Abstract：
:This paper evaluates numerically coupled blood flow and wall structure interactions in a representative stented abdominal aortic aneurysm (AAA) model, leading potentially to endovascular graft (EVG) failure. A total of 12 biomechanical contributors to possible EVG migration were considered. The results show that after EVG insertion for the given model, the peak AAA sac-pressure was reduced to 14.2 mmHg (11.8% of p(lumen)), and hence the maximum von Mises wall stress and wall deformation dropped by factors of 20 and 10, respectively. Thus, an EVG can significantly reduce sac pressure, mechanical stress, pulsatile wall motion, and the maximum diameter in AAAs and hence prevent AAA rupture effectively. In the absence of endoleaks, elevated sac-pressure can still be caused by fluid-structure interactions between the EVG, stagnant blood, and AAA wall. EVG migration forces vary from 1.4 to 7 N for different EVG geometries, material properties, and hemodynamic conditions. AAA-neck angle, iliac bifurcation angle, neck aorta-to-iliac diameter ratio, EVG size, aorto-uni-iliac EVG, and hypertension play important roles in generating forces potentially leading to EVG migration.
journal_name
Biomech Model Mechanobioljournal_title
Biomechanics and modeling in mechanobiologyauthors
Li Z,Kleinstreuer C,Farber Mdoi
10.1007/s10237-005-0003-0subject
Has Abstractpub_date
2005-12-01 00:00:00pages
221-34issue
4eissn
1617-7959issn
1617-7940journal_volume
4pub_type
杂志文章abstract：:Understanding the mechanical behavior of multicellular monolayers and spheroids is fundamental to tissue culture, organism development, and the early stages of tumor growth. Proliferating cells in monolayers and spheroids experience mechanical forces as they grow and divide and local inhomogeneities in the mechanical ...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-017-0989-0
更新日期：2018-06-01 00:00:00
abstract：:The influence of an aortic aneurysm on blood flow waveforms is well established, but how to exploit this link for diagnostic purposes still remains challenging. This work uses a combination of experimental and computational modelling to study how aneurysms of various size affect the waveforms. Experimental studies are...
journal_title：Biomechanics and modeling in mechanobiology
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更新日期：2017-08-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-016-0831-0
更新日期：2017-04-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-014-0631-3
更新日期：2015-08-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-017-0945-z
更新日期：2018-02-01 00:00:00
abstract：:The human heart is enclosed in the pericardial cavity. The pericardium consists of a layered thin sac and is separated from the myocardium by a thin film of fluid. It provides a fixture in space and frictionless sliding of the myocardium. The influence of the pericardium is essential for predictive mechanical simulati...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-018-1098-4
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-010-0204-z
更新日期：2010-12-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-020-01363-y
更新日期：2020-12-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
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更新日期：2021-01-03 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-013-0498-8
更新日期：2014-01-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
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更新日期：2020-08-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-007-0089-7
更新日期：2008-10-01 00:00:00
abstract：:A systematic correlation between finite element models (FEMs) and histopathology is needed to define deformation thresholds associated with traumatic brain injury (TBI). In this study, a FEM of a transected piglet brain was used to reverse engineer the range of optimal shear moduli for infant (5 days old, 553-658 Pa) ...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-014-0643-z
更新日期：2015-08-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-016-0850-x
更新日期：2017-06-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-014-0615-3
更新日期：2015-06-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-005-0001-2
更新日期：2005-12-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-006-0057-7
更新日期：2007-11-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-018-1045-4
更新日期：2018-12-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章,评审
doi：10.1007/s10237-015-0743-4
更新日期：2016-10-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-014-0646-9
更新日期：2015-10-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-009-0175-0
更新日期：2010-06-01 00:00:00
abstract：:An efficient solver for large-scale linear [Formula: see text] simulations was extended for nonlinear material behavior. The material model included damage-based tissue degradation and fracture. The new framework was applied to 20 trabecular biopsies with a mesh resolution of [Formula: see text]. Suitable material par...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-019-01254-x
更新日期：2020-06-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-019-01168-8
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-017-0897-3
更新日期：2017-08-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-016-0813-2
更新日期：2017-02-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-019-01150-4
更新日期：2019-10-01 00:00:00
