Abstract：
:There is a growing interest in the development of patient-specific finite element models of the human lumbar spine for both the assessment of injury risk and the development of treatment strategies. A current challenge in implementing these models is that the outer annulus fibrosus of the disc is composed of concentric sheets of aligned collagen fibers, the helical angles of which vary spatially. In finite element models, fiber angle is typically assumed to be constant, based on average experimental measurements from a small number of locations. The present study hypothesized that the full spatial distribution of fiber angles in the annulus fibrosus may be predicted for any disc geometry by assuming growth from a thin cylinder with constant fiber angle. This hypothesis was tested by developing an analytical model of disc growth and calibrating it with fiber angle measurements of adult bovine caudal discs. The calibrated model was then run on a representative human lumbar disc geometry. The model was able to accurately predict fiber angle distributions in both the experimental bovine caudal disc measurements and literature-reported human lumbar disc measurements. Despite its theoretical basis in development, the model requires only mature state geometry, making it practical for implementation in patient-specific finite element analyses, in which disc geometry is obtained from clinical imaging.
journal_name
Biomech Model Mechanobioljournal_title
Biomechanics and modeling in mechanobiologyauthors
Michalek AJdoi
10.1007/s10237-019-01150-4subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1363-1369issue
5eissn
1617-7959issn
1617-7940pii
10.1007/s10237-019-01150-4journal_volume
18pub_type
杂志文章abstract：:Congenital heart defects (CHDs) are abnormalities in the heart structure present at birth. One important condition is hypoplastic left heart syndrome (HLHS) where severely underdeveloped left ventricle (LV) cannot support systemic circulation. HLHS usually initiates as localized tissue malformations with no underlying...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-020-01413-5
更新日期：2021-01-22 00:00:00
abstract：:Conventional brain injury metrics are scalars that treat the whole head/brain as a single unit but do not characterize the distribution of brain responses. Here, we establish a network-based "response feature matrix" to characterize the magnitude and distribution of impact-induced brain strains. The network nodes and ...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-019-01261-y
更新日期：2020-06-01 00:00:00
abstract：:Both the clinically established diameter criterion and novel approaches of computational finite element (FE) analyses for rupture risk stratification of abdominal aortic aneurysms (AAA) are based on assumptions of population-averaged, uniform material properties for the AAA wall. The presence of inter-patient and intr...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-012-0436-1
更新日期：2013-08-01 00:00:00
abstract：:The collagen fibril network is an important factor for the depth-dependent mechanical behaviour of adult articular cartilage (AC). Recent studies show that collagen orientation is parallel to the articular surface throughout the tissue depth in perinatal animals, and that the collagen orientations transform to a depth...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-010-0233-7
更新日期：2011-04-01 00:00:00
abstract：:Determining the biomechanical behavior of heart valve leaflet tissues in a noninvasive manner remains an important clinical goal. While advances in 3D imaging modalities have made in vivo valve geometric data available, optimal methods to exploit such information in order to obtain functional information remain to be ...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-015-0732-7
更新日期：2016-08-01 00:00:00
abstract：:Knowledge of the complete three-dimensional (3D) mechanical behavior of soft tissues is essential in understanding their pathophysiology and in developing novel therapies. Despite significant progress made in experimentation and modeling, a complete approach for the full characterization of soft tissue 3D behavior rem...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-017-0943-1
更新日期：2018-02-01 00:00:00
abstract：:This paper presents a differential model of the corneal transport system capable of modelling thickness changes in response to osmotic perturbations applied to either limiting membrane. The work is directed towards understanding corneal behaviour in vivo. The model considers the coupled viscous flows within the cornea...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-004-0054-7
更新日期：2004-11-01 00:00:00
abstract：:Adherent cells sense their mechanical environment, which, in turn, regulates their functions. During the past decade, a growing body of evidence has indicated that a deformable, solid-state intracellular structure known as the cytoskeleton (CSK) plays a major role in transmitting and distributing mechanical stresses w...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章,评审
doi：10.1007/s10237-002-0009-9
更新日期：2002-06-01 00:00:00
abstract：:The key parameters determining the elastic properties of an unidirectional mineralized bone fibril-array decomposed in two further hierarchical levels are investigated using mean field methods. Modeling of the elastic properties of mineralized micro- and nanostructures requires accurate information about the underlyin...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-010-0190-1
更新日期：2010-10-01 00:00:00
abstract：:Micro-indentation is a new experimental approach to assess physical cellular properties. Here we attempt to quantify the contribution of geometrical parameters to a cylindrical plant cell's resistance to lateral deformation. This information is important to correctly interpret data obtained from experiments using the ...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-005-0010-1
更新日期：2006-11-01 00:00:00
abstract：:The basic aim of the present contribution is the qualitative simulation of healing phenomena typically encountered in hard and soft tissue mechanics. The mechanical framework is provided by the theory of open system thermodynamics, which will be formulated in the spatial as well as in the material motion context. Whil...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-003-0034-3
更新日期：2004-06-01 00:00:00
abstract：:Evidence suggests that mechanical load is related to structural destruction of disk annulus fibrosus (AF) either in adult disk degeneration or in child disk acute injury. Both biochemical and biomechanical properties are different between immature and mature disks. However, the effects of mechanical compression on imm...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-016-0823-0
更新日期：2017-04-01 00:00:00
abstract：:Elastin and collagen fibers play important roles in the mechanical properties of aortic media. Because knowledge of local fiber structures is required for detailed analysis of blood vessel wall mechanics, we investigated 3D microstructures of elastin and collagen fibers in thoracic aortas and monitored changes during ...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-016-0851-9
更新日期：2017-06-01 00:00:00
abstract：:The first carpometacarpal (CMC) joint, located at the base of the thumb and formed by the junction between the first metacarpal and trapezium, is a common site for osteoarthritis of the hand. The shape of both the first metacarpal and trapezium contributes to the intrinsic bony stability of the joint, and variability ...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-019-01257-8
更新日期：2020-08-01 00:00:00
abstract：:Mechanical cues that trigger pathological remodeling in smooth muscle tissues remain largely unknown and are thought to be pivotal triggers for strain-induced remodeling. Thus, an understanding of the effects mechanical stimulation is important to elucidate underlying mechanisms of disease states and in the developmen...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-011-0298-y
更新日期：2012-01-01 00:00:00
abstract：:The endothelial cells lining the inner wall of Schlemm's canal (SC) in the eye are relatively unique in that they support a basal-to-apical pressure gradient that causes these cells to deform, creating giant vacuoles and transendothelial pores through which the aqueous humor flows. Glaucoma is associated with an incre...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-014-0640-2
更新日期：2015-08-01 00:00:00
abstract：:Articular cartilage is a multicomponent, poroviscoelastic tissue with nonlinear mechanical properties vital to its function. A consequent goal of repair or replacement of injured cartilage is to achieve mechanical properties in the repair tissue similar to healthy native cartilage. Since fresh healthy human articular ...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-011-0338-7
更新日期：2012-05-01 00:00:00
abstract：:Detailed knowledge about the mechanical properties of brain can improve numerical modeling of the brain under various loading conditions. The success of this modeling depends on constitutive model and reliable extraction of its material constants. The isotropy of the brain tissue is a key factor which affects the form...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-019-01186-6
更新日期：2019-12-01 00:00:00
abstract：:It is believed that non-mammals have poor hearing at high frequencies because the sound-conduction performance of their single-ossicle middle ears declines above a certain frequency. To better understand this behavior, a dynamic three-dimensional finite-element model of the chicken middle ear was constructed. The effe...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-019-01207-4
更新日期：2020-02-01 00:00:00
abstract：:The paper describes the extension of a previously developed model of pressure-dependent contraction rate to the case of multiple lymphangions. Mechanical factors are key modulators of active lymphatic pumping. As part of the evolution of our lumped-parameter model to match experimental findings, we have designed an al...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-018-1042-7
更新日期：2018-10-01 00:00:00
abstract：:The reopening of fluid-occluded pulmonary airways generates microbubble flows which impart complex hydrodynamic stresses to the epithelial cells lining airway walls. In this study we used boundary element solutions and finite element techniques to investigate how cell rheology influences the deformation and injury of ...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-009-0175-0
更新日期：2010-06-01 00:00:00
abstract：:In contrast to most mechanical properties of the red cell, experimental information on stress relaxation (SR) of the membrane skeleton is scarce. On the other hand, many postulates or assumptions as to the value of the characteristic time of SR [Formula: see text] can be found in the literature. Here, an experiment is...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-016-0813-2
更新日期：2017-02-01 00:00:00
abstract：:Continuum mechanical tools are used to describe the deformation, energy density, and material symmetry of a lipid bilayer with spontaneous curvature. In contrast to conventional approaches in which lipid bilayers are modeled by material surfaces, here we rely on a three-dimensional approach in which a lipid bilayer is...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-012-0459-7
更新日期：2013-10-01 00:00:00
abstract：:A growing volume of experimental evidence demonstrates that mechanical stress plays a significant role in growth, proliferation, apoptosis, gene expression, electrophysiological properties and many other aspects of neurons. In this review, first, the mechanical microenvironment and properties of neurons under in vivo ...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章,评审
doi：10.1007/s10237-015-0743-4
更新日期：2016-10-01 00:00:00
abstract：:During angiogenesis, sprouting microvessels interact with the extracellular matrix (ECM) by degrading and reorganizing the matrix, applying traction forces, and producing deformation. Morphometric features of the resulting microvascular network are affected by the interaction between the matrix and angiogenic microves...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-014-0635-z
更新日期：2015-08-01 00:00:00
abstract：:Past research into brain injury biomechanics has focussed on short duration impulsive events as opposed to the oscillatory loadings associated with Shaken Baby Syndrome (SBS). A series of 2D finite element models of an axial slice of the infant head were created to provide qualitative information on the behaviour of t...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-007-0079-9
更新日期：2008-04-01 00:00:00
abstract：:Accurate and reliable assessment of bone quality requires predictive methods which could probe bone microstructure and provide information on bone mechanical properties. Multiscale modelling and simulation represent a fast and powerful way to predict bone mechanical properties based on experimental information on bone...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-015-0695-8
更新日期：2016-02-01 00:00:00
abstract：:Intracellular calcium dynamics plays an important role in the regulation of vascular endothelial cellular functions. In order to probe the intracellular calcium dynamic response under synergistic effect of wall shear stress (WSS) and adenosine triphosphate (ATP) signals, a novel microfluidic device, which provides the...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-018-1076-x
更新日期：2019-02-01 00:00:00
abstract：:The influence of an aortic aneurysm on blood flow waveforms is well established, but how to exploit this link for diagnostic purposes still remains challenging. This work uses a combination of experimental and computational modelling to study how aneurysms of various size affect the waveforms. Experimental studies are...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-017-0884-8
更新日期：2017-08-01 00:00:00
abstract：:It has been demonstrated that interstitial fluid (IF) flow can play a crucial role in tumor cell progression. Swartz and collaborators (Cancer Cell 11: 526-538, Shields et al. 2007) demonstrated that cells that secrete the lymphoid homing chemokines CCL21/CCL19 and express their receptor CCR7 could use flow to bias th...
journal_title：Biomechanics and modeling in mechanobiology
pub_type： 杂志文章
doi：10.1007/s10237-019-01128-2
更新日期：2019-08-01 00:00:00
