Abstract:
:Bacterial biofilms are communities of microorganisms attached to a surface. Biofilm formation is critical not only for environmental survival but also for successful infection. Helicobacter pylori is one of the most common causes of bacterial infection in humans. Some studies demonstrated that this microorganism has biofilm forming ability in the environment and on human gastric mucosa epithelium as well as on in vitro abiotic surfaces. In the environment, H. pylori could be embedded in drinking water biofilms through water distribution system in developed and developing countries so that the drinking water may serve as a reservoir for H. pylori infection. In the human stomach, H. pylori forms biofilms on the surface of gastric mucosa, suggesting one possible explanation for eradication therapy failure. Finally, based on the results of in vitro analyses, H. pylori biofilm formation can decrease susceptibility to antibiotics and H. pylori antibiotic resistance mutations are more frequently generated in biofilms than in planktonic cells. These observations indicated that H. pylori biofilm formation may play an important role in preventing and controlling H. pylori infections. Therefore, investigation of H. pylori biofilm formation could be effective in elucidating the detailed mechanisms of infection and colonization by this microorganism.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Yonezawa H,Osaki T,Kamiya Sdoi
10.1155/2015/914791subject
Has Abstractpub_date
2015-01-01 00:00:00pages
914791eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章,评审abstract::Owing to its hydrophilicity, negative charge, small size, and labile degradation by endogenous nucleases, small interfering RNA (siRNA) delivery must be achieved by a carrier system. In this study, cationic copolymers composed of low-molecular-weight polyethylenimine and polythiophenes were synthesized and evaluated a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/406389
更新日期:2015-01-01 00:00:00
abstract::Upregulated gene 11 (URG11), a new gene upregulated by hepatitis B virus X protein, is involved in the development and progression of several tumors, including liver, stomach, lung, and colon cancers. However, the role of URG11 in prostate cancer remains yet to be elucidated. By determined expression in human prostate...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4060728
更新日期:2018-05-31 00:00:00
abstract::Only a few species of the large Astragalus genus, widely used for medicinal purposes, have been thoroughly studied for phytochemical composition. The aim of our research was to investigate the rarely studied species A. glycyphyllos L. and A. cicer L. for the distribution of mineral elements and phytochemicals in whole...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6318630
更新日期:2018-01-21 00:00:00
abstract::Stimuli responsive pH- and temperature-sensitive hydrogel drug delivery systems, as those based on N-isopropylacrylamide (NiPAAm) and itaconic acid (IA), have been attracting much of the attention of the scientific community nowadays, especially in the field of drug release. By adjusting comonomer composition, the mat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/364930
更新日期:2014-01-01 00:00:00
abstract::A Multilayered Multidisk Tablet (MLMDT) comprising two drug-loaded disks enveloped by three drug-free barrier layers was developed for use in chronotherapeutic disorders, employing two model drugs, theophylline and diltiazem HCl. The MLMDT was designed to achieve two pulses of drug release separated by a lag phase. Th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/569470
更新日期:2013-01-01 00:00:00
abstract::cir-ITCH, a well-known tumor-suppressive circular RNA, plays a critical role in different cancers. However, its expression and functional role in prostate cancer (PCa) are unclear. Herein, we explored the potential mechanism and tumor-inhibiting role of cir-ITCH in PCa. Using reverse transcriptase polymerase chain rea...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7586521
更新日期:2020-08-20 00:00:00
abstract::Impact of bone mesenchymal stem cell (BMSC) transfusion on chronic smoking-induced lung inflammation is poorly understood. In this study, a rat model of smoking-related lung injury was induced and the rats were treated with vehicle or BMSCs for two weeks. Different subsets of CD4+ T cells, cytokines, and anti-elastin ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/932923
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to evaluate the efficacy and safety of transcatheter arterial chemoembolization (TACE) using warmed and nonwarmed miriplatin for hepatocellular carcinoma. Eighty patients (117 nodules), treated between January 2010 and June 2013, were evaluated. Thirty-two and 85 nodules were treated with non...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/359296
更新日期:2014-01-01 00:00:00
abstract:Background:Reproductive system cancer is an important cause of morbidity and mortality worldwide which threatens women's health and lives. Breast, cervical, and ovarian cancer have the higher incidence and mortality among a series of gynecology malignant tumor. We aimed to compare and assess the temporal trends of comm...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5307459
更新日期:2018-03-21 00:00:00
abstract::MicroRNAs orchestrate the expression of the genome and impact many, if not all, cellular processes. Their deregulation is thus often causative of human malignancies, including cancers. Numerous studies have implicated microRNAs in the different steps of tumorigenesis including initiation, progression, metastasis, and ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/642916
更新日期:2014-01-01 00:00:00
abstract::The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/604385
更新日期:2015-01-01 00:00:00
abstract::The purpose of the study is to evaluate the relationship between NIH-CPSI and IIEF-5 in Chinese men with CP/CPPS. A large cross-sectional and multicenter survey was conducted from July 2012 to January 2014. Men were recruited from urology clinics which were located at the five cities in China. All men participated in ...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2015/560239
更新日期:2015-01-01 00:00:00
abstract::Natural medical plant is considered as a good source of tyrosinase inhibitors. Red vine leaf extract (RVLE) can be applied to a wide variety of medical disciplines, such as treatments for chronic venous insufficiency over many decades. This study investigated the tyrosinase inhibitory activity of RVLE containing galli...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5232680
更新日期:2017-01-01 00:00:00
abstract::The AT-hook transcription factor, AKNA, is a nuclear protein that affects a few physiological and pathological processes including cancer. Here, we investigated the role of AKNA in gastric cancer (GC). By using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot assays, AKNA was found deregulat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6726759
更新日期:2020-05-13 00:00:00
abstract::Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 3(2) full fact...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/563651
更新日期:2013-01-01 00:00:00
abstract:Background:The mechanism of inflammatory reaction after intracerebral hemorrhage remains unclear, which to some extent restrains the therapeutic development of hemorrhagic stroke. The present study attempts to verify whether NLRP6 plays an important role in inflammatory reaction after intracerebral hemorrhage and ident...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6182464
更新日期:2020-06-07 00:00:00
abstract:Objective:The presence of radiological signs of femoroacetabular impingement (FAI) is not necessarily associated with symptoms. Hence, the prevalence of cam and pincer deformities in the overall population may be underestimated. The purpose of this study was to screen an unselected cohort of people without hip symptoms...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8562329
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to investigate whether osteopontin (OPN) variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population. Polymorphisms at the 9175th position in exon 7 of OPN and rs17524488 were genotyped using direct sequencing in 186 unrelated AS patients and 188 ethnica...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3458439
更新日期:2018-01-18 00:00:00
abstract::Introduction. Luteolin, a falconoid compound in many Chinese herbs and formula, plays important roles in cardiovascular diseases. The underlying mechanism of luteolin remains to be further elaborated. Methods. A model of hydrogen peroxide- (H2O2-) induced H9C2 cells apoptosis was established. Cell viabilities were exa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5125836
更新日期:2016-01-01 00:00:00
abstract::A potent fibrinolytic enzyme-producing Bacillus cereus IND1 was isolated from the Indian food, rice. Solid-state fermentation was carried out using agroresidues for the production of fibrinolytic enzyme. Among the substrates, wheat bran supported more enzyme production and has been used for the optimized enzyme produc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/725064
更新日期:2014-01-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder caused by selective loss of dopaminergic neurons in the substantia nigra pars compacta which leads to dysfunction of cerebral pathways critical for the control of movements. The diagnosis of PD is based on motor symptoms, such as bradykinesia, akinesia, muscular...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/519816
更新日期:2014-01-01 00:00:00
abstract::The aims of this work were to evaluate the in vitro and in vivo schistosomicidal properties of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and to determine its HPLC profile. For the in vitro experiment, four pairs of adult worms, obtained from infected mice, were exposed to different conce...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/941318
更新日期:2014-01-01 00:00:00
abstract::The administration of probiotic bacteria for health benefit has rapidly expanded in recent years, with a global market worth $32.6 billion predicted by 2014. The oral administration of most of the probiotics results in the lack of ability to survive in a high proportion of the harsh conditions of acidity and bile conc...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/620719
更新日期:2013-01-01 00:00:00
abstract::Preformulation is an important step in the rational formulation of an active pharmaceutical ingredient (API). Micromeritics properties: bulk density (BD) and tapped density (TD), compressibility index (Carr's index), Hauser's ratio (H), and sieve analysis were performed in order to determine the best excipients to be ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/307032
更新日期:2015-01-01 00:00:00
abstract::Introduction. Pelvic organ prolapse (POP) and urinary incontinence (UI) have increasing prevalence in the elderly population. The aim of this study was to compare the comorbidities of these procedures between <70 y/o and ≥70 y/o patients. Materials and Methods. In our retrospective study over a period of 2.5 years, 40...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5184595
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/7497314
更新日期:2018-03-26 00:00:00
abstract::Synthetic lethality (SL) is a novel strategy for anticancer therapies, whereby mutations of two genes will kill a cell but mutation of a single gene will not. Therefore, a cancer-specific mutation combined with a drug-induced mutation, if they have SL interactions, will selectively kill cancer cells. While numerous SL...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/196034
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9549036
更新日期:2016-01-01 00:00:00
abstract::Brachial plexus injury often involves traumatic root avulsion resulting in permanent paralysis of the innervated muscles. The lack of sufficient regeneration from spinal motoneurons to the peripheral nerve (PN) is considered to be one of the major causes of the unsatisfactory outcome of various surgical interventions ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/658753
更新日期:2014-01-01 00:00:00
abstract::Angiogenesis is essential for tumor growth and metastasis. Over the last decades, a substantial progress has been achieved in defining different patterns of tumor microcirculation. Sprouting angiogenesis, the oldest model of microcirculation, is the de novo vessel formation from preexisting blood vessels. Vessel split...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/986768
更新日期:2014-01-01 00:00:00