Abstract:
:Methadone remains the most common form of pharmacological therapy for opioid dependence; however, there is a lack of explanation for the reports of its relatively low success rate in achieving complete abstinence. One hypothesis is that in vivo binding of methadone to the plasma glycoprotein alpha-1-acid glycoprotein (AGP), to a degree dependent on the molecular structure, may render the drug inactive. This study sought to determine whether alterations present in the glycosylation pattern of AGP in patients undergoing various stages of methadone therapy (titration < two weeks, harm reduction < one year, long-term > one and a half years) could affect the affinity of the glycoprotein to bind methadone. The composition of AGP glycosylation was determined using high pH anion exchange chromatography (HPAEC) and intrinsic fluorescence analysed to determine the extent of binding to methadone. The monosaccharides galactose and N-acetyl-glucosamine were elevated in all methadone treatment groups indicating alterations in AGP glycosylation. AGP from all patients receiving methadone therapy exhibited a greater degree of binding than the normal population. This suggests that analysing the glycosylation of AGP in patients receiving methadone may aid in determining whether the therapy is likely to be effective.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Behan JL,Cruickshank YE,Matthews-Smith G,Bruce M,Smith KDdoi
10.1155/2013/108902subject
Has Abstractpub_date
2013-01-01 00:00:00pages
108902eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract:OBJECTIVE:This study evaluated the frequencies of allergic symptoms and rate of upper respiratory infections during the past year in the general population, kitchen workers (KW) and health care workers (HCW). METHODS:The European Community Respiratory Health Survey (ECRHS) was used to inquire retrospectively about ast...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/285420
更新日期:2013-01-01 00:00:00
abstract:Introduction:The aim of the study was to analyze which variables influenced the completion of a cold loop hysteroscopic myomectomy in a one-step procedure in a large cohort of patients. Materials and Methods:A retrospective cohort study of 1434 cold loop resectoscopic myomectomies consecutively performed. The study po...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8429047
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/453469
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doi:10.1155/2014/797603
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
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journal_title:BioMed research international
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doi:10.1155/2017/5232680
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2018/1578643
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/236745
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/438295
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8149682
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
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doi:10.1155/2015/124537
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pub_type: 临床试验,杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2020-06-16 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/542016
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/917640
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/783967
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5207031
更新日期:2018-07-03 00:00:00