Abstract：
:Adherent cells normally apply forces as a generic means of sensing and responding to the mechanical nature of their surrounding environment. How these forces vary as a function of the extracellular rigidity is critical to understanding the regulatory functions that drive important phenomena such as wound healing or muscle contraction. In recognition of this fact, experiments have been conducted to understand cell rigidity-sensing properties under known conditions of the extracellular environment, opening new possibilities for modeling this active behavior. In this work, we provide a physics-based constitutive model taking into account the main structural components of the cell to reproduce its most significant contractile properties such as the traction forces exerted as a function of time and the extracellular stiffness. This model shows how the interplay between the time-dependent response of the acto-myosin contractile system and the elastic response of the cell components determines the mechano-sensing behavior of single cells.
journal_name
Biomech Model Mechanobioljournal_title
Biomechanics and modeling in mechanobiologyauthors
Borau C,Kamm RD,García-Aznar JMdoi
10.1007/s10237-013-0508-xsubject
Has Abstractpub_date
2014-04-01 00:00:00pages
451-62issue
2eissn
1617-7959issn
1617-7940journal_volume
13pub_type
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