Chromatographic fingerprint analysis and effects of the medicinal plant species Mitracarpus frigidus on adult Schistosoma mansoni worms.

Abstract:

:The aims of this work were to evaluate the in vitro and in vivo schistosomicidal properties of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and to determine its HPLC profile. For the in vitro experiment, four pairs of adult worms, obtained from infected mice, were exposed to different concentrations of MFM (100 to 400 μg/mL) for 24 and 48 h and analyzed under an inverted microscope. For the in vivo experiment, mice were inoculated with cercariae and, 20 days after infection, MFM (100 and 300 mg/kg) was administered orally for the following 25 days. Mice were euthanized after 60 days. MFM showed in vitro schistosomicidal activity, exhibiting the opening of the gynaecophoral canal of some male schistosomes, the presence of contorted muscles, vesicles, and the darkening of the paired worms skin. In vivo experiments showed that MFM treatments significantly reduced total worm count, as praziquantel, showing a decrease in liver and spleen weight. Also, a significant reduction in granuloma density was observed. MFM treatment did not cause alterations in the liver function of either infected or noninfected mice. The HPLC chromatogram profile showed the presence of kaempferol-O-rutinoside, rutin, kaempferol, psychorubrin, and ursolic acid.

journal_name

Biomed Res Int

authors

Fabri RL,Aragão DM,Florêncio JR,Pinto Nde C,Mattos AC,Coelho PM,Castañon MC,Vasconcelos EG,Pinto Pde F,Scio E

doi

10.1155/2014/941318

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

941318

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

杂志文章
  • Ethanol extract of Cordyceps militaris grown on germinated soybeans attenuates dextran-sodium-sulfate- (DSS-) induced colitis by suppressing the expression of matrix metalloproteinases and inflammatory mediators.

    abstract::The effect of Cordyceps militaris (CM) grown on germinated soybeans (GSC) in the inflammatory bowel disease (IBD) model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS-) induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC si...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/102918

    authors: Park DK,Park HJ

    更新日期:2013-01-01 00:00:00

  • Effects of 8-Week Hatha Yoga Training on Metabolic and Inflammatory Markers in Healthy, Female Chinese Subjects: A Randomized Clinical Trial.

    abstract::We aimed to determine the effects of an 8 wk Hatha yoga training on blood glucose, insulin, lipid profiles, endothelial microparticles (EMPs), and inflammatory status in healthy, lean, and female Chinese subjects. A total of 30 healthy, female Chinese subjects were recruited and randomized into control or yoga practic...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2016/5387258

    authors: Chen N,Xia X,Qin L,Luo L,Han S,Wang G,Zhang R,Wan Z

    更新日期:2016-01-01 00:00:00

  • Construction Formula of Biological Age Using the Principal Component Analysis.

    abstract::The biological age (BA) equation is a prediction model that utilizes an algorithm to combine various biological markers of ageing. Different from traditional concepts, the BA equation does not emphasize the importance of a golden index but focuses on using indices of vital organs to represent the senescence of whole b...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/4697017

    authors: Jia L,Zhang W,Jia R,Zhang H,Chen X

    更新日期:2016-01-01 00:00:00

  • The Alcohol Extract of Coreopsis tinctoria Nutt Ameliorates Diabetes and Diabetic Nephropathy in db/db Mice through miR-192/miR-200b and PTEN/AKT and ZEB2/ECM Pathways.

    abstract::The study aims to investigate the effects of the alcohol extract of Coreopsis tinctoria Nutt (AC) on diabetic nephropathy (DN) mice. A total of 30 db/db (DN) mice were divided into 3 groups, which were treated with AC (300 mg/kg/day), metformin (180 mg/kg/day), or saline by gavage for 10 weeks. Ten db/m mice treated w...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5280514

    authors: Yu S,Zhao H,Yang W,Amat R,Peng J,Li Y,Deng K,Mao X,Jiao Y

    更新日期:2019-03-28 00:00:00

  • Effects of Arteriovenous Thrombolysis Combined with Mechanical Thrombectomy on Efficacy and Neurological Function of Acute Cerebral Infarct Patients.

    abstract:Objective:To investigate the effects of arteriovenous thrombolysis combined with mechanical thrombectomy on clinical efficacy, neurological function, and the changes of nerve injury markers of acute cerebral infarct (ACI) patients. Methods:A total of 143 cases with ACI admitted to our hospital from June 2017 to June 2...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9743075

    authors: Ding T,Tang L,Hu B,Yuan J,Li X,Wen J

    更新日期:2020-10-09 00:00:00

  • A 12-Week Assessment of the Treatment of White Spot Lesions with CPP-ACP Paste and/or Fluoride Varnish.

    abstract::This 12-week clinical study evaluated the impact of 10% CPP-ACP and 5% sodium fluoride varnish regimes on the regression of nonorthodontic white spot lesions (WSLs). The study included 21 children with 101 WSLs who were randomised into four treatment regimes: weekly clinical applications of fluoride varnish for the fi...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2016/8357621

    authors: Güçlü ZA,Alaçam A,Coleman NJ

    更新日期:2016-01-01 00:00:00

  • LraI from Lactococcus raffinolactis BGTRK10-1, an Isoschizomer of EcoRI, Exhibits Ion Concentration-Dependent Specific Star Activity.

    abstract::Restriction enzymes are the main defence system against foreign DNA, in charge of preserving genome integrity. Lactococcus raffinolactis BGTRK10-1 expresses LraI Type II restriction-modification enzyme, whose activity is similar to that shown for EcoRI; LraI methyltransferase protects DNA from EcoRI cleavage. The gene...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/5657085

    authors: Miljkovic M,Malesevic M,Filipic B,Vukotic G,Kojic M

    更新日期:2018-01-29 00:00:00

  • Organotypic culture of breast tumor explants as a multicellular system for the screening of natural compounds with antineoplastic potential.

    abstract::Breast cancer is the leading cause of death in women worldwide. The search for novel compounds with antitumor activity, with less adverse effects and higher efficacy, and the development of methods to evaluate their toxicity is an area of intense research. In this study we implemented the preparation and culture of br...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/618021

    authors: Carranza-Torres IE,Guzmán-Delgado NE,Coronado-Martínez C,Bañuelos-García JI,Viveros-Valdez E,Morán-Martínez J,Carranza-Rosales P

    更新日期:2015-01-01 00:00:00

  • Unraveling the lipolytic activity of thermophilic bacteria isolated from a volcanic environment.

    abstract::In a bioprospecting effort towards novel thermostable lipases, we assessed the lipolytic profile of 101 bacterial strains isolated from the volcanic area of Santorini, Aegean Sea, Greece. Screening of lipase activity was performed both in agar plates and liquid cultures using olive oil as carbon source. Significant di...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/703130

    authors: Stathopoulou PM,Savvides AL,Karagouni AD,Hatzinikolaou DG

    更新日期:2013-01-01 00:00:00

  • Pandemic Avian Influenza and Intra/Interhaemagglutinin Subtype Electrostatic Variation among Viruses Isolated from Avian, Mammalian, and Human Hosts.

    abstract::Host jump can result in deadly pandemic events when avian influenza A viruses broaden their host specificity and become able to infect mammals, including humans. Haemagglutinin-the major capsid protein in influenza A viruses-is subjected to high rate mutations, of which several occur at its "head": the receptor-bindin...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3870508

    authors: Righetto I,Filippini F

    更新日期:2018-05-17 00:00:00

  • Overexpression of MicroRNA-122 Resists Oxidative Stress-Induced Human Umbilical Vascular Endothelial Cell Injury by Inhibition of p53.

    abstract::Deep venous thrombosis (DVT) constitutes a great threat to health worldwide. Endothelial cell injury and dysfunction comprise the critical contributor for the development of DVT. However, the mechanism behind it remains poorly elucidated. The study is aimed at investigating the role of microRNA-122 (miR-122) and oxida...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9791608

    authors: Li HQ,Pan ZY,Yang Z,Zhang DB,Chen Q

    更新日期:2020-10-27 00:00:00

  • Phytoestrogen α-Zearalanol attenuates homocysteine-induced apoptosis in human umbilical vein endothelial cells.

    abstract::Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. The enhanced nitrative stress plays an important role in homocysteine-induced endothelial dysfunction. Previous studies have showed that phytoestrogen α -zearalanol alleviated endothelial injury in ovariectomized hyperhomocysteinemic rats;...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2013/813450

    authors: Liu T,Hou DD,Zhao Q,Liu W,Zhen PP,Xu JP,Wang K,Huang HX,Li X,Zhang H,Xu HB,Wang W

    更新日期:2013-01-01 00:00:00

  • The macrophage galactose-type lectin-1 (MGL1) recognizes Taenia crassiceps antigens, triggers intracellular signaling, and is critical for resistance to this infection.

    abstract::C-type lectins are multifunctional sugar-binding molecules expressed on dendritic cells (DCs) and macrophages that internalize antigens for processing and presentation. Macrophage galactose-type lectin 1 (MGL1) recognizes glycoconjugates expressing Lewis X structures which contain galactose residues, and it is selecti...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/615865

    authors: Montero-Barrera D,Valderrama-Carvajal H,Terrazas CA,Rojas-Hernández S,Ledesma-Soto Y,Vera-Arias L,Carrasco-Yépez M,Gómez-García L,Martínez-Saucedo D,Becerra-Díaz M,Terrazas LI

    更新日期:2015-01-01 00:00:00

  • Enhanced oral bioavailability of efavirenz by solid lipid nanoparticles: in vitro drug release and pharmacokinetics studies.

    abstract::Solid lipid nanoparticle is an efficient lipid based drug delivery system which can enhance the bioavailability of poorly water soluble drugs. Efavirenz is a highly lipophilic drug from nonnucleoside inhibitor category for treatment of HIV. Present work illustrates development of an SLN formulation for Efavirenz with ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/363404

    authors: Gaur PK,Mishra S,Bajpai M,Mishra A

    更新日期:2014-01-01 00:00:00

  • A Review of NEPA, a Novel Fixed Antiemetic Combination with the Potential for Enhancing Guideline Adherence and Improving Control of Chemotherapy-Induced Nausea and Vomiting.

    abstract::Combination antiemetic regimens targeting multiple molecular pathways associated with emesis have become the standard of care for prevention of chemotherapy-induced nausea and vomiting (CINV) related to highly and moderately emetogenic chemotherapies. Antiemetic consensus guidelines from several professional societies...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/651879

    authors: Hesketh PJ,Aapro M,Jordan K,Schwartzberg L,Bosnjak S,Rugo H

    更新日期:2015-01-01 00:00:00

  • No evidence for an association of vitamin D deficiency and migraine: a systematic review of the literature.

    abstract::Vitamin D deficiency is associated with a number of human disorders, including cardiovascular disease, cancer, diabetes, frailty, and infections. Since an association between vitamin D and migraine has also been recently speculated, we performed an electronic search on Medline, Scopus, and Web of Science using the key...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/827635

    authors: Lippi G,Cervellin G,Mattiuzzi C

    更新日期:2014-01-01 00:00:00

  • Candida Bloodstream Infections in Italy: Changing Epidemiology during 16 Years of Surveillance.

    abstract::Although considerable progress has been made in the management of patients with invasive fungal infections, Candida bloodstream infections are still widespread in hospital settings. Incidence rates vary geographically, often because of different patient populations. The aim of the present study was to describe the epi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/256580

    authors: Caggiano G,Coretti C,Bartolomeo N,Lovero G,De Giglio O,Montagna MT

    更新日期:2015-01-01 00:00:00

  • Lung cancer stem cell lose their stemness default state after exposure to microgravity.

    abstract::Microgravity influences cell differentiation by modifying the morphogenetic field in which stem cells are embedded. Preliminary data showed indeed that stem cells are committed to selective differentiation when exposed to real or simulated microgravity. Our study provides evidence that a similar event occurs when canc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/470253

    authors: Pisanu ME,Noto A,De Vitis C,Masiello MG,Coluccia P,Proietti S,Giovagnoli MR,Ricci A,Giarnieri E,Cucina A,Ciliberto G,Bizzarri M,Mancini R

    更新日期:2014-01-01 00:00:00

  • Evaluation of granulocyte colony-stimulating factor effects on treatment-resistant thin endometrium in women undergoing in vitro fertilization.

    abstract::The aim of the study was to assess the granulocyte colony-stimulating factor (G-CSF) effects on unresponsive thin (<7 mm) endometrium in women undergoing in vitro fertilization (IVF). We included thirty-seven subjects who had thin unresponsive endometrium on the day of triggering ovulation. These patients also failed ...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2014/913235

    authors: Kunicki M,Łukaszuk K,Woclawek-Potocka I,Liss J,Kulwikowska P,Szczyptańska J

    更新日期:2014-01-01 00:00:00

  • Development and remodeling of the vertebrate blood-gas barrier.

    abstract::During vertebrate development, the lung inaugurates as an endodermal bud from the primitive foregut. Dichotomous subdivision of the bud results in arborizing airways that form the prospective gas exchanging chambers, where a thin blood-gas barrier (BGB) is established. In the mammalian lung, this proceeds through conv...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/101597

    authors: Makanya A,Anagnostopoulou A,Djonov V

    更新日期:2013-01-01 00:00:00

  • Composition Analysis and Feature Selection of the Oral Microbiota Associated with Periodontal Disease.

    abstract::Periodontitis is an inflammatory disease involving complex interactions between oral microorganisms and the host immune response. Understanding the structure of the microbiota community associated with periodontitis is essential for improving classifications and diagnoses of various types of periodontal diseases and w...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3130607

    authors: Chen WP,Chang SH,Tang CY,Liou ML,Tsai SJ,Lin YL

    更新日期:2018-11-15 00:00:00

  • Young Children Display Diurnal Patterns of Salivary IgA and Alpha-Amylase Expression Which Are Independent of Food Intake and Demographic Factors.

    abstract:Background:Salivary alpha-amylase (sAA) and salivary immunoglobulin A (sIgA) have been proposed as biomarkers for research on the mucosal immune system and on stress. Expression of both sAA and sIgA has been described to follow opposing diurnal patterns. This knowledge is crucial for the interpretation of studies using...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/3687416

    authors: Lim PW,Nambiar S,Muhardi L,Abdul Kader UH,Garssen J,Sandalova E

    更新日期:2019-01-14 00:00:00

  • Overexpression of D-xylose reductase (xyl1) gene and antisense inhibition of D-xylulokinase (xyiH) gene increase xylitol production in Trichoderma reesei.

    abstract::T. reesei is an efficient cellulase producer and biomass degrader. To improve xylitol production in Trichoderma reesei strains by genetic engineering, two approaches were used in this study. First, the presumptive D-xylulokinase gene in T. reesei (xyiH), which has high homology to known fungi D-xylulokinase genes, was...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/169705

    authors: Hong Y,Dashtban M,Kepka G,Chen S,Qin W

    更新日期:2014-01-01 00:00:00

  • Effect of High Dietary Tryptophan on Intestinal Morphology and Tight Junction Protein of Weaned Pig.

    abstract::Tryptophan (Trp) plays an essential role in pig behavior and growth performances. However, little is known about Trp's effects on tight junction barrier and intestinal health in weaned pigs. In the present study, twenty-four (24) weaned pigs were randomly assigned to one of the three treatments with 8 piglets/treatmen...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2912418

    authors: Tossou MC,Liu H,Bai M,Chen S,Cai Y,Duraipandiyan V,Liu H,Adebowale TO,Al-Dhabi NA,Long L,Tarique H,Oso AO,Liu G,Yin Y

    更新日期:2016-01-01 00:00:00

  • Diagnostic and Therapeutic Biomarkers in Glioblastoma: Current Status and Future Perspectives.

    abstract::Glioblastoma (GBM) is a primary neuroepithelial tumor of the central nervous system, characterized by an extremely aggressive clinical phenotype. Patients with GBM have a poor prognosis and only 3-5% of them survive for more than 5 years. The current GBM treatment standards include maximal resection followed by radiot...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/8013575

    authors: Szopa W,Burley TA,Kramer-Marek G,Kaspera W

    更新日期:2017-01-01 00:00:00

  • Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on T Cell Differentiation in Primary Biliary Cholangitis.

    abstract::Exposure to dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is reported to affect the autoimmune system and increase the risk of autoimmune disease. Generally, dioxin exerts its toxicity via aryl hydrocarbon receptor (AhR). Primary biliary cholangitis (PBC) is a chronic autoimmune disease, and its pathoge...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/1754975

    authors: She C,Wang J,Tang N,Liu Z,Xu L,Liu B

    更新日期:2020-08-24 00:00:00

  • Prevalence of Extended Spectrum β-Lactamase and Antimicrobial Susceptibility Pattern of Clinical Isolates of Pseudomonas from Patients of Khyber Pakhtunkhwa, Pakistan.

    abstract::Majority of gram negative pathogenic bacteria are responsible for extended spectrum β-lactamases (ESBLs) production, which show resistance to some newer generation of antibiotics. The study was aimed at evaluating the prevalence of ESBL and antibiotic susceptibility pattern of Pseudomonas isolates collected during 201...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/6068429

    authors: Ahmad M,Hassan M,Khalid A,Tariq I,Asad MH,Samad A,Mahmood Q,Murtaza G

    更新日期:2016-01-01 00:00:00

  • Adult Onset Vitiligo: Multivariate Analysis Suggests the Need for a Thyroid Screening.

    abstract::Background. There are limited epidemiological studies evaluating the effect of age at onset on disease features in vitiligo. Objectives. To identify factors associated with adult onset vitiligo in comparison with childhood onset vitiligo. Patients and Methods. We retrospectively collected medical records of 191 patien...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8065765

    authors: Lazzeri L,Colucci R,Cammi A,Dragoni F,Moretti S

    更新日期:2016-01-01 00:00:00

  • The importance of the ionic product for water to understand the physiology of the acid-base balance in humans.

    abstract::Human plasma is an aqueous solution that has to abide by chemical rules such as the principle of electrical neutrality and the constancy of the ionic product for water. These rules define the acid-base balance in the human body. According to the electroneutrality principle, plasma has to be electrically neutral and th...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/695281

    authors: Adeva-Andany MM,Carneiro-Freire N,Donapetry-García C,Rañal-Muíño E,López-Pereiro Y

    更新日期:2014-01-01 00:00:00

  • Strategies to characterize fungal lipases for applications in medicine and dairy industry.

    abstract::Lipases are water-soluble enzymes that act on insoluble substrates and catalyze the hydrolysis of long-chain triglycerides. Lipases play a vital role in the food, detergent, chemical, and pharmaceutical industries. In the past, fungal lipases gained significant attention in the industries due to their substrate specif...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/154549

    authors: Gopinath SC,Anbu P,Lakshmipriya T,Hilda A

    更新日期:2013-01-01 00:00:00