00

abstract：:A computationally efficient method is described for simulating the dynamics of the left ventricle (LV) in three dimensions. LV motion is represented as a combination of a limited number of deformation modes, chosen to represent observed cardiac motions while conserving volume in the LV wall. The contribution of each m...

journal_title：Biomechanics and modeling in mechanobiology

authors： Hong BD,Moulton MJ,Secomb TW

更新日期：2019-12-01 00:00:00

abstract：:There is a growing interest in the development of patient-specific finite element models of the human lumbar spine for both the assessment of injury risk and the development of treatment strategies. A current challenge in implementing these models is that the outer annulus fibrosus of the disc is composed of concentri...

journal_title：Biomechanics and modeling in mechanobiology

authors： Michalek AJ

更新日期：2019-10-01 00:00:00

abstract：:Plaque progression and vulnerability are influenced by many risk factors. Our goal is to find a simple method to combine multiple risk factors for better plaque development prediction. Intravascular ultrasound data at baseline and follow-up were acquired from nine patients, and fluid-structure interaction models were ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Wang L,Tang D,Maehara A,Molony D,Zheng J,Samady H,Wu Z,Lu W,Zhu J,Ma G,Giddens DP,Stone GW,Mintz GS

更新日期：2019-10-01 00:00:00

abstract：:Computational models of the heart have reached a level of maturity that enables sophisticated patient-specific simulations and hold potential for important applications in diagnosis and therapy planning. However, such clinical use puts strict demands on the reliability and accuracy of the models and requires the sensi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Campos JO,Sundnes J,Dos Santos RW,Rocha BM

更新日期：2019-10-01 00:00:00

abstract：:Articular cartilage is a complex, anisotropic, stratified tissue with remarkable resilience and mechanical properties. It has been subject to extensive modelling as a multiphase medium, with many recent studies examining the impact of increasing detail in the representation of this tissue's fine scale structure. Howev...

journal_title：Biomechanics and modeling in mechanobiology

authors： Klika V,Whiteley JP,Brown CP,Gaffney EA

更新日期：2019-08-01 00:00:00

abstract：:The superficial femoral artery (SFA) is a typical atherosclerosis-prone site. We aimed to explore whether the tortuosity of the SFA associates with the occurrence of atherosclerosis and investigate how vascular tortuosity influences the characteristics of blood flow. Ten patients diagnosed with atherosclerotic disease...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li X,Liu X,Li X,Xu L,Chen X,Liang F

更新日期：2019-08-01 00:00:00

abstract：:In this paper we introduce a novel method for prescribing terminal boundary conditions in one-dimensional arterial flow networks. This is carried out by coupling the terminal arterial vessel with a poro-elastic tube, representing the flow resistance offered by microcirculation. The performance of the proposed porous m...

journal_title：Biomechanics and modeling in mechanobiology

authors： Coccarelli A,Prakash A,Nithiarasu P

更新日期：2019-08-01 00:00:00

abstract：:It has been demonstrated that interstitial fluid (IF) flow can play a crucial role in tumor cell progression. Swartz and collaborators (Cancer Cell 11: 526-538, Shields et al. 2007) demonstrated that cells that secrete the lymphoid homing chemokines CCL21/CCL19 and express their receptor CCR7 could use flow to bias th...

journal_title：Biomechanics and modeling in mechanobiology

authors： Urdal J,Waldeland JO,Evje S

更新日期：2019-08-01 00:00:00

abstract：:Hemolysis is a major concern in blood-circulating devices, which arises due to hydrodynamic loading on red blood cells from ambient flow environment. Hemolysis estimation models have often been used to aid hemocompatibility design. The preponderance of hemolysis models was formulated on the basis of laminar flows. How...

journal_title：Biomechanics and modeling in mechanobiology

authors： Wu P,Gao Q,Hsu PL

更新日期：2019-06-01 00:00:00

abstract：:Medical studies have consistently shown that the best defense against cancer is early detection. Due to this, many efforts have been made to develop methods of screening patient blood quickly and cheaply. These methods range from separation via differences in size, electrostatic potential, chemical potential, antibody...

journal_title：Biomechanics and modeling in mechanobiology

authors： Becton M,Averett RD,Wang X

更新日期：2019-04-01 00:00:00

abstract：:The human heart is enclosed in the pericardial cavity. The pericardium consists of a layered thin sac and is separated from the myocardium by a thin film of fluid. It provides a fixture in space and frictionless sliding of the myocardium. The influence of the pericardium is essential for predictive mechanical simulati...

journal_title：Biomechanics and modeling in mechanobiology

authors： Pfaller MR,Hörmann JM,Weigl M,Nagler A,Chabiniok R,Bertoglio C,Wall WA

更新日期：2019-04-01 00:00:00

abstract：:Intracellular calcium dynamics plays an important role in the regulation of vascular endothelial cellular functions. In order to probe the intracellular calcium dynamic response under synergistic effect of wall shear stress (WSS) and adenosine triphosphate (ATP) signals, a novel microfluidic device, which provides the...

journal_title：Biomechanics and modeling in mechanobiology

authors： Chen ZZ,Yuan WM,Xiang C,Zeng DP,Liu B,Qin KR

更新日期：2019-02-01 00:00:00

abstract：:The calcaneus bone is formed of extensive trabecular bone and is therefore well suited to be used as an example of loaded bone to establish the ability of combining microfinite element (microFE) technique with high-resolution peripheral quantitative computed tomography (HR-pQCT) in determining its mechanical propertie...

journal_title：Biomechanics and modeling in mechanobiology

authors： Alsayednoor J,Metcalf L,Rochester J,Dall'Ara E,McCloskey E,Lacroix D

更新日期：2018-12-01 00:00:00

abstract：:Computational fluid dynamics (CFD) is an increasingly used method for investigation of hemodynamic parameters and their alterations under pathological conditions, which are important indicators for diagnosis of cardiovascular disease. In hemodynamic simulation models, the employment of appropriate boundary conditions ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Xu P,Liu X,Zhang H,Ghista D,Zhang D,Shi C,Huang W

更新日期：2018-12-01 00:00:00

abstract：:In the present work, a constitutive model for articular cartilage is proposed in finite elasto-viscoplasticity. For simplification, articular cartilage is supposed to be a typical composite composed of a soft basis and a fiber assembly. The stress tensor and free energy function are hence accordingly divided into two ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zhu Y

更新日期：2018-12-01 00:00:00

abstract：:Cardiovascular implantable devices alter the biofluid dynamics and biochemistry of the blood in which they are placed. These perturbations can lead to thrombus formation which may or may not be desired, depending on the application. In this work, a computational model is developed that couples biofluid dynamics and bi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Horn JD,Maitland DJ,Hartman J,Ortega JM

更新日期：2018-12-01 00:00:00

abstract：:Experiments have demonstrated biological tissues grow by mechanically sensing their localized curvature, therefore making geometry a key consideration for tissue scaffold design. We developed a simulation approach for modeling tissue growth on beam-based geometries of repeating unit cells, with four lattice topologies...

journal_title：Biomechanics and modeling in mechanobiology

authors： Egan PF,Shea KA,Ferguson SJ

更新日期：2018-10-01 00:00:00