Kinetics of Tyrosinase Inhibitory Activity Using Vitis vinifera Leaf Extracts.

Abstract:

:Natural medical plant is considered as a good source of tyrosinase inhibitors. Red vine leaf extract (RVLE) can be applied to a wide variety of medical disciplines, such as treatments for chronic venous insufficiency over many decades. This study investigated the tyrosinase inhibitory activity of RVLE containing gallic acid, chlorogenic acid, epicatechin, rutin, and resveratrol which are effective for skin hyperpigmentation. The five components contents are 1.03, 0.2, 18.55, 6.45, and 0.48 mg/g for gallic acid, chlorogenic acid, epicatechin, rutin, and resveratrol. The kinetic study showed the tyrosinase inhibitory of RVLE via a competitive reaction mechanism. RVLE solution has an IC50 (the half inhibitory concentration) value of 3.84 mg/mL for tyrosinase inhibition, that is, an effective tyrosinase inhibitory activity, and can be used as a whitening agent for cosmetic formulations in the future.

journal_name

Biomed Res Int

authors

Lin YS,Chen HJ,Huang JP,Lee PC,Tsai CR,Hsu TF,Huang WY

doi

10.1155/2017/5232680

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

5232680

eissn

2314-6133

issn

2314-6141

journal_volume

2017

pub_type

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