A novel method for non-invasively detecting the severity and location of aortic aneurysms.

Abstract:

:The influence of an aortic aneurysm on blood flow waveforms is well established, but how to exploit this link for diagnostic purposes still remains challenging. This work uses a combination of experimental and computational modelling to study how aneurysms of various size affect the waveforms. Experimental studies are carried out on fusiform-type aneurysm models, and a comparison of results with those from a one-dimensional fluid-structure interaction model shows close agreement. Further mathematical analysis of these results allows the definition of several indicators that characterize the impact of an aneurysm on waveforms. These indicators are then further studied in a computational model of a systemic blood flow network. This demonstrates the methods' ability to detect the location and severity of an aortic aneurysm through the analysis of flow waveforms in clinically accessible locations. Therefore, the proposed methodology shows a high potential for non-invasive aneurysm detectors/monitors.

authors

Sazonov I,Khir AW,Hacham WS,Boileau E,Carson JM,van Loon R,Ferguson C,Nithiarasu P

doi

10.1007/s10237-017-0884-8

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

1225-1242

issue

4

eissn

1617-7959

issn

1617-7940

pii

10.1007/s10237-017-0884-8

journal_volume

16

pub_type

杂志文章
  • Influence of power-law rheology on cell injury during microbubble flows.

    abstract::The reopening of fluid-occluded pulmonary airways generates microbubble flows which impart complex hydrodynamic stresses to the epithelial cells lining airway walls. In this study we used boundary element solutions and finite element techniques to investigate how cell rheology influences the deformation and injury of ...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-009-0175-0

    authors: Dailey HL,Ghadiali SN

    更新日期:2010-06-01 00:00:00

  • A growth-based model for the prediction of fiber angle distribution in the intervertebral disc annulus fibrosus.

    abstract::There is a growing interest in the development of patient-specific finite element models of the human lumbar spine for both the assessment of injury risk and the development of treatment strategies. A current challenge in implementing these models is that the outer annulus fibrosus of the disc is composed of concentri...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-019-01150-4

    authors: Michalek AJ

    更新日期:2019-10-01 00:00:00

  • Velocity profiles in the human ductus venosus: a numerical fluid structure interaction study.

    abstract::The veins distributing oxygenated blood from the placenta to the fetal body have been given much attention in clinical Doppler velocimetry studies, in particular the ductus venosus. The ductus venosus is embedded in the left liver lobe and connects the intra-abdominal portion of the umbilical vein (IUV) directly to th...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-012-0460-1

    authors: Leinan PR,Degroote J,Kiserud T,Skallerud B,Vierendeels J,Hellevik LR

    更新日期:2013-10-01 00:00:00

  • Modeling left ventricular dynamics with characteristic deformation modes.

    abstract::A computationally efficient method is described for simulating the dynamics of the left ventricle (LV) in three dimensions. LV motion is represented as a combination of a limited number of deformation modes, chosen to represent observed cardiac motions while conserving volume in the LV wall. The contribution of each m...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-019-01168-8

    authors: Hong BD,Moulton MJ,Secomb TW

    更新日期:2019-12-01 00:00:00

  • Growing skin: tissue expansion in pediatric forehead reconstruction.

    abstract::Tissue expansion is a common surgical procedure to grow extra skin through controlled mechanical over-stretch. It creates skin that matches the color, texture, and thickness of the surrounding tissue, while minimizing scars and risk of rejection. Despite intense research in tissue expansion and skin growth, there is a...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-011-0357-4

    authors: Zöllner AM,Buganza Tepole A,Gosain AK,Kuhl E

    更新日期:2012-07-01 00:00:00

  • A computational thrombus formation model: application to an idealized two-dimensional aneurysm treated with bare metal coils.

    abstract::Cardiovascular implantable devices alter the biofluid dynamics and biochemistry of the blood in which they are placed. These perturbations can lead to thrombus formation which may or may not be desired, depending on the application. In this work, a computational model is developed that couples biofluid dynamics and bi...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-018-1059-y

    authors: Horn JD,Maitland DJ,Hartman J,Ortega JM

    更新日期:2018-12-01 00:00:00

  • Stochastic multiscale modelling of cortical bone elasticity based on high-resolution imaging.

    abstract::Accurate and reliable assessment of bone quality requires predictive methods which could probe bone microstructure and provide information on bone mechanical properties. Multiscale modelling and simulation represent a fast and powerful way to predict bone mechanical properties based on experimental information on bone...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-015-0695-8

    authors: Sansalone V,Gagliardi D,Desceliers C,Bousson V,Laredo JD,Peyrin F,Haïat G,Naili S

    更新日期:2016-02-01 00:00:00

  • A computational model that predicts reverse growth in response to mechanical unloading.

    abstract::Ventricular growth is widely considered to be an important feature in the adverse progression of heart diseases, whereas reverse ventricular growth (or reverse remodeling) is often considered to be a favorable response to clinical intervention. In recent years, a number of theoretical models have been proposed to mode...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-014-0598-0

    authors: Lee LC,Genet M,Acevedo-Bolton G,Ordovas K,Guccione JM,Kuhl E

    更新日期:2015-04-01 00:00:00

  • Mechanomics analysis of hESCs under combined mechanical shear, stretch, and compression.

    abstract::Human embryonic stem cells (hESCs) can differentiate to three germ layers within biochemical and biomechanical niches. The complicated mechanical environments in vivo could have diverse effects on the fate decision and biological functions of hESCs. To globally screen mechanosensitive molecules, three typical types of...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-020-01378-5

    authors: Zhang F,Wang J,Lü D,Zheng L,Shangguan B,Gao Y,Wu Y,Long M

    更新日期:2020-08-18 00:00:00

  • Modeling active muscle contraction in mitral valve leaflets during systole: a first approach.

    abstract::The present study addresses the effect of muscle activation contributions to mitral valve leaflet response during systole. State-of-art passive hyperelastic material modeling is employed in combination with a simple active stress part. Fiber families are assumed in the leaflets: one defined by the collagen and one def...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-010-0215-9

    authors: Skallerud B,Prot V,Nordrum IS

    更新日期:2011-02-01 00:00:00

  • Inclusion-induced boundary layers in lipid vesicles.

    abstract::The equilibrium shapes of lipid vesicles are perturbed by rigid inclusions. In a two-dimensional vesicle, that may also model a cylindrically elongated tubule, the shape modifications can be determined analytically, and turn out to be significant even far from the inclusion. On the contrary, previous numerical work ha...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-006-0066-6

    authors: Biscari P,Napoli G

    更新日期:2007-09-01 00:00:00

  • A comparison of healthy human and swine articular cartilage dynamic indentation mechanics.

    abstract::Articular cartilage is a multicomponent, poroviscoelastic tissue with nonlinear mechanical properties vital to its function. A consequent goal of repair or replacement of injured cartilage is to achieve mechanical properties in the repair tissue similar to healthy native cartilage. Since fresh healthy human articular ...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-011-0338-7

    authors: Ronken S,Arnold MP,Ardura García H,Jeger A,Daniels AU,Wirz D

    更新日期:2012-05-01 00:00:00

  • A mechanical model of posterior vitreous detachment and generation of vitreoretinal tractions.

    abstract::We propose a mechanical model of generation of vitreoretinal tractions in the presence of posterior vitreous detachment (PVD). PVD is a common occurrence with aging, and it consists in the separation of the vitreous body from the retina at the back pole of the eye, due to progressive shrinking of the vitreous gel. Dur...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-020-01360-1

    authors: Di Michele F,Tatone A,Romano MR,Repetto R

    更新日期:2020-12-01 00:00:00

  • Analysis of mechanical parameters on the thromboembolism using a patient-specific computational model.

    abstract::Ischemic stroke is a major cause of death and long-term disabilities worldwide. In this paper, we aim to represent a comprehensive simulation of the motion of emboli through cerebrovascular network within patient-specific computational model. The model consists of major arteries of the circle of Willis reconstructed f...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-016-0762-9

    authors: Khodaee F,Vahidi B,Fatouraee N

    更新日期:2016-10-01 00:00:00

  • White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities.

    abstract::A systematic correlation between finite element models (FEMs) and histopathology is needed to define deformation thresholds associated with traumatic brain injury (TBI). In this study, a FEM of a transected piglet brain was used to reverse engineer the range of optimal shear moduli for infant (5 days old, 553-658 Pa) ...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-014-0643-z

    authors: Sullivan S,Eucker SA,Gabrieli D,Bradfield C,Coats B,Maltese MR,Lee J,Smith C,Margulies SS

    更新日期:2015-08-01 00:00:00

  • Divided medium-based model for analyzing the dynamic reorganization of the cytoskeleton during cell deformation.

    abstract::Cell deformability and mechanical responses of living cells depend closely on the dynamic changes in the structural architecture of the cytoskeleton (CSK). To describe the dynamic reorganization and the heterogeneity of the prestressed multi-modular CSK, we developed a two-dimensional model for the CSK which was taken...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-006-0057-7

    authors: Milan JL,Wendling-Mansuy S,Jean M,Chabrand P

    更新日期:2007-11-01 00:00:00

  • Mathematical modelling of corneal swelling.

    abstract::This paper presents a differential model of the corneal transport system capable of modelling thickness changes in response to osmotic perturbations applied to either limiting membrane. The work is directed towards understanding corneal behaviour in vivo. The model considers the coupled viscous flows within the cornea...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-004-0054-7

    authors: Li LY,Tighe BJ,Ruberti JW

    更新日期:2004-11-01 00:00:00

  • Experimental analysis of the transverse mechanical behaviour of annulus fibrosus tissue.

    abstract::Uniaxial tensile and relaxation tests were carried out on annulus fibrosus samples carved out in the circumferential direction. Images were shot perpendicularly to the loading direction. Digital image correlation techniques accurately measured the evolution of full displacement fields in both transverse directions: pl...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-013-0524-x

    authors: Baldit A,Ambard D,Cherblanc F,Royer P

    更新日期:2014-06-01 00:00:00

  • An elasto-viscoplastic model to describe the ratcheting behavior of articular cartilage.

    abstract::In the present work, a constitutive model for articular cartilage is proposed in finite elasto-viscoplasticity. For simplification, articular cartilage is supposed to be a typical composite composed of a soft basis and a fiber assembly. The stress tensor and free energy function are hence accordingly divided into two ...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-018-1062-3

    authors: Zhu Y

    更新日期:2018-12-01 00:00:00

  • A novel porous media-based approach to outflow boundary resistances of 1D arterial blood flow models.

    abstract::In this paper we introduce a novel method for prescribing terminal boundary conditions in one-dimensional arterial flow networks. This is carried out by coupling the terminal arterial vessel with a poro-elastic tube, representing the flow resistance offered by microcirculation. The performance of the proposed porous m...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-019-01122-8

    authors: Coccarelli A,Prakash A,Nithiarasu P

    更新日期:2019-08-01 00:00:00

  • Remineralization of mechanical loaded resin-dentin interface: a transitional and synchronized multistep process.

    abstract::This study evaluated the ability of different in vitro mechanical loading tests to promote new mineral formation at bonded dentin interfaces. This research demonstrated a sequential transition in the dentin remineralizing procedure through the analysis of the mineral and matrix gradients. Mechanical loading in phospho...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-014-0573-9

    authors: Toledano M,Aguilera FS,Cabello I,Osorio R

    更新日期:2014-11-01 00:00:00

  • A simulation study on the significant nanomechanical heterogeneous properties of collagen.

    abstract::Nanomechanics of individual collagen fibrils govern the mechanical behavior of the majority of connective tissues, yet the current models lack significant details. Majority of the current models assume a rod-shape molecule with homogenous mechanical properties. Recent X-ray crystallography revealed significantly diffe...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-014-0615-3

    authors: Zhou Z,Minary-Jolandan M,Qian D

    更新日期:2015-06-01 00:00:00

  • Development of fibroblast-seeded collagen gels under planar biaxial mechanical constraints: a biomechanical study.

    abstract::Prior studies indicated that mechanical loading influences cell turnover and matrix remodeling in tissues, suggesting that mechanical stimuli can play an active role in engineering artificial tissues. While most tissue culture studies focus on influence of uniaxial loading or constraints, effects of multi-axial loadin...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-012-0448-x

    authors: Hu JJ,Liu YC,Chen GW,Wang MX,Lee PY

    更新日期:2013-10-01 00:00:00

  • Perfluorocarbon induces alveolar epithelial cell response through structural and mechanical remodeling.

    abstract::During total liquid ventilation, lung cells are exposed to perfluorocarbon (PFC) whose chemophysical properties highly differ from standard aqueous cell feeding medium (DMEM). We herein perform a systematic study of structural and mechanical properties of A549 alveolar epithelial cells in order to characterize their r...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-018-1005-z

    authors: André Dias S,Planus E,Angely C,Lotteau L,Tissier R,Filoche M,Louis B,Pelle G,Isabey D

    更新日期:2018-08-01 00:00:00

  • Valve-related modes of pump failure in collecting lymphatics: numerical and experimental investigation.

    abstract::Lymph is transported along collecting lymphatic vessels by intrinsic and extrinsic pumping. The walls have muscle of a type intermediate between blood-vascular smooth muscle and myocardium; a contracting segment between two valves (a lymphangion) constitutes a pump. This intrinsic mechanism is investigated ex vivo in ...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-017-0933-3

    authors: Bertram CD,Macaskill C,Davis MJ,Moore JE Jr

    更新日期:2017-12-01 00:00:00

  • Collagen fibre orientation in human bridging veins.

    abstract::Bridging veins (BVs) drain the blood from the cerebral cortex into dural sinuses. BVs have one end attached to the brain and the other to the superior sagittal sinus (SSS), which is attached to the skull. Relative movement between these two structures can cause BV to rupture producing acute subdural haematoma, a head ...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-020-01349-w

    authors: Kapeliotis M,Gavrila Laic RA,Peñas AJ,Vander Sloten J,Vanden Berghe P,Famaey N,Depreitere B

    更新日期:2020-12-01 00:00:00

  • Urethral lumen occlusion by artificial sphincteric devices: a computational biomechanics approach.

    abstract::The action induced by artificial sphincteric devices to provide urinary continence is related to the problem of evaluating the interaction between the occlusive cuff and the urethral duct. The intensity and distribution of the force induced within the region of application determine a different occlusion process and p...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-017-0897-3

    authors: Natali AN,Carniel EL,Fontanella CG,Todros S,De Benedictis GM,Cerruto MA,Artibani W

    更新日期:2017-08-01 00:00:00

  • Simulated tissue growth for 3D printed scaffolds.

    abstract::Experiments have demonstrated biological tissues grow by mechanically sensing their localized curvature, therefore making geometry a key consideration for tissue scaffold design. We developed a simulation approach for modeling tissue growth on beam-based geometries of repeating unit cells, with four lattice topologies...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-018-1040-9

    authors: Egan PF,Shea KA,Ferguson SJ

    更新日期:2018-10-01 00:00:00

  • On the mechanics of myopia and its influence on retinal detachment.

    abstract::A mechanics-based mathematical model of retinal detachment due to the geometric changes of the eye associated with the evolution of myopia is developed. This includes deformation of the retina due to biological growth of the retina, as well as elastic deformation imposed on the retina by the myopic change in shape of ...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-019-01234-1

    authors: Lakawicz JM,Bottega WJ,Fine HF,Prenner JL

    更新日期:2020-04-01 00:00:00

  • Instrumentation and procedures for estimating the constitutive parameters of inhomogeneous elastic membranes.

    abstract::This study presents a method for estimating the spatial variations in material properties of elastic membranes, such as biological tissue, which contain both inhomogeneous strain fields and inhomogeneous material properties. In order to validate the method, an inhomogeneous, isotropic rubber membrane was biaxially loa...

    journal_title:Biomechanics and modeling in mechanobiology

    pub_type: 杂志文章

    doi:10.1007/s10237-002-0019-7

    authors: Nielsen PM,Malcolm DT,Hunter PJ,Charette PG

    更新日期:2002-12-01 00:00:00