Abstract：
:Tissue expansion is a common surgical procedure to grow extra skin through controlled mechanical over-stretch. It creates skin that matches the color, texture, and thickness of the surrounding tissue, while minimizing scars and risk of rejection. Despite intense research in tissue expansion and skin growth, there is a clear knowledge gap between heuristic observation and mechanistic understanding of the key phenomena that drive the growth process. Here, we show that a continuum mechanics approach, embedded in a custom-designed finite element model, informed by medical imaging, provides valuable insight into the biomechanics of skin growth. In particular, we model skin growth using the concept of an incompatible growth configuration. We characterize its evolution in time using a second-order growth tensor parameterized in terms of a scalar-valued internal variable, the in-plane area growth. When stretched beyond the physiological level, new skin is created, and the in-plane area growth increases. For the first time, we simulate tissue expansion on a patient-specific geometric model, and predict stress, strain, and area gain at three expanded locations in a pediatric skull: in the scalp, in the forehead, and in the cheek. Our results may help the surgeon to prevent tissue over-stretch and make informed decisions about expander geometry, size, placement, and inflation. We anticipate our study to open new avenues in reconstructive surgery and enhance treatment for patients with birth defects, burn injuries, or breast tumor removal.
journal_name
Biomech Model Mechanobioljournal_title
Biomechanics and modeling in mechanobiologyauthors
Zöllner AM,Buganza Tepole A,Gosain AK,Kuhl Edoi
10.1007/s10237-011-0357-4subject
Has Abstractpub_date
2012-07-01 00:00:00pages
855-67issue
6eissn
1617-7959issn
1617-7940journal_volume
11pub_type
杂志文章abstract：:We propose a multiscale mechanobiological model of bone remodelling to investigate the site-specific evolution of bone volume fraction across the midshaft of a femur. The model includes hormonal regulation and biochemical coupling of bone cell populations, the influence of the microstructure on bone turnover rate, and...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-015-0705-x
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abstract：:A mechanics-based mathematical model of retinal detachment due to the geometric changes of the eye associated with the evolution of myopia is developed. This includes deformation of the retina due to biological growth of the retina, as well as elastic deformation imposed on the retina by the myopic change in shape of ...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-019-01234-1
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abstract：:It is believed that non-mammals have poor hearing at high frequencies because the sound-conduction performance of their single-ossicle middle ears declines above a certain frequency. To better understand this behavior, a dynamic three-dimensional finite-element model of the chicken middle ear was constructed. The effe...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-019-01207-4
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abstract：:It was reported that a single-strand DNA (ssDNA) could be inbreathed spontaneously into a carbon nanotube (CNT). In this work, the complementary process, i.e. pulling a piece of ssDNA out of a single-walled (SW) CNT, is simulated using molecular dynamic methods. The pulling force is found to fluctuate around a plateau...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-010-0228-4
更新日期：2011-04-01 00:00:00
abstract：:In myocardial infarction, muscle tissue of the heart is damaged as a result of ceased or severely impaired blood flow. Survivors have an increased risk of further complications, possibly leading to heart failure. Material properties play an important role in determining post-infarction outcome. Due to spatial variatio...
journal_title：Biomechanics and modeling in mechanobiology
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doi：10.1007/s10237-018-1028-5
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journal_title：Biomechanics and modeling in mechanobiology
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doi：10.1007/s10237-019-01118-4
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journal_title：Biomechanics and modeling in mechanobiology
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doi：10.1007/s10237-013-0528-6
更新日期：2014-08-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-007-0088-8
更新日期：2008-10-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
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更新日期：2003-11-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-012-0406-7
更新日期：2013-04-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
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doi：10.1007/s10237-020-01325-4
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journal_title：Biomechanics and modeling in mechanobiology
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doi：10.1007/s10237-020-01375-8
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
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更新日期：2005-03-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-018-1045-4
更新日期：2018-12-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-006-0025-2
更新日期：2006-06-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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更新日期：2010-02-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
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journal_title：Biomechanics and modeling in mechanobiology
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