Abstract:
:Computational models of the heart have reached a level of maturity that enables sophisticated patient-specific simulations and hold potential for important applications in diagnosis and therapy planning. However, such clinical use puts strict demands on the reliability and accuracy of the models and requires the sensitivity of the model predictions due to errors and uncertainty in the model inputs to be quantified. The models typically contain a large number of parameters, which are difficult to measure and therefore associated with considerable uncertainty. Additionally, patient-specific geometries are usually constructed by semi-manual processing of medical images and must be assumed to be a potential source of model uncertainty. In this paper, we assess the model accuracy by considering the impact of geometrical uncertainties, which typically occur in image-based computational geometries. An approach based on 17 AHA segments diagram is used to consider uncertainties in wall thickness and also in the material properties and fiber orientation, and we perform a comprehensive uncertainty quantification and sensitivity analysis based on polynomial chaos expansions. The quantities considered include stress, strain and global deformation parameters of the left ventricle. The results indicate that important quantities of interest may be more affected by wall thickness, and highlight the need for accurate geometry reconstructions in patient-specific cardiac mechanics models.
journal_name
Biomech Model Mechanobioljournal_title
Biomechanics and modeling in mechanobiologyauthors
Campos JO,Sundnes J,Dos Santos RW,Rocha BMdoi
10.1007/s10237-019-01153-1subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1415-1427issue
5eissn
1617-7959issn
1617-7940pii
10.1007/s10237-019-01153-1journal_volume
18pub_type
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