Abstract:
:Articular cartilage is a complex, anisotropic, stratified tissue with remarkable resilience and mechanical properties. It has been subject to extensive modelling as a multiphase medium, with many recent studies examining the impact of increasing detail in the representation of this tissue's fine scale structure. However, further investigation of simple models with minimal constitutive relations can nonetheless inform our understanding at the foundations of soft tissue simulation. Here, we focus on the impact of heterogeneity with regard to the volume fractions of solid and fluid within the cartilage. Once swelling pressure due to cartilage fixed charge is also present, we demonstrate that the multiphase modelling framework is substantially more complicated, and thus investigate this complexity, especially in the simple setting of a confined compression experiment. Our findings highlight the importance of locally, and thus heterogeneously, approaching pore compaction for load bearing in cartilage models, while emphasising that such effects can be represented by simple constitutive relations. In addition, simulation predictions are observed for the sensitivity of stress and displacement in the cartilage to variations in the initial state of the cartilage and thus the details of experimental protocol, once the tissue is heterogeneous. These findings are for the simplest models given only heterogeneity in volume fractions and swelling pressure, further emphasising that the complex behaviours associated with the interaction of volume fraction heterogeneity and swelling pressure are likely to persist for simulations of cartilage representations with more fine-grained structural detail of the tissue.
journal_name
Biomech Model Mechanobioljournal_title
Biomechanics and modeling in mechanobiologyauthors
Klika V,Whiteley JP,Brown CP,Gaffney EAdoi
10.1007/s10237-019-01123-7subject
Has Abstractpub_date
2019-08-01 00:00:00pages
953-968issue
4eissn
1617-7959issn
1617-7940pii
10.1007/s10237-019-01123-7journal_volume
18pub_type
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