Development of bioadhesive chitosan superporous hydrogel composite particles based intestinal drug delivery system.

Abstract:

:Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 3(2) full factorial design was applied to optimize the concentration of chitosan and HPMC. The drug loaded bioadhesive SPHC particles were filled in capsule, and the capsule was coated with cellulose acetate phthalate and evaluated for drug content, in vitro drug release, and stability studies. To ascertain the drug release kinetics, the drug release profiles were fitted for mathematical models. The prepared system remains bioadhesive up to eight hours in intestine and showed Hixson-Crowell release with anomalous nonfickian type of drug transport. The application of SPHC polymer particles as a biomaterial carrier opens a new insight into bioadhesive drug delivery system and could be a future platform for other molecules for intestinal delivery.

journal_name

Biomed Res Int

authors

Chavda H,Modhia I,Mehta A,Patel R,Patel C

doi

10.1155/2013/563651

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

563651

eissn

2314-6133

issn

2314-6141

journal_volume

2013

pub_type

杂志文章
  • An Ultrasound Simulation Model for the Pulsatile Blood Flow Modulated by the Motion of Stenosed Vessel Wall.

    abstract::This paper presents an ultrasound simulation model for pulsatile blood flow, modulated by the motion of a stenosed vessel wall. It aims at generating more realistic ultrasonic signals to provide an environment for evaluating ultrasound signal processing and imaging and a framework for investigating the behaviors of bl...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8502873

    authors: Zhang Q,Zhang Y,Zhou Y,Zhang K,Zhang K,Gao L

    更新日期:2016-01-01 00:00:00

  • Weaker Self-Esteem in Adolescence Predicts Smoking.

    abstract:BACKGROUND:To study whether weaker self-esteem in adolescence is connected with smoking behavior in adulthood. METHODS:An age cohort born in 1979 responded to the Lawrence Self-Esteem Questionnaire (LAWSEQ) at the age of 16 (n = 1,072). Respondents' smoking behavior was monitored annually during adolescence and 75.3% ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/687541

    authors: Saari AJ,Kentala J,Mattila KJ

    更新日期:2015-01-01 00:00:00

  • Enhanced Production of Polymyxin E in Paenibacillus polymyxa by Replacement of Glucose by Starch.

    abstract::Polymyxin E or colistin, produced by Paenibacillus polymyxa, is an important antibiotic against Gram-negative pathogens. The objective of this study is to evaluate the effect of starch in fermentation medium on colistin biosynthesis in P. polymyxa. The results indicated that replacement of glucose by starch stimulated...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/1934309

    authors: Yu Z,Sun Z,Yin J,Qiu J

    更新日期:2018-10-14 00:00:00

  • Correlation between Pathological Characteristics and Young's Modulus Value of Spastic Gastrocnemius in a Spinal Cord Injury Rat Model.

    abstract::The goal of the present study were (1) to investigate the pathological characteristics of gastrocnemius muscle (GM) and quantitatively assess GM tissue stiffness in rat models with spinal cord injury (SCI) and (2) to explore the correlation between pathological characteristics changes and Young's modulus value of GM. ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/5387948

    authors: Jiang L,Wang YJ,Wang QY,Wang Q,Wei XM,Li N,Guo WP,Dou ZL

    更新日期:2017-01-01 00:00:00

  • Transforaminal Percutaneous Endoscopic Lumbar Decompression by Using Rigid Bendable Burr for Lumbar Lateral Recess Stenosis: Technique and Clinical Outcome.

    abstract:Background:Open laminectomy has been regarded as the standard surgical procedure for lumbar lateral recess stenosis during the last decades. Although percutaneous endoscopic lumbar decompression has led to successful results comparable with open decompression, its application in LSS with is still challenging and techni...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2601232

    authors: Tang S,Jin S,Liao X,Huang K,Luo J,Zhu T

    更新日期:2018-11-26 00:00:00

  • CYLD Deubiquitinase Negatively Regulates High Glucose-Induced NF-κB Inflammatory Signaling in Mesangial Cells.

    abstract::Nuclear factor-kappa B (NF-κB) is the key part of multiple signal transduction of inflammation in the pathogenesis of diabetic nephropathy (DN). The ubiquitin-proteasome system is extensively involved in the regulation of the NF-κB pathway. Cylindromatosis (CYLD) has deubiquitinase activity and acts as a negative regu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/3982906

    authors: Li Y,Huang W,Xu Y,Zhou L,Liang Y,Gao C,Long Y,Xu Y

    更新日期:2017-01-01 00:00:00

  • Endoscopic Management of Foreign Bodies in the Upper Gastrointestinal Tract of Adults.

    abstract:BACKGROUND:Foreign object ingestion and food bolus impaction are a common clinical problem. We report our clinical experiences in endoscopic management for adults, foreign body ingestion, and food bolus impaction. METHOD:A retrospective chart review study was conducted on adult patients with foreign body ingestion and...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/658602

    authors: Yao CC,Wu IT,Lu LS,Lin SC,Liang CM,Kuo YH,Yang SC,Wu CK,Wang HM,Kuo CH,Chiou SS,Wu KL,Chiu YC,Chuah SK,Tai WC

    更新日期:2015-01-01 00:00:00

  • Genotypic and antimicrobial characterisation of Propionibacterium acnes isolates from surgically excised lumbar disc herniations.

    abstract::The anaerobic skin commensal Propionibacterium acnes is an underestimated cause of human infections and clinical conditions. Previous studies have suggested a role for the bacterium in lumbar disc herniation and infection. To further investigate this, five biopsy samples were surgically excised from each of 64 patient...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/530382

    authors: Rollason J,McDowell A,Albert HB,Barnard E,Worthington T,Hilton AC,Vernallis A,Patrick S,Elliott T,Lambert P

    更新日期:2013-01-01 00:00:00

  • Treatment of cardiovascular disease by traditional Chinese medicine against pregnane X receptor.

    abstract::Recently, cardiovascular disease, also known as loop circulatory system diseases or disorders, is one of the serious diseases including heart disease, stroke, atherosclerosis, myocardial infarction, hypertension, hypotension, and thrombosis. Human pregnane X receptor, PXR, plays a crucial role in exogenous and endobio...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/950191

    authors: Chen KB,Chen HY,Chen KC,Chen CY

    更新日期:2014-01-01 00:00:00

  • Performance enhancement of a web-based picture archiving and communication system using commercial off-the-shelf server clusters.

    abstract::The rapid development of picture archiving and communication systems (PACSs) thoroughly changes the way of medical informatics communication and management. However, as the scale of a hospital's operations increases, the large amount of digital images transferred in the network inevitably decreases system efficiency. ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/657417

    authors: Liu YL,Shih CT,Chang YJ,Chang SJ,Wu J

    更新日期:2014-01-01 00:00:00

  • In Vitro Anticancer Potential of Berberis lycium Royle Extracts against Human Hepatocarcinoma (HepG2) Cells.

    abstract::Human liver cancer has emerged as a serious health concern in the world, associated with poorly available therapies. The Berberis genus contains vital medicinal plants with miraculous healing properties and a wide range of bioactivities. In this study, different crude extracts of B. lycium Royle were prepared and scre...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8256809

    authors: Mustafa K,Mohamed H,Shah AM,Yu S,Akhlaq M,Xiao H,Li S,Naz T,Nosheen S,Bai X,Song Y

    更新日期:2020-10-14 00:00:00

  • Mechanisms of T-cell immunosuppression by mesenchymal stromal cells: what do we know so far?

    abstract::Mesenchymal stromal cells (MSCs) are multipotent cells, which can give rise to several cell types including osteoblasts, adipocytes, and chondroblasts. These cells can be found in a variety of adult and fetal tissues, such as bone marrow, adipose tissue, cord blood, and placenta. In recent years, the biological proper...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/216806

    authors: Haddad R,Saldanha-Araujo F

    更新日期:2014-01-01 00:00:00

  • Evaluation of Drug Susceptibility of Microorganisms in Odontogenic Inflammations and Dental Surgery Procedures Performed on an Outpatient Basis.

    abstract::Bacterial infections are the most common cause of purulent soft tissue inflammations in the head and neck area. These bacteria are also responsible for the majority of inflammatory complications after third molar removal. The key to success of antibacterial treatment in both cases is the use of an appropriate antibact...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/2010453

    authors: Bogacz M,Morawiec T,Śmieszek-Wilczewska J,Janowska-Bogacz K,Bubiłek-Bogacz A,Rój R,Pinocy K,Mertas A

    更新日期:2019-10-07 00:00:00

  • Chronic Hypoxia-Induced Microvessel Proliferation and Basal Membrane Degradation in the Bone Marrow of Rats Regulated through the IL-6/JAK2/STAT3/MMP-9 Pathway.

    abstract::Chronic hypoxia (CH) is characterized by long-term hypoxia that is associated with microvessel proliferation and basal membrane (BM) degradation in tissues. The IL-6/JAK2/STAT3/MMP-9 pathway has been described in a variety of human cancers and plays an essential role in microvessel proliferation and BM degradation. Th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9204708

    authors: Zhu M,Yang M,Yang Q,Liu W,Geng H,Pan L,Wang L,Ge R,Ji L,Cui S,Li Z

    更新日期:2020-01-23 00:00:00

  • Diffusion tensor histogram analysis of pediatric diffuse intrinsic pontine glioma.

    abstract:PURPOSE:To evaluate tumor structure in children with diffuse intrinsic pontine glioma (DIPG) using histogram analyses of mean diffusivity (MD), determine potential treatment and corticosteroid-related effects on MD, and monitor changes in MD distributions over time. MATERIALS AND METHODS:DTI was performed on a 1.5T GE...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/647356

    authors: Steffen-Smith EA,Sarlls JE,Pierpaoli C,Shih JH,Bent RS,Walker L,Warren KE

    更新日期:2014-01-01 00:00:00

  • Systemic and Ocular Hemodynamic Risk Factors in Glaucoma.

    abstract::Primary open angle glaucoma (POAG) is a multifactorial disease characterized by progressive retinal ganglion cell death and visual field loss. It is known that alterations in intraocular pressure (IOP), blood pressure (BP), and ocular perfusion pressure (OPP) can play a significant role in the pathogenesis of the dise...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/141905

    authors: Choi J,Kook MS

    更新日期:2015-01-01 00:00:00

  • Prevalence, Intensity, and Factors Associated with Urogenital Schistosomiasis among Women of Reproductive Age in Mbogwe District Council, Geita Region, Tanzania.

    abstract:Background:Urogenital schistosomiasis remains a public health problem in Tanzania. Control programs mostly target school-going children ignoring other vulnerable groups like women of child bearing age. Previous evidence has shown that women of reproductive age suffer greatest morbidities in endemic areas. This study so...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/5923025

    authors: Rite EE,Kapalata SN,Munisi DZ

    更新日期:2020-10-23 00:00:00

  • Effects of Physical Activity Programs on the Improvement of Dementia Symptom: A Meta-Analysis.

    abstract::Objective. To confirm that physical activity program improves the symptoms of dementia and the most effective physical activity was selected to help establish exercise programs. Methods. Three databases, PubMed, Science Direct, and Willey online, were used to collect articles. The databases were published between Janu...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析

    doi:10.1155/2016/2920146

    authors: Lee HS,Park SW,Park YJ

    更新日期:2016-01-01 00:00:00

  • Cholesterol Degradation and Production of Extracellular Cholesterol Oxidase from Bacillus pumilus W1 and Serratia marcescens W8.

    abstract::Cholesterol is a waxy substance present in all types of the body cells. The presence of higher concentration of low density lipoprotein (LDL) is characterized by abnormal cholesterol level and is associated with cardiovascular diseases which lead to the development of atheroma in arteries known as atherosclerosis. The...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/1359528

    authors: Wali H,Rehman FU,Umar A,Ahmed S

    更新日期:2019-04-28 00:00:00

  • Nonionic surfactant vesicles in ocular delivery: innovative approaches and perspectives.

    abstract::With the recent advancement in the field of ocular therapy, drug delivery approaches have been elevated to a new concept in terms of nonionic surfactant vesicles (NSVs), that is, the ability to deliver the therapeutic agent to a patient in a staggered profile. However the major drawbacks of the conventional drug deliv...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/263604

    authors: Sahoo RK,Biswas N,Guha A,Sahoo N,Kuotsu K

    更新日期:2014-01-01 00:00:00

  • Metabolic demand and muscle activation during different forms of bodyweight supported locomotion in men with incomplete SCI.

    abstract::Body weight supported locomotor training uses neuroplasticity principles to improve recovery following a spinal cord injury (SCI). Steady state locomotion using the same body weight support (BWS) percent was compared in 7 males (42.6 ± 4.29 years) with incomplete SCI and matched (gender, age) noninjured controls (42.7...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2014/632765

    authors: Fenuta AM,Hicks AL

    更新日期:2014-01-01 00:00:00

  • Humeral Diaphyseal Fracture Nonunion: An Audit of the Outcome from Intramedullary Nailing and DCP Plating.

    abstract:Purpose:This study aims to compare the functional outcomes of nonunion humeral diaphyseal fractures following conservative treatment when managed surgically with either a plate or intramedullary (IM) nail fixation. Methods:This was a retrospective study of 56 patients with nonunion humeral fractures following conserva...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9107898

    authors: Micic I,Kholinne E,Kwak JM,Sun Y,Nanda A,Kim H,Koh KH,Jeon IH

    更新日期:2019-07-22 00:00:00

  • Efficacy of rhBMP-2 Loaded PCL/β-TCP/bdECM Scaffold Fabricated by 3D Printing Technology on Bone Regeneration.

    abstract::This study was undertaken to evaluate the effect of 3D printed polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) scaffold containing bone demineralized and decellularized extracellular matrix (bdECM) and human recombinant bone morphogenetic protein-2 (rhBMP-2) on bone regeneration. Scaffolds were divided into PCL/...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2876135

    authors: Bae EB,Park KH,Shim JH,Chung HY,Choi JW,Lee JJ,Kim CH,Jeon HJ,Kang SS,Huh JB

    更新日期:2018-02-27 00:00:00

  • Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis.

    abstract::Natural products are valuable sources for drug discovery because they have a wide variety of useful chemical components and biological properties. A quick reevaluation of the potential therapeutic properties of established natural products was made possible by the recent development of the methodology and improvement ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/6716547

    authors: Jeon YJ,Shin JI,Lee S,Lee YG,Kim JB,Kwon HC,Kim SH,Kim I,Lee K,Han YS

    更新日期:2018-08-01 00:00:00

  • Histological, histochemical, and protein changes after induced malocclusion by occlusion alteration of Wistar rats.

    abstract::Although disorders of the stomatognathic system are common, the mechanisms involved are unknown. Our objective was to study the changes in the masseter muscles after unilateral exodontia. Molar extraction was performed on Wistar rats (left side), and the animals were sacrificed after either 14 or 26 days. The masseter...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/563463

    authors: Guerra Cde S,Carla Lara Pereira Y,Issa JP,Luiz KG,Guimarães EA,Gerlach RF,Iyomasa MM

    更新日期:2014-01-01 00:00:00

  • Association between Sedentary Behaviour and Physical, Cognitive, and Psychosocial Status among Older Adults in Assisted Living.

    abstract:OBJECTIVE:Identification of the factors that influence sedentary behaviour in older adults is important for the design of appropriate intervention strategies. In this study, we determined the prevalence of sedentary behaviour and its association with physical, cognitive, and psychosocial status among older adults resid...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/9160504

    authors: Leung PM,Ejupi A,van Schooten KS,Aziz O,Feldman F,Mackey DC,Ashe MC,Robinovitch SN

    更新日期:2017-01-01 00:00:00

  • CSF-S100B Is a Potential Candidate Biomarker for Neuromyelitis Optica Spectrum Disorders.

    abstract::Astrocytic impairment is a pathologic feature of neuromyelitis optica spectrum disorder (NMOSD). S100B and glial fibrillary acidic protein (GFAP) are the two most commonly used astrocytic markers. The aim of this study was to evaluate whether CSF-S100B could serve as a marker of NMOSD. We enrolled 49 NMOSD patients [2...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2018/5381239

    authors: Wei Y,Chang H,Li X,Du L,Xu W,Cong H,Yao Y,Zhang X,Yin L

    更新日期:2018-10-22 00:00:00

  • Suppression of lncRNA MALAT1 Reduces LPS- or IL-17A-Induced Inflammatory Response in Human Middle Ear Epithelial Cells via the NF-κB Signaling Pathway.

    abstract::Otitis media (OM) is a common inflammatory disease of the middle ear cavity and mainly occurs in children. As a critical regulator of inflammation response, the nuclear factor kappa B (NF-κB) pathway has been found to play an essential role in the pathogenesis of various human diseases. The aim of this study was to ex...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2021/8844119

    authors: Yang X,Zhang Q,Lu H,Wang C,Xia L

    更新日期:2021-01-06 00:00:00

  • The steady-state serum concentration of genistein aglycone is affected by formulation: a bioequivalence study of bone products.

    abstract::An FDA-regulated, prescription medical food (Fosteum; 27 mg natural genistein, 200 IU cholecalciferol, 20 mg citrated zinc bisglycinate (4 mg elemental zinc) per capsule) and an over-the-counter (OTC) supplement (Citracal Plus Bone Density Builder; 27 mg synthetic genistein, 600 mg elemental calcium (calcium citrate),...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2013/273498

    authors: Bitto A,Burnett BP,Polito F,Russo S,D'Anna R,Pillai L,Squadrito F,Altavilla D,Levy RM

    更新日期:2013-01-01 00:00:00

  • Late adherent human bone marrow stromal cells form bone and restore the hematopoietic microenvironment in vivo.

    abstract::Bone marrow stromal cells (BMSCs) are a valuable resource for skeletal regenerative medicine because of their osteogenic potential. In spite of the very general term "stem cell," this population of cells is far from homogeneous, and different BMSCs clones have greatly different phenotypic properties and, therefore, po...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/790842

    authors: Vianna VF,Bonfim DC,Cavalcanti Ados S,Fernandes MC,Kahn SA,Casado PL,Lima IC,Murray SS,Murray EJ,Duarte ME

    更新日期:2013-01-01 00:00:00