Abstract:
:As a degenerative and inflammatory desease of elderly patients, about 80% of abdominal aortic aneurysms (AAA) show considerable wall calcification. Effect of calcifications on computational wall stress analyses of AAAs has been rarely treated in literature so far. Calcifications are heterogeneously distributed, non-fibrous, stiff plaques which are most commonly found near the luminal surface in between the intima and the media layer of the vessel wall. In this study, we therefore investigate the influence of calcifications as separate AAA constituents on finite element simulation results. Thus, three AAAs are reconstructed with regard to intraluminal thrombus (ILT), calcifications and vessel wall. Each patient-specific AAA is simulated twice, once including all three AAA constituents and once neglecting calcifications as it is still common in literature. Parameters for constitutive modeling of calcifications are thereby taken from experiments performed by the authors, showing that calcifications exhibit an almost linear stress-strain behavior with a Young's modulus E ≥ 40 MPa. Simulation results show that calcifications exhibit significant load-bearing effects and reduce stress in adjacent vessel wall. Average stress within the vessel wall is reduced by 9.7 to 59.2%. For two out of three AAAs, peak wall stress decreases when taking calcifications into consideration (8.9 and 28.9%). For one AAA, simulated peak wall stress increases by 5.5% due to stress peaks near calcification borders. However, such stress singularities due to sudden stiffness jumps are physiologically doubtful. It can further be observed that large calcifications are mostly situated in concavely shaped regions of the AAA wall. We deduce that AAA shape is influenced by existent calcifications, thus crucial errors occur if they are neglected in computational wall stress analyses. A general increase in rupture risk for calcified AAAs is doubted.
journal_name
Biomech Model Mechanobioljournal_title
Biomechanics and modeling in mechanobiologyauthors
Maier A,Gee MW,Reeps C,Eckstein HH,Wall WAdoi
10.1007/s10237-010-0191-0subject
Has Abstractpub_date
2010-10-01 00:00:00pages
511-21issue
5eissn
1617-7959issn
1617-7940journal_volume
9pub_type
杂志文章abstract::By following the common definition of forward-dynamics simulations, i.e. predicting movement based on (neural) muscle activity, this work describes, for the first time, a forward-dynamics simulation framework of a musculoskeletal system, in which all components are represented as continuous, three-dimensional, volumet...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-016-0850-x
更新日期:2017-06-01 00:00:00
abstract::This study evaluated the ability of different in vitro mechanical loading tests to promote new mineral formation at bonded dentin interfaces. This research demonstrated a sequential transition in the dentin remineralizing procedure through the analysis of the mineral and matrix gradients. Mechanical loading in phospho...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-014-0573-9
更新日期:2014-11-01 00:00:00
abstract::It has been demonstrated that interstitial fluid (IF) flow can play a crucial role in tumor cell progression. Swartz and collaborators (Cancer Cell 11: 526-538, Shields et al. 2007) demonstrated that cells that secrete the lymphoid homing chemokines CCL21/CCL19 and express their receptor CCR7 could use flow to bias th...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01128-2
更新日期:2019-08-01 00:00:00
abstract::Computational models of the heart have reached a level of maturity that enables sophisticated patient-specific simulations and hold potential for important applications in diagnosis and therapy planning. However, such clinical use puts strict demands on the reliability and accuracy of the models and requires the sensi...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01153-1
更新日期:2019-10-01 00:00:00
abstract::A systematic correlation between finite element models (FEMs) and histopathology is needed to define deformation thresholds associated with traumatic brain injury (TBI). In this study, a FEM of a transected piglet brain was used to reverse engineer the range of optimal shear moduli for infant (5 days old, 553-658 Pa) ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-014-0643-z
更新日期:2015-08-01 00:00:00
abstract::It is believed that non-mammals have poor hearing at high frequencies because the sound-conduction performance of their single-ossicle middle ears declines above a certain frequency. To better understand this behavior, a dynamic three-dimensional finite-element model of the chicken middle ear was constructed. The effe...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01207-4
更新日期:2020-02-01 00:00:00
abstract::Hemolysis is a major concern in blood-circulating devices, which arises due to hydrodynamic loading on red blood cells from ambient flow environment. Hemolysis estimation models have often been used to aid hemocompatibility design. The preponderance of hemolysis models was formulated on the basis of laminar flows. How...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-018-01108-y
更新日期:2019-06-01 00:00:00
abstract::Balance is achieved and maintained by a balance system called a labyrinth that is composed of three semicircular canals and the otolith organs that sense linear gravity and acceleration. Within each semicircular canal, there is a gelatinous structure called the cupula, which is deformed under the influence of the surr...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-017-0912-8
更新日期:2017-10-01 00:00:00
abstract::Bone, because of its hierarchical composite structure, exhibits an excellent combination of stiffness and toughness, which is due substantially to the structural order and deformation at the smaller length scales. Here, we focus on the mineralized collagen fibril, consisting of hydroxyapatite plates with nanometric di...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-010-0223-9
更新日期:2011-04-01 00:00:00
abstract::Aortic valve (AV) calcification is a highly prevalent disease with serious impact on mortality and morbidity. The exact causes and mechanisms of AV calcification are unclear, although previous studies suggest that mechanical forces play a role. It has been clinically demonstrated that calcification preferentially occu...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-011-0306-2
更新日期:2012-01-01 00:00:00
abstract::The present study addresses the effect of muscle activation contributions to mitral valve leaflet response during systole. State-of-art passive hyperelastic material modeling is employed in combination with a simple active stress part. Fiber families are assumed in the leaflets: one defined by the collagen and one def...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-010-0215-9
更新日期:2011-02-01 00:00:00
abstract::Plaque progression and vulnerability are influenced by many risk factors. Our goal is to find a simple method to combine multiple risk factors for better plaque development prediction. Intravascular ultrasound data at baseline and follow-up were acquired from nine patients, and fluid-structure interaction models were ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01143-3
更新日期:2019-10-01 00:00:00
abstract::Tissue morphogenesis in multicellular organisms is accompanied by proliferative cell behaviors: cell division (increase in cell number after each cell cycle) and cell growth (increase in cell volume during each cell cycle). These proliferative cell behaviors can be regulated by multicellular dynamics to achieve proper...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-012-0458-8
更新日期:2013-10-01 00:00:00
abstract::Computational fluid dynamics (CFD) is an increasingly used method for investigation of hemodynamic parameters and their alterations under pathological conditions, which are important indicators for diagnosis of cardiovascular disease. In hemodynamic simulation models, the employment of appropriate boundary conditions ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-018-1045-4
更新日期:2018-12-01 00:00:00
abstract::The reopening of fluid-occluded pulmonary airways generates microbubble flows which impart complex hydrodynamic stresses to the epithelial cells lining airway walls. In this study we used boundary element solutions and finite element techniques to investigate how cell rheology influences the deformation and injury of ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-009-0175-0
更新日期:2010-06-01 00:00:00
abstract::The aim of the study was to establish a user-friendly approach for single fluorescence particle 3D localization and tracking with nanometre precision in a standard fluorescence microscope using a point spread function (PSF) approach, and to evaluate validity and precision for different analysis methods and optical con...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-013-0499-7
更新日期:2014-04-01 00:00:00
abstract::A growing volume of experimental evidence demonstrates that mechanical stress plays a significant role in growth, proliferation, apoptosis, gene expression, electrophysiological properties and many other aspects of neurons. In this review, first, the mechanical microenvironment and properties of neurons under in vivo ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章,评审
doi:10.1007/s10237-015-0743-4
更新日期:2016-10-01 00:00:00
abstract::Conventional brain injury metrics are scalars that treat the whole head/brain as a single unit but do not characterize the distribution of brain responses. Here, we establish a network-based "response feature matrix" to characterize the magnitude and distribution of impact-induced brain strains. The network nodes and ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01261-y
更新日期:2020-06-01 00:00:00
abstract::The influence of an aortic aneurysm on blood flow waveforms is well established, but how to exploit this link for diagnostic purposes still remains challenging. This work uses a combination of experimental and computational modelling to study how aneurysms of various size affect the waveforms. Experimental studies are...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-017-0884-8
更新日期:2017-08-01 00:00:00
abstract::We propose and analyse the properties of a new class of models for the electromechanics of cardiac tissue. The set of governing equations consists of nonlinear elasticity using a viscoelastic and orthotropic exponential constitutive law, for both active stress and active strain formulations of active mechanics, couple...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01237-y
更新日期:2020-04-01 00:00:00
abstract::A general theory for computing and identifying the stress field in a residually stressed tissue is presented in this paper. The theory is based on the assumption that a stress free state is obtained by letting each point deform independently of its adjacent points. This local unloading represents an initial strain, an...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-005-0008-8
更新日期:2006-03-01 00:00:00
abstract::Micro-indentation is a new experimental approach to assess physical cellular properties. Here we attempt to quantify the contribution of geometrical parameters to a cylindrical plant cell's resistance to lateral deformation. This information is important to correctly interpret data obtained from experiments using the ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-005-0010-1
更新日期:2006-11-01 00:00:00
abstract::The present study examines the possibility of attenuating blood pulses by means of introducing prosthetic viscoelastic materials able to absorb energy and damp such pulses. Vascular prostheses made of polymeric materials modify the mechanical properties of blood vessels. The effect of these materials on the blood puls...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-017-0980-9
更新日期:2018-04-01 00:00:00
abstract::Accurate and reliable assessment of bone quality requires predictive methods which could probe bone microstructure and provide information on bone mechanical properties. Multiscale modelling and simulation represent a fast and powerful way to predict bone mechanical properties based on experimental information on bone...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-015-0695-8
更新日期:2016-02-01 00:00:00
abstract::Large scale changes to lipid bilayer shapes are well represented by the Helfrich model. However, there are membrane processes that take place at smaller length scales that this model cannot address. In this work, we present a one-dimensional continuum model that captures the mechanics of the lipid bilayer membrane at ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-013-0528-6
更新日期:2014-08-01 00:00:00
abstract::Medical studies have consistently shown that the best defense against cancer is early detection. Due to this, many efforts have been made to develop methods of screening patient blood quickly and cheaply. These methods range from separation via differences in size, electrostatic potential, chemical potential, antibody...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-018-1093-9
更新日期:2019-04-01 00:00:00
abstract::The controlled cortical impact (CCI) model is widely used in many laboratories to study traumatic brain injury (TBI). Although external impact parameters during CCI tests could be clearly defined, little is known about the internal tissue-level mechanical responses of the rat brain. Furthermore, the external impact pa...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-010-0212-z
更新日期:2010-12-01 00:00:00
abstract::The first carpometacarpal (CMC) joint, located at the base of the thumb and formed by the junction between the first metacarpal and trapezium, is a common site for osteoarthritis of the hand. The shape of both the first metacarpal and trapezium contributes to the intrinsic bony stability of the joint, and variability ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01257-8
更新日期:2020-08-01 00:00:00
abstract::The two main load bearing tissues of the intervertebral disc are the nucleus pulposus and the annulus fibrosus. Both tissues are composed of the same basic components, but differ in their organization and relative amounts. With degeneration, the clear distinction between the two tissues disappears. The changes in bioc...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-016-0835-9
更新日期:2017-04-01 00:00:00
abstract::Locust wings are able to sustain millions of cycles of mechanical loading during the lifetime of the insect. Previous studies have shown that cross veins play an important role in delaying crack propagation in the wings. Do cross veins thus also influence the fatigue behaviour of the wings? Since many important fatigu...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-017-0930-6
更新日期:2017-12-01 00:00:00