mTOR in viral hepatitis and hepatocellular carcinoma: function and treatment.

abstract：:Significant positive effects, particularly on psychological state in patients who completed the follow-up pulmonary rehabilitation programs, are indicated by a large number of studies. Yet, a remarkable proportion of selected patients drop out from these programs. In this study, we investigated existing differences on...

journal_title：BioMed research international

authors： Tselebis A,Kosmas E,Bratis D,Pachi A,Ilias I,Harikiopoulou M,Theodorakopoulou E,Velentzas K,Dumitru S,Moussas G,Siafakas N,Tzanakis N

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to detect oral bacteremia and offer the antibiotic resistance patterns. Bacterial resistance pattern was evaluated in 50 patients. A spectrophotometer device equipped with UV and electrophoresis of the extracted samples on agarose gel for antibiogram test were used. PCR test 15 minutes after ...

journal_title：BioMed research international

authors： Rezazadeh F,Azad A,Khorami A,Modaresi F,Rezaie Z

更新日期：2020-10-01 00:00:00

abstract：:To further understand the potential expression relationships of miRNAs in miRNA gene clusters and gene families, a global analysis was performed in 4 paired tumor (breast cancer) and adjacent normal tissue samples using deep sequencing datasets. The compositions of miRNA gene clusters and families are not random, and ...

journal_title：BioMed research international

authors： Guo L,Yang S,Zhao Y,Zhang H,Wu Q,Chen F

更新日期：2014-01-01 00:00:00

abstract：:Apolipoprotein E4 (Apo E4) is the major genetic risk factor in the causation of Alzheimer's disease (AD). In this study we utilize virtual screening of the world's largest traditional Chinese medicine (TCM) database and investigate potential compounds for the inhibition of ApoE4. We present the top three TCM candidate...

journal_title：BioMed research international

authors： Huang HJ,Chen HY,Lee CC,Chen CY

更新日期：2014-01-01 00:00:00

abstract：Background:Large scalp defects, especially those complicated by calvarial defects, titanium mesh exposure, or cerebrospinal fluid (CSF) leak, pose a challenge for the neurosurgeon and plastic surgeon. Here, we describe our experience of reconstructing the complex scalp defect with free flap transfer. Methods:From Octo...

journal_title：BioMed research international

authors： Chen F,Ju H,Huang A,Yi Y,Cao Y,Xie W,Wang X,Fu G

更新日期：2020-01-10 00:00:00

abstract：:Numerous studies have shown that long noncoding RNAs (lncRNAs) play essential roles in the development and progression of human cardiovascular diseases. However, whether lncRNA ezrin antisense RNA 1 (EZR-AS1) is associated with the progression of coronary heart disease (CHD) remains unclear. Accordingly, the aim of th...

journal_title：BioMed research international

authors： You G,Long X,Song F,Huang J,Tian M,Xiao Y,Deng S,Wu Q

更新日期：2020-05-22 00:00:00

abstract：:Objective. This study was aimed at analyzing the expressions of long noncoding RNAs (lncRNAs) in Botulinum Toxin Type A (BoNTA) treated human dermal fibroblasts (HDFs) in vitro. Methods. We used RNA sequencing to characterize the lncRNAs and mRNAs transcriptome in the control and BoNTA treated group, in conjunction wi...

journal_title：BioMed research international

authors： Miao YY,Liu J,Zhu J,Tao YL,Zhang JA,Luo D,Zhou BR

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:There is an unmet need for a specific cardiovascular risk (CV) algorithm for rheumatoid arthritis (RA) patients. Lipoprotein data are often not available in RA cohorts but could be obtained from frozen blood samples. The objective of this study was to estimate the storage effect on lipoproteins in long-term (...

journal_title：BioMed research international

authors： Arts EE,Popa CD,Smith JP,Arntz OJ,van de Loo FA,Donders R,Semb AG,Kitas GD,van Riel PL,Fransen J

更新日期：2014-01-01 00:00:00

abstract：:There is mounting evidence that burnout is a risk factor for cardiovascular disease (CVD). Stress-related dysregulation of the sympathetic and parasympathetic system and the hypothalamic pituitary adrenal (HPA) axis may explain the enhanced risk for CVD. To test this hypothesis, 55 patients (34 males and 21 females) w...

journal_title：BioMed research international

authors： de Vente W,van Amsterdam JG,Olff M,Kamphuis JH,Emmelkamp PM

更新日期：2015-01-01 00:00:00

abstract：:This research investigated the protective role of Leea macrophylla extract on CCl4-induced acute liver injury in rats. Different fractions of Leea macrophylla (Roxb.) crude extract were subjected to analysis for antioxidative effects. Rats were randomly divided into four groups as normal control, hepatic control, and ...

journal_title：BioMed research international

authors： Akhter S,Rahman MA,Aklima J,Hasan MR,Chowdhury JM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemotherapy and an autologou...

journal_title：BioMed research international

authors： Jiménez-Hernández E,Dueñas-González MT,Arellano-Galindo J,Medrano-Ortíz-De-Zárate ME,Bekker-Méndez VC,Berges-García A,Solís-Labastida K,Sánchez-Jara B,Tiznado-García HM,Jaimes-Reyes EZ,García-Jiménez X,Espinoza-Hernández L,Núñez-

更新日期：2015-01-01 00:00:00

abstract：:J-proteins are molecular chaperones and present in a wide variety of organisms from prokaryote to eukaryote. Based on their domain organizations, J-proteins can be classified into 4 types, that is, Type I, Type II, Type III, and Type IV. Different types of J-proteins play distinct roles in influencing cancer propertie...

journal_title：BioMed research international

authors： Feng P,Lin H,Chen W,Zuo Y

更新日期：2014-01-01 00:00:00

abstract：:Diverse high energy diets have been utilized to precipitate obesity and related metabolic disorders in rodent models, though the dietary intervention has not absolutely been standardized. The present study established usage of a customized semipurified normal control diet (NCD) and high fat diet (HFD), for research st...

journal_title：BioMed research international

authors： Sasidharan SR,Joseph JA,Anandakumar S,Venkatesan V,Ariyattu Madhavan CN,Agarwal A

更新日期：2013-01-01 00:00:00

abstract：:The small nucleolar RNA host gene 12 (SNHG12) has been reported to play an important role in the tumorigenesis and progression of PCa, but the functional underlying mechanism has not been studied clearly. We detected the expression level of SNHG12 in PCa tissues and matched adjacent normal tissues that were collected ...

journal_title：BioMed research international

authors： Chen Z,Qi T,Qin XP,Wang J,Huang ZS,Hu XY,Chen G,Qu LJ,Zhuo YM

更新日期：2020-12-22 00:00:00

abstract：:Adverse drug reactions (ADRs) are responsible for drug candidate failure during clinical trials. It is crucial to investigate biological pathways contributing to ADRs. Here, we applied a large-scale analysis to identify overrepresented ADR-pathway combinations through merging clinical phenotypic data, biological pathw...

journal_title：BioMed research international

authors： Chen X,Wang Y,Wang P,Lian B,Li C,Wang J,Li X,Jiang W

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Foreign object ingestion and food bolus impaction are a common clinical problem. We report our clinical experiences in endoscopic management for adults, foreign body ingestion, and food bolus impaction. METHOD:A retrospective chart review study was conducted on adult patients with foreign body ingestion and...

journal_title：BioMed research international

authors： Yao CC,Wu IT,Lu LS,Lin SC,Liang CM,Kuo YH,Yang SC,Wu CK,Wang HM,Kuo CH,Chiou SS,Wu KL,Chiu YC,Chuah SK,Tai WC

更新日期：2015-01-01 00:00:00

abstract：:This study aims to ascertain whether cytokines in the aqueous humor can predict macular edema (ME) in diabetic patients following uncomplicated phacoemulsification cataract surgery. Undiluted aqueous humor samples were obtained from 136 consecutive type 2 diabetic patients who underwent cataract surgery. The concentra...

journal_title：BioMed research international

authors： Dong N,Xu B,Wang B,Chu L,Tang X

更新日期：2015-01-01 00:00:00

abstract：:Elevated levels of resistin and epidermal growth factor receptor (EGFR) facilitate the development of breast cancer, although there are no reports of any correlation between these proteins. This study analyzed 392 human breast cancer tissue specimens and 42 samples of adjacent normal tissue. Rates of positive and stro...

journal_title：BioMed research international

authors： Zeng Y,Tang CH,Wang Y,Lu HJ,Huang BF,Wang Q,Shao JK,Jin LL,Wang CQ,Teng LS

更新日期：2020-11-28 00:00:00

abstract：Background:Previous studies have investigated the association between the use of bisphosphonates and the development of breast cancer, which presented controversial results. Thus, this meta-analysis was conducted to summarize the current evidence of the association of bisphosphonate use with breast cancer risk. Method...

journal_title：BioMed research international

authors： Peng R,Liang X,Zhang G,Yao Y,Chen Z,Pan X,Wang J,Liu G

更新日期：2020-10-06 00:00:00

abstract：:Effects of in ovo injection of Q10 on hatchability, performance (feed intake (FI), body weight gain (BWG), feed/gain ratio (F/G)) traits, and immune status of Ross × Ross 308 broiler chicks, hatched from eggs laid by a 38-week-old breeder flock, were determined through 42 days after hatch. Eggs containing live embryos...

journal_title：BioMed research international

authors： Kalantar M,Hosseini SM,Hosseini MR,Kalantar MH,Farmanullah,Yang LG

更新日期：2019-02-04 00:00:00

abstract：:Introduction. The lateral lumbar interbody fusion (LLIF) surgical approach has potential advantages over other approaches but is associated with some unique neurologic risks due to the proximity of the lumbosacral plexus. The present study analyzed complications following LLIF surgical approach using a novel single fl...

journal_title：BioMed research international

authors： Nunley P,Sandhu F,Frank K,Stone M

更新日期：2016-01-01 00:00:00

abstract：Introduction:Even today, despite medical progress and intensive health education, odontogenic infections leading to surgical intervention and hospitalization are common in children and young people. The aim of this study was to give a detailed overview of clinical and economic data on children and young people treated ...

journal_title：BioMed research international

authors： Doll C,Carl F,Neumann K,Voss JO,Hartwig S,Waluga R,Heiland M,Raguse JD

更新日期：2018-08-26 00:00:00

abstract：:How to decrease intraoperative bleeding, shorten surgical time, and increase safety in spinal surgery is an important issue. Ultrasonic bone removers and FloSeal have been proven to increase safety, reduce the surgical duration, and decrease intraoperative bleeding in skull base surgery. Therefore, we aimed to compare...

journal_title：BioMed research international

authors： Chen HT,Hsu CC,Lu ML,Chen SH,Chen JM,Wu RW

更新日期：2019-05-19 00:00:00

abstract：:Correlation of parametrized image texture features (ITF) analyses conducted in different regions of interest (ROIs) overcomes limitations and reliably reflects image quality. The aim of this study is to propose a nonparametrical method and classify the quality of a magnetic resonance (MR) image that has undergone cont...

journal_title：BioMed research international

authors： Obuchowicz R,Piórkowski A,Urbanik A,Strzelecki M

更新日期：2019-11-20 00:00:00

abstract：:Artery calcification is a well-recognized predictor of late atherosclerotic complications. In the intima media, calcification starts with apoptosis of vascular smooth muscle cells (VSMCs) and the release of calcifying matrix vesicles with diameter of 0.5-15 μm that can be observed microscopically. In complicated plaqu...

journal_title：BioMed research international

authors： Chistiakov DA,Myasoedova VA,Melnichenko AA,Grechko AV,Orekhov AN

更新日期：2017-01-01 00:00:00

abstract：:The cyprinid genus Pteronotropis is endemic to southeastern Gulf of Mexico and Atlantic Ocean of North America. Never before has the genus been demonstrated to be monophyletic. We investigate both the phylogenetic relationships and the phylogeography of some species in the genus using mitochondrial ND2 sequences. In n...

journal_title：BioMed research international

authors： Mayden RL,Allen J

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To analyze the clinical relevance of the levels of TNFα blockers and anti-drug antibodies (anti-drug Ab) in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) treated with adalimumab (ADA), etanercept (ETA), or infliximab (INF) for a prolonged period of time. METHODS:Clinical characteristics...

journal_title：BioMed research international

authors： Arstikyte I,Kapleryte G,Butrimiene I,Venalis A

更新日期：2015-01-01 00:00:00

abstract：:Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) is an effective anti-inflammatory drug in treating rheumatoid arthritis (RA) for over 15 years in China. However, as a special form of bisphosphonate, the antiosteoporotic effect of 99Tc-MDP is unclear. We systematically investigated the effects of 99Tc-...

journal_title：BioMed research international

authors： Shi L,Ning Y,Xu L,Li J,Zhang X

更新日期：2018-10-14 00:00:00

abstract：:Mutations in the kinase domain of epidermal growth factor receptor (EGFR) have high levels of basal receptor phosphorylation and are associated with clinical responsiveness to Iressa in patients with nonsmall cell lung cancer (NSCLC). This study aimed to assess the feasibility of morpholino-[(124)I]IPQA derivative as ...

journal_title：BioMed research international

authors： Yeh SH,Lin CF,Kong FL,Wang HE,Hsieh YJ,Gelovani JG,Liu RS

更新日期：2013-01-01 00:00:00

abstract：:Herein the extraction method of fucoidan from Laminaria japonica is reported. Firstly, chitosan, chitosan-N-2-hydroxypropyl trimethyl ammonium chloride (HACC), and hexadecyltrimethylammonium bromide (CPAB) were used to extract the fucoidan. The results showed that chitosan was the optimal extractant compared with the ...

journal_title：BioMed research international

authors： Xing R,Liu S,Yu H,Chen X,Qin Y,Li K,Li P

更新日期：2013-01-01 00:00:00