abstract：:In clinical endodontics, preoperative estimation of root canal curvature is crucial regarding the prevention of iatrogenic errors. Reproduction of the two-dimensional radiographic images causes certain proximal view curvatures not seen. Therefore, the present study is aimed at investigating the degree of root canal cu...

journal_title：BioMed research international

authors： Faraj BM

更新日期：2021-01-13 00:00:00

abstract：Background:Since the dawn of human history, foodborne diseases have been a problem for all societies, and it is an increasing public health issue worldwide. The objective of this study is to examine knowledge, practice, and attitude in food safety among college students in the city Gondar, northwest Ethiopia. Methods:...

journal_title：BioMed research international

authors： Azanaw J,Dagne H,Andualem Z,Adane T

更新日期：2021-01-12 00:00:00

abstract：Background:Thyroid cancer is the most common endocrine malignancy, with a recent global increase of 20% in age-related incidence. Ultrasonography and ultrasonography-guided fine-needle aspiration biopsy (FNAB) are the most widely used diagnostic tests for thyroid nodules; however, it is estimated that up to 25% of thyr...

journal_title：BioMed research international

authors： Nan BY,Xiong GF,Zhao ZR,Gu X,Huang XS

更新日期：2021-01-12 00:00:00

abstract：:Prostate cancer is a life-threatening and highly heterogeneous malignancy. In the past decade, circulating tumor cells (CTCs) have been suggested to play a critical role in the occurrence and progression of prostate cancer. In particular, as the "seed" of the cancer metastasis cascade, CTCs determine numerous biologic...

journal_title：BioMed research international

authors： Yang M,Zhang X,Guo L,Liu X,Wu J,Zhu H

更新日期：2021-01-08 00:00:00

abstract：:Otitis media (OM) is a common inflammatory disease of the middle ear cavity and mainly occurs in children. As a critical regulator of inflammation response, the nuclear factor kappa B (NF-κB) pathway has been found to play an essential role in the pathogenesis of various human diseases. The aim of this study was to ex...

journal_title：BioMed research international

authors： Yang X,Zhang Q,Lu H,Wang C,Xia L

更新日期：2021-01-06 00:00:00

abstract：:Lung injury was the common and serious complication of sepsis, a systemic inflammatory response syndrome caused by severe infections. Chinese medicine had unique advantages in attenuating inflammatory response, such as Zuojinfang (ZJF). ZJF was a classical compound herb formula composed of Coptidis Rhizoma and Euodiae...

journal_title：BioMed research international

authors： Yin J,Yu Z,Hou C,Peng Y,Xiao J,Jiang J

更新日期：2021-01-06 00:00:00

abstract：:Neonatal respiratory distress syndrome (NRDS) is a common disease that occurs in premature infants. However, the mechanisms underlying the disease remain unclear. microRNAs (miRNAs) have been indicated to play a crucial role in the development of NRDS. In this study, we aimed to explore the regulatory mechanisms of mi...

journal_title：BioMed research international

authors： Zhang YH,Chen AL,Yu RQ,Jia BB,Ye DN,Wang M,Mei YZ,Fang GD,Jiang SY,Zhou Q,Zhang B

更新日期：2021-01-05 00:00:00

abstract：Background:We investigated the potential safety of remimazolam and propofol in malignant hyperthermia- (HM-) susceptible patients using ryanodine receptor 1- (RYR1-) expressing human embryonic kidney- (HEK-) 293 cells. Methods:We compared the enhanced responsiveness of HEK-293 cells expressing wild-type RYR1 with that...

journal_title：BioMed research international

authors： Watanabe T,Miyoshi H,Noda Y,Narasaki S,Morio A,Toyota Y,Kimura H,Mukaida K,Yasuda T,Tsutsumi YM

更新日期：2021-01-04 00:00:00

abstract：:Carotenoids produced by microbial sources are of industrial and medicinal importance due to their antioxidant and anticancer properties. In the current study, optimization of β-carotene production in M. circinelloides strain 277.49 was achieved using response surface methodology (RSM). Cerulenin and ketoconazole were ...

journal_title：BioMed research international

authors： Naz T,Nazir Y,Nosheen S,Ullah S,Halim H,Fazili ABA,Li S,Mustafa K,Mohamed H,Yang W,Song Y

更新日期：2020-12-29 00:00:00

abstract：Background:The use of modern family planning methods among women of reproductive age (15-49 years) is of public health importance in Ethiopia. Nationally, modern family planning method use remains as low as 35%. Understanding factors associated with the use of modern family planning methods may help to improve maternal...

journal_title：BioMed research international

authors： Mulatu T,Sintayehu Y,Dessie Y,Deressa M

更新日期：2020-12-29 00:00:00

abstract：:A series of halo-substituted mixed ester/amide-based analogues 4a-l have been prepared as jack bean urease inhibitor, which showed good to excellent inhibition of enzyme activity. The role of halo-substituted benzoyl moieties and alkyl substituted anilines in urease inhibitory kinetics was also investigated. The alkyl...

journal_title：BioMed research international

authors： Rashid M,Rafique H,Roshan S,Shamas S,Iqbal Z,Ashraf Z,Abbas Q,Hassan M,Qureshi ZUR,Asad MHHB

更新日期：2020-12-24 00:00:00

abstract：:The small nucleolar RNA host gene 12 (SNHG12) has been reported to play an important role in the tumorigenesis and progression of PCa, but the functional underlying mechanism has not been studied clearly. We detected the expression level of SNHG12 in PCa tissues and matched adjacent normal tissues that were collected ...

journal_title：BioMed research international

authors： Chen Z,Qi T,Qin XP,Wang J,Huang ZS,Hu XY,Chen G,Qu LJ,Zhuo YM

更新日期：2020-12-22 00:00:00

abstract：:Long noncoding RNAs play an essential role in bladder cancer progression. The role of long noncoding RNA EGFR-AS1 in bladder cancer needs further study. We used clinical specimens to analyze the relationship between EGFR-AS1 and bladder cancer patients' characteristics. The functional experiments and mechanism studies...

journal_title：BioMed research international

authors： Wang A,Jiang A,Gan X,Wang Z,Huang J,Dong K,Liu B,Wang L,Chen M

更新日期：2020-12-22 00:00:00

abstract：:N6-methyladenosine (m6A) plays an important role in many cancers. However, few studies have examined the role of m6A in colorectal CRC. To examine the effect of m6A on CRC, we studied the genome of 591 CRC cases from The Cancer Genome Atlas (TCGA). The relationship between the messenger RNA (mRNA) expression, copy num...

journal_title：BioMed research international

authors： Zhang Q,Cai Y,Kurbatov V,Khan SA,Lu L,Zhang Y,Johnson CH

更新日期：2020-12-19 00:00:00

abstract：Introduction:This study examines the utility of electroencephalography (EEG) in clinical decision making in acute ischemic stroke (AIS) patients in regards to the prescription of antiseizure medications. Methods:Patients were grouped as having positive EEG (+) for epileptiform activity or negative EEG (-). These studi...

journal_title：BioMed research international

authors： Rao R,Monlezun DJ,Kimbrough T,Burkett BJ,Samai A,Martin-Schild S

更新日期：2020-12-19 00:00:00

abstract：Background:Physical activity has been found to maintain and improve cognitive function and consequently improve health-related quality of life (HRQoL). The relationships between different types of physical activities, cognitive function, and HRQoL have not been studied sufficiently and compared in different age and gen...

journal_title：BioMed research international

authors： Alsubaie SF,Alkathiry AA,Abdelbasset WK,Nambi G

更新日期：2020-12-18 00:00:00

abstract：Aims:To investigate demographics and socioeconomic status in patients with ulnar nerve compression and the influence of socioeconomic factors on patient-reported outcome measurements (PROM) as evaluated by QuickDASH (short version of Disabilities of Arm, Shoulder and Hand) after surgery for ulnar nerve compression at t...

journal_title：BioMed research international

authors： Zimmerman M,Nyman E,Steen Carlsson K,Dahlin LB

更新日期：2020-12-18 00:00:00

abstract：:Cardiac computed tomography angiography (CCTA) is widely used as a diagnostic tool for evaluation of coronary artery disease (CAD). Despite the excellent capability to rule-out CAD, CCTA may overestimate the degree of stenosis; furthermore, CCTA analysis can be time consuming, often requiring advanced postprocessing t...

journal_title：BioMed research international

authors： Muscogiuri G,Van Assen M,Tesche C,De Cecco CN,Chiesa M,Scafuri S,Guglielmo M,Baggiano A,Fusini L,Guaricci AI,Rabbat MG,Pontone G

更新日期：2020-12-16 00:00:00

abstract：Background:Diabetes mellitus (DM) is a common disease that has an adverse impact on most orthopedic surgeries, and its prevalence has gradually increased in recent years. We aim to investigate the influence of DM on comorbidities and complications of patients undergoing primary total lower extremity arthroplasty. Meth...

journal_title：BioMed research international

authors： Qin W,Huang X,Yang H,Shen M

更新日期：2020-12-15 00:00:00

abstract：:The aim of this study is to investigate the stress distributions of different restoration options for class II mesio-occluso-distal (MOD) cavities. A class II MOD cavity with proximal box gingival floor 1 mm below cementoenamel junction was designed in a mandibular first molar tooth model. 3D finite-element analysis (...

journal_title：BioMed research international

authors： Alp Ş,Gulec Alagoz L,Ulusoy N

更新日期：2020-12-15 00:00:00

abstract：Methods:This prospective single-blinded clinical trial included 72 ASA I-II stage children aged 1-36 months with cCHD who were scheduled to undergo TTE under sedation. Children were assigned to group A (n = 37) with a previous history of cardiac surgery and group B (n = 35) with no history of cardiac surgery. Doses of ...

journal_title：BioMed research international

authors： Gu H,Song Y,Bai J

更新日期：2020-12-12 00:00:00

abstract：:Triglyceride-glucose index (TyG index) is associated with type 2 diabetes mellitus (T2DM), but research on this relationship is limited in Japan. The purpose of this study was to evaluate the correlation between TyG index and the risk of T2DM in the Japanese population. Here, 12732 participants were selected from the ...

journal_title：BioMed research international

authors： Liu EQ,Weng YP,Zhou AM,Zeng CL

更新日期：2020-12-11 00:00:00

abstract：:Exosomal miRNAs are currently being explored as a novel class of biomarkers in cardiovascular diseases. However, few reports have focused on the value of circulating exosomal miRNAs as biomarkers for stable coronary artery disease (SCAD). Here, we aimed to investigate whether miRNAs involved in cardiovascular diseases...

journal_title：BioMed research international

authors： Zhang P,Liang T,Chen Y,Wang X,Wu T,Xie Z,Luo J,Yu Y,Yu H

更新日期：2020-12-11 00:00:00

abstract：Background:Antiretroviral therapy transformed HIV infection into a chronic disease but accelerated cardiovascular disease (CVD). Both of epicardial adipose tissue (EAT) and pericardial fat (PCF) have close relationships with CVD. The associations between these two cardiac adipose tissue and HIV are unclear. Methods:El...

journal_title：BioMed research international

authors： Song G,Qiao W,Sun L,Yu X

更新日期：2020-12-09 00:00:00

abstract：Objective:Cognitive impairment is considered to be an important complication of spinal cord injury (SCI), but its underlying mechanism remains unclear. The purpose of this study is to explore whether serum CCL21 can be used as a potential biomarker of cognitive impairment in SCI. Methods:In Neck-Shoulder and Lumbocrur...

journal_title：BioMed research international

authors： Chen Y,Liang L,Cao S,Hou G,Zhang Q,Ma H,Shi B

更新日期：2020-12-09 00:00:00

abstract：:One of the female causes of infertility is anovulation which is treatable with gonadotropin hormones. These hormones affect the molecular organization of the uterus such as glycoconjugates that are the first site of contact between the blastocyst and the uterus. The objective of this project was to study the alteratio...

journal_title：BioMed research international

authors： Aliabadi E,Makoolati Z,Talaei-Khozani T,Ardekani FM,Aliabadi A

更新日期：2020-12-04 00:00:00

abstract：:Craniofacial reconstruction is to estimate a person's face model from the skull. It can be applied in many fields such as forensic medicine, archaeology, and face animation. Craniofacial reconstruction is based on the relationship between the skull and the face to reconstruct the facial appearance from the skull. Howe...

journal_title：BioMed research international

authors： Wen Y,Mingquan Z,Pengyue L,Guohua G,Xiaoning L,Kang L

更新日期：2020-12-04 00:00:00

abstract：:COVID-19 is a pandemic which has spread to more than 200 countries. Its high transmission rate makes it difficult to control. To date, no specific treatment has been found as a cure for the disease. Therefore, prediction of COVID-19 cases provides a useful insight to mitigate the disease. This study aims to model and ...

journal_title：BioMed research international

authors： Attanayake AMCH,Perera SSN

更新日期：2020-12-03 00:00:00

abstract：:The aim of this study is to reveal the certain human papillomavirus (HPV) genotype distribution between cervical cancer and esophageal cancer in the both high-incidence geographic regions. For this study, we collected and detected the infection of HPV in 120 paraffin-embedded esophageal tissues and 152 paraffin-embedd...

journal_title：BioMed research international

authors： Zheng Y,Fan Y,Zeng Y,Liu S,Gao L

更新日期：2020-12-02 00:00:00

abstract：:Elevated levels of resistin and epidermal growth factor receptor (EGFR) facilitate the development of breast cancer, although there are no reports of any correlation between these proteins. This study analyzed 392 human breast cancer tissue specimens and 42 samples of adjacent normal tissue. Rates of positive and stro...

journal_title：BioMed research international

authors： Zeng Y,Tang CH,Wang Y,Lu HJ,Huang BF,Wang Q,Shao JK,Jin LL,Wang CQ,Teng LS

更新日期：2020-11-28 00:00:00

abstract：Objective:ANGPTL7 is a member of the angiogenin-like protein family. Compared to other members, ANGPTL7 is the least known. Recent studies have explored the relationship between ANGPTL7 and multiple pathological processes and diseases. However, there is no research about ANGPTL7 in neonates. This study was designed to ...

journal_title：BioMed research international

authors： Xia X,Ren Z,Yan L,Zheng X,Yang H,Kang M,Yan H,Zhong Z,Xu F,Miao J,Wang J,Li Y,Wei W,Yang J

更新日期：2020-11-27 00:00:00

abstract：Background:Gegen Qinlian (GGQL) decoction is a common Chinese herbal compound for the treatment of ulcerative colitis (UC). In this study, we aimed to identify its molecular target and the mechanism involved in UC treatment by network pharmacology and molecular docking. Material and Methods. The active ingredients of P...

journal_title：BioMed research international

authors： Wei M,Li H,Li Q,Qiao Y,Ma Q,Xie R,Wang R,Liu Y,Wei C,Li B,Zheng C,Sun B,Yu B

更新日期：2020-11-24 00:00:00

abstract：:This study was performed to assess the efficacy and safety of a topical diclofenac solution in patients with knee osteoarthritis (OA). PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases were searched for randomized controlled trials until June 2020. The WOMAC pain, stiffness, physical function subs...

journal_title：BioMed research international

authors： Ling T,Li JJ,Xu RJ,Wang B,Ge WH

更新日期：2020-11-24 00:00:00

abstract：:Different opinions exist on the relationship between the C-reactive protein-to-albumin ratio (CAR) and the prognosis of colon cancer. This study is aimed at evaluating the relationship between CAR and prognosis of stage II-III colon cancer and establishing a clinical prognosis model. Patients were randomised to a trai...

journal_title：BioMed research international

authors： Xu Y,Liang F,Chen Y,Wang Z,Zhong H,Tang W

更新日期：2020-11-22 00:00:00

abstract：:A metabolic disorder is considered one of the hallmarks of cancer. Multiple differentially expressed metabolic genes have been identified in colon cancer (CC), and their biological functions and prognostic values have been well explored. The purpose of the present study was to establish a metabolic signature to optimi...

journal_title：BioMed research international

authors： Luo D,Shan Z,Liu Q,Cai S,Li Q,Li X

更新日期：2020-11-17 00:00:00

abstract：:Despite remarkable therapeutic advances have been made in the last few decades, non-small cell lung cancer (NSCLC) is still one of the leading causes of death worldwide. Brain metastases are a common complication of a wide range of human malignancies and in particular NSCLC. Brain-derived neurotrophic factor (BDNF), b...

journal_title：BioMed research international

authors： Lombardi M,D'Ascanio M,Scarpino S,Scozzi D,Giordano M,Costarelli L,Raj ER,Mancini R,Cardillo G,Cardaci V,Innammorato M,Vecchione A,Ricci A

更新日期：2020-11-17 00:00:00

abstract：Background:Adverse drug reactions (ADRs) are the known cause of morbidity and mortality, resulting in increased hospitalization, healthcare costs, complications, and decreased adherence in patients with depression. This study is aimed at evaluating adverse drug reactions due to antidepressants among patients with depre...

journal_title：BioMed research international

authors： Sankhi S,Marasine NR,Sankhi S,Lamichhane R

更新日期：2020-11-16 00:00:00

abstract：:Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective effects of quercetin o...

journal_title：BioMed research international

authors： Machado-Junior PA,Araújo NPS,Souza ABF,Castro TF,Oliveira M,Costa GP,Matos NA,Vieira PMA,Talvani A,Bezerra FS,Cangussú SD

更新日期：2020-11-15 00:00:00

abstract：Background:Strongyloidiasis is an intestinal parasitic infection mainly caused by Strongyloides stercoralis. Although it is a predominant parasite in tropics and subtropics where sanitation and hygiene are poorly practiced, the true prevalence of strongyloidiasis is not known due to low-sensitivity diagnostic methods. ...

journal_title：BioMed research international

authors： Hailu T,Nibret E,Amor A,Munshea A

更新日期：2020-11-15 00:00:00

abstract：:Transient receptor potential polycystic 2 (TRPP2) exerts vital roles in various types of cancer; however, its underlying mechanisms remain largely unknown. This study is aimed at investigating whether knockdown of TRPP2 affected the AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) signaling pathway and...

journal_title：BioMed research international

authors： Li K,Chen L,Lin Z,Zhu J,Fang Y,Du J,Shen B,Wu K,Liu Y

更新日期：2020-11-14 00:00:00