Abstract:
:This paper presents a differential model of the corneal transport system capable of modelling thickness changes in response to osmotic perturbations applied to either limiting membrane. The work is directed towards understanding corneal behaviour in vivo. The model considers the coupled viscous flows within the corneal stroma and across the epithelial and endothelial membranes. The flows within the stroma are established based on transport theory in porous media, while the flows across the membranes are described using the phenomenological equations of irreversible thermodynamics. The ability of the numerical model to reproduce corneal thickness changes in response to endothelial perturbations was tested against available experimental data. The sensitivity of the model to changes in stromal and membrane transport coefficients was examined.
journal_name
Biomech Model Mechanobioljournal_title
Biomechanics and modeling in mechanobiologyauthors
Li LY,Tighe BJ,Ruberti JWdoi
10.1007/s10237-004-0054-7subject
Has Abstractpub_date
2004-11-01 00:00:00pages
114-23issue
2eissn
1617-7959issn
1617-7940journal_volume
3pub_type
杂志文章abstract::In this paper, the heat and flow characteristic of third-grade non-Newtonian biofluids flow through a vertical porous human vessel due to peristaltic wall motion are studied. The third-grade model can describe shear thinning (or shear thickening) and normal stress differences, which is acceptable for biofluids modelin...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-017-0945-z
更新日期:2018-02-01 00:00:00
abstract::The superficial femoral artery (SFA) is a typical atherosclerosis-prone site. We aimed to explore whether the tortuosity of the SFA associates with the occurrence of atherosclerosis and investigate how vascular tortuosity influences the characteristics of blood flow. Ten patients diagnosed with atherosclerotic disease...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01118-4
更新日期:2019-08-01 00:00:00
abstract::Pelvic floor dysfunction and pelvic organ prolapse have been associated with damage to the levator ani (LA) muscle, but the exact mechanisms linking them remain unknown. It has been postulated that factors such as vaginal birth and ageing may contribute to long-term, irreversible LA muscle damage. To investigate the b...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-010-0249-z
更新日期:2011-07-01 00:00:00
abstract::The collagen fibril network is an important factor for the depth-dependent mechanical behaviour of adult articular cartilage (AC). Recent studies show that collagen orientation is parallel to the articular surface throughout the tissue depth in perinatal animals, and that the collagen orientations transform to a depth...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-010-0233-7
更新日期:2011-04-01 00:00:00
abstract::Prior studies indicated that mechanical loading influences cell turnover and matrix remodeling in tissues, suggesting that mechanical stimuli can play an active role in engineering artificial tissues. While most tissue culture studies focus on influence of uniaxial loading or constraints, effects of multi-axial loadin...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-012-0448-x
更新日期:2013-10-01 00:00:00
abstract::It was reported that a single-strand DNA (ssDNA) could be inbreathed spontaneously into a carbon nanotube (CNT). In this work, the complementary process, i.e. pulling a piece of ssDNA out of a single-walled (SW) CNT, is simulated using molecular dynamic methods. The pulling force is found to fluctuate around a plateau...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-010-0228-4
更新日期:2011-04-01 00:00:00
abstract::During total liquid ventilation, lung cells are exposed to perfluorocarbon (PFC) whose chemophysical properties highly differ from standard aqueous cell feeding medium (DMEM). We herein perform a systematic study of structural and mechanical properties of A549 alveolar epithelial cells in order to characterize their r...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-018-1005-z
更新日期:2018-08-01 00:00:00
abstract::Lymph is transported along collecting lymphatic vessels by intrinsic and extrinsic pumping. The walls have muscle of a type intermediate between blood-vascular smooth muscle and myocardium; a contracting segment between two valves (a lymphangion) constitutes a pump. This intrinsic mechanism is investigated ex vivo in ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-017-0933-3
更新日期:2017-12-01 00:00:00
abstract::The immersed boundary method (IBM) has been frequently utilized to simulate the motion and deformation of biological cells and capsules in various flow situations. Despite the convenience in dealing with flow-membrane interaction, direct implementation of membrane viscosity in IBM suffers severe numerical instability....
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-020-01363-y
更新日期:2020-12-01 00:00:00
abstract::Computational fluid dynamics (CFD) is an increasingly used method for investigation of hemodynamic parameters and their alterations under pathological conditions, which are important indicators for diagnosis of cardiovascular disease. In hemodynamic simulation models, the employment of appropriate boundary conditions ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-018-1045-4
更新日期:2018-12-01 00:00:00
abstract::Elastin and collagen fibers play important roles in the mechanical properties of aortic media. Because knowledge of local fiber structures is required for detailed analysis of blood vessel wall mechanics, we investigated 3D microstructures of elastin and collagen fibers in thoracic aortas and monitored changes during ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-016-0851-9
更新日期:2017-06-01 00:00:00
abstract::A growing volume of experimental evidence demonstrates that mechanical stress plays a significant role in growth, proliferation, apoptosis, gene expression, electrophysiological properties and many other aspects of neurons. In this review, first, the mechanical microenvironment and properties of neurons under in vivo ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章,评审
doi:10.1007/s10237-015-0743-4
更新日期:2016-10-01 00:00:00
abstract::Cell deformability and mechanical responses of living cells depend closely on the dynamic changes in the structural architecture of the cytoskeleton (CSK). To describe the dynamic reorganization and the heterogeneity of the prestressed multi-modular CSK, we developed a two-dimensional model for the CSK which was taken...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-006-0057-7
更新日期:2007-11-01 00:00:00
abstract::The present study examines the possibility of attenuating blood pulses by means of introducing prosthetic viscoelastic materials able to absorb energy and damp such pulses. Vascular prostheses made of polymeric materials modify the mechanical properties of blood vessels. The effect of these materials on the blood puls...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-017-0980-9
更新日期:2018-04-01 00:00:00
abstract::Accurate and reliable assessment of bone quality requires predictive methods which could probe bone microstructure and provide information on bone mechanical properties. Multiscale modelling and simulation represent a fast and powerful way to predict bone mechanical properties based on experimental information on bone...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-015-0695-8
更新日期:2016-02-01 00:00:00
abstract::Biological materials can undergo large deformations and also show viscoelastic behaviour. One such material is the network of actin filaments found in biological cells, giving the cell much of its mechanical stiffness. A theory for predicting the relaxation behaviour of actin networks cross-linked with the cross-linke...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-012-0406-7
更新日期:2013-04-01 00:00:00
abstract::This paper aimed to develop a clinically validated bone remodeling algorithm by integrating bone's dynamic properties in a multi-stage fashion based on a four-year clinical follow-up of implant treatment. The configurational effects of fixed partial dentures (FPDs) were explored using a multi-stage remodeling rule. Th...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-016-0826-x
更新日期:2017-04-01 00:00:00
abstract::We propose a mechanical model of generation of vitreoretinal tractions in the presence of posterior vitreous detachment (PVD). PVD is a common occurrence with aging, and it consists in the separation of the vitreous body from the retina at the back pole of the eye, due to progressive shrinking of the vitreous gel. Dur...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-020-01360-1
更新日期:2020-12-01 00:00:00
abstract::We use supersonic shear wave imaging (SSI) technique to measure not only the linear but also the nonlinear elastic properties of brain matter. Here, we tested six porcine brains ex vivo and measured the velocities of the plane shear waves induced by acoustic radiation force at different states of pre-deformation when ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-015-0658-0
更新日期:2015-10-01 00:00:00
abstract::Articular cartilage is a multicomponent, poroviscoelastic tissue with nonlinear mechanical properties vital to its function. A consequent goal of repair or replacement of injured cartilage is to achieve mechanical properties in the repair tissue similar to healthy native cartilage. Since fresh healthy human articular ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-011-0338-7
更新日期:2012-05-01 00:00:00
abstract::The two main load bearing tissues of the intervertebral disc are the nucleus pulposus and the annulus fibrosus. Both tissues are composed of the same basic components, but differ in their organization and relative amounts. With degeneration, the clear distinction between the two tissues disappears. The changes in bioc...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-016-0835-9
更新日期:2017-04-01 00:00:00
abstract::We propose a multiscale mechanobiological model of bone remodelling to investigate the site-specific evolution of bone volume fraction across the midshaft of a femur. The model includes hormonal regulation and biochemical coupling of bone cell populations, the influence of the microstructure on bone turnover rate, and...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-015-0705-x
更新日期:2016-02-01 00:00:00
abstract::Articular cartilages swell and shrink depending on the ionic strength of the electrolyte they are in contact with. This electro-chemo-mechanical coupling is due to the presence of fixed electrical charges on proteoglycans (PGs). In addition, at nonphysiological pH, collagen fibers become charged. Therefore, variation ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-009-0158-1
更新日期:2010-02-01 00:00:00
abstract::To investigate the relationship between cellular microelasticity and the structural features of cytoskeletons (CSKs), a microindentation test for apical cell membranes and observation of the spatio-distribution of actin CSKs of fibroblasts were performed by fluorescence and atomic force microscopy (FM/AFM). The indent...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-006-0048-8
更新日期:2006-11-01 00:00:00
abstract::Nasal emission is a speech disorder where undesired airflow enters the nasal cavity during speech due to inadequate closure of the velopharyngeal valve. Nasal emission is typically inaudible with large velopharyngeal openings and very distorting with small openings. This study aims to understand how flow characteristi...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01280-9
更新日期:2020-10-01 00:00:00
abstract::We propose and analyse the properties of a new class of models for the electromechanics of cardiac tissue. The set of governing equations consists of nonlinear elasticity using a viscoelastic and orthotropic exponential constitutive law, for both active stress and active strain formulations of active mechanics, couple...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01237-y
更新日期:2020-04-01 00:00:00
abstract::The first carpometacarpal (CMC) joint, located at the base of the thumb and formed by the junction between the first metacarpal and trapezium, is a common site for osteoarthritis of the hand. The shape of both the first metacarpal and trapezium contributes to the intrinsic bony stability of the joint, and variability ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01257-8
更新日期:2020-08-01 00:00:00
abstract::The human heart is enclosed in the pericardial cavity. The pericardium consists of a layered thin sac and is separated from the myocardium by a thin film of fluid. It provides a fixture in space and frictionless sliding of the myocardium. The influence of the pericardium is essential for predictive mechanical simulati...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-018-1098-4
更新日期:2019-04-01 00:00:00
abstract::The present study aims at investigating biomechanical failure behaviour of human aneurismal aortic tissues so as to diagnose the rupture risk of aneurysms more accurately. An inflation test is performed on aneurismal aortic tissues up to failure and full-field measurements are achieved using stereo digital image corre...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-011-0356-5
更新日期:2012-07-01 00:00:00
abstract::Ischemic stroke is a major cause of death and long-term disabilities worldwide. In this paper, we aim to represent a comprehensive simulation of the motion of emboli through cerebrovascular network within patient-specific computational model. The model consists of major arteries of the circle of Willis reconstructed f...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-016-0762-9
更新日期:2016-10-01 00:00:00