Transcriptional and biochemical effects of cadmium and manganese on the defense system of Octopus vulgaris paralarvae.

Abstract:

:Due to anthropogenic activities the relative concentrations of cadmium and manganese have increased in the marine environment. Cephalopods are able to accumulate such metals and, as inhabitant of coastal waters, Octopus vulgaris is continuously exposed to anthropogenic activities. Since no study is available on the effects of heavy metals at molecular level in developing octopuses, herein we exposed 1-day-old paralarvae for 24 h to 10, 100, and 1000 μg/L of CdCl2 or MnCl2. Cd exerted a concentration-dependent inhibition of survival and a reduction in growth rate was shown while Mn exposure did not affect the survival rate even at the highest concentrations. Gene expression profiles of hsp70, sod, cat, and gst genes were analyzed by quantitative real-time PCR and defined patterns of transcription were observed. Moreover posttranscriptional analyses were also performed suggesting the impairment of metabolic functions, under strong oxidative conditions (as occurred in paralarvae exposed to Cd) or the complete detoxification events (as occurred in paralarvae exposed to Mn).

journal_name

Biomed Res Int

authors

Nicosia A,Salamone M,Mazzola S,Cuttitta A

doi

10.1155/2015/437328

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

437328

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

杂志文章
  • Clinical Features, Outcomes, and Risk Factors of Bloodstream Infections due to Stenotrophomonas maltophilia in a Tertiary-Care Hospital of China: A Retrospective Analysis.

    abstract::Background. Stenotrophomonas maltophilia bacteremia (SMB) is the most perilous situation as compared to other types of S. maltophilia infection. The present study aimed to investigate the clinical features, distribution, drug resistance, and predictors of survival of SMB in a tertiary-care hospital of China. Methods. ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/4931501

    authors: Chen Y,Suo J,Du M,Chen L,Liu Y,Wang L,Liang Z

    更新日期:2019-12-09 00:00:00

  • Ethanol extract of Cordyceps militaris grown on germinated soybeans attenuates dextran-sodium-sulfate- (DSS-) induced colitis by suppressing the expression of matrix metalloproteinases and inflammatory mediators.

    abstract::The effect of Cordyceps militaris (CM) grown on germinated soybeans (GSC) in the inflammatory bowel disease (IBD) model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS-) induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC si...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/102918

    authors: Park DK,Park HJ

    更新日期:2013-01-01 00:00:00

  • Phylogeography of Pteronotropis signipinnis, P. euryzonus, and the P. hypselopterus Complex (Teleostei: Cypriniformes), with Comments on Diversity and History of the Gulf and Atlantic Coastal Streams.

    abstract::The cyprinid genus Pteronotropis is endemic to southeastern Gulf of Mexico and Atlantic Ocean of North America. Never before has the genus been demonstrated to be monophyletic. We investigate both the phylogenetic relationships and the phylogeography of some species in the genus using mitochondrial ND2 sequences. In n...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/675260

    authors: Mayden RL,Allen J

    更新日期:2015-01-01 00:00:00

  • Laser Scanning In Vivo Confocal Microscopy of Clear Grafts after Penetrating Keratoplasty.

    abstract:PURPOSE:To evaluate the changes of keratocytes and dendritic cells in the central clear graft by laser scanning in vivo confocal microscopy after penetrating keratoplasty (PK). METHODS:Thirty adult subjects receiving PK at Shandong Eye Institute and with clear grafts and no sign of immune rejection after surgery were ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/5159746

    authors: Wang D,Song P,Wang S,Sun D,Wang Y,Zhang Y,Gao H

    更新日期:2016-01-01 00:00:00

  • N-(11)C-Methyl-Dopamine PET Imaging of Sympathetic Nerve Injury in a Swine Model of Acute Myocardial Ischemia: A Comparison with (13)N-Ammonia PET.

    abstract:OBJECTIVE:Using a swine model of acute myocardial ischemia, we sought to validate N-(11)C-methyl-dopamine ((11)C-MDA) as an agent capable of imaging cardiac sympathetic nerve injury. METHODS:Acute myocardial ischemia was surgically generated in Chinese minipigs. ECG and serum enzyme levels were used to detect the pres...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8430637

    authors: Zhou W,Wang X,He Y,Nie Y,Zhang G,Wang C,Wang C,Wang X

    更新日期:2016-01-01 00:00:00

  • Role of the eNOS-NO system in regulating the antiproteinuric effects of VEGF receptor 2 inhibition in diabetes.

    abstract::Subtle perturbations in intraglomerular VEGF/VEGFR-2 signaling or in the influencing microenvironment can profoundly affect renal function, resulting in the apparently paradoxical observation that VEGF blockade attenuates proteinuria development in experimental diabetes despite exerting the opposite effect under other...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/201475

    authors: Advani A,Connelly KA,Advani SL,Thai K,Zhang Y,Kelly DJ,Gilbert RE

    更新日期:2013-01-01 00:00:00

  • P2Y receptor modulation of ATP release in the urothelium.

    abstract::The release of ATP from the urothelium in response to stretch during filling demonstrates the importance of the purinergic system for the physiological functioning of the bladder. This study examined the effect of P2 receptor agonists on ATP release from two urothelial cell lines (RT4 and UROtsa cells). Hypotonic Kreb...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/830374

    authors: Mansfield KJ,Hughes JR

    更新日期:2014-01-01 00:00:00

  • A game system for cognitive rehabilitation.

    abstract::Brain injury such as traumatic brain injury (TBI) and stroke is the major cause of long-term disabilities in many countries. The increasing rate of brain damaged victims and the heterogeneity of impairments decrease rehabilitation effectiveness and competence resulting in higher cost of rehabilitation treatment. On th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/493562

    authors: Shapi'i A,Mat Zin NA,Elaklouk AM

    更新日期:2015-01-01 00:00:00

  • Bone-Healing Capacity of PCL/PLGA/Duck Beak Scaffold in Critical Bone Defects in a Rabbit Model.

    abstract::Bone defects are repaired using either natural or synthetic bone grafts. Poly(ϵ-caprolactone) (PCL), β-tricalcium phosphate (TCP), and poly(lactic-co-glycolic acid) (PLGA) are widely used as synthetic materials for tissue engineering. This study aimed to investigate the bone-healing capacity of PCL/PLGA/duck beak scaf...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2136215

    authors: Lee JY,Son SJ,Son JS,Kang SS,Choi SH

    更新日期:2016-01-01 00:00:00

  • Control of respiratory motion by hypnosis intervention during radiotherapy of lung cancer I.

    abstract::The uncertain position of lung tumor during radiotherapy compromises the treatment effect. To effectively control respiratory motion during radiotherapy of lung cancer without any side effects, a novel control scheme, hypnosis, has been introduced in lung cancer treatment. In order to verify the suggested method, six ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/574934

    authors: Li R,Deng J,Xie Y

    更新日期:2013-01-01 00:00:00

  • Effects of Propranolol on Neurodevelopmental Outcomes in Patients with Infantile Hemangioma: A Case-Control Study.

    abstract:Background:The aim of this study was to examine whether oral propranolol has any effect on neurodevelopment outcomes in young children with problematic infantile hemangiomas (IHs). Methods:Thirty-six children with a diagnosis of problematic IH who were treated with oral propranolol were compared with 34 healthy childr...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/5821369

    authors: Wang C,Wang Q,Xiang B,Chen S,Xiong F,Ji Y

    更新日期:2018-02-25 00:00:00

  • Intra-QT spectral coherence as a possible noninvasive marker of sustained ventricular tachycardia.

    abstract::Sudden cardiac death is the main cause of mortality in patients affected by chronic heart failure (CHF) and with history of myocardial infarction. No study yet investigated the intra-QT phase spectral coherence as a possible tool in stratifying the arrhythmic susceptibility in patients at risk of sudden cardiac death ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/583035

    authors: Piccirillo G,Moscucci F,Persi A,Di Barba D,Pappadà MA,Rossi P,Quaglione R,Nguyen BL,Barillà F,Casenghi M,Magrì D

    更新日期:2014-01-01 00:00:00

  • Expression of Adiponectin Receptors on Peripheral Blood Leukocytes of Hypertensive Children Is Associated with the Severity of Hypertension.

    abstract::The aim of the study was to find out whether peripheral blood leukocyte adiponectin receptors 1 and 2 (AdipoR1, AdipoR2) protein expression patterns (flow cytometry) differ between the primary hypertension children (n = 57) and healthy controls (n = 19) and if their expression levels are related to selected clinical p...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/742646

    authors: Gackowska L,Litwin M,Trojanek J,Eljaszewicz A,Kubiszewska I,Niemirska A,Wierzbicka A,Michalkiewicz J

    更新日期:2015-01-01 00:00:00

  • Impact of MRSA Transmission and Infection in a Neonatal Intensive Care Unit in China: A Bundle Intervention Study during 2014-2017.

    abstract::Objective. To evaluate the efficacy of bundle intervention on healthcare-associated (HA) methicillin-resistant Staphylococcus Aureus (MRSA) infection in the neonatal intensive care unit (NICU). Methods. In this study, 11,277 infants having undergone treatment at the NICU in Xiamen, China, from January 2014 to February...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5490413

    authors: Huang H,Ran J,Yang J,Li P,Zhuang G

    更新日期:2019-07-10 00:00:00

  • Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges.

    abstract::Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the co...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2018/1462802

    authors: Perše M,Večerić-Haler Ž

    更新日期:2018-09-12 00:00:00

  • Seasonal Variation in Essential Oils Composition and the Biological and Pharmaceutical Protective Effects of Mentha longifolia Leaves Grown in Tunisia.

    abstract::This research assessed the seasonal variation of the chemical composition and antibacterial and anticholinesterase activities of essential oils extracted from M. longifolia leaves. The leaves organic fractions were also investigated for their biological activities and pharmacological functions. The essential oil highe...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/7856517

    authors: Zouari-Bouassida K,Trigui M,Makni S,Jlaiel L,Tounsi S

    更新日期:2018-12-09 00:00:00

  • Carapa guianensis Aublet (Andiroba) Seed Oil: Chemical Composition and Antileishmanial Activity of Limonoid-Rich Fractions.

    abstract::Leishmaniasis is a complex of diseases caused by protozoa of the genus Leishmania and affects millions of people around the world. Several species of plants are used by traditional communities for the treatment of this disease, among which is Carapa guianensis Aubl. (Meliaceae), popularly known as andiroba. The object...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/5032816

    authors: Oliveira IDSDS,Moragas Tellis CJ,Chagas MDSDS,Behrens MD,Calabrese KDS,Abreu-Silva AL,Almeida-Souza F

    更新日期:2018-09-06 00:00:00

  • Particle Swarm Optimization for Positioning the Coil of Transcranial Magnetic Stimulation.

    abstract::The distribution of the induced electric field (E-field) during transcranial magnetic stimulation (TMS) depends on the individual anatomical structure of the brain as well as coil positioning. Inappropriate stimulation may degrade the efficacy of TMS or even induce adverse effects. Therefore, optimizing the E-field ac...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9461018

    authors: Li C,Liu C,Yang L,He L,Wu T

    更新日期:2019-11-03 00:00:00

  • Systemic treatment with strontium ranelate accelerates the filling of a bone defect and improves the material level properties of the healing bone.

    abstract::Rapid bone defect filling with normal bone is a challenge in orthopaedics and dentistry. Strontium ranelate (SrRan) has been shown to in vitro decrease bone resorption and increase bone formation, and represents a potential agent with the capacity to accelerate bone defect filling. In this study, bone tibial defects o...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/549785

    authors: Zacchetti G,Dayer R,Rizzoli R,Ammann P

    更新日期:2014-01-01 00:00:00

  • RIRS with Vacuum-Assisted Ureteral Access Sheath versus MPCNL for the Treatment of 2-4 cm Renal Stone.

    abstract:Objective:Comparison of outcomes between RIRS with vacuum-assisted ureteral access sheath (V-UAS) and MPCNL in the treatment of renal stone. Materials and Methods:28 patients with 2-4 cm renal stone were treated using RIRS with 14/16 F V-UAS. The outcomes were compared to those who underwent MPCNL with 16 F Amplatz sh...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8052013

    authors: Lai D,He Y,Li X,Chen M,Zeng X

    更新日期:2020-05-14 00:00:00

  • Design of CGMP production of 18F- and 68Ga-radiopharmaceuticals.

    abstract:OBJECTIVE:Radiopharmaceutical production process must adhere to current good manufacturing process (CGMP) compliance to ensure the quality of precursor, prodrug (active pharmaceutical ingredient, API), and the final drug product that meet acceptance criteria. We aimed to develop an automated system for production of CG...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/680195

    authors: Chi YT,Chu PC,Chao HY,Shieh WC,Chen CC

    更新日期:2014-01-01 00:00:00

  • Tankyrase Promotes Aerobic Glycolysis and Proliferation of Ovarian Cancer through Activation of Wnt/β-Catenin Signaling.

    abstract::Tankyrase (TNKS) plays important roles in the malignancy of several cancers such as human lung tumor, breast cancer, and hepatocellular cancer. However, its exact functions and molecular mechanisms in ovarian cancer remain unclear. In this study, we found that TNKS was aberrantly overexpressed in human ovarian cancer ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/2686340

    authors: Yang HY,Shen JX,Wang Y,Liu Y,Shen DY,Quan S

    更新日期:2019-02-20 00:00:00

  • A Fast Semiautomatic Algorithm for Centerline-Based Vocal Tract Segmentation.

    abstract::Vocal tract morphology is an important factor in voice production. Its analysis has potential implications for educational matters as well as medical issues like voice therapy. The knowledge of the complex adjustments in the spatial geometry of the vocal tract during phonation is still limited. For a major part, this ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/906356

    authors: Poznyakovskiy AA,Mainka A,Platzek I,Mürbe D

    更新日期:2015-01-01 00:00:00

  • Assessing apoptosis gene expression profiling with a PCR array in the hippocampus of Ts65Dn mice.

    abstract::It is well known that Down syndrome (DS) is a condition in which extra genetic material causes delays in the way a child develops, both mentally and physically. Intellectual disability is the foremost and most debilitating trait, which caused loss of cognitive abilities and the development of early onset Alzheimer's d...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/214618

    authors: Yu B,Zhang B,Zhou WB,Wang QW,Yuan P,Yang YQ,Kong J

    更新日期:2015-01-01 00:00:00

  • TTBK2: a tau protein kinase beyond tau phosphorylation.

    abstract::Tau tubulin kinase 2 (TTBK2) is a kinase known to phosphorylate tau and tubulin. It has recently drawn much attention due to its involvement in multiple important cellular processes. Here, we review the current understanding of TTBK2, including its sequence, structure, binding sites, phosphorylation substrates, and ce...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/575170

    authors: Liao JC,Yang TT,Weng RR,Kuo CT,Chang CW

    更新日期:2015-01-01 00:00:00

  • Gene Expression Profile of Colon Mucosa after Cytotoxic Insult in wt and Apc-Mutated Pirc Rats: Possible Relation to Resistance to Apoptosis during Carcinogenesis.

    abstract::Apc-mutated Pirc rats, spontaneously developing intestinal tumours, are resistant to 1,2-dimethylhydrazine- (DMH-) induced colon apoptosis. To understand this phenomenon, we analyzed the expression of genotoxic stress-related genes Mgmt, Gsta1, and Gstp1 in the colon of wt and Pirc rats in basal conditions and 24 h af...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/1310342

    authors: Femia AP,Luceri C,Lodovici M,Crucitta S,Caderni G

    更新日期:2016-01-01 00:00:00

  • A Prediction Model for Membrane Proteins Using Moments Based Features.

    abstract::The most expedient unit of the human body is its cell. Encapsulated within the cell are many infinitesimal entities and molecules which are protected by a cell membrane. The proteins that are associated with this lipid based bilayer cell membrane are known as membrane proteins and are considered to play a significant ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8370132

    authors: Butt AH,Khan SA,Jamil H,Rasool N,Khan YD

    更新日期:2016-01-01 00:00:00

  • Comparison of Clinical Outcomes of Two-Level PELD and Foraminoplasty PELD for Highly Migrated Disc Herniations: A Comparative Study.

    abstract:Objective:The aim of this study is to compare the clinical outcomes of two-level percutaneous endoscopic lumbar discectomy (PELD) and foraminoplasty PELD in treating highly migrated lumbar disc herniations. Methods:Patients with highly migrated lumbar disc herniations were enrolled from May 2014 to June 2016. Low back...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9681424

    authors: Wu X,Fan G,He S,Gu X,Yang Y

    更新日期:2019-10-13 00:00:00

  • Conformation-dependent high-affinity potent ricin-neutralizing monoclonal antibodies.

    abstract::Ricin is a potential biothreat agent with no approved antidote available for ricin poisoning. The aim of this study was to develop potent antibody-based antiricin antidotes. Four strong ricin resistant hybridoma clones secreting antiricin monoclonal antibodies (mAbs) were developed. All four mAbs are bound to conforma...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/471346

    authors: Hu WG,Yin J,Chau D,Hu CC,Lillico D,Yu J,Negrych LM,Cherwonogrodzky JW

    更新日期:2013-01-01 00:00:00

  • Mass Spectrometry Amyloid Typing Is Reproducible across Multiple Organ Sites.

    abstract::We have determined patient's amyloid subtype through immunohistochemical and proteomic analyses of formalin-fixed, paraffin-embedded (FFPE) tissue samples from two affected organs per patient. Amyloid typing, via immunohistochemistry (IHC) and laser microdissection followed by the combination of liquid chromatography ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/3689091

    authors: Holub D,Flodrova P,Pika T,Flodr P,Hajduch M,Dzubak P

    更新日期:2019-01-31 00:00:00