Effects of Polyphenol Compounds and Nitrogen Oxide Donors on Lipid Oxidation, Membrane-Skeletal Proteins, and Erythrocyte Structure under Hypoxia.

Abstract:

:This study shows that membrane-associated cytoskeletal protein structures and the erythrocyte morphology undergo profound changes during hypoxia. Hypoxia also intensified oxidative processes in the lipid phase of the bilayer of red blood cell membranes. Sodium nitroprusside impaired the morphology of red blood cells and altered quantitative and qualitative composition of membrane-skeletal proteins. The findings suggest that hypoxia causes changes at all levels of red blood cell organization, which can cause the functional disorders of hemoglobin oxygen-transporting properties and, eventually, the complete degradation of red blood cells. The use of flavonoids has a protective effect against hypoxia.

journal_name

Biomed Res Int

authors

Revin VV,Gromova NV,Revina ES,Prosnikova KV,Revina NV,Bochkareva SS,Stepushkina OG,Grunyushkin IP,Tairova MR,Incina VI

doi

10.1155/2019/6758017

subject

Has Abstract

pub_date

2019-12-07 00:00:00

pages

6758017

eissn

2314-6133

issn

2314-6141

journal_volume

2019

pub_type

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