Abstract:
:Natural medical plant is considered as a good source of tyrosinase inhibitors. Red vine leaf extract (RVLE) can be applied to a wide variety of medical disciplines, such as treatments for chronic venous insufficiency over many decades. This study investigated the tyrosinase inhibitory activity of RVLE containing gallic acid, chlorogenic acid, epicatechin, rutin, and resveratrol which are effective for skin hyperpigmentation. The five components contents are 1.03, 0.2, 18.55, 6.45, and 0.48 mg/g for gallic acid, chlorogenic acid, epicatechin, rutin, and resveratrol. The kinetic study showed the tyrosinase inhibitory of RVLE via a competitive reaction mechanism. RVLE solution has an IC50 (the half inhibitory concentration) value of 3.84 mg/mL for tyrosinase inhibition, that is, an effective tyrosinase inhibitory activity, and can be used as a whitening agent for cosmetic formulations in the future.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Lin YS,Chen HJ,Huang JP,Lee PC,Tsai CR,Hsu TF,Huang WYdoi
10.1155/2017/5232680subject
Has Abstractpub_date
2017-01-01 00:00:00pages
5232680eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
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