A simulation study on the significant nanomechanical heterogeneous properties of collagen.

abstract：:The level of hematocrit (Hct) is known to affect mean arterial pressure (MAP) by influencing blood viscosity. In the healthy population, an increase in Hct (and corresponding increase in viscosity) tends to raise MAP. However, data from a clinical study of type 2 diabetic patients indicate that this relationship is no...

journal_title：Biomechanics and modeling in mechanobiology

authors： Branigan T,Bolster D,Vázquez BY,Intaglietta M,Tartakovsky DM

更新日期：2011-07-01 00:00:00

abstract：:The controlled cortical impact (CCI) model is widely used in many laboratories to study traumatic brain injury (TBI). Although external impact parameters during CCI tests could be clearly defined, little is known about the internal tissue-level mechanical responses of the rat brain. Furthermore, the external impact pa...

journal_title：Biomechanics and modeling in mechanobiology

authors： Mao H,Yang KH,King AI,Yang K

更新日期：2010-12-01 00:00:00

abstract：:Collagen degradation is one of the early signs of osteoarthritis. It is not known how collagen degradation affects chondrocyte volume and morphology. Thus, the aim of this study was to investigate the effect of enzymatically induced collagen degradation on cell volume and shape changes in articular cartilage after a h...

journal_title：Biomechanics and modeling in mechanobiology

authors： Turunen SM,Lammi MJ,Saarakkala S,Han SK,Herzog W,Tanska P,Korhonen RK

更新日期：2013-06-01 00:00:00

abstract：:The paper describes the extension of a previously developed model of pressure-dependent contraction rate to the case of multiple lymphangions. Mechanical factors are key modulators of active lymphatic pumping. As part of the evolution of our lumped-parameter model to match experimental findings, we have designed an al...

journal_title：Biomechanics and modeling in mechanobiology

authors： Bertram CD,Macaskill C,Davis MJ,Moore JE Jr

更新日期：2018-10-01 00:00:00

abstract：:As a degenerative and inflammatory desease of elderly patients, about 80% of abdominal aortic aneurysms (AAA) show considerable wall calcification. Effect of calcifications on computational wall stress analyses of AAAs has been rarely treated in literature so far. Calcifications are heterogeneously distributed, non-fi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Maier A,Gee MW,Reeps C,Eckstein HH,Wall WA

更新日期：2010-10-01 00:00:00

abstract：:In myocardial infarction, muscle tissue of the heart is damaged as a result of ceased or severely impaired blood flow. Survivors have an increased risk of further complications, possibly leading to heart failure. Material properties play an important role in determining post-infarction outcome. Due to spatial variatio...

journal_title：Biomechanics and modeling in mechanobiology

authors： Balaban G,Finsberg H,Funke S,Håland TF,Hopp E,Sundnes J,Wall S,Rognes ME

更新日期：2018-10-01 00:00:00

abstract：:The immersed boundary method (IBM) has been frequently utilized to simulate the motion and deformation of biological cells and capsules in various flow situations. Despite the convenience in dealing with flow-membrane interaction, direct implementation of membrane viscosity in IBM suffers severe numerical instability....

journal_title：Biomechanics and modeling in mechanobiology

authors： Li P,Zhang J

更新日期：2020-12-01 00:00:00

abstract：:Tissue expansion is a common surgical procedure to grow extra skin through controlled mechanical over-stretch. It creates skin that matches the color, texture, and thickness of the surrounding tissue, while minimizing scars and risk of rejection. Despite intense research in tissue expansion and skin growth, there is a...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zöllner AM,Buganza Tepole A,Gosain AK,Kuhl E

更新日期：2012-07-01 00:00:00

abstract：:This research studies dynamic culture for 3D tissue construct development with computational fluid dynamics. It proposes a mathematical model to evaluate the impact of flow rates and flow shear stress on cell growth in 3D constructs under perfusion. The modeling results show that dynamic flow, even at flow rate as low...

journal_title：Biomechanics and modeling in mechanobiology

authors： Liu D,Chua CK,Leong KF

更新日期：2013-01-01 00:00:00

abstract：:The primary capillary plexus in early yolk sacs is remodeled into matured vitelline vessels aligned in the direction of blood flow at the onset of cardiac contraction. We hypothesized that the influence of fluid shear stress on cellular behaviors may be an underlying mechanism by which some existing capillary channels...

journal_title：Biomechanics and modeling in mechanobiology

authors： Blatnik JS,Schmid-Schönbein GW,Sung LA

更新日期：2005-12-01 00:00:00

abstract：:An efficient solver for large-scale linear [Formula: see text] simulations was extended for nonlinear material behavior. The material model included damage-based tissue degradation and fracture. The new framework was applied to 20 trabecular biopsies with a mesh resolution of [Formula: see text]. Suitable material par...

journal_title：Biomechanics and modeling in mechanobiology

authors： Stipsitz M,Zysset PK,Pahr DH

更新日期：2020-06-01 00:00:00

abstract：:Large scale changes to lipid bilayer shapes are well represented by the Helfrich model. However, there are membrane processes that take place at smaller length scales that this model cannot address. In this work, we present a one-dimensional continuum model that captures the mechanics of the lipid bilayer membrane at ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Rangamani P,Benjamini A,Agrawal A,Smit B,Steigmann DJ,Oster G

更新日期：2014-08-01 00:00:00

abstract：:In this manuscript, we present a combined experimental and computational technique that can identify the heterogeneous elastic properties of planar soft tissues. By combining inverse membrane analysis, digital image correlation, and bulge inflation tests, we are able to identify a tissue's mechanical properties locall...

journal_title：Biomechanics and modeling in mechanobiology

authors： Davis FM,Luo Y,Avril S,Duprey A,Lu J

更新日期：2015-10-01 00:00:00

abstract：:Hemolysis is a major concern in blood-circulating devices, which arises due to hydrodynamic loading on red blood cells from ambient flow environment. Hemolysis estimation models have often been used to aid hemocompatibility design. The preponderance of hemolysis models was formulated on the basis of laminar flows. How...

journal_title：Biomechanics and modeling in mechanobiology

authors： Wu P,Gao Q,Hsu PL

更新日期：2019-06-01 00:00:00

abstract：:This paper evaluates numerically coupled blood flow and wall structure interactions in a representative stented abdominal aortic aneurysm (AAA) model, leading potentially to endovascular graft (EVG) failure. A total of 12 biomechanical contributors to possible EVG migration were considered. The results show that after...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li Z,Kleinstreuer C,Farber M

更新日期：2005-12-01 00:00:00

abstract：:Mineralized collagen fibrils have been usually analyzed like a two-phase composite material where crystals are considered as platelets that constitute the reinforcement phase. Different models have been used to describe the elastic behavior of the material. In this work, it is shown that when Halpin-Tsai equations are...

journal_title：Biomechanics and modeling in mechanobiology

authors： Vercher A,Giner E,Arango C,Tarancón JE,Fuenmayor FJ

更新日期：2014-04-01 00:00:00

abstract：:Formins promote actin assembly and are involved in force-dependent cytoskeletal remodeling. However, how force alters the formin functions still needs to be investigated. Here, using atomic force microscopy and biomembrane force probe, we investigated how mechanical force affects formin-mediated actin interactions at ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li Z,Lee H,Eskin SG,Ono S,Zhu C,McIntire LV

更新日期：2020-10-01 00:00:00

abstract：:Ventricular growth is widely considered to be an important feature in the adverse progression of heart diseases, whereas reverse ventricular growth (or reverse remodeling) is often considered to be a favorable response to clinical intervention. In recent years, a number of theoretical models have been proposed to mode...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lee LC,Genet M,Acevedo-Bolton G,Ordovas K,Guccione JM,Kuhl E

更新日期：2015-04-01 00:00:00

abstract：:Both the clinically established diameter criterion and novel approaches of computational finite element (FE) analyses for rupture risk stratification of abdominal aortic aneurysms (AAA) are based on assumptions of population-averaged, uniform material properties for the AAA wall. The presence of inter-patient and intr...

journal_title：Biomechanics and modeling in mechanobiology

authors： Reeps C,Maier A,Pelisek J,Härtl F,Grabher-Meier V,Wall WA,Essler M,Eckstein HH,Gee MW

更新日期：2013-08-01 00:00:00

abstract：:Continuum mechanical tools are used to describe the deformation, energy density, and material symmetry of a lipid bilayer with spontaneous curvature. In contrast to conventional approaches in which lipid bilayers are modeled by material surfaces, here we rely on a three-dimensional approach in which a lipid bilayer is...

journal_title：Biomechanics and modeling in mechanobiology

authors： Maleki M,Seguin B,Fried E

更新日期：2013-10-01 00:00:00

abstract：:Articular cartilage is a complex, anisotropic, stratified tissue with remarkable resilience and mechanical properties. It has been subject to extensive modelling as a multiphase medium, with many recent studies examining the impact of increasing detail in the representation of this tissue's fine scale structure. Howev...

journal_title：Biomechanics and modeling in mechanobiology

authors： Klika V,Whiteley JP,Brown CP,Gaffney EA

更新日期：2019-08-01 00:00:00

abstract：:The two main load bearing tissues of the intervertebral disc are the nucleus pulposus and the annulus fibrosus. Both tissues are composed of the same basic components, but differ in their organization and relative amounts. With degeneration, the clear distinction between the two tissues disappears. The changes in bioc...

journal_title：Biomechanics and modeling in mechanobiology

authors： van Rijsbergen MM,Barthelemy VM,Vrancken AC,Crijns SP,Wilke HJ,Wilson W,van Rietbergen B,Ito K

更新日期：2017-04-01 00:00:00

abstract：:The action induced by artificial sphincteric devices to provide urinary continence is related to the problem of evaluating the interaction between the occlusive cuff and the urethral duct. The intensity and distribution of the force induced within the region of application determine a different occlusion process and p...

journal_title：Biomechanics and modeling in mechanobiology

authors： Natali AN,Carniel EL,Fontanella CG,Todros S,De Benedictis GM,Cerruto MA,Artibani W

更新日期：2017-08-01 00:00:00

abstract：:Finite element (FE) simulations of contractile responses of vascular muscular thin films (vMTFs) and endothelial cells resting on an array of microposts under stimulation of soluble factors were conducted in comparison with experimental measurements reported in the literature. Two types of constitutive models were emp...

journal_title：Biomechanics and modeling in mechanobiology

authors： Liu T

更新日期：2017-08-01 00:00:00

abstract：:Load-induced fluid flow acts as an important biophysical signal for bone cell mechanotransduction in vivo, where the mechanical environment is thought to be monitored by integrin and primary cilia mechanoreceptors on the cell body. However, precisely how integrin- and primary cilia-based mechanosensors interact with t...

journal_title：Biomechanics and modeling in mechanobiology

authors： Vaughan TJ,Mullen CA,Verbruggen SW,McNamara LM

更新日期：2015-08-01 00:00:00

abstract：:Aortic valve (AV) calcification is a highly prevalent disease with serious impact on mortality and morbidity. The exact causes and mechanisms of AV calcification are unclear, although previous studies suggest that mechanical forces play a role. It has been clinically demonstrated that calcification preferentially occu...

journal_title：Biomechanics and modeling in mechanobiology

authors： Yap CH,Saikrishnan N,Yoganathan AP

更新日期：2012-01-01 00:00:00

abstract：:Schlemm's canal (SC) endothelial cells are likely important in the physiology and pathophysiology of the aqueous drainage system of the eye, particularly in glaucoma. The mechanical stiffness of these cells determines, in part, the extent to which they can support a pressure gradient and thus can be used to place limi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zeng D,Juzkiw T,Read AT,Chan DW,Glucksberg MR,Ethier CR,Johnson M

更新日期：2010-02-01 00:00:00

abstract：:Knowledge of the complete three-dimensional (3D) mechanical behavior of soft tissues is essential in understanding their pathophysiology and in developing novel therapies. Despite significant progress made in experimentation and modeling, a complete approach for the full characterization of soft tissue 3D behavior rem...

journal_title：Biomechanics and modeling in mechanobiology

authors： Avazmohammadi R,Li DS,Leahy T,Shih E,Soares JS,Gorman JH,Gorman RC,Sacks MS

更新日期：2018-02-01 00:00:00

abstract：:Balance is achieved and maintained by a balance system called a labyrinth that is composed of three semicircular canals and the otolith organs that sense linear gravity and acceleration. Within each semicircular canal, there is a gelatinous structure called the cupula, which is deformed under the influence of the surr...

journal_title：Biomechanics and modeling in mechanobiology

authors： Djukic T,Filipovic N

更新日期：2017-10-01 00:00:00

abstract：:Computational studies of chondrocyte mechanics, and cell mechanics in general, have typically been performed using single cell models embedded in an extracellular matrix construct. The assumption of a single cell microstructural model may not capture intercellular interactions or accurately reflect the macroscale mech...

journal_title：Biomechanics and modeling in mechanobiology

authors： Halloran JP,Sibole SC,Erdemir A

更新日期：2018-02-01 00:00:00