Abstract:
:To further understand the potential expression relationships of miRNAs in miRNA gene clusters and gene families, a global analysis was performed in 4 paired tumor (breast cancer) and adjacent normal tissue samples using deep sequencing datasets. The compositions of miRNA gene clusters and families are not random, and clustered and homologous miRNAs may have close relationships with overlapped miRNA species. Members in the miRNA group always had various expression levels, and even some showed larger expression divergence. Despite the dynamic expression as well as individual difference, these miRNAs always indicated consistent or similar deregulation patterns. The consistent deregulation expression may contribute to dynamic and coordinated interaction between different miRNAs in regulatory network. Further, we found that those clustered or homologous miRNAs that were also identified as sense and antisense miRNAs showed larger expression divergence. miRNA gene clusters and families indicated important biological roles, and the specific distribution and expression further enrich and ensure the flexible and robust regulatory network.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Guo L,Yang S,Zhao Y,Zhang H,Wu Q,Chen Fdoi
10.1155/2014/782490subject
Has Abstractpub_date
2014-01-01 00:00:00pages
782490eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::[This corrects the article DOI: 10.1155/2018/2109865.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2019/6212386
更新日期:2019-12-13 00:00:00
abstract:Background:Many studies, comparing the health associated risks of electronic cigarettes with conventional cigarettes focus mainly on the common chemical compounds found between them. Aim:Review chemical compounds found exclusively in electronic cigarettes and describe their toxic effects, focusing on electronic-cigare...
journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/241780
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
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abstract::Heart failure commonly results from an irreparable damage due to cardiovascular diseases (CVDs), the leading cause of morbidity and mortality in the United States. In recent years, the rapid advancements in stem cell research have garnered much praise for paving the way to novel therapies in reversing myocardial injur...
journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2016/8301624
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/6316059
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journal_title:BioMed research international
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更新日期:2019-03-12 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/169841
更新日期:2015-01-01 00:00:00
abstract::In vitro research performed on eukaryotic or prokaryotic cell cultures usually represents the initial step for characterization of a novel photosensitizer (PS) intended for application in photodynamic therapy (PDT) of cancer or photodynamic inactivation (PDI) of microorganisms. Although many experimental steps of PS t...
journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
abstract::Neuroendocrine tumors (NETs) are tumors originated from neuroendocrine cells in the body. The localization and the detection of the extent of NETs are important for diagnosis and treatment, which should be individualized according to the tumor type, burden, and symptoms. Molecular imaging of NETs with high sensitivity...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/102819
更新日期:2013-01-01 00:00:00
abstract:Background:Physical activity has been found to maintain and improve cognitive function and consequently improve health-related quality of life (HRQoL). The relationships between different types of physical activities, cognitive function, and HRQoL have not been studied sufficiently and compared in different age and gen...
journal_title:BioMed research international
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doi:10.1155/2020/8856284
更新日期:2020-12-18 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/415651
更新日期:2014-01-01 00:00:00
abstract::Platelets are anuclear cells and are devoid of genomic DNA, but they are capable of de novo protein synthesis from mRNA derived from their progenitor cells, megakaryocytes. There is mounting evidence that microRNA (miRNA) plays an important role in regulating gene expression in platelets. miR-223 is the most abundant ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/981841
更新日期:2015-01-01 00:00:00
abstract::Human epididymis protein 4 (HE4) is an available tumor biomarker mainly for detecting ovarian cancer. However, it is unknown whether it can be a novel indicator for diagnosis of diabetic kidney disease (DKD). The aim of this study was to investigate the possibility of serum HE4 as a novel biomarker for DKD in patients...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4831459
更新日期:2019-11-11 00:00:00
abstract::Systemic lupus erythematosus (SLE) is characterized by systemic end-organ damage. We investigated the involvement of IRF5, TLR-7, MECP2, STAT4, and TNFSF4 genes and TNF-α, IFN-γ, IL-2, IL-12, IL-6, and IL-10 cytokines in SLE pathogenesis and in organ damage in Jordanian patients. Blood was collected from 51 patients a...
journal_title:BioMed research international
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doi:10.1155/2019/1703842
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abstract::Compressive sensing (CS) offers compression of data below the Nyquist rate, making it an attractive solution in the field of medical imaging, and has been extensively used for ultrasound (US) compression and sparse recovery. In practice, CS offers a reduction in data sensing, transmission, and storage. Compressive sen...
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pub_type: 杂志文章,评审
doi:10.1155/2019/7861651
更新日期:2019-11-15 00:00:00
abstract:Background:Studies of previous cohorts have demonstrated a controversial association between extreme body mass index (BMI) and complication rates following total hip arthroplasty (THA). The purpose of this study was to compare 30-day perioperative complications in underweight (BMI <18.50 kg/m2), normal-weight (BMI 18.5...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4370382
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