A hybrid bioregulatory model of angiogenesis during bone fracture healing.

abstract：:A contact finite element (FE) formulation is introduced, amenable to patient-specific analysis of cumulative cartilage mechano-stimulus attributable to habitual functional activity. CT scans of individual human ankles are segmented to delineate bony margins. Each bone surface is projected outward to create a second su...

journal_title：Biomechanics and modeling in mechanobiology

authors： Anderson DD,Goldsworthy JK,Shivanna K,Grosland NM,Pedersen DR,Thomas TP,Tochigi Y,Marsh JL,Brown TD

更新日期：2006-06-01 00:00:00

abstract：:Prior studies indicated that mechanical loading influences cell turnover and matrix remodeling in tissues, suggesting that mechanical stimuli can play an active role in engineering artificial tissues. While most tissue culture studies focus on influence of uniaxial loading or constraints, effects of multi-axial loadin...

journal_title：Biomechanics and modeling in mechanobiology

authors： Hu JJ,Liu YC,Chen GW,Wang MX,Lee PY

更新日期：2013-10-01 00:00:00

abstract：:Experimental evidence suggests that interstitial fluid flow is a stimulus for mechanoadaptation in bone. Bone adaptation is sensitive to the frequency of loading and rest insertion between load cycles. We investigated the effects of permeability, frequency and rest insertion on fluid flow in bone using finite-element ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Pereira AF,Shefelbine SJ

更新日期：2014-01-01 00:00:00

abstract：:Tissue morphogenesis in multicellular organisms is accompanied by proliferative cell behaviors: cell division (increase in cell number after each cell cycle) and cell growth (increase in cell volume during each cell cycle). These proliferative cell behaviors can be regulated by multicellular dynamics to achieve proper...

journal_title：Biomechanics and modeling in mechanobiology

authors： Okuda S,Inoue Y,Eiraku M,Sasai Y,Adachi T

更新日期：2013-10-01 00:00:00

abstract：:This study presents a method for estimating the spatial variations in material properties of elastic membranes, such as biological tissue, which contain both inhomogeneous strain fields and inhomogeneous material properties. In order to validate the method, an inhomogeneous, isotropic rubber membrane was biaxially loa...

journal_title：Biomechanics and modeling in mechanobiology

authors： Nielsen PM,Malcolm DT,Hunter PJ,Charette PG

更新日期：2002-12-01 00:00:00

abstract：:Determining the biomechanical behavior of heart valve leaflet tissues in a noninvasive manner remains an important clinical goal. While advances in 3D imaging modalities have made in vivo valve geometric data available, optimal methods to exploit such information in order to obtain functional information remain to be ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Aggarwal A,Sacks MS

更新日期：2016-08-01 00:00:00

abstract：:Both the clinically established diameter criterion and novel approaches of computational finite element (FE) analyses for rupture risk stratification of abdominal aortic aneurysms (AAA) are based on assumptions of population-averaged, uniform material properties for the AAA wall. The presence of inter-patient and intr...

journal_title：Biomechanics and modeling in mechanobiology

authors： Reeps C,Maier A,Pelisek J,Härtl F,Grabher-Meier V,Wall WA,Essler M,Eckstein HH,Gee MW

更新日期：2013-08-01 00:00:00

abstract：:Nasal emission is a speech disorder where undesired airflow enters the nasal cavity during speech due to inadequate closure of the velopharyngeal valve. Nasal emission is typically inaudible with large velopharyngeal openings and very distorting with small openings. This study aims to understand how flow characteristi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Sundström E,Boyce S,Oren L

更新日期：2020-10-01 00:00:00

abstract：:The paper describes the extension of a previously developed model of pressure-dependent contraction rate to the case of multiple lymphangions. Mechanical factors are key modulators of active lymphatic pumping. As part of the evolution of our lumped-parameter model to match experimental findings, we have designed an al...

journal_title：Biomechanics and modeling in mechanobiology

authors： Bertram CD,Macaskill C,Davis MJ,Moore JE Jr

更新日期：2018-10-01 00:00:00

abstract：:Disease alters tissue microstructure, which in turn affects the macroscopic mechanical properties of tissue. In elasticity imaging, the macroscopic response is measured and is used to infer the spatial distribution of the elastic constitutive parameters. When an empirical constitutive model is used, these parameters c...

journal_title：Biomechanics and modeling in mechanobiology

authors： Liu T,Hall TJ,Barbone PE,Oberai AA

更新日期：2017-04-01 00:00:00

abstract：:Adherent cells normally apply forces as a generic means of sensing and responding to the mechanical nature of their surrounding environment. How these forces vary as a function of the extracellular rigidity is critical to understanding the regulatory functions that drive important phenomena such as wound healing or mu...

journal_title：Biomechanics and modeling in mechanobiology

authors： Borau C,Kamm RD,García-Aznar JM

更新日期：2014-04-01 00:00:00

abstract：:Bridging veins (BVs) drain the blood from the cerebral cortex into dural sinuses. BVs have one end attached to the brain and the other to the superior sagittal sinus (SSS), which is attached to the skull. Relative movement between these two structures can cause BV to rupture producing acute subdural haematoma, a head ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Kapeliotis M,Gavrila Laic RA,Peñas AJ,Vander Sloten J,Vanden Berghe P,Famaey N,Depreitere B

更新日期：2020-12-01 00:00:00

abstract：:We use supersonic shear wave imaging (SSI) technique to measure not only the linear but also the nonlinear elastic properties of brain matter. Here, we tested six porcine brains ex vivo and measured the velocities of the plane shear waves induced by acoustic radiation force at different states of pre-deformation when ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Jiang Y,Li G,Qian LX,Liang S,Destrade M,Cao Y

更新日期：2015-10-01 00:00:00

abstract：:Skin expansion delivers newly grown skin that maintains histological and mechanical features of the original tissue. Although it is the gold standard for cutaneous defect correction today, the underlying mechanisms remain poorly understood. Here we present a novel technique to quantify anisotropic prestrain, deformati...

journal_title：Biomechanics and modeling in mechanobiology

authors： Buganza Tepole A,Gart M,Purnell CA,Gosain AK,Kuhl E

更新日期：2015-10-01 00:00:00

abstract：:Articular cartilages swell and shrink depending on the ionic strength of the electrolyte they are in contact with. This electro-chemo-mechanical coupling is due to the presence of fixed electrical charges on proteoglycans (PGs). In addition, at nonphysiological pH, collagen fibers become charged. Therefore, variation ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Loret B,Simões FM

更新日期：2010-02-01 00:00:00

abstract：:Adherent cells sense their mechanical environment, which, in turn, regulates their functions. During the past decade, a growing body of evidence has indicated that a deformable, solid-state intracellular structure known as the cytoskeleton (CSK) plays a major role in transmitting and distributing mechanical stresses w...

journal_title：Biomechanics and modeling in mechanobiology

authors： Stamenović D,Ingber DE

更新日期：2002-06-01 00:00:00

abstract：:Actin stress fibers (SFs), a contractile apparatus in nonmuscle cells, possess a contractile unit that is apparently similar to the sarcomere of myofibrils in muscles. The function of SFs has thus often been addressed based on well-characterized properties of muscles. However, unlike the fixed number of myosin molecul...

journal_title：Biomechanics and modeling in mechanobiology

authors： Saito T,Huang W,Matsui TS,Kuragano M,Takahashi M,Deguchi S

更新日期：2020-08-10 00:00:00

abstract：:Schlemm's canal (SC) endothelial cells are likely important in the physiology and pathophysiology of the aqueous drainage system of the eye, particularly in glaucoma. The mechanical stiffness of these cells determines, in part, the extent to which they can support a pressure gradient and thus can be used to place limi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zeng D,Juzkiw T,Read AT,Chan DW,Glucksberg MR,Ethier CR,Johnson M

更新日期：2010-02-01 00:00:00

abstract：:Collagen degradation is one of the early signs of osteoarthritis. It is not known how collagen degradation affects chondrocyte volume and morphology. Thus, the aim of this study was to investigate the effect of enzymatically induced collagen degradation on cell volume and shape changes in articular cartilage after a h...

journal_title：Biomechanics and modeling in mechanobiology

authors： Turunen SM,Lammi MJ,Saarakkala S,Han SK,Herzog W,Tanska P,Korhonen RK

更新日期：2013-06-01 00:00:00

abstract：:It was reported that a single-strand DNA (ssDNA) could be inbreathed spontaneously into a carbon nanotube (CNT). In this work, the complementary process, i.e. pulling a piece of ssDNA out of a single-walled (SW) CNT, is simulated using molecular dynamic methods. The pulling force is found to fluctuate around a plateau...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li Z,Yang W

更新日期：2011-04-01 00:00:00

abstract：:The veins distributing oxygenated blood from the placenta to the fetal body have been given much attention in clinical Doppler velocimetry studies, in particular the ductus venosus. The ductus venosus is embedded in the left liver lobe and connects the intra-abdominal portion of the umbilical vein (IUV) directly to th...

journal_title：Biomechanics and modeling in mechanobiology

authors： Leinan PR,Degroote J,Kiserud T,Skallerud B,Vierendeels J,Hellevik LR

更新日期：2013-10-01 00:00:00

abstract：:In this paper, the heat and flow characteristic of third-grade non-Newtonian biofluids flow through a vertical porous human vessel due to peristaltic wall motion are studied. The third-grade model can describe shear thinning (or shear thickening) and normal stress differences, which is acceptable for biofluids modelin...

journal_title：Biomechanics and modeling in mechanobiology

authors： Akbarzadeh P

更新日期：2018-02-01 00:00:00

abstract：:The immersed boundary method (IBM) has been frequently utilized to simulate the motion and deformation of biological cells and capsules in various flow situations. Despite the convenience in dealing with flow-membrane interaction, direct implementation of membrane viscosity in IBM suffers severe numerical instability....

journal_title：Biomechanics and modeling in mechanobiology

authors： Li P,Zhang J

更新日期：2020-12-01 00:00:00

abstract：:A growing volume of experimental evidence demonstrates that mechanical stress plays a significant role in growth, proliferation, apoptosis, gene expression, electrophysiological properties and many other aspects of neurons. In this review, first, the mechanical microenvironment and properties of neurons under in vivo ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Wang Y,Wang W,Li Z,Hao S,Wang B

更新日期：2016-10-01 00:00:00

abstract：:Computational fluid dynamics (CFD) is an increasingly used method for investigation of hemodynamic parameters and their alterations under pathological conditions, which are important indicators for diagnosis of cardiovascular disease. In hemodynamic simulation models, the employment of appropriate boundary conditions ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Xu P,Liu X,Zhang H,Ghista D,Zhang D,Shi C,Huang W

更新日期：2018-12-01 00:00:00

abstract：:To investigate the relationship between cellular microelasticity and the structural features of cytoskeletons (CSKs), a microindentation test for apical cell membranes and observation of the spatio-distribution of actin CSKs of fibroblasts were performed by fluorescence and atomic force microscopy (FM/AFM). The indent...

journal_title：Biomechanics and modeling in mechanobiology

authors： Kidoaki S,Matsuda T,Yoshikawa K

更新日期：2006-11-01 00:00:00

abstract：:The endothelial cells lining the inner wall of Schlemm's canal (SC) in the eye are relatively unique in that they support a basal-to-apical pressure gradient that causes these cells to deform, creating giant vacuoles and transendothelial pores through which the aqueous humor flows. Glaucoma is associated with an incre...

journal_title：Biomechanics and modeling in mechanobiology

authors： Vargas-Pinto R,Lai J,Gong H,Ethier CR,Johnson M

更新日期：2015-08-01 00:00:00

abstract：:In adaptive bone remodeling, mechanical signals such as stress/strain caused by loading/deformation are believed to play important roles as regulators of the process in which osteoclastic resorption and osteoblastic formation are coordinated under a local mechanical environment. The mechanism by which cells sense and ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Adachi T,Sato K,Tomita Y

更新日期：2003-11-01 00:00:00

abstract：:In its permanent quest of mechanobiological homeostasis, our vasculature significantly adapts across multiple length and timescales in various physiological and pathological conditions. Computational modeling of vascular growth and remodeling (G&R) has significantly improved our insights into the mechanobiological pro...

journal_title：Biomechanics and modeling in mechanobiology

authors： Mousavi SJ,Farzaneh S,Avril S

更新日期：2019-12-01 00:00:00

abstract：:The present study addresses the effect of muscle activation contributions to mitral valve leaflet response during systole. State-of-art passive hyperelastic material modeling is employed in combination with a simple active stress part. Fiber families are assumed in the leaflets: one defined by the collagen and one def...

journal_title：Biomechanics and modeling in mechanobiology

authors： Skallerud B,Prot V,Nordrum IS

更新日期：2011-02-01 00:00:00