Finite element analysis of the pressure-induced deformation of Schlemm's canal endothelial cells.

abstract：:We use supersonic shear wave imaging (SSI) technique to measure not only the linear but also the nonlinear elastic properties of brain matter. Here, we tested six porcine brains ex vivo and measured the velocities of the plane shear waves induced by acoustic radiation force at different states of pre-deformation when ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Jiang Y,Li G,Qian LX,Liang S,Destrade M,Cao Y

更新日期：2015-10-01 00:00:00

abstract：:Inflammation, a precursor to many diseases including cancer and atherosclerosis, induces differential surface expression of specific vascular molecules. Blood-borne nanoparticles (NPs), loaded with therapeutic and imaging agents, can recognize and use these molecules as vascular docking sites. Here, a computational mo...

journal_title：Biomechanics and modeling in mechanobiology

authors： Hossain SS,Hughes TJ,Decuzzi P

更新日期：2014-06-01 00:00:00

abstract：:Computational fluid dynamics (CFD) is an increasingly used method for investigation of hemodynamic parameters and their alterations under pathological conditions, which are important indicators for diagnosis of cardiovascular disease. In hemodynamic simulation models, the employment of appropriate boundary conditions ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Xu P,Liu X,Zhang H,Ghista D,Zhang D,Shi C,Huang W

更新日期：2018-12-01 00:00:00

abstract：:Prior studies indicated that mechanical loading influences cell turnover and matrix remodeling in tissues, suggesting that mechanical stimuli can play an active role in engineering artificial tissues. While most tissue culture studies focus on influence of uniaxial loading or constraints, effects of multi-axial loadin...

journal_title：Biomechanics and modeling in mechanobiology

authors： Hu JJ,Liu YC,Chen GW,Wang MX,Lee PY

更新日期：2013-10-01 00:00:00

abstract：:Articular cartilage is a complex, anisotropic, stratified tissue with remarkable resilience and mechanical properties. It has been subject to extensive modelling as a multiphase medium, with many recent studies examining the impact of increasing detail in the representation of this tissue's fine scale structure. Howev...

journal_title：Biomechanics and modeling in mechanobiology

authors： Klika V,Whiteley JP,Brown CP,Gaffney EA

更新日期：2019-08-01 00:00:00

abstract：:As a degenerative and inflammatory desease of elderly patients, about 80% of abdominal aortic aneurysms (AAA) show considerable wall calcification. Effect of calcifications on computational wall stress analyses of AAAs has been rarely treated in literature so far. Calcifications are heterogeneously distributed, non-fi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Maier A,Gee MW,Reeps C,Eckstein HH,Wall WA

更新日期：2010-10-01 00:00:00

abstract：:A systematic correlation between finite element models (FEMs) and histopathology is needed to define deformation thresholds associated with traumatic brain injury (TBI). In this study, a FEM of a transected piglet brain was used to reverse engineer the range of optimal shear moduli for infant (5 days old, 553-658 Pa) ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Sullivan S,Eucker SA,Gabrieli D,Bradfield C,Coats B,Maltese MR,Lee J,Smith C,Margulies SS

更新日期：2015-08-01 00:00:00

abstract：:In this paper, the heat and flow characteristic of third-grade non-Newtonian biofluids flow through a vertical porous human vessel due to peristaltic wall motion are studied. The third-grade model can describe shear thinning (or shear thickening) and normal stress differences, which is acceptable for biofluids modelin...

journal_title：Biomechanics and modeling in mechanobiology

authors： Akbarzadeh P

更新日期：2018-02-01 00:00:00

abstract：:During total liquid ventilation, lung cells are exposed to perfluorocarbon (PFC) whose chemophysical properties highly differ from standard aqueous cell feeding medium (DMEM). We herein perform a systematic study of structural and mechanical properties of A549 alveolar epithelial cells in order to characterize their r...

journal_title：Biomechanics and modeling in mechanobiology

authors： André Dias S,Planus E,Angely C,Lotteau L,Tissier R,Filoche M,Louis B,Pelle G,Isabey D

更新日期：2018-08-01 00:00:00

abstract：:The equilibrium shapes of lipid vesicles are perturbed by rigid inclusions. In a two-dimensional vesicle, that may also model a cylindrically elongated tubule, the shape modifications can be determined analytically, and turn out to be significant even far from the inclusion. On the contrary, previous numerical work ha...

journal_title：Biomechanics and modeling in mechanobiology

authors： Biscari P,Napoli G

更新日期：2007-09-01 00:00:00

abstract：:In its permanent quest of mechanobiological homeostasis, our vasculature significantly adapts across multiple length and timescales in various physiological and pathological conditions. Computational modeling of vascular growth and remodeling (G&R) has significantly improved our insights into the mechanobiological pro...

journal_title：Biomechanics and modeling in mechanobiology

authors： Mousavi SJ,Farzaneh S,Avril S

更新日期：2019-12-01 00:00:00

abstract：:Ventricular growth is widely considered to be an important feature in the adverse progression of heart diseases, whereas reverse ventricular growth (or reverse remodeling) is often considered to be a favorable response to clinical intervention. In recent years, a number of theoretical models have been proposed to mode...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lee LC,Genet M,Acevedo-Bolton G,Ordovas K,Guccione JM,Kuhl E

更新日期：2015-04-01 00:00:00

abstract：:The reopening of fluid-occluded pulmonary airways generates microbubble flows which impart complex hydrodynamic stresses to the epithelial cells lining airway walls. In this study we used boundary element solutions and finite element techniques to investigate how cell rheology influences the deformation and injury of ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Dailey HL,Ghadiali SN

更新日期：2010-06-01 00:00:00

abstract：:Flow-induced damage to red blood cells has been an issue of considerable importance since the introduction of the first cardiovascular devices. Early blood damage prediction models were based on measurements of damage by shear stress only. Subsequently, these models were extrapolated to include other components of the...

journal_title：Biomechanics and modeling in mechanobiology

authors： Faghih MM,Sharp MK

更新日期：2020-02-01 00:00:00

abstract：:The compliance of the proximal aortic wall is a major determinant of cardiac afterload. Aortic compliance is often estimated based on cross-sectional area changes over the pulse pressure, under the assumption of a negligible longitudinal stretch during the pulse. However, the proximal aorta is subjected to significant...

journal_title：Biomechanics and modeling in mechanobiology

authors： Pagoulatou SZ,Ferraro M,Trachet B,Bikia V,Rovas G,Crowe LA,Vallée JP,Adamopoulos D,Stergiopulos N

更新日期：2020-07-31 00:00:00

abstract：:Aortic valve (AV) calcification is a highly prevalent disease with serious impact on mortality and morbidity. The exact causes and mechanisms of AV calcification are unclear, although previous studies suggest that mechanical forces play a role. It has been clinically demonstrated that calcification preferentially occu...

journal_title：Biomechanics and modeling in mechanobiology

authors： Yap CH,Saikrishnan N,Yoganathan AP

更新日期：2012-01-01 00:00:00

abstract：:Bridging veins (BVs) drain the blood from the cerebral cortex into dural sinuses. BVs have one end attached to the brain and the other to the superior sagittal sinus (SSS), which is attached to the skull. Relative movement between these two structures can cause BV to rupture producing acute subdural haematoma, a head ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Kapeliotis M,Gavrila Laic RA,Peñas AJ,Vander Sloten J,Vanden Berghe P,Famaey N,Depreitere B

更新日期：2020-12-01 00:00:00

abstract：:A general theory for computing and identifying the stress field in a residually stressed tissue is presented in this paper. The theory is based on the assumption that a stress free state is obtained by letting each point deform independently of its adjacent points. This local unloading represents an initial strain, an...

journal_title：Biomechanics and modeling in mechanobiology

authors： Olsson T,Stålhand J,Klarbring A

更新日期：2006-03-01 00:00:00

abstract：:Skin expansion delivers newly grown skin that maintains histological and mechanical features of the original tissue. Although it is the gold standard for cutaneous defect correction today, the underlying mechanisms remain poorly understood. Here we present a novel technique to quantify anisotropic prestrain, deformati...

journal_title：Biomechanics and modeling in mechanobiology

authors： Buganza Tepole A,Gart M,Purnell CA,Gosain AK,Kuhl E

更新日期：2015-10-01 00:00:00

abstract：:Long-term adaptation of soft tissues is realized through growth and remodeling (G&R). Mathematical models are powerful tools in testing hypotheses on G&R and supporting the design and interpretation of experiments. Most theoretical G&R studies concentrate on description of either growth or remodeling. Our model combin...

journal_title：Biomechanics and modeling in mechanobiology

authors： Machyshyn IM,Bovendeerd PH,van de Ven AA,Rongen PM,van de Vosse FN

更新日期：2010-12-01 00:00:00

abstract：:An efficient solver for large-scale linear [Formula: see text] simulations was extended for nonlinear material behavior. The material model included damage-based tissue degradation and fracture. The new framework was applied to 20 trabecular biopsies with a mesh resolution of [Formula: see text]. Suitable material par...

journal_title：Biomechanics and modeling in mechanobiology

authors： Stipsitz M,Zysset PK,Pahr DH

更新日期：2020-06-01 00:00:00

abstract：:A mechanics-based mathematical model of retinal detachment due to the geometric changes of the eye associated with the evolution of myopia is developed. This includes deformation of the retina due to biological growth of the retina, as well as elastic deformation imposed on the retina by the myopic change in shape of ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lakawicz JM,Bottega WJ,Fine HF,Prenner JL

更新日期：2020-04-01 00:00:00

abstract：:By following the common definition of forward-dynamics simulations, i.e. predicting movement based on (neural) muscle activity, this work describes, for the first time, a forward-dynamics simulation framework of a musculoskeletal system, in which all components are represented as continuous, three-dimensional, volumet...

journal_title：Biomechanics and modeling in mechanobiology

authors： Röhrle O,Sprenger M,Schmitt S

更新日期：2017-06-01 00:00:00

abstract：:We propose a multiscale mechanobiological model of bone remodelling to investigate the site-specific evolution of bone volume fraction across the midshaft of a femur. The model includes hormonal regulation and biochemical coupling of bone cell populations, the influence of the microstructure on bone turnover rate, and...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lerebours C,Buenzli PR,Scheiner S,Pivonka P

更新日期：2016-02-01 00:00:00

abstract：:Understanding the mechanical behavior of multicellular monolayers and spheroids is fundamental to tissue culture, organism development, and the early stages of tumor growth. Proliferating cells in monolayers and spheroids experience mechanical forces as they grow and divide and local inhomogeneities in the mechanical ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lejeune E,Linder C

更新日期：2018-06-01 00:00:00

abstract：:Experiments have demonstrated biological tissues grow by mechanically sensing their localized curvature, therefore making geometry a key consideration for tissue scaffold design. We developed a simulation approach for modeling tissue growth on beam-based geometries of repeating unit cells, with four lattice topologies...

journal_title：Biomechanics and modeling in mechanobiology

authors： Egan PF,Shea KA,Ferguson SJ

更新日期：2018-10-01 00:00:00

abstract：:Evidence suggests that mechanical load is related to structural destruction of disk annulus fibrosus (AF) either in adult disk degeneration or in child disk acute injury. Both biochemical and biomechanical properties are different between immature and mature disks. However, the effects of mechanical compression on imm...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li P,Gan Y,Xu Y,Song L,Wang H,Zhang C,Wang L,Zhao C,Luo L,Zhou Q

更新日期：2017-04-01 00:00:00

abstract：:Determining the biomechanical behavior of heart valve leaflet tissues in a noninvasive manner remains an important clinical goal. While advances in 3D imaging modalities have made in vivo valve geometric data available, optimal methods to exploit such information in order to obtain functional information remain to be ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Aggarwal A,Sacks MS

更新日期：2016-08-01 00:00:00

abstract：:The present study examines the possibility of attenuating blood pulses by means of introducing prosthetic viscoelastic materials able to absorb energy and damp such pulses. Vascular prostheses made of polymeric materials modify the mechanical properties of blood vessels. The effect of these materials on the blood puls...

journal_title：Biomechanics and modeling in mechanobiology

authors： Menacho J,Rotllant L,Molins JJ,Reyes G,García-Granada AA,Balcells M,Martorell J

更新日期：2018-04-01 00:00:00

abstract：:This paper aimed to develop a clinically validated bone remodeling algorithm by integrating bone's dynamic properties in a multi-stage fashion based on a four-year clinical follow-up of implant treatment. The configurational effects of fixed partial dentures (FPDs) were explored using a multi-stage remodeling rule. Th...

journal_title：Biomechanics and modeling in mechanobiology

authors： Liao Z,Yoda N,Chen J,Zheng K,Sasaki K,Swain MV,Li Q

更新日期：2017-04-01 00:00:00