Abstract：
:A mechanics-based mathematical model of retinal detachment due to the geometric changes of the eye associated with the evolution of myopia is developed. This includes deformation of the retina due to biological growth of the retina, as well as elastic deformation imposed on the retina by the myopic change in shape of the much stiffer choroid and sclera. The problem is formulated as a propagating boundary value problem in the calculus of variations, which yields self-consistent governing equations, boundary conditions, and transversality conditions that establish the location of the propagating boundaries that correspond to equilibrium configurations of the detaching ocular system. Axisymmetric conditions are considered, and exact, analytical solutions to the corresponding boundary value problem are obtained for detaching retinas with and without a tear. Based upon application of the model presented herein to the emmetropic retina, a value of the bond energy of the retina to retinal pigment epithelium interface is estimated using material properties found in the literature. Simulations based on the analytical solutions are performed for a detachment in the retina located at either the posterior or superior pole of the eye. The results support the clinical finding of an increased prevalence of retinal detachment in myopic eyes and provide insight into the potential causation for the increased prevalence.
journal_name
Biomech Model Mechanobioljournal_title
Biomechanics and modeling in mechanobiologyauthors
Lakawicz JM,Bottega WJ,Fine HF,Prenner JLdoi
10.1007/s10237-019-01234-1subject
Has Abstractpub_date
2020-04-01 00:00:00pages
603-620issue
2eissn
1617-7959issn
1617-7940pii
10.1007/s10237-019-01234-1journal_volume
19pub_type
杂志文章abstract：:Lymph is transported along collecting lymphatic vessels by intrinsic and extrinsic pumping. The walls have muscle of a type intermediate between blood-vascular smooth muscle and myocardium; a contracting segment between two valves (a lymphangion) constitutes a pump. This intrinsic mechanism is investigated ex vivo in ...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-017-0933-3
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
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更新日期：2004-06-01 00:00:00
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
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journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章,评审
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abstract：:Pelvic floor dysfunction and pelvic organ prolapse have been associated with damage to the levator ani (LA) muscle, but the exact mechanisms linking them remain unknown. It has been postulated that factors such as vaginal birth and ageing may contribute to long-term, irreversible LA muscle damage. To investigate the b...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-010-0249-z
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