Abstract:
:Uniaxial tensile and relaxation tests were carried out on annulus fibrosus samples carved out in the circumferential direction. Images were shot perpendicularly to the loading direction. Digital image correlation techniques accurately measured the evolution of full displacement fields in both transverse directions: plane of fibres and plane of lamellae. In the fibre plane, strains were governed by the reorientation of fibres along the loading direction. This implies strong transverse shrinkage with quasi-linear behaviour. Conversely, a wide range of behaviour was observed in the lamella plane: from shrinkage to swelling. Strong nonlinear evolutions were generally obtained. The strain field in the lamella plane generally presented a central strip section with more pronounced swelling. Our physical interpretation relies on the porous nature of annulus tissue and its anisotropic stiffness. Indeed, the liquid over-pressure generated inside the sample by the strong shrinkage in the fibre plane discharges in the perpendicular direction since rigidity is lower in the lamella plane. Regarding the strain field measured in the lamella plane, this interpretation agrees with (a) symmetric strain distribution with respect to the longitudinal axis of samples, (b) the reversal in behaviour from shrinkage to swelling and (c) the decrease in strain during relaxation tests associated with outward flows. The variety of transverse behaviours observed experimentally could result from uncertainties regarding the initial reference state of tissue samples. Since the mechanical behaviour is highly nonlinear, experimental results underline that a slight uncertainty concerning the pre-stress applied to samples can lead to wide variability in the mechanical properties identified.
journal_name
Biomech Model Mechanobioljournal_title
Biomechanics and modeling in mechanobiologyauthors
Baldit A,Ambard D,Cherblanc F,Royer Pdoi
10.1007/s10237-013-0524-xsubject
Has Abstractpub_date
2014-06-01 00:00:00pages
643-52issue
3eissn
1617-7959issn
1617-7940journal_volume
13pub_type
杂志文章abstract::There is a growing interest in the development of patient-specific finite element models of the human lumbar spine for both the assessment of injury risk and the development of treatment strategies. A current challenge in implementing these models is that the outer annulus fibrosus of the disc is composed of concentri...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01150-4
更新日期:2019-10-01 00:00:00
abstract::Tissue morphogenesis in multicellular organisms is accompanied by proliferative cell behaviors: cell division (increase in cell number after each cell cycle) and cell growth (increase in cell volume during each cell cycle). These proliferative cell behaviors can be regulated by multicellular dynamics to achieve proper...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-012-0458-8
更新日期:2013-10-01 00:00:00
abstract::Tissue expansion is a common surgical procedure to grow extra skin through controlled mechanical over-stretch. It creates skin that matches the color, texture, and thickness of the surrounding tissue, while minimizing scars and risk of rejection. Despite intense research in tissue expansion and skin growth, there is a...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-011-0357-4
更新日期:2012-07-01 00:00:00
abstract::Continuum mechanical tools are used to describe the deformation, energy density, and material symmetry of a lipid bilayer with spontaneous curvature. In contrast to conventional approaches in which lipid bilayers are modeled by material surfaces, here we rely on a three-dimensional approach in which a lipid bilayer is...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-012-0459-7
更新日期:2013-10-01 00:00:00
abstract::Large scale changes to lipid bilayer shapes are well represented by the Helfrich model. However, there are membrane processes that take place at smaller length scales that this model cannot address. In this work, we present a one-dimensional continuum model that captures the mechanics of the lipid bilayer membrane at ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-013-0528-6
更新日期:2014-08-01 00:00:00
abstract::The veins distributing oxygenated blood from the placenta to the fetal body have been given much attention in clinical Doppler velocimetry studies, in particular the ductus venosus. The ductus venosus is embedded in the left liver lobe and connects the intra-abdominal portion of the umbilical vein (IUV) directly to th...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-012-0460-1
更新日期:2013-10-01 00:00:00
abstract::Articular cartilage is a multicomponent, poroviscoelastic tissue with nonlinear mechanical properties vital to its function. A consequent goal of repair or replacement of injured cartilage is to achieve mechanical properties in the repair tissue similar to healthy native cartilage. Since fresh healthy human articular ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-011-0338-7
更新日期:2012-05-01 00:00:00
abstract::In contrast to most mechanical properties of the red cell, experimental information on stress relaxation (SR) of the membrane skeleton is scarce. On the other hand, many postulates or assumptions as to the value of the characteristic time of SR [Formula: see text] can be found in the literature. Here, an experiment is...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-016-0813-2
更新日期:2017-02-01 00:00:00
abstract::In adaptive bone remodeling, mechanical signals such as stress/strain caused by loading/deformation are believed to play important roles as regulators of the process in which osteoclastic resorption and osteoblastic formation are coordinated under a local mechanical environment. The mechanism by which cells sense and ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-003-0029-0
更新日期:2003-11-01 00:00:00
abstract::In this study, we hypothesized that spatial relationships exist between the local mechanical environment and inflammatory marker expression in atherosclerotic plaques, and that these relationships are plaque-progression dependent. Histologic cross-sections were collected at regular intervals along the length of diseas...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-009-0151-8
更新日期:2009-12-01 00:00:00
abstract::Cardiovascular implantable devices alter the biofluid dynamics and biochemistry of the blood in which they are placed. These perturbations can lead to thrombus formation which may or may not be desired, depending on the application. In this work, a computational model is developed that couples biofluid dynamics and bi...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-018-1059-y
更新日期:2018-12-01 00:00:00
abstract::Nanomechanics of individual collagen fibrils govern the mechanical behavior of the majority of connective tissues, yet the current models lack significant details. Majority of the current models assume a rod-shape molecule with homogenous mechanical properties. Recent X-ray crystallography revealed significantly diffe...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-014-0615-3
更新日期:2015-06-01 00:00:00
abstract::The key parameters determining the elastic properties of an unidirectional mineralized bone fibril-array decomposed in two further hierarchical levels are investigated using mean field methods. Modeling of the elastic properties of mineralized micro- and nanostructures requires accurate information about the underlyin...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-010-0190-1
更新日期:2010-10-01 00:00:00
abstract::Load-induced fluid flow acts as an important biophysical signal for bone cell mechanotransduction in vivo, where the mechanical environment is thought to be monitored by integrin and primary cilia mechanoreceptors on the cell body. However, precisely how integrin- and primary cilia-based mechanosensors interact with t...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-014-0631-3
更新日期:2015-08-01 00:00:00
abstract::Schlemm's canal (SC) endothelial cells are likely important in the physiology and pathophysiology of the aqueous drainage system of the eye, particularly in glaucoma. The mechanical stiffness of these cells determines, in part, the extent to which they can support a pressure gradient and thus can be used to place limi...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-009-0156-3
更新日期:2010-02-01 00:00:00
abstract::Cartilage matrix mechanical function is largely determined by interactions between the collagen fibrillar network and the proteoglycan gel. Although the molecular physics of these matrix constituents have been characterized and modern imaging methods are capable of localized measurement of molecular densities and orie...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-006-0036-z
更新日期:2007-01-01 00:00:00
abstract::Mathematical and computational modeling of the dynamic process where tissue scaffolds are cultured in perfusion bioreactors is able to provide insight into the cell and tissue growth which can facilitate the design of tissue scaffolds and selection of optimal operating conditions. To date, a resolved-scale simulation ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-014-0606-4
更新日期:2015-04-01 00:00:00
abstract::The basic aim of the present contribution is the qualitative simulation of healing phenomena typically encountered in hard and soft tissue mechanics. The mechanical framework is provided by the theory of open system thermodynamics, which will be formulated in the spatial as well as in the material motion context. Whil...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-003-0034-3
更新日期:2004-06-01 00:00:00
abstract::During total liquid ventilation, lung cells are exposed to perfluorocarbon (PFC) whose chemophysical properties highly differ from standard aqueous cell feeding medium (DMEM). We herein perform a systematic study of structural and mechanical properties of A549 alveolar epithelial cells in order to characterize their r...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-018-1005-z
更新日期:2018-08-01 00:00:00
abstract::We propose and analyse the properties of a new class of models for the electromechanics of cardiac tissue. The set of governing equations consists of nonlinear elasticity using a viscoelastic and orthotropic exponential constitutive law, for both active stress and active strain formulations of active mechanics, couple...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-019-01237-y
更新日期:2020-04-01 00:00:00
abstract::Past research into brain injury biomechanics has focussed on short duration impulsive events as opposed to the oscillatory loadings associated with Shaken Baby Syndrome (SBS). A series of 2D finite element models of an axial slice of the infant head were created to provide qualitative information on the behaviour of t...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-007-0079-9
更新日期:2008-04-01 00:00:00
abstract::During angiogenesis, sprouting microvessels interact with the extracellular matrix (ECM) by degrading and reorganizing the matrix, applying traction forces, and producing deformation. Morphometric features of the resulting microvascular network are affected by the interaction between the matrix and angiogenic microves...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-014-0635-z
更新日期:2015-08-01 00:00:00
abstract::Locust wings are able to sustain millions of cycles of mechanical loading during the lifetime of the insect. Previous studies have shown that cross veins play an important role in delaying crack propagation in the wings. Do cross veins thus also influence the fatigue behaviour of the wings? Since many important fatigu...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-017-0930-6
更新日期:2017-12-01 00:00:00
abstract::Skin expansion delivers newly grown skin that maintains histological and mechanical features of the original tissue. Although it is the gold standard for cutaneous defect correction today, the underlying mechanisms remain poorly understood. Here we present a novel technique to quantify anisotropic prestrain, deformati...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-015-0650-8
更新日期:2015-10-01 00:00:00
abstract::In the present work, a constitutive model for articular cartilage is proposed in finite elasto-viscoplasticity. For simplification, articular cartilage is supposed to be a typical composite composed of a soft basis and a fiber assembly. The stress tensor and free energy function are hence accordingly divided into two ...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-018-1062-3
更新日期:2018-12-01 00:00:00
abstract::Disease alters tissue microstructure, which in turn affects the macroscopic mechanical properties of tissue. In elasticity imaging, the macroscopic response is measured and is used to infer the spatial distribution of the elastic constitutive parameters. When an empirical constitutive model is used, these parameters c...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-016-0831-0
更新日期:2017-04-01 00:00:00
abstract::The influence of an aortic aneurysm on blood flow waveforms is well established, but how to exploit this link for diagnostic purposes still remains challenging. This work uses a combination of experimental and computational modelling to study how aneurysms of various size affect the waveforms. Experimental studies are...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-017-0884-8
更新日期:2017-08-01 00:00:00
abstract::This paper presents a differential model of the corneal transport system capable of modelling thickness changes in response to osmotic perturbations applied to either limiting membrane. The work is directed towards understanding corneal behaviour in vivo. The model considers the coupled viscous flows within the cornea...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-004-0054-7
更新日期:2004-11-01 00:00:00
abstract::A contact finite element (FE) formulation is introduced, amenable to patient-specific analysis of cumulative cartilage mechano-stimulus attributable to habitual functional activity. CT scans of individual human ankles are segmented to delineate bony margins. Each bone surface is projected outward to create a second su...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-006-0025-2
更新日期:2006-06-01 00:00:00
abstract::This study evaluated the ability of different in vitro mechanical loading tests to promote new mineral formation at bonded dentin interfaces. This research demonstrated a sequential transition in the dentin remineralizing procedure through the analysis of the mineral and matrix gradients. Mechanical loading in phospho...
journal_title:Biomechanics and modeling in mechanobiology
pub_type: 杂志文章
doi:10.1007/s10237-014-0573-9
更新日期:2014-11-01 00:00:00