Tracking of fluorescence nanoparticles with nanometre resolution in a biological system: assessing local viscosity and microrheology.

abstract：:Experimental evidence suggests that interstitial fluid flow is a stimulus for mechanoadaptation in bone. Bone adaptation is sensitive to the frequency of loading and rest insertion between load cycles. We investigated the effects of permeability, frequency and rest insertion on fluid flow in bone using finite-element ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Pereira AF,Shefelbine SJ

更新日期：2014-01-01 00:00:00

abstract：:Cardiovascular implantable devices alter the biofluid dynamics and biochemistry of the blood in which they are placed. These perturbations can lead to thrombus formation which may or may not be desired, depending on the application. In this work, a computational model is developed that couples biofluid dynamics and bi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Horn JD,Maitland DJ,Hartman J,Ortega JM

更新日期：2018-12-01 00:00:00

abstract：:The monitoring of the ciliated walls in the uterine tube has supreme importance in enhancing the sperm to reach the egg (capacitation processes), and at peristaltic ciliary flow has a more favorable residual time along the canal when compared to the peristaltic flow. Based on the importance of this study, a mathematic...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zaher AZ,Moawad AMA,Mekheimer KS,Bhatti MM

更新日期：2021-01-03 00:00:00

abstract：:Tissue expansion is a common surgical procedure to grow extra skin through controlled mechanical over-stretch. It creates skin that matches the color, texture, and thickness of the surrounding tissue, while minimizing scars and risk of rejection. Despite intense research in tissue expansion and skin growth, there is a...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zöllner AM,Buganza Tepole A,Gosain AK,Kuhl E

更新日期：2012-07-01 00:00:00

abstract：:Collagen degradation is one of the early signs of osteoarthritis. It is not known how collagen degradation affects chondrocyte volume and morphology. Thus, the aim of this study was to investigate the effect of enzymatically induced collagen degradation on cell volume and shape changes in articular cartilage after a h...

journal_title：Biomechanics and modeling in mechanobiology

authors： Turunen SM,Lammi MJ,Saarakkala S,Han SK,Herzog W,Tanska P,Korhonen RK

更新日期：2013-06-01 00:00:00

abstract：:The collagen fibril network is an important factor for the depth-dependent mechanical behaviour of adult articular cartilage (AC). Recent studies show that collagen orientation is parallel to the articular surface throughout the tissue depth in perinatal animals, and that the collagen orientations transform to a depth...

journal_title：Biomechanics and modeling in mechanobiology

authors： van Turnhout MC,Kranenbarg S,van Leeuwen JL

更新日期：2011-04-01 00:00:00

abstract：:Cell deformability and mechanical responses of living cells depend closely on the dynamic changes in the structural architecture of the cytoskeleton (CSK). To describe the dynamic reorganization and the heterogeneity of the prestressed multi-modular CSK, we developed a two-dimensional model for the CSK which was taken...

journal_title：Biomechanics and modeling in mechanobiology

authors： Milan JL,Wendling-Mansuy S,Jean M,Chabrand P

更新日期：2007-11-01 00:00:00

abstract：:A computationally efficient method is described for simulating the dynamics of the left ventricle (LV) in three dimensions. LV motion is represented as a combination of a limited number of deformation modes, chosen to represent observed cardiac motions while conserving volume in the LV wall. The contribution of each m...

journal_title：Biomechanics and modeling in mechanobiology

authors： Hong BD,Moulton MJ,Secomb TW

更新日期：2019-12-01 00:00:00

abstract：:Finite element (FE) simulations of contractile responses of vascular muscular thin films (vMTFs) and endothelial cells resting on an array of microposts under stimulation of soluble factors were conducted in comparison with experimental measurements reported in the literature. Two types of constitutive models were emp...

journal_title：Biomechanics and modeling in mechanobiology

authors： Liu T

更新日期：2017-08-01 00:00:00

abstract：:A contact finite element (FE) formulation is introduced, amenable to patient-specific analysis of cumulative cartilage mechano-stimulus attributable to habitual functional activity. CT scans of individual human ankles are segmented to delineate bony margins. Each bone surface is projected outward to create a second su...

journal_title：Biomechanics and modeling in mechanobiology

authors： Anderson DD,Goldsworthy JK,Shivanna K,Grosland NM,Pedersen DR,Thomas TP,Tochigi Y,Marsh JL,Brown TD

更新日期：2006-06-01 00:00:00

abstract：:Evidence suggests that mechanical load is related to structural destruction of disk annulus fibrosus (AF) either in adult disk degeneration or in child disk acute injury. Both biochemical and biomechanical properties are different between immature and mature disks. However, the effects of mechanical compression on imm...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li P,Gan Y,Xu Y,Song L,Wang H,Zhang C,Wang L,Zhao C,Luo L,Zhou Q

更新日期：2017-04-01 00:00:00

abstract：:Computational studies of chondrocyte mechanics, and cell mechanics in general, have typically been performed using single cell models embedded in an extracellular matrix construct. The assumption of a single cell microstructural model may not capture intercellular interactions or accurately reflect the macroscale mech...

journal_title：Biomechanics and modeling in mechanobiology

authors： Halloran JP,Sibole SC,Erdemir A

更新日期：2018-02-01 00:00:00

abstract：:The immersed boundary method (IBM) has been frequently utilized to simulate the motion and deformation of biological cells and capsules in various flow situations. Despite the convenience in dealing with flow-membrane interaction, direct implementation of membrane viscosity in IBM suffers severe numerical instability....

journal_title：Biomechanics and modeling in mechanobiology

authors： Li P,Zhang J

更新日期：2020-12-01 00:00:00

abstract：:Prior studies indicated that mechanical loading influences cell turnover and matrix remodeling in tissues, suggesting that mechanical stimuli can play an active role in engineering artificial tissues. While most tissue culture studies focus on influence of uniaxial loading or constraints, effects of multi-axial loadin...

journal_title：Biomechanics and modeling in mechanobiology

authors： Hu JJ,Liu YC,Chen GW,Wang MX,Lee PY

更新日期：2013-10-01 00:00:00

abstract：:Ischemic stroke is a major cause of death and long-term disabilities worldwide. In this paper, we aim to represent a comprehensive simulation of the motion of emboli through cerebrovascular network within patient-specific computational model. The model consists of major arteries of the circle of Willis reconstructed f...

journal_title：Biomechanics and modeling in mechanobiology

authors： Khodaee F,Vahidi B,Fatouraee N

更新日期：2016-10-01 00:00:00

abstract：:The reopening of fluid-occluded pulmonary airways generates microbubble flows which impart complex hydrodynamic stresses to the epithelial cells lining airway walls. In this study we used boundary element solutions and finite element techniques to investigate how cell rheology influences the deformation and injury of ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Dailey HL,Ghadiali SN

更新日期：2010-06-01 00:00:00

abstract：:Biological materials can undergo large deformations and also show viscoelastic behaviour. One such material is the network of actin filaments found in biological cells, giving the cell much of its mechanical stiffness. A theory for predicting the relaxation behaviour of actin networks cross-linked with the cross-linke...

journal_title：Biomechanics and modeling in mechanobiology

authors： Fallqvist B,Kroon M

更新日期：2013-04-01 00:00:00

abstract：:Bone tissue regeneration using scaffolds is receiving an increasing interest in orthopedic surgery and tissue engineering applications. In this study, we present the geometrical characterization of a specific family of scaffolds based on a face cubic centered (FCC) arrangement of empty pores leading to analytical form...

journal_title：Biomechanics and modeling in mechanobiology

authors： Sanz-Herrera JA,Garcia-Aznar JM,Doblare M

更新日期：2008-10-01 00:00:00

abstract：:The endothelial cells lining the inner wall of Schlemm's canal (SC) in the eye are relatively unique in that they support a basal-to-apical pressure gradient that causes these cells to deform, creating giant vacuoles and transendothelial pores through which the aqueous humor flows. Glaucoma is associated with an incre...

journal_title：Biomechanics and modeling in mechanobiology

authors： Vargas-Pinto R,Lai J,Gong H,Ethier CR,Johnson M

更新日期：2015-08-01 00:00:00

abstract：:Formins promote actin assembly and are involved in force-dependent cytoskeletal remodeling. However, how force alters the formin functions still needs to be investigated. Here, using atomic force microscopy and biomembrane force probe, we investigated how mechanical force affects formin-mediated actin interactions at ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li Z,Lee H,Eskin SG,Ono S,Zhu C,McIntire LV

更新日期：2020-10-01 00:00:00

abstract：:In its permanent quest of mechanobiological homeostasis, our vasculature significantly adapts across multiple length and timescales in various physiological and pathological conditions. Computational modeling of vascular growth and remodeling (G&R) has significantly improved our insights into the mechanobiological pro...

journal_title：Biomechanics and modeling in mechanobiology

authors： Mousavi SJ,Farzaneh S,Avril S

更新日期：2019-12-01 00:00:00

abstract：:The compliance of the proximal aortic wall is a major determinant of cardiac afterload. Aortic compliance is often estimated based on cross-sectional area changes over the pulse pressure, under the assumption of a negligible longitudinal stretch during the pulse. However, the proximal aorta is subjected to significant...

journal_title：Biomechanics and modeling in mechanobiology

authors： Pagoulatou SZ,Ferraro M,Trachet B,Bikia V,Rovas G,Crowe LA,Vallée JP,Adamopoulos D,Stergiopulos N

更新日期：2020-07-31 00:00:00

abstract：:Elastin and collagen fibers play important roles in the mechanical properties of aortic media. Because knowledge of local fiber structures is required for detailed analysis of blood vessel wall mechanics, we investigated 3D microstructures of elastin and collagen fibers in thoracic aortas and monitored changes during ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Sugita S,Matsumoto T

更新日期：2017-06-01 00:00:00

abstract：:Schlemm's canal (SC) endothelial cells are likely important in the physiology and pathophysiology of the aqueous drainage system of the eye, particularly in glaucoma. The mechanical stiffness of these cells determines, in part, the extent to which they can support a pressure gradient and thus can be used to place limi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zeng D,Juzkiw T,Read AT,Chan DW,Glucksberg MR,Ethier CR,Johnson M

更新日期：2010-02-01 00:00:00

abstract：:Nanomechanics of individual collagen fibrils govern the mechanical behavior of the majority of connective tissues, yet the current models lack significant details. Majority of the current models assume a rod-shape molecule with homogenous mechanical properties. Recent X-ray crystallography revealed significantly diffe...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zhou Z,Minary-Jolandan M,Qian D

更新日期：2015-06-01 00:00:00

abstract：:Bone, because of its hierarchical composite structure, exhibits an excellent combination of stiffness and toughness, which is due substantially to the structural order and deformation at the smaller length scales. Here, we focus on the mineralized collagen fibril, consisting of hydroxyapatite plates with nanometric di...

journal_title：Biomechanics and modeling in mechanobiology

authors： Yuan F,Stock SR,Haeffner DR,Almer JD,Dunand DC,Brinson LC

更新日期：2011-04-01 00:00:00

abstract：:Load-induced fluid flow acts as an important biophysical signal for bone cell mechanotransduction in vivo, where the mechanical environment is thought to be monitored by integrin and primary cilia mechanoreceptors on the cell body. However, precisely how integrin- and primary cilia-based mechanosensors interact with t...

journal_title：Biomechanics and modeling in mechanobiology

authors： Vaughan TJ,Mullen CA,Verbruggen SW,McNamara LM

更新日期：2015-08-01 00:00:00

abstract：:Hemolysis is a major concern in blood-circulating devices, which arises due to hydrodynamic loading on red blood cells from ambient flow environment. Hemolysis estimation models have often been used to aid hemocompatibility design. The preponderance of hemolysis models was formulated on the basis of laminar flows. How...

journal_title：Biomechanics and modeling in mechanobiology

authors： Wu P,Gao Q,Hsu PL

更新日期：2019-06-01 00:00:00

abstract：:The paper describes the extension of a previously developed model of pressure-dependent contraction rate to the case of multiple lymphangions. Mechanical factors are key modulators of active lymphatic pumping. As part of the evolution of our lumped-parameter model to match experimental findings, we have designed an al...

journal_title：Biomechanics and modeling in mechanobiology

authors： Bertram CD,Macaskill C,Davis MJ,Moore JE Jr

更新日期：2018-10-01 00:00:00

abstract：:The present study examines the possibility of attenuating blood pulses by means of introducing prosthetic viscoelastic materials able to absorb energy and damp such pulses. Vascular prostheses made of polymeric materials modify the mechanical properties of blood vessels. The effect of these materials on the blood puls...

journal_title：Biomechanics and modeling in mechanobiology

authors： Menacho J,Rotllant L,Molins JJ,Reyes G,García-Granada AA,Balcells M,Martorell J

更新日期：2018-04-01 00:00:00