Abstract:
:Due to anthropogenic activities the relative concentrations of cadmium and manganese have increased in the marine environment. Cephalopods are able to accumulate such metals and, as inhabitant of coastal waters, Octopus vulgaris is continuously exposed to anthropogenic activities. Since no study is available on the effects of heavy metals at molecular level in developing octopuses, herein we exposed 1-day-old paralarvae for 24 h to 10, 100, and 1000 μg/L of CdCl2 or MnCl2. Cd exerted a concentration-dependent inhibition of survival and a reduction in growth rate was shown while Mn exposure did not affect the survival rate even at the highest concentrations. Gene expression profiles of hsp70, sod, cat, and gst genes were analyzed by quantitative real-time PCR and defined patterns of transcription were observed. Moreover posttranscriptional analyses were also performed suggesting the impairment of metabolic functions, under strong oxidative conditions (as occurred in paralarvae exposed to Cd) or the complete detoxification events (as occurred in paralarvae exposed to Mn).
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Nicosia A,Salamone M,Mazzola S,Cuttitta Adoi
10.1155/2015/437328subject
Has Abstractpub_date
2015-01-01 00:00:00pages
437328eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract::Background. Stenotrophomonas maltophilia bacteremia (SMB) is the most perilous situation as compared to other types of S. maltophilia infection. The present study aimed to investigate the clinical features, distribution, drug resistance, and predictors of survival of SMB in a tertiary-care hospital of China. Methods. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4931501
更新日期:2019-12-09 00:00:00
abstract::The effect of Cordyceps militaris (CM) grown on germinated soybeans (GSC) in the inflammatory bowel disease (IBD) model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS-) induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC si...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/102918
更新日期:2013-01-01 00:00:00
abstract::The cyprinid genus Pteronotropis is endemic to southeastern Gulf of Mexico and Atlantic Ocean of North America. Never before has the genus been demonstrated to be monophyletic. We investigate both the phylogenetic relationships and the phylogeography of some species in the genus using mitochondrial ND2 sequences. In n...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/675260
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To evaluate the changes of keratocytes and dendritic cells in the central clear graft by laser scanning in vivo confocal microscopy after penetrating keratoplasty (PK). METHODS:Thirty adult subjects receiving PK at Shandong Eye Institute and with clear grafts and no sign of immune rejection after surgery were ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5159746
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Using a swine model of acute myocardial ischemia, we sought to validate N-(11)C-methyl-dopamine ((11)C-MDA) as an agent capable of imaging cardiac sympathetic nerve injury. METHODS:Acute myocardial ischemia was surgically generated in Chinese minipigs. ECG and serum enzyme levels were used to detect the pres...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8430637
更新日期:2016-01-01 00:00:00
abstract::Subtle perturbations in intraglomerular VEGF/VEGFR-2 signaling or in the influencing microenvironment can profoundly affect renal function, resulting in the apparently paradoxical observation that VEGF blockade attenuates proteinuria development in experimental diabetes despite exerting the opposite effect under other...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/201475
更新日期:2013-01-01 00:00:00
abstract::The release of ATP from the urothelium in response to stretch during filling demonstrates the importance of the purinergic system for the physiological functioning of the bladder. This study examined the effect of P2 receptor agonists on ATP release from two urothelial cell lines (RT4 and UROtsa cells). Hypotonic Kreb...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/830374
更新日期:2014-01-01 00:00:00
abstract::Brain injury such as traumatic brain injury (TBI) and stroke is the major cause of long-term disabilities in many countries. The increasing rate of brain damaged victims and the heterogeneity of impairments decrease rehabilitation effectiveness and competence resulting in higher cost of rehabilitation treatment. On th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/493562
更新日期:2015-01-01 00:00:00
abstract::Bone defects are repaired using either natural or synthetic bone grafts. Poly(ϵ-caprolactone) (PCL), β-tricalcium phosphate (TCP), and poly(lactic-co-glycolic acid) (PLGA) are widely used as synthetic materials for tissue engineering. This study aimed to investigate the bone-healing capacity of PCL/PLGA/duck beak scaf...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2136215
更新日期:2016-01-01 00:00:00
abstract::The uncertain position of lung tumor during radiotherapy compromises the treatment effect. To effectively control respiratory motion during radiotherapy of lung cancer without any side effects, a novel control scheme, hypnosis, has been introduced in lung cancer treatment. In order to verify the suggested method, six ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/574934
更新日期:2013-01-01 00:00:00
abstract:Background:The aim of this study was to examine whether oral propranolol has any effect on neurodevelopment outcomes in young children with problematic infantile hemangiomas (IHs). Methods:Thirty-six children with a diagnosis of problematic IH who were treated with oral propranolol were compared with 34 healthy childr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5821369
更新日期:2018-02-25 00:00:00
abstract::Sudden cardiac death is the main cause of mortality in patients affected by chronic heart failure (CHF) and with history of myocardial infarction. No study yet investigated the intra-QT phase spectral coherence as a possible tool in stratifying the arrhythmic susceptibility in patients at risk of sudden cardiac death ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/583035
更新日期:2014-01-01 00:00:00
abstract::The aim of the study was to find out whether peripheral blood leukocyte adiponectin receptors 1 and 2 (AdipoR1, AdipoR2) protein expression patterns (flow cytometry) differ between the primary hypertension children (n = 57) and healthy controls (n = 19) and if their expression levels are related to selected clinical p...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/742646
更新日期:2015-01-01 00:00:00
abstract::Objective. To evaluate the efficacy of bundle intervention on healthcare-associated (HA) methicillin-resistant Staphylococcus Aureus (MRSA) infection in the neonatal intensive care unit (NICU). Methods. In this study, 11,277 infants having undergone treatment at the NICU in Xiamen, China, from January 2014 to February...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5490413
更新日期:2019-07-10 00:00:00
abstract::Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the co...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1462802
更新日期:2018-09-12 00:00:00
abstract::This research assessed the seasonal variation of the chemical composition and antibacterial and anticholinesterase activities of essential oils extracted from M. longifolia leaves. The leaves organic fractions were also investigated for their biological activities and pharmacological functions. The essential oil highe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7856517
更新日期:2018-12-09 00:00:00
abstract::Leishmaniasis is a complex of diseases caused by protozoa of the genus Leishmania and affects millions of people around the world. Several species of plants are used by traditional communities for the treatment of this disease, among which is Carapa guianensis Aubl. (Meliaceae), popularly known as andiroba. The object...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5032816
更新日期:2018-09-06 00:00:00
abstract::The distribution of the induced electric field (E-field) during transcranial magnetic stimulation (TMS) depends on the individual anatomical structure of the brain as well as coil positioning. Inappropriate stimulation may degrade the efficacy of TMS or even induce adverse effects. Therefore, optimizing the E-field ac...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9461018
更新日期:2019-11-03 00:00:00
abstract::Rapid bone defect filling with normal bone is a challenge in orthopaedics and dentistry. Strontium ranelate (SrRan) has been shown to in vitro decrease bone resorption and increase bone formation, and represents a potential agent with the capacity to accelerate bone defect filling. In this study, bone tibial defects o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/549785
更新日期:2014-01-01 00:00:00
abstract:Objective:Comparison of outcomes between RIRS with vacuum-assisted ureteral access sheath (V-UAS) and MPCNL in the treatment of renal stone. Materials and Methods:28 patients with 2-4 cm renal stone were treated using RIRS with 14/16 F V-UAS. The outcomes were compared to those who underwent MPCNL with 16 F Amplatz sh...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8052013
更新日期:2020-05-14 00:00:00
abstract:OBJECTIVE:Radiopharmaceutical production process must adhere to current good manufacturing process (CGMP) compliance to ensure the quality of precursor, prodrug (active pharmaceutical ingredient, API), and the final drug product that meet acceptance criteria. We aimed to develop an automated system for production of CG...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/680195
更新日期:2014-01-01 00:00:00
abstract::Tankyrase (TNKS) plays important roles in the malignancy of several cancers such as human lung tumor, breast cancer, and hepatocellular cancer. However, its exact functions and molecular mechanisms in ovarian cancer remain unclear. In this study, we found that TNKS was aberrantly overexpressed in human ovarian cancer ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2686340
更新日期:2019-02-20 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/906356
更新日期:2015-01-01 00:00:00
abstract::It is well known that Down syndrome (DS) is a condition in which extra genetic material causes delays in the way a child develops, both mentally and physically. Intellectual disability is the foremost and most debilitating trait, which caused loss of cognitive abilities and the development of early onset Alzheimer's d...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/214618
更新日期:2015-01-01 00:00:00
abstract::Tau tubulin kinase 2 (TTBK2) is a kinase known to phosphorylate tau and tubulin. It has recently drawn much attention due to its involvement in multiple important cellular processes. Here, we review the current understanding of TTBK2, including its sequence, structure, binding sites, phosphorylation substrates, and ce...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/575170
更新日期:2015-01-01 00:00:00
abstract::Apc-mutated Pirc rats, spontaneously developing intestinal tumours, are resistant to 1,2-dimethylhydrazine- (DMH-) induced colon apoptosis. To understand this phenomenon, we analyzed the expression of genotoxic stress-related genes Mgmt, Gsta1, and Gstp1 in the colon of wt and Pirc rats in basal conditions and 24 h af...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1310342
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8370132
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9681424
更新日期:2019-10-13 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/471346
更新日期:2013-01-01 00:00:00
abstract::We have determined patient's amyloid subtype through immunohistochemical and proteomic analyses of formalin-fixed, paraffin-embedded (FFPE) tissue samples from two affected organs per patient. Amyloid typing, via immunohistochemistry (IHC) and laser microdissection followed by the combination of liquid chromatography ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3689091
更新日期:2019-01-31 00:00:00