A new model to simulate the elastic properties of mineralized collagen fibril.

abstract：:The paper describes the extension of a previously developed model of pressure-dependent contraction rate to the case of multiple lymphangions. Mechanical factors are key modulators of active lymphatic pumping. As part of the evolution of our lumped-parameter model to match experimental findings, we have designed an al...

journal_title：Biomechanics and modeling in mechanobiology

authors： Bertram CD,Macaskill C,Davis MJ,Moore JE Jr

更新日期：2018-10-01 00:00:00

abstract：:One of only a few approved and available anabolic treatments for severe osteoporosis is daily injections of PTH (1-34). This drug has a specific dual action which can act either anabolically or catabolically depending on the type of administration, i.e. intermittent or continuous, respectively. In this paper, we prese...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lavaill M,Trichilo S,Scheiner S,Forwood MR,Cooper DML,Pivonka P

更新日期：2020-10-01 00:00:00

abstract：:The collagen fibril network is an important factor for the depth-dependent mechanical behaviour of adult articular cartilage (AC). Recent studies show that collagen orientation is parallel to the articular surface throughout the tissue depth in perinatal animals, and that the collagen orientations transform to a depth...

journal_title：Biomechanics and modeling in mechanobiology

authors： van Turnhout MC,Kranenbarg S,van Leeuwen JL

更新日期：2011-04-01 00:00:00

abstract：:A contact finite element (FE) formulation is introduced, amenable to patient-specific analysis of cumulative cartilage mechano-stimulus attributable to habitual functional activity. CT scans of individual human ankles are segmented to delineate bony margins. Each bone surface is projected outward to create a second su...

journal_title：Biomechanics and modeling in mechanobiology

authors： Anderson DD,Goldsworthy JK,Shivanna K,Grosland NM,Pedersen DR,Thomas TP,Tochigi Y,Marsh JL,Brown TD

更新日期：2006-06-01 00:00:00

abstract：:The aim of the study was to establish a user-friendly approach for single fluorescence particle 3D localization and tracking with nanometre precision in a standard fluorescence microscope using a point spread function (PSF) approach, and to evaluate validity and precision for different analysis methods and optical con...

journal_title：Biomechanics and modeling in mechanobiology

authors： Marki A,Ermilov E,Zakrzewicz A,Koller A,Secomb TW,Pries AR

更新日期：2014-04-01 00:00:00

abstract：:Finite element (FE) simulations of contractile responses of vascular muscular thin films (vMTFs) and endothelial cells resting on an array of microposts under stimulation of soluble factors were conducted in comparison with experimental measurements reported in the literature. Two types of constitutive models were emp...

journal_title：Biomechanics and modeling in mechanobiology

authors： Liu T

更新日期：2017-08-01 00:00:00

abstract：:By following the common definition of forward-dynamics simulations, i.e. predicting movement based on (neural) muscle activity, this work describes, for the first time, a forward-dynamics simulation framework of a musculoskeletal system, in which all components are represented as continuous, three-dimensional, volumet...

journal_title：Biomechanics and modeling in mechanobiology

authors： Röhrle O,Sprenger M,Schmitt S

更新日期：2017-06-01 00:00:00

abstract：:Tissue expansion is a common surgical procedure to grow extra skin through controlled mechanical over-stretch. It creates skin that matches the color, texture, and thickness of the surrounding tissue, while minimizing scars and risk of rejection. Despite intense research in tissue expansion and skin growth, there is a...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zöllner AM,Buganza Tepole A,Gosain AK,Kuhl E

更新日期：2012-07-01 00:00:00

abstract：:Inflammation, a precursor to many diseases including cancer and atherosclerosis, induces differential surface expression of specific vascular molecules. Blood-borne nanoparticles (NPs), loaded with therapeutic and imaging agents, can recognize and use these molecules as vascular docking sites. Here, a computational mo...

journal_title：Biomechanics and modeling in mechanobiology

authors： Hossain SS,Hughes TJ,Decuzzi P

更新日期：2014-06-01 00:00:00

abstract：:This paper aimed to develop a clinically validated bone remodeling algorithm by integrating bone's dynamic properties in a multi-stage fashion based on a four-year clinical follow-up of implant treatment. The configurational effects of fixed partial dentures (FPDs) were explored using a multi-stage remodeling rule. Th...

journal_title：Biomechanics and modeling in mechanobiology

authors： Liao Z,Yoda N,Chen J,Zheng K,Sasaki K,Swain MV,Li Q

更新日期：2017-04-01 00:00:00

abstract：:In the present work, a constitutive model for articular cartilage is proposed in finite elasto-viscoplasticity. For simplification, articular cartilage is supposed to be a typical composite composed of a soft basis and a fiber assembly. The stress tensor and free energy function are hence accordingly divided into two ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zhu Y

更新日期：2018-12-01 00:00:00

abstract：:Mineralized collagen fibrils have been usually analyzed like a two-phase composite material where crystals are considered as platelets that constitute the reinforcement phase. Different models have been used to describe the elastic behavior of the material. In this work, it is shown that when Halpin-Tsai equations are...

journal_title：Biomechanics and modeling in mechanobiology

authors： Vercher A,Giner E,Arango C,Tarancón JE,Fuenmayor FJ

更新日期：2014-04-01 00:00:00

abstract：:Formins promote actin assembly and are involved in force-dependent cytoskeletal remodeling. However, how force alters the formin functions still needs to be investigated. Here, using atomic force microscopy and biomembrane force probe, we investigated how mechanical force affects formin-mediated actin interactions at ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li Z,Lee H,Eskin SG,Ono S,Zhu C,McIntire LV

更新日期：2020-10-01 00:00:00

abstract：:In this paper, the heat and flow characteristic of third-grade non-Newtonian biofluids flow through a vertical porous human vessel due to peristaltic wall motion are studied. The third-grade model can describe shear thinning (or shear thickening) and normal stress differences, which is acceptable for biofluids modelin...

journal_title：Biomechanics and modeling in mechanobiology

authors： Akbarzadeh P

更新日期：2018-02-01 00:00:00

abstract：:This paper evaluates numerically coupled blood flow and wall structure interactions in a representative stented abdominal aortic aneurysm (AAA) model, leading potentially to endovascular graft (EVG) failure. A total of 12 biomechanical contributors to possible EVG migration were considered. The results show that after...

journal_title：Biomechanics and modeling in mechanobiology

authors： Li Z,Kleinstreuer C,Farber M

更新日期：2005-12-01 00:00:00

abstract：:Digital models based on finite element (FE) analysis are widely used in orthopaedics to predict the stress or strain in the bone due to bone-implant interaction. The usability of the model depends strongly on the bone material description. The material model that is most commonly used is based on a constant Young's mo...

journal_title：Biomechanics and modeling in mechanobiology

authors： Henyš P,Čapek L

更新日期：2017-02-01 00:00:00

abstract：:Computational studies of chondrocyte mechanics, and cell mechanics in general, have typically been performed using single cell models embedded in an extracellular matrix construct. The assumption of a single cell microstructural model may not capture intercellular interactions or accurately reflect the macroscale mech...

journal_title：Biomechanics and modeling in mechanobiology

authors： Halloran JP,Sibole SC,Erdemir A

更新日期：2018-02-01 00:00:00

abstract：:It is believed that non-mammals have poor hearing at high frequencies because the sound-conduction performance of their single-ossicle middle ears declines above a certain frequency. To better understand this behavior, a dynamic three-dimensional finite-element model of the chicken middle ear was constructed. The effe...

journal_title：Biomechanics and modeling in mechanobiology

authors： Muyshondt PGG,Dirckx JJJ

更新日期：2020-02-01 00:00:00

abstract：:Lymph is transported along collecting lymphatic vessels by intrinsic and extrinsic pumping. The walls have muscle of a type intermediate between blood-vascular smooth muscle and myocardium; a contracting segment between two valves (a lymphangion) constitutes a pump. This intrinsic mechanism is investigated ex vivo in ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Bertram CD,Macaskill C,Davis MJ,Moore JE Jr

更新日期：2017-12-01 00:00:00

abstract：:The calcaneus bone is formed of extensive trabecular bone and is therefore well suited to be used as an example of loaded bone to establish the ability of combining microfinite element (microFE) technique with high-resolution peripheral quantitative computed tomography (HR-pQCT) in determining its mechanical propertie...

journal_title：Biomechanics and modeling in mechanobiology

authors： Alsayednoor J,Metcalf L,Rochester J,Dall'Ara E,McCloskey E,Lacroix D

更新日期：2018-12-01 00:00:00

abstract：:A growing volume of experimental evidence demonstrates that mechanical stress plays a significant role in growth, proliferation, apoptosis, gene expression, electrophysiological properties and many other aspects of neurons. In this review, first, the mechanical microenvironment and properties of neurons under in vivo ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Wang Y,Wang W,Li Z,Hao S,Wang B

更新日期：2016-10-01 00:00:00

abstract：:We propose and analyse the properties of a new class of models for the electromechanics of cardiac tissue. The set of governing equations consists of nonlinear elasticity using a viscoelastic and orthotropic exponential constitutive law, for both active stress and active strain formulations of active mechanics, couple...

journal_title：Biomechanics and modeling in mechanobiology

authors： Propp A,Gizzi A,Levrero-Florencio F,Ruiz-Baier R

更新日期：2020-04-01 00:00:00

abstract：:We use supersonic shear wave imaging (SSI) technique to measure not only the linear but also the nonlinear elastic properties of brain matter. Here, we tested six porcine brains ex vivo and measured the velocities of the plane shear waves induced by acoustic radiation force at different states of pre-deformation when ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Jiang Y,Li G,Qian LX,Liang S,Destrade M,Cao Y

更新日期：2015-10-01 00:00:00

abstract：:Recently, physiological and biomechanical studies on animal models with metal implants filling full-thickness cartilage defects have resulted in good clinical outcomes. The knowledge of the time-dependent macroscopic behavior of cartilage surrounding the metal implant is essential for understanding the joint function ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Manda K,Eriksson A

更新日期：2012-05-01 00:00:00

abstract：:Congenital heart defects (CHDs) are abnormalities in the heart structure present at birth. One important condition is hypoplastic left heart syndrome (HLHS) where severely underdeveloped left ventricle (LV) cannot support systemic circulation. HLHS usually initiates as localized tissue malformations with no underlying...

journal_title：Biomechanics and modeling in mechanobiology

authors： Salman HE,Alser M,Shekhar A,Gould RA,Benslimane FM,Butcher JT,Yalcin HC

更新日期：2021-01-22 00:00:00

abstract：:Bridging veins (BVs) drain the blood from the cerebral cortex into dural sinuses. BVs have one end attached to the brain and the other to the superior sagittal sinus (SSS), which is attached to the skull. Relative movement between these two structures can cause BV to rupture producing acute subdural haematoma, a head ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Kapeliotis M,Gavrila Laic RA,Peñas AJ,Vander Sloten J,Vanden Berghe P,Famaey N,Depreitere B

更新日期：2020-12-01 00:00:00

abstract：:This study presents a method for estimating the spatial variations in material properties of elastic membranes, such as biological tissue, which contain both inhomogeneous strain fields and inhomogeneous material properties. In order to validate the method, an inhomogeneous, isotropic rubber membrane was biaxially loa...

journal_title：Biomechanics and modeling in mechanobiology

authors： Nielsen PM,Malcolm DT,Hunter PJ,Charette PG

更新日期：2002-12-01 00:00:00

abstract：:Adherent cells normally apply forces as a generic means of sensing and responding to the mechanical nature of their surrounding environment. How these forces vary as a function of the extracellular rigidity is critical to understanding the regulatory functions that drive important phenomena such as wound healing or mu...

journal_title：Biomechanics and modeling in mechanobiology

authors： Borau C,Kamm RD,García-Aznar JM

更新日期：2014-04-01 00:00:00

abstract：:Aortic valve (AV) calcification is a highly prevalent disease with serious impact on mortality and morbidity. The exact causes and mechanisms of AV calcification are unclear, although previous studies suggest that mechanical forces play a role. It has been clinically demonstrated that calcification preferentially occu...

journal_title：Biomechanics and modeling in mechanobiology

authors： Yap CH,Saikrishnan N,Yoganathan AP

更新日期：2012-01-01 00:00:00

abstract：:Past research into brain injury biomechanics has focussed on short duration impulsive events as opposed to the oscillatory loadings associated with Shaken Baby Syndrome (SBS). A series of 2D finite element models of an axial slice of the infant head were created to provide qualitative information on the behaviour of t...

journal_title：Biomechanics and modeling in mechanobiology

authors： Couper Z,Albermani F

更新日期：2008-04-01 00:00:00