Abstract:
:The human heart is enclosed in the pericardial cavity. The pericardium consists of a layered thin sac and is separated from the myocardium by a thin film of fluid. It provides a fixture in space and frictionless sliding of the myocardium. The influence of the pericardium is essential for predictive mechanical simulations of the heart. However, there is no consensus on physiologically correct and computationally tractable pericardial boundary conditions. Here, we propose to model the pericardial influence as a parallel spring and dashpot acting in normal direction to the epicardium. Using a four-chamber geometry, we compare a model with pericardial boundary conditions to a model with fixated apex. The influence of pericardial stiffness is demonstrated in a parametric study. Comparing simulation results to measurements from cine magnetic resonance imaging reveals that adding pericardial boundary conditions yields a better approximation with respect to atrioventricular plane displacement, atrial filling, and overall spatial approximation error. We demonstrate that this simple model of pericardial-myocardial interaction can correctly predict the pumping mechanisms of the heart as previously assessed in clinical studies. Utilizing a pericardial model not only can provide much more realistic cardiac mechanics simulations but also allows new insights into pericardial-myocardial interaction which cannot be assessed in clinical measurements yet.
journal_name
Biomech Model Mechanobioljournal_title
Biomechanics and modeling in mechanobiologyauthors
Pfaller MR,Hörmann JM,Weigl M,Nagler A,Chabiniok R,Bertoglio C,Wall WAdoi
10.1007/s10237-018-1098-4subject
Has Abstractpub_date
2019-04-01 00:00:00pages
503-529issue
2eissn
1617-7959issn
1617-7940pii
10.1007/s10237-018-1098-4journal_volume
18pub_type
杂志文章abstract::Cell deformability and mechanical responses of living cells depend closely on the dynamic changes in the structural architecture of the cytoskeleton (CSK). To describe the dynamic reorganization and the heterogeneity of the prestressed multi-modular CSK, we developed a two-dimensional model for the CSK which was taken...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-006-0057-7
更新日期:2007-11-01 00:00:00
abstract::Bone, because of its hierarchical composite structure, exhibits an excellent combination of stiffness and toughness, which is due substantially to the structural order and deformation at the smaller length scales. Here, we focus on the mineralized collagen fibril, consisting of hydroxyapatite plates with nanometric di...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-010-0223-9
更新日期:2011-04-01 00:00:00
abstract::The level of hematocrit (Hct) is known to affect mean arterial pressure (MAP) by influencing blood viscosity. In the healthy population, an increase in Hct (and corresponding increase in viscosity) tends to raise MAP. However, data from a clinical study of type 2 diabetic patients indicate that this relationship is no...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-010-0258-y
更新日期:2011-07-01 00:00:00
abstract::Human embryonic stem cells (hESCs) can differentiate to three germ layers within biochemical and biomechanical niches. The complicated mechanical environments in vivo could have diverse effects on the fate decision and biological functions of hESCs. To globally screen mechanosensitive molecules, three typical types of...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-020-01378-5
更新日期:2020-08-18 00:00:00
abstract::The mechanotransduction of adipocytes is not well characterized in the literature. In this study, we employ stochastic modeling fitted to experiments for characterizing the influence of mechanical stretching delivered to adipocyte monolayers on the probabilities of commitment to the adipocyte lineage, mitosis, and gro...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-011-0371-6
更新日期:2012-09-01 00:00:00
abstract::During total liquid ventilation, lung cells are exposed to perfluorocarbon (PFC) whose chemophysical properties highly differ from standard aqueous cell feeding medium (DMEM). We herein perform a systematic study of structural and mechanical properties of A549 alveolar epithelial cells in order to characterize their r...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-018-1005-z
更新日期:2018-08-01 00:00:00
abstract::A contact finite element (FE) formulation is introduced, amenable to patient-specific analysis of cumulative cartilage mechano-stimulus attributable to habitual functional activity. CT scans of individual human ankles are segmented to delineate bony margins. Each bone surface is projected outward to create a second su...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-006-0025-2
更新日期:2006-06-01 00:00:00
abstract::Mechanical cues that trigger pathological remodeling in smooth muscle tissues remain largely unknown and are thought to be pivotal triggers for strain-induced remodeling. Thus, an understanding of the effects mechanical stimulation is important to elucidate underlying mechanisms of disease states and in the developmen...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-011-0298-y
更新日期:2012-01-01 00:00:00
abstract::Experimental evidence suggests that interstitial fluid flow is a stimulus for mechanoadaptation in bone. Bone adaptation is sensitive to the frequency of loading and rest insertion between load cycles. We investigated the effects of permeability, frequency and rest insertion on fluid flow in bone using finite-element ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-013-0498-8
更新日期:2014-01-01 00:00:00
abstract::Load-induced fluid flow acts as an important biophysical signal for bone cell mechanotransduction in vivo, where the mechanical environment is thought to be monitored by integrin and primary cilia mechanoreceptors on the cell body. However, precisely how integrin- and primary cilia-based mechanosensors interact with t...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-014-0631-3
更新日期:2015-08-01 00:00:00
abstract::This paper aimed to develop a clinically validated bone remodeling algorithm by integrating bone's dynamic properties in a multi-stage fashion based on a four-year clinical follow-up of implant treatment. The configurational effects of fixed partial dentures (FPDs) were explored using a multi-stage remodeling rule. Th...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-016-0826-x
更新日期:2017-04-01 00:00:00
abstract::The present study addresses the effect of muscle activation contributions to mitral valve leaflet response during systole. State-of-art passive hyperelastic material modeling is employed in combination with a simple active stress part. Fiber families are assumed in the leaflets: one defined by the collagen and one def...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-010-0215-9
更新日期:2011-02-01 00:00:00
abstract::We propose a mechanical model of generation of vitreoretinal tractions in the presence of posterior vitreous detachment (PVD). PVD is a common occurrence with aging, and it consists in the separation of the vitreous body from the retina at the back pole of the eye, due to progressive shrinking of the vitreous gel. Dur...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-020-01360-1
更新日期:2020-12-01 00:00:00
abstract::Locust wings are able to sustain millions of cycles of mechanical loading during the lifetime of the insect. Previous studies have shown that cross veins play an important role in delaying crack propagation in the wings. Do cross veins thus also influence the fatigue behaviour of the wings? Since many important fatigu...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-017-0930-6
更新日期:2017-12-01 00:00:00
abstract::Lattice Boltzmann models (LBM) are rapidly showing their ability to simulate a lot of fluid dynamics problems that previously required very complex approaches. This study presents a LBM for simulating diffusion-advection transport of substrate in a 2-D laminar flow. The model considers the substrate influx into a set ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-009-0164-3
更新日期:2010-04-01 00:00:00
abstract::In the present work, a constitutive model for articular cartilage is proposed in finite elasto-viscoplasticity. For simplification, articular cartilage is supposed to be a typical composite composed of a soft basis and a fiber assembly. The stress tensor and free energy function are hence accordingly divided into two ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-018-1062-3
更新日期:2018-12-01 00:00:00
abstract::Collagen degradation is one of the early signs of osteoarthritis. It is not known how collagen degradation affects chondrocyte volume and morphology. Thus, the aim of this study was to investigate the effect of enzymatically induced collagen degradation on cell volume and shape changes in articular cartilage after a h...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-012-0409-4
更新日期:2013-06-01 00:00:00
abstract::Cartilage matrix mechanical function is largely determined by interactions between the collagen fibrillar network and the proteoglycan gel. Although the molecular physics of these matrix constituents have been characterized and modern imaging methods are capable of localized measurement of molecular densities and orie...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-006-0036-z
更新日期:2007-01-01 00:00:00
abstract::Ventricular growth is widely considered to be an important feature in the adverse progression of heart diseases, whereas reverse ventricular growth (or reverse remodeling) is often considered to be a favorable response to clinical intervention. In recent years, a number of theoretical models have been proposed to mode...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-014-0598-0
更新日期:2015-04-01 00:00:00
abstract::The first carpometacarpal (CMC) joint, located at the base of the thumb and formed by the junction between the first metacarpal and trapezium, is a common site for osteoarthritis of the hand. The shape of both the first metacarpal and trapezium contributes to the intrinsic bony stability of the joint, and variability ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01257-8
更新日期:2020-08-01 00:00:00
abstract::An efficient solver for large-scale linear [Formula: see text] simulations was extended for nonlinear material behavior. The material model included damage-based tissue degradation and fracture. The new framework was applied to 20 trabecular biopsies with a mesh resolution of [Formula: see text]. Suitable material par...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01254-x
更新日期:2020-06-01 00:00:00
abstract::Adherent cells sense their mechanical environment, which, in turn, regulates their functions. During the past decade, a growing body of evidence has indicated that a deformable, solid-state intracellular structure known as the cytoskeleton (CSK) plays a major role in transmitting and distributing mechanical stresses w...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章,评审
doi:10.1007/s10237-002-0009-9
更新日期:2002-06-01 00:00:00
abstract::In its permanent quest of mechanobiological homeostasis, our vasculature significantly adapts across multiple length and timescales in various physiological and pathological conditions. Computational modeling of vascular growth and remodeling (G&R) has significantly improved our insights into the mechanobiological pro...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01184-8
更新日期:2019-12-01 00:00:00
abstract::Uniaxial tensile and relaxation tests were carried out on annulus fibrosus samples carved out in the circumferential direction. Images were shot perpendicularly to the loading direction. Digital image correlation techniques accurately measured the evolution of full displacement fields in both transverse directions: pl...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-013-0524-x
更新日期:2014-06-01 00:00:00
abstract::The influence of an aortic aneurysm on blood flow waveforms is well established, but how to exploit this link for diagnostic purposes still remains challenging. This work uses a combination of experimental and computational modelling to study how aneurysms of various size affect the waveforms. Experimental studies are...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-017-0884-8
更新日期:2017-08-01 00:00:00
abstract::Medical studies have consistently shown that the best defense against cancer is early detection. Due to this, many efforts have been made to develop methods of screening patient blood quickly and cheaply. These methods range from separation via differences in size, electrostatic potential, chemical potential, antibody...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-018-1093-9
更新日期:2019-04-01 00:00:00
abstract::The key parameters determining the elastic properties of an unidirectional mineralized bone fibril-array decomposed in two further hierarchical levels are investigated using mean field methods. Modeling of the elastic properties of mineralized micro- and nanostructures requires accurate information about the underlyin...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-010-0190-1
更新日期:2010-10-01 00:00:00
abstract::One of only a few approved and available anabolic treatments for severe osteoporosis is daily injections of PTH (1-34). This drug has a specific dual action which can act either anabolically or catabolically depending on the type of administration, i.e. intermittent or continuous, respectively. In this paper, we prese...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-020-01307-6
更新日期:2020-10-01 00:00:00
abstract::The immersed boundary method (IBM) has been frequently utilized to simulate the motion and deformation of biological cells and capsules in various flow situations. Despite the convenience in dealing with flow-membrane interaction, direct implementation of membrane viscosity in IBM suffers severe numerical instability....
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-020-01363-y
更新日期:2020-12-01 00:00:00
abstract::Articular cartilage is a multicomponent, poroviscoelastic tissue with nonlinear mechanical properties vital to its function. A consequent goal of repair or replacement of injured cartilage is to achieve mechanical properties in the repair tissue similar to healthy native cartilage. Since fresh healthy human articular ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-011-0338-7
更新日期:2012-05-01 00:00:00