Study of the combined effects of PTH treatment and mechanical loading in postmenopausal osteoporosis using a new mechanistic PK-PD model.

abstract：:This study presents a method for estimating the spatial variations in material properties of elastic membranes, such as biological tissue, which contain both inhomogeneous strain fields and inhomogeneous material properties. In order to validate the method, an inhomogeneous, isotropic rubber membrane was biaxially loa...

journal_title：Biomechanics and modeling in mechanobiology

authors： Nielsen PM,Malcolm DT,Hunter PJ,Charette PG

更新日期：2002-12-01 00:00:00

abstract：:The endothelial cells lining the inner wall of Schlemm's canal (SC) in the eye are relatively unique in that they support a basal-to-apical pressure gradient that causes these cells to deform, creating giant vacuoles and transendothelial pores through which the aqueous humor flows. Glaucoma is associated with an incre...

journal_title：Biomechanics and modeling in mechanobiology

authors： Vargas-Pinto R,Lai J,Gong H,Ethier CR,Johnson M

更新日期：2015-08-01 00:00:00

abstract：:A growing volume of experimental evidence demonstrates that mechanical stress plays a significant role in growth, proliferation, apoptosis, gene expression, electrophysiological properties and many other aspects of neurons. In this review, first, the mechanical microenvironment and properties of neurons under in vivo ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Wang Y,Wang W,Li Z,Hao S,Wang B

更新日期：2016-10-01 00:00:00

abstract：:Both the clinically established diameter criterion and novel approaches of computational finite element (FE) analyses for rupture risk stratification of abdominal aortic aneurysms (AAA) are based on assumptions of population-averaged, uniform material properties for the AAA wall. The presence of inter-patient and intr...

journal_title：Biomechanics and modeling in mechanobiology

authors： Reeps C,Maier A,Pelisek J,Härtl F,Grabher-Meier V,Wall WA,Essler M,Eckstein HH,Gee MW

更新日期：2013-08-01 00:00:00

abstract：:Experimental evidence suggests that interstitial fluid flow is a stimulus for mechanoadaptation in bone. Bone adaptation is sensitive to the frequency of loading and rest insertion between load cycles. We investigated the effects of permeability, frequency and rest insertion on fluid flow in bone using finite-element ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Pereira AF,Shefelbine SJ

更新日期：2014-01-01 00:00:00

abstract：:Medical studies have consistently shown that the best defense against cancer is early detection. Due to this, many efforts have been made to develop methods of screening patient blood quickly and cheaply. These methods range from separation via differences in size, electrostatic potential, chemical potential, antibody...

journal_title：Biomechanics and modeling in mechanobiology

authors： Becton M,Averett RD,Wang X

更新日期：2019-04-01 00:00:00

abstract：:The paper describes the extension of a previously developed model of pressure-dependent contraction rate to the case of multiple lymphangions. Mechanical factors are key modulators of active lymphatic pumping. As part of the evolution of our lumped-parameter model to match experimental findings, we have designed an al...

journal_title：Biomechanics and modeling in mechanobiology

authors： Bertram CD,Macaskill C,Davis MJ,Moore JE Jr

更新日期：2018-10-01 00:00:00

abstract：:A predictive Lagrangian-Eulerian finite element eye model was used to analyze 2.27 and 0.45 kg trinitrotoluene equivalent blasts detonated from 24 different locations. Free air and ground level blasts were simulated directly in front of the eye and at lateral offset locations with box, average, less protective, and mo...

journal_title：Biomechanics and modeling in mechanobiology

authors： Weaver AA,Stitzel SM,Stitzel JD

更新日期：2017-04-01 00:00:00

abstract：:A three-dimensional finite-element fluid/structure interaction model of an intravascular lymphatic valve was constructed, and its properties were investigated under both favourable and adverse pressure differences, simulating valve opening and valve closure, respectively. The shear modulus of the neo-Hookean material ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Bertram CD

更新日期：2020-12-01 00:00:00

abstract：:The controlled cortical impact (CCI) model is widely used in many laboratories to study traumatic brain injury (TBI). Although external impact parameters during CCI tests could be clearly defined, little is known about the internal tissue-level mechanical responses of the rat brain. Furthermore, the external impact pa...

journal_title：Biomechanics and modeling in mechanobiology

authors： Mao H,Yang KH,King AI,Yang K

更新日期：2010-12-01 00:00:00

abstract：:Growth and remodeling in the heart is driven by a combination of mechanical and hormonal signals that produce different patterns of growth in response to exercise, pregnancy, and various pathologies. In particular, increases in afterload lead to concentric hypertrophy, a thickening of the walls that increases the cont...

journal_title：Biomechanics and modeling in mechanobiology

authors： Estrada AC,Yoshida K,Saucerman JJ,Holmes JW

更新日期：2020-09-24 00:00:00

abstract：:A contact finite element (FE) formulation is introduced, amenable to patient-specific analysis of cumulative cartilage mechano-stimulus attributable to habitual functional activity. CT scans of individual human ankles are segmented to delineate bony margins. Each bone surface is projected outward to create a second su...

journal_title：Biomechanics and modeling in mechanobiology

authors： Anderson DD,Goldsworthy JK,Shivanna K,Grosland NM,Pedersen DR,Thomas TP,Tochigi Y,Marsh JL,Brown TD

更新日期：2006-06-01 00:00:00

abstract：:Finite element (FE) simulations of contractile responses of vascular muscular thin films (vMTFs) and endothelial cells resting on an array of microposts under stimulation of soluble factors were conducted in comparison with experimental measurements reported in the literature. Two types of constitutive models were emp...

journal_title：Biomechanics and modeling in mechanobiology

authors： Liu T

更新日期：2017-08-01 00:00:00

abstract：:The collagen fibril network is an important factor for the depth-dependent mechanical behaviour of adult articular cartilage (AC). Recent studies show that collagen orientation is parallel to the articular surface throughout the tissue depth in perinatal animals, and that the collagen orientations transform to a depth...

journal_title：Biomechanics and modeling in mechanobiology

authors： van Turnhout MC,Kranenbarg S,van Leeuwen JL

更新日期：2011-04-01 00:00:00

abstract：:There is a growing interest in the development of patient-specific finite element models of the human lumbar spine for both the assessment of injury risk and the development of treatment strategies. A current challenge in implementing these models is that the outer annulus fibrosus of the disc is composed of concentri...

journal_title：Biomechanics and modeling in mechanobiology

authors： Michalek AJ

更新日期：2019-10-01 00:00:00

abstract：:Cardiovascular implantable devices alter the biofluid dynamics and biochemistry of the blood in which they are placed. These perturbations can lead to thrombus formation which may or may not be desired, depending on the application. In this work, a computational model is developed that couples biofluid dynamics and bi...

journal_title：Biomechanics and modeling in mechanobiology

authors： Horn JD,Maitland DJ,Hartman J,Ortega JM

更新日期：2018-12-01 00:00:00

abstract：:Tissue expansion is a common surgical procedure to grow extra skin through controlled mechanical over-stretch. It creates skin that matches the color, texture, and thickness of the surrounding tissue, while minimizing scars and risk of rejection. Despite intense research in tissue expansion and skin growth, there is a...

journal_title：Biomechanics and modeling in mechanobiology

authors： Zöllner AM,Buganza Tepole A,Gosain AK,Kuhl E

更新日期：2012-07-01 00:00:00

abstract：:During total liquid ventilation, lung cells are exposed to perfluorocarbon (PFC) whose chemophysical properties highly differ from standard aqueous cell feeding medium (DMEM). We herein perform a systematic study of structural and mechanical properties of A549 alveolar epithelial cells in order to characterize their r...

journal_title：Biomechanics and modeling in mechanobiology

authors： André Dias S,Planus E,Angely C,Lotteau L,Tissier R,Filoche M,Louis B,Pelle G,Isabey D

更新日期：2018-08-01 00:00:00

abstract：:Cell deformability and mechanical responses of living cells depend closely on the dynamic changes in the structural architecture of the cytoskeleton (CSK). To describe the dynamic reorganization and the heterogeneity of the prestressed multi-modular CSK, we developed a two-dimensional model for the CSK which was taken...

journal_title：Biomechanics and modeling in mechanobiology

authors： Milan JL,Wendling-Mansuy S,Jean M,Chabrand P

更新日期：2007-11-01 00:00:00

abstract：:This research studies dynamic culture for 3D tissue construct development with computational fluid dynamics. It proposes a mathematical model to evaluate the impact of flow rates and flow shear stress on cell growth in 3D constructs under perfusion. The modeling results show that dynamic flow, even at flow rate as low...

journal_title：Biomechanics and modeling in mechanobiology

authors： Liu D,Chua CK,Leong KF

更新日期：2013-01-01 00:00:00

abstract：:Computational studies of chondrocyte mechanics, and cell mechanics in general, have typically been performed using single cell models embedded in an extracellular matrix construct. The assumption of a single cell microstructural model may not capture intercellular interactions or accurately reflect the macroscale mech...

journal_title：Biomechanics and modeling in mechanobiology

authors： Halloran JP,Sibole SC,Erdemir A

更新日期：2018-02-01 00:00:00

abstract：:Detailed knowledge about the mechanical properties of brain can improve numerical modeling of the brain under various loading conditions. The success of this modeling depends on constitutive model and reliable extraction of its material constants. The isotropy of the brain tissue is a key factor which affects the form...

journal_title：Biomechanics and modeling in mechanobiology

authors： Felfelian AM,Baradaran Najar A,Jafari Nedoushan R,Salehi H

更新日期：2019-12-01 00:00:00

abstract：:The compliance of the proximal aortic wall is a major determinant of cardiac afterload. Aortic compliance is often estimated based on cross-sectional area changes over the pulse pressure, under the assumption of a negligible longitudinal stretch during the pulse. However, the proximal aorta is subjected to significant...

journal_title：Biomechanics and modeling in mechanobiology

authors： Pagoulatou SZ,Ferraro M,Trachet B,Bikia V,Rovas G,Crowe LA,Vallée JP,Adamopoulos D,Stergiopulos N

更新日期：2020-07-31 00:00:00

abstract：:In contrast to most mechanical properties of the red cell, experimental information on stress relaxation (SR) of the membrane skeleton is scarce. On the other hand, many postulates or assumptions as to the value of the characteristic time of SR [Formula: see text] can be found in the literature. Here, an experiment is...

journal_title：Biomechanics and modeling in mechanobiology

authors： Fischer TM

更新日期：2017-02-01 00:00:00

abstract：:Computational fluid dynamics (CFD) is an increasingly used method for investigation of hemodynamic parameters and their alterations under pathological conditions, which are important indicators for diagnosis of cardiovascular disease. In hemodynamic simulation models, the employment of appropriate boundary conditions ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Xu P,Liu X,Zhang H,Ghista D,Zhang D,Shi C,Huang W

更新日期：2018-12-01 00:00:00

abstract：:Understanding the mechanical behavior of multicellular monolayers and spheroids is fundamental to tissue culture, organism development, and the early stages of tumor growth. Proliferating cells in monolayers and spheroids experience mechanical forces as they grow and divide and local inhomogeneities in the mechanical ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Lejeune E,Linder C

更新日期：2018-06-01 00:00:00

abstract：:Conventional brain injury metrics are scalars that treat the whole head/brain as a single unit but do not characterize the distribution of brain responses. Here, we establish a network-based "response feature matrix" to characterize the magnitude and distribution of impact-induced brain strains. The network nodes and ...

journal_title：Biomechanics and modeling in mechanobiology

authors： Wu S,Zhao W,Rowson B,Rowson S,Ji S

更新日期：2020-06-01 00:00:00

abstract：:Flow-induced damage to red blood cells has been an issue of considerable importance since the introduction of the first cardiovascular devices. Early blood damage prediction models were based on measurements of damage by shear stress only. Subsequently, these models were extrapolated to include other components of the...

journal_title：Biomechanics and modeling in mechanobiology

authors： Faghih MM,Sharp MK

更新日期：2020-02-01 00:00:00

abstract：:Adherent cells normally apply forces as a generic means of sensing and responding to the mechanical nature of their surrounding environment. How these forces vary as a function of the extracellular rigidity is critical to understanding the regulatory functions that drive important phenomena such as wound healing or mu...

journal_title：Biomechanics and modeling in mechanobiology

authors： Borau C,Kamm RD,García-Aznar JM

更新日期：2014-04-01 00:00:00

abstract：:This paper aimed to develop a clinically validated bone remodeling algorithm by integrating bone's dynamic properties in a multi-stage fashion based on a four-year clinical follow-up of implant treatment. The configurational effects of fixed partial dentures (FPDs) were explored using a multi-stage remodeling rule. Th...

journal_title：Biomechanics and modeling in mechanobiology

authors： Liao Z,Yoda N,Chen J,Zheng K,Sasaki K,Swain MV,Li Q

更新日期：2017-04-01 00:00:00