Construction Formula of Biological Age Using the Principal Component Analysis.

abstract：:Aims. We describe a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantify and compare simultaneously global methylation and hydroxymethylation in human DNA of different tissues. Materials and Methods. Blood and saliva DNA from fourteen volunteers was processed for epigenetic endpoints using LC-M...

journal_title：BioMed research international

authors： Godderis L,Schouteden C,Tabish A,Poels K,Hoet P,Baccarelli AA,Van Landuyt K

更新日期：2015-01-01 00:00:00

abstract：:As the fifth most common cancer in men and the eighth most common cancer in women, hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, with standard chemotherapy and radiation being minimally effective in prolonging survival. Virus hepatitis, particularly HBV and HCV infection is th...

journal_title：BioMed research international

authors： Wang Z,Jin W,Jin H,Wang X

更新日期：2014-01-01 00:00:00

abstract：:Periodontal remodeling and alveolar bone resorption and formation play essential roles during orthodontic tooth movement (OTM). In the process, human periodontal ligament cells (HPDLCs) sense and respond to orthodontic forces, contributing to the alveolar bone formation. However, the underlying mechanism in this proce...

journal_title：BioMed research international

authors： Yang Y,Wang BK,Chang ML,Wan ZQ,Han GL

更新日期：2018-11-05 00:00:00

abstract：:Cardiovascular disease (CVD) is the most common cause of death in the world. Recent studies have shown an association between adrenal insufficiency (AI) and increased cardiovascular risk (CVR). Patients with AI receive glucocorticoid (GC) replacement therapy which can lead to varying levels of blood cortisol. It was s...

journal_title：BioMed research international

authors： Rahvar AH,Haas CS,Danneberg S,Harbeck B

更新日期：2017-01-01 00:00:00

abstract：:Variations in human genome (e.g., single nucleotide polymorphisms, SNPs) may be associated with hereditary diseases, their complications, comorbidities, and drug responses. Using Web service SNP_TATA_Comparator presented in our previous paper, here we analyzed immediate surroundings of known SNP markers of diseases an...

journal_title：BioMed research international

authors： Ponomarenko P,Rasskazov D,Suslov V,Sharypova E,Savinkova L,Podkolodnaya O,Podkolodny NL,Tverdokhleb NN,Chadaeva I,Ponomarenko M,Kolchanov N

更新日期：2016-01-01 00:00:00

abstract：:Platelets are anuclear cells and are devoid of genomic DNA, but they are capable of de novo protein synthesis from mRNA derived from their progenitor cells, megakaryocytes. There is mounting evidence that microRNA (miRNA) plays an important role in regulating gene expression in platelets. miR-223 is the most abundant ...

journal_title：BioMed research international

authors： Shi R,Zhou X,Ji WJ,Zhang YY,Ma YQ,Zhang JQ,Li YM

更新日期：2015-01-01 00:00:00

abstract：:The aims of this work were to evaluate the in vitro and in vivo schistosomicidal properties of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and to determine its HPLC profile. For the in vitro experiment, four pairs of adult worms, obtained from infected mice, were exposed to different conce...

journal_title：BioMed research international

authors： Fabri RL,Aragão DM,Florêncio JR,Pinto Nde C,Mattos AC,Coelho PM,Castañon MC,Vasconcelos EG,Pinto Pde F,Scio E

更新日期：2014-01-01 00:00:00

abstract：:Farnesyl pyrophosphate synthase (FPPS) plays a vital role in the mevalonate pathway and has been shown to be involved in hypertrophy and cardiovascular diseases. Lentivirus-mediated RNA interference (RNAi) to knock down a gene of interest has become a promising new tool for the establishment of transgenic animals. The...

journal_title：BioMed research international

authors： Yang J,Zhao CZ,Chen B,Chen F,Han J,Hu SJ

更新日期：2015-01-01 00:00:00

abstract：:Microgravity influences cell differentiation by modifying the morphogenetic field in which stem cells are embedded. Preliminary data showed indeed that stem cells are committed to selective differentiation when exposed to real or simulated microgravity. Our study provides evidence that a similar event occurs when canc...

journal_title：BioMed research international

authors： Pisanu ME,Noto A,De Vitis C,Masiello MG,Coluccia P,Proietti S,Giovagnoli MR,Ricci A,Giarnieri E,Cucina A,Ciliberto G,Bizzarri M,Mancini R

更新日期：2014-01-01 00:00:00

abstract：:Diabetes-triggered apoptosis of Schwann cells (SC) contributes to the degradation of diabetic peripheral neuropathy (DNP). In recent years, mesenchymal stem cells (MSC) were applied to DPN repair and it was demonstrated that paracrine secretion played a key role in neuroprotection exerted by MSC. Erythropoietin (EPO) ...

journal_title：BioMed research international

authors： Zhang S,Shi B

更新日期：2017-01-01 00:00:00

abstract：INTRODUCTION:The use of unlicensed food and herbal supplements to enhance sexual functions is drastically increasing. This phenomenon, combined with the availability of these products over the Internet, represents a challenge from a clinical and a public health perspective. METHODS:A comprehensive multilingual assessm...

journal_title：BioMed research international

authors： Corazza O,Martinotti G,Santacroce R,Chillemi E,Di Giannantonio M,Schifano F,Cellek S

更新日期：2014-01-01 00:00:00

abstract：:Type 1 diabetes is an autoimmune disease which is due to the lack of β cells. The ideal therapy to cure the disease is pancreas transplantation, but its application is confined to a limited number of people due to the shortage of organ and the need for life-long immunosuppression. Regenerative medicine methods such as...

journal_title：BioMed research international

authors： Wu D,Wan J,Huang Y,Guo Y,Xu T,Zhu M,Fan X,Zhu S,Ling C,Li X,Lu J,Zhu H,Zhou P,Lu Y,Wang Z

更新日期：2015-01-01 00:00:00

abstract：:The complexity and diversity of eukaryotic organisms are a feat of nature's engineering. Pulling the strings of such an intricate machinery requires an even more masterful and crafty approach. Only the number and type of responses that they generate exceed the staggering proportions of environmental signals perceived ...

journal_title：BioMed research international

authors： Bhattacharjee S,Renganaath K,Mehrotra R,Mehrotra S

更新日期：2013-01-01 00:00:00

abstract：:To compare the clinical efficacy and radiological outcome of treating 4-level cervical spondylotic myelopathy (CSM) with either anterior cervical discectomy and fusion (ACDF) or "skip" corpectomy and fusion, 48 patients with 4-level CSM who had undergone ACDF or SCF at our hospital were analyzed retrospectively betwee...

journal_title：BioMed research international

authors： Li F,Li Z,Huang X,Chen Z,Zhang F,Shen H,Kang Y,Zhang Y,Cai B,Hou T

更新日期：2015-01-01 00:00:00

abstract：:IL-1 family includes IL-38 (IL-1F10) and the subfamily of IL-36 and is the central mediators of inflammatory diseases, including pustular psoriasis, atopic dermatitis, rheumatoid arthritis, and gut inflammation. The purpose of the study was to evaluate on tissue of the patients with inflammatory bowel disease (IBD), t...

journal_title：BioMed research international

authors： Fonseca-Camarillo G,Furuzawa-Carballeda J,Iturriaga-Goyon E,Yamamoto-Furusho JK

更新日期：2018-12-10 00:00:00

abstract：:Human adipose-derived stem cells (hASCs) are an attractive cell source for therapeutic applicability in diverse fields for the repair and regeneration of damaged or malfunctioning tissues and organs. There is a growing number of cell therapies using stem cells due to their characteristics of modulation of immune syste...

journal_title：BioMed research international

authors： de Paula AC,Sáfar GA,Góes AM,Bemquerer MP,Ribeiro MA,Stumpf HO

更新日期：2015-01-01 00:00:00

abstract：:Angiopoietin-like protein 4 (ANGPTL4) is widely known as a key regulator of lipid metabolism. We investigated the relationship between ANGPTL4 expression in serum or urine and blood lipid or urine protein levels of patients with hyperlipidemia- (HL-) related proteinuria. Sixty-eight patients with HL-related proteinuri...

journal_title：BioMed research international

authors： Gao X,Zhang M,Feng W,Xu Z,Wang Y,Shi L,Zhang J

更新日期：2020-03-23 00:00:00

abstract：:Otitis media (OM) is a common inflammatory disease of the middle ear cavity and mainly occurs in children. As a critical regulator of inflammation response, the nuclear factor kappa B (NF-κB) pathway has been found to play an essential role in the pathogenesis of various human diseases. The aim of this study was to ex...

journal_title：BioMed research international

authors： Yang X,Zhang Q,Lu H,Wang C,Xia L

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:This study investigated whether the 1 : 2 ω-3/ω-6 ratio may reduce proinflammatory response in human alveolar cells (A549) exposed to an ex vivo inflammatory stimulus (bronchoalveolar lavage fluid (BALF) of acute respiratory distress syndrome (ARDS) patients). Methods. We exposed A549 cells to the BALF colle...

journal_title：BioMed research international

authors： Cotogni P,Trombetta A,Muzio G,Maggiora M,Canuto RA

更新日期：2015-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal condition primarily characterized by the selective loss of upper and lower motor neurons. At present, the diagnosis and monitoring of ALS is based on clinical examination, electrophysiological findings, medical history, and exclusion of confounding disorders. There is the...

journal_title：BioMed research international

authors： Robelin L,Gonzalez De Aguilar JL

更新日期：2014-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/6353510.]. ...

journal_title：BioMed research international

authors： Skjerdal T,Gefferth A,Spajic M,Estanga EG,De Cesare A,Vitali S,Pasquali F,Bovo F,Manfreda G,Mancusi R,Trevisiani M,Tessema GT,Fagereng T,Moen LH,Lyshaug L,Koidis A,Delgado-Pando G,Stratakos AC,Boeri M,From C,Syed

更新日期：2018-09-26 00:00:00

abstract：:The efficiency of oat bran and barley bran in lowering the induced hyperlipidemia and hypercholesterolemia in blood of male Albino rats (Rattus rattus) was studied. Twenty rats were divided into four groups each consisted of five rats and fed the specified test diets for eight weeks. The first group (G1) is the negati...

journal_title：BioMed research international

authors： El Rabey HA,Al-Seeni MN,Amer HM

更新日期：2013-01-01 00:00:00

abstract：:The neonatal immune system is still immature, which makes it more susceptible to the infectious agents. Neonatal immune activation is associated with increased permeability of the blood-brain barrier, causing an inflammatory cascade in the CNS and altering behavioral and neurochemical parameters. One of the hypotheses...

journal_title：BioMed research international

authors： Dias P,Freiberger V,Ventura L,Bragagnolo D,Dutra ML,Horewicz VV,Comim CM

更新日期：2019-08-05 00:00:00

abstract：:Using the dual-process model of assimilative-tenacity (TGP) and accommodative-flexibility (FGA), the study aims to identify trajectories of TGP and FGA over five time points within a 9-year period, explore the relationships between the trajectories of TGP and FGA, and explore if participants from distinct TGP and FGA ...

journal_title：BioMed research international

authors： Martinent G,Bailly N,Ferrand C,Gana K,Giraudeau C,Joulain M

更新日期：2017-01-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have extensively analyzed single SNP effects on a wide variety of common and complex diseases and found many genetic variants associated with diseases. However, there is still a large portion of the genetic variants left unexplained. This missing heritability problem might be due...

journal_title：BioMed research international

authors： Lee S,Kim Y,Kwon MS,Park T

更新日期：2015-01-01 00:00:00

abstract：:Adult orthodontics may confront problems related to the bonding performance of orthodontic brackets to new generation restorative materials used for crown or laminate restorations. The aim of the present study was to investigate the shear bond strength of ceramic brackets to two new generation CAD/CAM interpenetrating...

journal_title：BioMed research international

authors： Özarslan MM,Üstün Ö,Buyukkaplan US,Barutcigil Ç,Türker N,Barutcigil K

更新日期：2018-05-30 00:00:00

abstract：:Protein structure prediction (PSP) is computationally a very challenging problem. The challenge largely comes from the fact that the energy function that needs to be minimised in order to obtain the native structure of a given protein is not clearly known. A high resolution 20 × 20 energy model could better capture th...

journal_title：BioMed research international

authors： Rashid MA,Newton MA,Hoque MT,Sattar A

更新日期：2013-01-01 00:00:00

abstract：:The occurrence of head and neck cancer (HNC) is associated with smoking and alcohol drinking. Tobacco smoking exposes smokers to a series of carcinogenic chemicals. Cytochrome P450 enzymes (CYP450s), such as CYP1A1, CYP1B1, and CYP2D6, usually metabolize carcinogens to their inactive derivatives, but they occasionally...

journal_title：BioMed research international

authors： Khlifi R,Messaoud O,Rebai A,Hamza-Chaffai A

更新日期：2013-01-01 00:00:00

abstract：:The zebrafish constitutes a powerful model organism with unique advantages for investigating the vertebrate circadian timing system and its regulation by light. In particular, the remarkably early and rapid development of the zebrafish circadian system has facilitated exploring the factors that control the onset of ci...

journal_title：BioMed research international

authors： Ben-Moshe Z,Foulkes NS,Gothilf Y

更新日期：2014-01-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a severe and progressive disease, a key feature of which is pulmonary vascular remodeling. Growth factors, cytokines, and lipid mediators are involved in this remodeling process. Recent reports suggest that the peroxisome proliferator-activated receptors (PPARs) play important ...

journal_title：BioMed research international

authors： Liu G,Li X,Li Y,Tang X,Xu J,Li R,Hao P,Sun Y

更新日期：2013-01-01 00:00:00