What factors determine the number of nonmuscle myosin II in the sarcomeric unit of stress fibers?

abstract：:Inferior vena cava (IVC) filters are medical devices designed to provide a mechanical barrier to the passage of emboli from the deep veins of the legs to the heart and lungs. Despite decades of development and clinical use, IVC filters still fail to prevent the passage of all hazardous emboli. The objective of this st...

journal_title：Biomechanics and modeling in mechanobiology

authors： Aycock KI,Campbell RL,Manning KB,Craven BA

更新日期：2017-06-01 00:00:00

abstract：:In its permanent quest of mechanobiological homeostasis, our vasculature significantly adapts across multiple length and timescales in various physiological and pathological conditions. Computational modeling of vascular growth and remodeling (G&R) has significantly improved our insights into the mechanobiological pro...

journal_title：Biomechanics and modeling in mechanobiology

authors： Mousavi SJ,Farzaneh S,Avril S

更新日期：2019-12-01 00:00:00

abstract：:The reopening of fluid-occluded pulmonary airways generates microbubble flows which impart complex hydrodynamic stresses to the epithelial cells lining airway walls. In this study we used boundary element solutions and finite element techniques to investigate how cell rheology influences the deformation and injury of ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Dailey HL,Ghadiali SN

更新日期：2010-06-01 00:00:00

abstract：:An efficient solver for large-scale linear [Formula: see text] simulations was extended for nonlinear material behavior. The material model included damage-based tissue degradation and fracture. The new framework was applied to 20 trabecular biopsies with a mesh resolution of [Formula: see text]. Suitable material par...

journal_title：Biomechanics and modeling in mechanobiology

authors： Stipsitz M,Zysset PK,Pahr DH

更新日期：2020-06-01 00:00:00

abstract：:The veins distributing oxygenated blood from the placenta to the fetal body have been given much attention in clinical Doppler velocimetry studies, in particular the ductus venosus. The ductus venosus is embedded in the left liver lobe and connects the intra-abdominal portion of the umbilical vein (IUV) directly to th...

journal_title：Biomechanics and modeling in mechanobiology

authors： Leinan PR,Degroote J,Kiserud T,Skallerud B,Vierendeels J,Hellevik LR

更新日期：2013-10-01 00:00:00

abstract：:The mechanotransduction of adipocytes is not well characterized in the literature. In this study, we employ stochastic modeling fitted to experiments for characterizing the influence of mechanical stretching delivered to adipocyte monolayers on the probabilities of commitment to the adipocyte lineage, mitosis, and gro...

journal_title：Biomechanics and modeling in mechanobiology

authors： Shoham N,Gefen A

更新日期：2012-09-01 00:00:00

abstract：:This paper presents a differential model of the corneal transport system capable of modelling thickness changes in response to osmotic perturbations applied to either limiting membrane. The work is directed towards understanding corneal behaviour in vivo. The model considers the coupled viscous flows within the cornea...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li LY,Tighe BJ,Ruberti JW

更新日期：2004-11-01 00:00:00

abstract：:In this manuscript, we present a combined experimental and computational technique that can identify the heterogeneous elastic properties of planar soft tissues. By combining inverse membrane analysis, digital image correlation, and bulge inflation tests, we are able to identify a tissue's mechanical properties locall...

journal_title：Biomechanics and modeling in mechanobiology

authors： Davis FM,Luo Y,Avril S,Duprey A,Lu J

更新日期：2015-10-01 00:00:00

abstract：:The basic aim of the present contribution is the qualitative simulation of healing phenomena typically encountered in hard and soft tissue mechanics. The mechanical framework is provided by the theory of open system thermodynamics, which will be formulated in the spatial as well as in the material motion context. Whil...

journal_title：Biomechanics and modeling in mechanobiology

authors： Kuhl E,Steinmann P

更新日期：2004-06-01 00:00:00

abstract：:Flow-induced damage to red blood cells has been an issue of considerable importance since the introduction of the first cardiovascular devices. Early blood damage prediction models were based on measurements of damage by shear stress only. Subsequently, these models were extrapolated to include other components of the...

journal_title：Biomechanics and modeling in mechanobiology

authors： Faghih MM,Sharp MK

更新日期：2020-02-01 00:00:00

abstract：:Mechanical cues that trigger pathological remodeling in smooth muscle tissues remain largely unknown and are thought to be pivotal triggers for strain-induced remodeling. Thus, an understanding of the effects mechanical stimulation is important to elucidate underlying mechanisms of disease states and in the developmen...

journal_title：Biomechanics and modeling in mechanobiology

authors： Heise RL,Parekh A,Joyce EM,Chancellor MB,Sacks MS

更新日期：2012-01-01 00:00:00

abstract：:Pelvic floor dysfunction and pelvic organ prolapse have been associated with damage to the levator ani (LA) muscle, but the exact mechanisms linking them remain unknown. It has been postulated that factors such as vaginal birth and ageing may contribute to long-term, irreversible LA muscle damage. To investigate the b...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li X,Kruger JA,Nash MP,Nielsen PM

更新日期：2011-07-01 00:00:00

abstract：:Experimental evidence suggests that interstitial fluid flow is a stimulus for mechanoadaptation in bone. Bone adaptation is sensitive to the frequency of loading and rest insertion between load cycles. We investigated the effects of permeability, frequency and rest insertion on fluid flow in bone using finite-element ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Pereira AF,Shefelbine SJ

更新日期：2014-01-01 00:00:00

abstract：:Inflammation, a precursor to many diseases including cancer and atherosclerosis, induces differential surface expression of specific vascular molecules. Blood-borne nanoparticles (NPs), loaded with therapeutic and imaging agents, can recognize and use these molecules as vascular docking sites. Here, a computational mo...

journal_title：Biomechanics and modeling in mechanobiology

authors： Hossain SS,Hughes TJ,Decuzzi P

更新日期：2014-06-01 00:00:00

abstract：:Locust wings are able to sustain millions of cycles of mechanical loading during the lifetime of the insect. Previous studies have shown that cross veins play an important role in delaying crack propagation in the wings. Do cross veins thus also influence the fatigue behaviour of the wings? Since many important fatigu...

journal_title：Biomechanics and modeling in mechanobiology

authors： Rajabi H,Bazargan P,Pourbabaei A,Eshghi S,Darvizeh A,Gorb SN,Taylor D,Dirks JH

更新日期：2017-12-01 00:00:00

abstract：:Adherent cells normally apply forces as a generic means of sensing and responding to the mechanical nature of their surrounding environment. How these forces vary as a function of the extracellular rigidity is critical to understanding the regulatory functions that drive important phenomena such as wound healing or mu...

journal_title：Biomechanics and modeling in mechanobiology

authors： Borau C,Kamm RD,García-Aznar JM

更新日期：2014-04-01 00:00:00

abstract：:Elastin and collagen fibers play important roles in the mechanical properties of aortic media. Because knowledge of local fiber structures is required for detailed analysis of blood vessel wall mechanics, we investigated 3D microstructures of elastin and collagen fibers in thoracic aortas and monitored changes during ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Sugita S,Matsumoto T

更新日期：2017-06-01 00:00:00

abstract：:The immersed boundary method (IBM) has been frequently utilized to simulate the motion and deformation of biological cells and capsules in various flow situations. Despite the convenience in dealing with flow-membrane interaction, direct implementation of membrane viscosity in IBM suffers severe numerical instability....

journal_title：Biomechanics and modeling in mechanobiology

authors： Li P,Zhang J

更新日期：2020-12-01 00:00:00

abstract：:In this paper we introduce a novel method for prescribing terminal boundary conditions in one-dimensional arterial flow networks. This is carried out by coupling the terminal arterial vessel with a poro-elastic tube, representing the flow resistance offered by microcirculation. The performance of the proposed porous m...

journal_title：Biomechanics and modeling in mechanobiology

authors： Coccarelli A,Prakash A,Nithiarasu P

更新日期：2019-08-01 00:00:00

abstract：:Bridging veins (BVs) drain the blood from the cerebral cortex into dural sinuses. BVs have one end attached to the brain and the other to the superior sagittal sinus (SSS), which is attached to the skull. Relative movement between these two structures can cause BV to rupture producing acute subdural haematoma, a head ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Kapeliotis M,Gavrila Laic RA,Peñas AJ,Vander Sloten J,Vanden Berghe P,Famaey N,Depreitere B

更新日期：2020-12-01 00:00:00

abstract：:This research studies dynamic culture for 3D tissue construct development with computational fluid dynamics. It proposes a mathematical model to evaluate the impact of flow rates and flow shear stress on cell growth in 3D constructs under perfusion. The modeling results show that dynamic flow, even at flow rate as low...

journal_title：Biomechanics and modeling in mechanobiology

authors： Liu D,Chua CK,Leong KF

更新日期：2013-01-01 00:00:00

abstract：:Aortic valve (AV) calcification is a highly prevalent disease with serious impact on mortality and morbidity. The exact causes and mechanisms of AV calcification are unclear, although previous studies suggest that mechanical forces play a role. It has been clinically demonstrated that calcification preferentially occu...

journal_title：Biomechanics and modeling in mechanobiology

authors： Yap CH,Saikrishnan N,Yoganathan AP

更新日期：2012-01-01 00:00:00

abstract：:Nasal emission is a speech disorder where undesired airflow enters the nasal cavity during speech due to inadequate closure of the velopharyngeal valve. Nasal emission is typically inaudible with large velopharyngeal openings and very distorting with small openings. This study aims to understand how flow characteristi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Sundström E,Boyce S,Oren L

更新日期：2020-10-01 00:00:00

abstract：:A systematic correlation between finite element models (FEMs) and histopathology is needed to define deformation thresholds associated with traumatic brain injury (TBI). In this study, a FEM of a transected piglet brain was used to reverse engineer the range of optimal shear moduli for infant (5 days old, 553-658 Pa) ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Sullivan S,Eucker SA,Gabrieli D,Bradfield C,Coats B,Maltese MR,Lee J,Smith C,Margulies SS

更新日期：2015-08-01 00:00:00

abstract：:In adaptive bone remodeling, mechanical signals such as stress/strain caused by loading/deformation are believed to play important roles as regulators of the process in which osteoclastic resorption and osteoblastic formation are coordinated under a local mechanical environment. The mechanism by which cells sense and ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Adachi T,Sato K,Tomita Y

更新日期：2003-11-01 00:00:00

abstract：:Mathematical and computational modeling of the dynamic process where tissue scaffolds are cultured in perfusion bioreactors is able to provide insight into the cell and tissue growth which can facilitate the design of tissue scaffolds and selection of optimal operating conditions. To date, a resolved-scale simulation ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Hossain MS,Bergstrom DJ,Chen XB

更新日期：2015-04-01 00:00:00

abstract：:During total liquid ventilation, lung cells are exposed to perfluorocarbon (PFC) whose chemophysical properties highly differ from standard aqueous cell feeding medium (DMEM). We herein perform a systematic study of structural and mechanical properties of A549 alveolar epithelial cells in order to characterize their r...

journal_title：Biomechanics and modeling in mechanobiology

authors： André Dias S,Planus E,Angely C,Lotteau L,Tissier R,Filoche M,Louis B,Pelle G,Isabey D

更新日期：2018-08-01 00:00:00

abstract：:The paper describes the extension of a previously developed model of pressure-dependent contraction rate to the case of multiple lymphangions. Mechanical factors are key modulators of active lymphatic pumping. As part of the evolution of our lumped-parameter model to match experimental findings, we have designed an al...

journal_title：Biomechanics and modeling in mechanobiology

authors： Bertram CD,Macaskill C,Davis MJ,Moore JE Jr

更新日期：2018-10-01 00:00:00

abstract：:Congenital heart defects (CHDs) are abnormalities in the heart structure present at birth. One important condition is hypoplastic left heart syndrome (HLHS) where severely underdeveloped left ventricle (LV) cannot support systemic circulation. HLHS usually initiates as localized tissue malformations with no underlying...

journal_title：Biomechanics and modeling in mechanobiology

authors： Salman HE,Alser M,Shekhar A,Gould RA,Benslimane FM,Butcher JT,Yalcin HC

更新日期：2021-01-22 00:00:00

abstract：:Balance is achieved and maintained by a balance system called a labyrinth that is composed of three semicircular canals and the otolith organs that sense linear gravity and acceleration. Within each semicircular canal, there is a gelatinous structure called the cupula, which is deformed under the influence of the surr...

journal_title：Biomechanics and modeling in mechanobiology

authors： Djukic T,Filipovic N

更新日期：2017-10-01 00:00:00