Abstract:
:Artery calcification is a well-recognized predictor of late atherosclerotic complications. In the intima media, calcification starts with apoptosis of vascular smooth muscle cells (VSMCs) and the release of calcifying matrix vesicles with diameter of 0.5-15 μm that can be observed microscopically. In complicated plaques, calcification is generally less frequent. Calcifying vesicles are released by proatherosclerotic VSMCs into the collagen-rich matrix. The vesicles can penetrate into the intima media and protrude into the arterial lumen and thereby may represent a potential cause of atherothrombosis. In calcified fibrolipid plaques, the rate of calcification is increased but is followed with healing of a lesion rupture and exhibited by further erosion and/or intimal thickening. Generally, calcification directly correlates with the apoptosis of VSMCs and macrophages accompanied by the release of osteogenic matrix vesicles. This is a hallmark of atherosclerosis-related apoptosis of VSMCs that is commonly released in plaque stabilization.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Chistiakov DA,Myasoedova VA,Melnichenko AA,Grechko AV,Orekhov ANdoi
10.1155/2017/7463590subject
Has Abstractpub_date
2017-01-01 00:00:00pages
7463590eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
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